Article
Gastroenterology & Hepatology
Wen-Feng Hsu, Chi-Yang Chang, Chun-Chao Chang, Li-Chun Chang, Chien-Hua Chen, Chun-Che Lin, Yu-Min Lin, Chia-Long Lee, Hong-Yuan Wu, Hsin-Chung Lee, Yi-Chia Lee, Ming-Yao Su, Li-Ju Lin, Shu-Li Chia, Ming-Shiang Wu, Han-Mo Chiu
Summary: The study found that FIT-colonoscopy was associated with more than two-fold risk of significant bleeding, especially when polypectomy was performed.
Article
Biochemistry & Molecular Biology
Chia-Chun Chen, Pi-Yueh Chang, Yu-Sun Chang, Jeng-Fu You, Err-Cheng Chan, Jinn-Shiun Chen, Wen-Sy Tsai, Yen-Lin Huang, Chung-Wei Fan, Hung-Chih Hsu, Jy-Ming Chiang
Summary: This study identified a miRNA signature in stool samples that is associated with colorectal cancer (CRC). The miRNA signature showed high sensitivity and specificity in distinguishing CRC from control groups. It was also associated with poor outcome and can be used in combination with fecal immunochemical tests to identify high-risk individuals.
BIOMEDICAL JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Hongda Chen, Jufang Shi, Ming Lu, Yanjie Li, Lingbin Du, Xianzhen Liao, Donghua Wei, Dong Dong, Yi Gao, Chen Zhu, Rongbiao Ying, Weifang Zheng, Shipeng Yan, Haifan Xiao, Juan Zhang, Yunxin Kong, Furong Li, Shuangmei Zou, Chengcheng Liu, Hong Wang, Yuhan Zhang, Bin Lu, Chenyu Luo, Jie Cai, Jianbo Tian, Xiaoping Miao, Kefeng Ding, Hermann Brenner, Min Dai
Summary: This study compared the screening yield and cost of a risk-adapted screening approach with established screening strategies for population-based colorectal cancer screening. It found that the risk-adapted approach is a feasible and cost-effective strategy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Saray Duran-Sanchon, Lorena Moreno, Javier Gomez-Matas, Josep M. Auge, Miquel Serra-Burriel, Miriam Cuatrecasas, Leticia Moreira, Anna Serradesanferm, Angels Pozo, Jaume Grau, Maria Pellise, Meritxell Gironella, Antoni Castells
Summary: The miRFec algorithm can effectively identify individuals at highest risk for advanced colorectal neoplasia and differentiate patients with colorectal cancer from those with non-advanced adenomas or normal colonoscopy. By incorporating this algorithm, 34% of colonoscopies could be avoided, increasing the effectiveness and efficiency of FIT-based CRC screening programs.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Willemijn de Klaver, Pieter H. A. Wisse, Francine van Wifferen, Linda J. W. Bosch, Connie R. Jimenez, Rene W. M. van der Hulst, Remond J. A. Fijneman, Ernst J. Kuipers, Marjolein J. E. Greuter, Beatriz Carvalho, Manon C. W. Spaander, Evelien Dekker, Veerle M. H. Coupe, Meike de Wit, Gerrit A. Meijer
Summary: In this study, the multitarget FIT (mtFIT) showed improved diagnostic accuracy in detecting advanced neoplasia compared to FIT, particularly in detecting advanced adenomas. Early health technology assessment indicated that mtFIT-based screening could be cost-effective.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Robert S. Kerrison, Elizabeth Travis, Christina Dobson, Katriina L. Whitaker, Colin J. Rees, Stephen W. Duffy, Christian von Wagner
Summary: This study investigates the reasons why many people decline to undergo colonoscopy, identifying psychological, sociocultural, practical, health-related, and COVID-19-related factors as key barriers. Further studies with patients are needed to explore barriers to colonoscopy in depth.
