☆ 4.4 Article

Blunted neural response to errors as a trait marker of melancholic depression

BIOLOGICAL PSYCHOLOGY (2016)

Journal

BIOLOGICAL PSYCHOLOGY

Volume 113, Issue -, Pages 100-107

Publisher

ELSEVIER SCIENCE BV

DOI: 10.1016/j.biopsycho.2015.11.012

Keywords

Error-related negativity; Melancholia; Vulnerability; Depression

Categories

Psychology, Biological Behavioral Sciences Psychology Psychology, Experimental

Funding

National Institute of Mental Health [RO1 MH098093]

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Abstract

Identification of biomarkers of vulnerability for Major Depressive Disorder is a high priority, but heterogeneity of the diagnosis can hinder research. Biomarkers of vulnerability should also be present in the absence of the diagnosis. The present study examined the magnitude of the error-related negativity (ERN), an event-related potential component following errors in a sample with remitted melancholic depression (N=17), remitted non-melancholic depression (N=33), and healthy controls (N=55). Remitted melancholic depression was uniquely characterized by a blunted ERN relative to the other two groups. Individuals with remitted non-melancholic depression did not differ from controls in the magnitude of the ERN. This was the case despite the fact that the melancholic and non-melancholic groups did not differ in course or severity of their past illnesses, or in their current functioning. Results suggest that the blunted ERN may be a viable vulnerability marker for melancholia. (C) 2015 Elsevier B.V. All rights reserved.

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Clinical Neurology

Neurocognitive correlates of psychological resilience: Event-related potential studies

Xu Ding, Huihua Fang, Yutong Liu, Lin Zheng, Xiangru Zhu, Hongxia Duan, Jianhui Wu

Summary: This study aimed to explore the relationship between trait resilience and bottom-up automatic information processing in healthy adults. The results showed that higher resilience was associated with slower automatic detection speed and lower sensory sensitivity.

JOURNAL OF AFFECTIVE DISORDERS (2022)

Add to Collection

Article Psychology, Biological

Better safe than sorry: Divergent error-related negativity and error positivity in shame-prone adolescents*

Franziska Martin, Martin Holtmann, Tanja Legenbauer

Summary: The present study examines the relationship between shame proneness and performance monitoring in adolescents, specifically looking at the influence of shame proneness on the correlation between depressive symptoms and error-related negativity (ERN) or error positivity (Pe) amplitudes. The study found that shame proneness and ERN amplitudes were correlated, suggesting the importance of further research on the relationship between shame proneness and punishment sensitivity.

INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY (2022)

Add to Collection

Article Psychology, Biological

Error-related brain activity in pediatric major depressive disorder: An ERP and time-frequency investigation

C. Dell'Acqua, G. Hajcak, N. Amir, N. J. Santopetro, C. J. Brush, A. Meyer

Summary: This study aimed to examine error monitoring in early adolescents with depression. Analysing EEG data in both time and time-frequency domains, it revealed reduced ERN amplitude, reduced error-related theta power, and increased error-related beta power in the depression group compared to the control group. Furthermore, both theta and beta power were independently related to an increased likelihood of being diagnosed with depression, while the ERN was not.

INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY (2023)

Add to Collection

Article Psychology, Biological

Early correlates of error-related brain activity predict subjective timing of error awareness

Francesco Di Gregorio, Martin E. Maier, Marco Steinhauser

Summary: Humans are reliable in detecting errors in their behavior. Early error sensations refer to the subjective feeling of detecting an error before the erroneous response was executed. EEG results showed that early error sensations are associated with an earlier peak of the error-related negativity (Ne/ERN), indicating that early error-related activity influences metacognitive judgments on the time course of error awareness and contributes to error awareness.

PSYCHOPHYSIOLOGY (2022)

Add to Collection

Article Behavioral Sciences

A dimensional approach to the neuronal correlates of anxiety, depression, and perfectionism: A transdiagnostic dissociation of error-related brain activity

Ines Macedo, Rita Pasion, Fernando Barbosa, Fernando Ferreira-Santos

Summary: The study found that anxiety emerged as the main explanation for altered patterns of error monitoring in a transdiagnostic sample. Anxiety predicted increased ERN amplitudes, while perfectionism did not show significant results. Exploratory analyses revealed that anxiety and physiological depression led to a reduction in the Error Positivity component (Pe).