PATIENT EDUCATION AND COUNSELING
(2022)
Article
Public, Environmental & Occupational Health
Yinan Ren, Mingye Zhao, Dachuang Zhou, Qian Xing, Fangfang Gong, Wenxi Tang
Summary: This study evaluated the cost-effectiveness of colorectal cancer screening in China and found that FIT screening can save costs, while colonoscopy is cost-effective. In specific regions, high-income areas could consider strategies with more frequent electronic colonoscopy.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Gregory C. Knapp, Olusegun Alatise, Bolatito Olopade, Marguerite Samson, Olalekan Olasehinde, Funmilola Wuraola, Oluwole O. Odujoko, Akinwunmi O. Komolafe, Olujide O. Arije, Philip E. Castle, J. Joshua Smith, Martin R. Weiser, T. Peter Kingham
Summary: This study evaluated the feasibility and performance of FIT for CRC screening in Nigeria, showing good results in terms of feasibility and performance. However, concerns were raised about the practicality and cost effectiveness of FIT in low-resource settings such as Nigeria due to high FIT positivity and low positive predictive value for advanced neoplasia.
Article
Multidisciplinary Sciences
Kertu Liis Krigul, Oliver Aasmets, Kreete Lull, Tonis Org, Elin Org
Summary: Colorectal cancer is a challenging public health problem and successful treatment depends on the stage at diagnosis. This study demonstrates that analyzing microbiome in FIT tubes for CRC screening programs is feasible and may improve the sensitivity of CRC detection.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
D. E. F. W. M. van Toledo, J. E. G. IJspeert, M. C. W. Spaander, I. D. Nagtegaal, M. E. van Leerdam, I. Lansdorp-Vogelaar, E. Dekker
Summary: By analyzing the results of colonoscopy, it was found that the simultaneous presence of high-risk serrated polyps and high-risk adenomas, or the presence of only high-risk serrated polyps, is associated with an increased risk of metachronous colorectal cancer.
Article
Gastroenterology & Hepatology
Joo Hyun Park, Kyung Hee Cho, Junho Choi, Sungyoun Chun, Jae Kwang Lee, Hyunsoon Cho, Bun Kim
Summary: This study investigated the risk factors for CRC in FIT-positive patients and found that non-compliance with the second round of screening was identified as a major risk factor for CRC development. It is recommended to establish appropriate strategies for managing patient risk factors to increase compliance with the second round of CRC screening.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
P. H. A. Wisse, W. de Klaver, F. van Wifferen, L. Meiqari, M. Bierkens, M. J. E. Greuter, B. Carvalho, M. E. van Leerdam, M. C. W. Spaander, E. Dekker, V. M. H. Coupe, M. de Wit, G. A. Meijer
Summary: This study aims to validate the relative sensitivity of mtFIT compared to FIT in colorectal cancer (CRC) screening, and predict the lifetime health effects and costs using the Adenoma and Serrated Pathway to Colorectal CAncer model. The results of this study will provide important clinical utility information for the Dutch national CRC screening program.
Article
Oncology
Mingqing Zhang, Lizhong Zhao, Yongdan Zhang, Haoren Jing, Lianbo Wei, Zhixuan Li, Haixiang Zhang, Yong Zhang, Siwei Zhu, Shiwu Zhang, Xipeng Zhang
Summary: The increase in colorectal cancer incidence in China poses a significant social burden. A screening program initiated in Tianjin since 2012 has shown that combining different screening methods for high-risk factor questionnaire (HRFQ) and fecal immunochemical test (FIT) is an effective strategy for detecting colorectal cancer, advanced adenoma, and polyps compared to using HRFQ or FIT alone. However, further improvements are needed to promote colonoscopy compliance.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ming Lu, Le Wang, Yuhan Zhang, Chengcheng Liu, Bin Lu, Lingbin Du, Xianzhen Liao, Dong Dong, Donghua Wei, Yi Gao, Jufang Shi, Jiansong Ren, Hongda Chen, Min Dai
Summary: The risk-adapted screening combining Asia-Pacific Colorectal Screening score, FIT, and colonoscopy showed higher sensitivity for advanced neoplasm but lower specificity compared to FIT alone. Adjusting the positivity threshold tailored to clinical practice could save colonoscopy resources and cost.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Olusegun Alatise, Anna J. Dare, Patrick A. Akinyemi, Fatimah B. Abdulkareem, Samuel A. Olatoke, Gregory C. Knapp, T. Peter Kingham
Summary: Colorectal cancer screening with qualitative fecal immunochemical tests in Nigeria is feasible and acceptable to average-risk asymptomatic participants. However, the low positive predictive value for advanced neoplasia and high endoscopy burden investigating false positives suggests it might not be an appropriate screening tool in this setting.
LANCET GLOBAL HEALTH
(2022)