BEHAVIOURAL BRAIN RESEARCH (2021)

Add to Collection

Review Psychology, Biological

Age-related differences in the error-related negativity and error positivity in children and adolescents are moderated by sample and methodological characteristics: A meta-analysis

Rune Boen, Daniel S. Quintana, Cecile D. Ladouceur, Christian K. Tamnes

Summary: This study investigated the age and age moderation effects on error-related negativity (ERN) and error positivity (Pe) during development. The results showed that age was negatively associated with ERN, but not significantly associated with Pe, except for in a group comparison between younger and older adolescents. Task type and electrode site were found to moderate the age effects on ERN and Pe.

PSYCHOPHYSIOLOGY (2022)

Add to Collection

Article Neurosciences

The Event-Related Potentials Responding to Outcome Valence and Expectancy Violation during Feedback Processing

Yan Gu, Tianliang Liu, Xuemeng Zhang, Quanshan Long, Na Hu, Yi Zhang, Antao Chen

Summary: FRN is believed to encode reward prediction error, but studies have conflicting views on whether it reflects unsigned or signed prediction error. It is unclear if FRN is sensitive to the interaction of outcome valence and prediction error, or simply responsive to the absolute size of prediction error. The study demonstrates that FRN is sensitive to outcome valence and expectancy violation, exhibiting a preferential response depending on the emphasized dimension.

CEREBRAL CORTEX (2021)

Add to Collection

Article Psychiatry

Methods for quantifying the heterogeneity of psychopathology

John F. Buss, Ashley L. Watts, Lorenzo Lorenzo-Luaces

Summary: Specifiers for major depressive disorder are designed to reduce diagnostic heterogeneity, but recent literature challenges their effectiveness. This study uses distance metrics to quantify symptom heterogeneity and finds that the specifiers for atypical and melancholic depression do not significantly reduce heterogeneity.

BMC PSYCHIATRY (2023)

Add to Collection

Article Psychiatry

Heterogeneity in major depression and its melancholic and atypical specifiers: a secondary analysis of STAR*D

Lorenzo Lorenzo-Luaces, John F. Buss, Eiko Fried

Summary: The study aimed to investigate whether melancholic and atypical specifiers reduce heterogeneity in symptom presentation among patients with depression. The results indicated that there was more observed heterogeneity within the melancholic and atypical subgroups when considering the specifier and depressive symptoms. The study found no evidence that the specifiers decrease symptom heterogeneity, as most symptom profiles even in the specifier subgroups had five or fewer individuals.

BMC PSYCHIATRY (2021)

Add to Collection

Editorial Material Neurosciences

A commentary on establishing norms for error-related brain activity during the arrow flanker task among young adults

Peter E. Clayson, Emily S. Kappenman, William J. Gehring, Gregory A. Miller, Michael J. Larson

Summary: The large data set for ERN and Pe components of scalp-recorded ERP is not yet ready for use in research and especially clinical applications due to incomplete understanding of amplitude differences, lack of method standardization, and use of convenience samples. More research is encouraged to understand ERN score differences and factors influencing variation, as well as dissemination of protocols for data collection and processing to move towards standardization and useful norms in ERP studies.

NEUROIMAGE (2021)

Add to Collection

Article Psychiatry

The utility of the Sydney Melancholia Prototype Index (SMPI) for predicting response to electroconvulsive therapy in depression: A CARE Network study

S. Waite, P. C. Tor, T. Mohan, D. Davidson, S. Hussain, V. Dong, C. K. Loo, D. M. Martin

Summary: An enhanced understanding of clinical predictors of positive ECT outcome could assist with treatment decisions. Reliable predictors such as psychotic symptoms and age have been identified, but studies on melancholia and ECT response have been inconsistent.

JOURNAL OF PSYCHIATRIC RESEARCH (2022)

Add to Collection

Article Clinical Neurology

Incidence of melancholic depression by age of onset and gender in the Lundby population, 1947-1997

Linnea Nobbelin, Mats Bogren, Cecilia Mattisson, Louise Bradvik

Summary: This study investigates the incidence rates and characteristics of melancholic depression in the Lundby population. The results show that the incidence rate of melancholic depression is low, with a higher rate in females and a peak in the age group of 40-49. There is also a gender difference in the incidence rates of different types of depression.

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2023)

Add to Collection

Article Psychology, Clinical

A randomized trial of aerobic exercise for major depression: examining neural indicators of reward and cognitive control as predictors and treatment targets

C. J. Brush, Greg Hajcak, Anthony J. Bocchine, Andrew A. Ude, Kristina M. Muniz, Dan Foti, Brandon L. Alderman

Summary: Aerobic exercise is effective in alleviating depressive symptoms in adults with major depression, particularly for those with increased symptom severity and a larger reward processing at baseline. Although aerobic exercise did not modify the reward processing and cognitive control, there is preliminary support for the utility of reward processing in predicting response to exercise as a treatment for depression.

PSYCHOLOGICAL MEDICINE (2022)

Add to Collection

Article Psychology, Biological

Hormonal contraceptive use moderates the association between worry and error-related brain activity

Courtney C. C. Louis, Chelsea Kneip, Tim P. P. Moran, Adriene M. M. Beltz, Kelly L. L. Klump, Jason S. S. Moser

Summary: This study found that there is a significant association between anxiety and error-related cognitive control mechanism called ERN in women. The relationship is more significant in women using hormonal contraceptives compared to those who are not.

INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY (2022)

Add to Collection

Article Psychology, Multidisciplinary

Understanding Trajectories to Anxiety and Depression: Neural Responses to Errors and Rewards as Indices of Susceptibility to Stressful Life Events

Anna Weinberg, Autumn Kujawa, Anja Riesel

Summary: This article discusses the impact of neural responses to errors and rewards on depression and anxiety, and proposes that exposure to stressful life events may play a crucial role in determining the outcome of these responses.

CURRENT DIRECTIONS IN PSYCHOLOGICAL SCIENCE (2022)

Add to Collection

Article Neurosciences

P3 amplitude attenuation secondary to increases in target-to-target interval (TTI) during spatial serial order recall: implications for EEG models of working memory function

William C. Hochberger, Jenna L. Axelrod, Casey Sarapas, Stewart A. Shankman, S. Kristian Hill

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2018)

Add to Collection

Article Clinical Neurology

Considering sex differences clarifies the effects of depression on facial emotion processing during fMRI

L. M. Jenkins, A. D. Kendall, M. T. Kassel, V. G. Patron, J. R. Gowins, C. Dion, S. A. Shankman, S. L. Weisenbach, P. Maki, S. A. Langenecker

JOURNAL OF AFFECTIVE DISORDERS (2018)

Add to Collection

Article Psychiatry

Trait attentional control modulates neurofunctional response to threat distractors in anxiety and depression

Heide Klumpp, Kerry L. Kinney, Amy E. Kennedy, Stewart A. Shankman, Scott A. Langenecker, Anand Kumar, K. Luan Phan

JOURNAL OF PSYCHIATRIC RESEARCH (2018)

Add to Collection

Article Psychology, Biological

Effect of Comorbid Post-Traumatic Stress Disorder and Panic Disorder on Defensive Responding

Andrea C. Katz, Anna Weinberg, Stephanie M. Gorka, Randy P. Auerbach, Stewart A. Shankman

JOURNAL OF PSYCHOPHYSIOLOGY (2018)

Add to Collection

Article Clinical Neurology

Multidimensional imaging techniques for prediction of treatment response in major depressive disorder

Scott A. Langenecker, Heide Klumpp, Amy T. Peters, Natania A. Crane, Sophie R. DelDonno, Katie L. Bessette, Olusola Ajilore, Alex Leow, Stewart A. Shankman, Sara J. Walker, Michael T. Ransom, David T. Hsu, K. Luan Phan, Jon-Kar Zubieta, Brian J. Mickey, Jonathan P. Stange

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2019)

Add to Collection

Article Psychiatry

Altered selection during language processing in individuals at high risk for psychosis

Teresa Vargas, Hannah Snyder, Marie Banich, Rae Newberry, Stewart A. Shankrnan, Gregory P. Strauss, Vijay Anand Mittal

SCHIZOPHRENIA RESEARCH (2018)

Add to Collection

Editorial Material Psychology, Clinical

The utility of an RDoC motor domain to understand psychomotor symptoms in depression

S. Walther, J. A. Bernard, V. A. Mittal, S. A. Shankman

PSYCHOLOGICAL MEDICINE (2019)

Add to Collection

Article Psychology, Clinical

The Titrated Monetary Incentive Delay Task: Sensitivity, convergent and divergent validity, and neural correlates in an RDoC sample

Sophie R. DelDonno, Aimee James Karstens, Brian Cerny, Leah R. Kling, Lisanne M. Jenkins, Jonathan P. Stange, Robin Nusslock, Stewart A. Shankman, Scott A. Langenecker

JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY (2019)

Add to Collection

Article Psychiatry

Startle during threat longitudinally predicts functional impairment independent of DSM diagnoses

Elizabeth S. Stevens, Lynne Lieberman, Carter J. Funkhouser, Kelly A. Correa, Stewart A. Shankman

PSYCHIATRY RESEARCH (2019)

Add to Collection

Article Psychology, Biological

Blunted neural response to gains versus losses associated with both risk-prone and risk-averse behavior in a clinically diverse sample

Ashley A. Huggins, Anna Weinberg, Stephanie M. Gorka, Stewart A. Shankman

PSYCHOPHYSIOLOGY (2019)

Add to Collection

Article Clinical Neurology

Error-related neural activity and alcohol use disorder: Differences from risk to remission

Stephanie M. Gorka, Lynne Lieberman, Kayla A. Kreutzer, Vivian Carrillo, Anna Weinberg, Stewart A. Shankman

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2019)

Add to Collection

Article Clinical Neurology

Inhibition Predicts the Course of Depression and Anxiety Symptoms Among Adolescents The Moderating Role of Familial Risk

Elizabeth S. S. Stevens, Carter J. J. Funkhouser, Randy P. P. Auerbach, Ardesheer Talati, Marc G. G. Gameroff, Jonathan E. E. Posner, Myrna M. M. Weissman, Stewart A. A. Shankman

Summary: Numerous theoretical models suggest that difficulties in inhibiting automatic responses contribute to the onset and/or maintenance of internalizing symptoms. Inhibition deficits and internalizing disorders have a familial and genetic association, indicating that inhibition deficits may be a significant predictor of internalizing symptoms in individuals with high familial risk. This longitudinal study examined the prospective associations between inhibition and anxiety and depressive symptoms in a sample transitioning from adolescence to early adulthood. The results showed that poor inhibition predicted higher levels of anxiety and depressive symptoms in individuals with high familial risk for major depressive disorder, supporting impaired inhibition as an indicator of risk for later internalizing symptoms in high-risk individuals.

JOURNAL OF NERVOUS AND MENTAL DISEASE (2023)

Add to Collection

Article Psychology, Clinical

The role of intolerance of uncertainty in current and remitted internalizing and externalizing psychopathology

Kelly A. Correa, Huiting Liu, Stewart A. Shankman

JOURNAL OF ANXIETY DISORDERS (2019)

Add to Collection

Article Psychology, Clinical

Positive and Negative Emotionality at Age 3 Predicts Change in Frontal EEG Asymmetry across Early Childhood

Brandon L. Goldstein, Stewart A. Shankman, Autumn Kujawa, Dana C. Torpey-Newman, Margaret W. Dyson, Thomas M. Olino, Daniel N. Klein

JOURNAL OF ABNORMAL CHILD PSYCHOLOGY (2019)

Add to Collection

Article Psychology, Clinical

Neural Responsiveness to Reward as an Index of Depressive Symptom Change Following Cognitive-Behavioral Therapy and SSRI Treatment

Katie L. Burkhouse, Stephanie M. Gorka, Heide Klumpp, Amy E. Kennedy, Shannon Karich, Jennifer Francis, Olusola Ajilore, Michelle G. Craske, Scott A. Langenecker, Stewart A. Shankman, Greg Hajcak, K. Luan Phan

JOURNAL OF CLINICAL PSYCHIATRY (2018)

Add to Collection

Review Psychology, Biological

Two's company: Biobehavioral research with dyads

Robert W. Levenson

Summary: This article describes the development of paradigms for studying dyadic interaction in the laboratory, methods, and analytics for dealing with dyadic data. It provides research findings from the author and others, with a particular focus on dyadic measures of linkage or synchrony in physiology, expressive behavior, and subjective affective experience.

BIOLOGICAL PSYCHOLOGY (2024)

Add to Collection

Article Psychology, Biological

Neural activation and connectivity in offspring of depressed mothers during monetary and social reward tasks

Thomas M. Olino, Matthew Mattoni

Summary: This study examined brain function in offspring of mothers with and without depression using monetary and social reward tasks. The results showed no significant differences in task activation and functional connectivity between the two groups. The study discussed the possibility of developmental timing in finding differences.

BIOLOGICAL PSYCHOLOGY (2024)

Add to Collection

© Peeref 2019-2024. All rights reserved.