Article
Immunology
Joske Hoes, Audrey J. King, Tessa M. Schurink-van 't Klooster, Johannes Berkhof, Johannes A. Bogaards, Hester E. de Melker
Summary: The bivalent HPV vaccine administered in a 2-dose schedule has proven to be highly effective in preventing HPV infections among preadolescent girls in the Netherlands, with a 4-year postvaccination effectiveness rate of 84.0% against HPV-16/18 and 86.5% against cross-protective types HPV-31/33/45.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Mingzhu Li, Chao Zhao, Yun Zhao, Jingran Li, Lihui Wei
Summary: The incidence rate and mortality rate of cervical cancer have been increasing among young women in China. To address this, it is crucial to improve HPV vaccination rates, especially among the younger population. China currently offers five types of HPV vaccines, all of which have undergone clinical trials and have been proven to be safe, effective, and immunogenic in preventing persistent HPV infections and genital precancerous lesions. However, the low vaccination rate in China calls for increased efforts to reduce the incidence and mortality rates of cervical cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ngiap Chuan Tan, Qifan Tan, Wai Keong Aau, Chung Wai Mark Ng
Summary: Changes to the national childhood immunization schedule in Singapore have increased vaccination uptake and reduced healthcare costs. The new schedule includes additional vaccines and reduces the number of clinic visits required.
Article
Immunology
Marisa M. Mussi-Pinhata, Shawn Ward, Lauren Laimon, Stephen Pelton, Jennifer Canniff, Amanda Golner, Frederic Bone, Lassallete Newton, Petronella Muresan, Terence Fenton, Michael J. Johnson, Esau C. Joao, Breno R. Santos, Jose H. Pilotto, Ricardo H. Oliveira, Jorge A. Pinto, Andrea G. B. L. Dal Bo, Regis Kreitchmann, Nahida Chakhtoura, Geraldo Duarte, Adriana Weinberg
Summary: Infants born to PCV-10 immunized mothers had lower antibody responses and seroprotection after the primary immunization with PCV-10 compared to infants born to PPV-23 or placebo recipients. Administration of PPV-23 may be preferred over PCV-10 in pregnant women with HIV.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Kathy Baisley, Troy J. Kemp, Aimee R. Kreimer, Partha Basu, John Changalucha, Allan Hildesheim, Carolina Porras, Hilary Whitworth, Rolando Herrero, Charles J. Lacey, John T. Schiller, Eric Lucas, Paul Mutani, Joakim Dillner, Jackton Indangasi, Richard Muwonge, Richard J. Hayes, Ligia A. Pinto, Deborah Watson-Jones
Summary: A study in Tanzania found that one dose of HPV vaccine might provide sufficient protection against persistent HPV infection. A one-dose schedule would reduce costs, simplify vaccine delivery, and expand access to the vaccine.
LANCET GLOBAL HEALTH
(2022)
Article
Multidisciplinary Sciences
Nathaniel S. Chapman, Ruben J. G. Hulswit, Jonna L. B. Westover, Robert Stass, Guido C. Paesen, Elad Binshtein, Joseph X. Reidy, Taylor B. Engdahl, Laura S. Handal, Alejandra Flores, Brian B. Gowen, Thomas A. Bowden, James E. Crowe
Summary: This article describes a dual-mechanism human monoclonal antibody combination against RVFV that shows potent efficacy in a mouse model, highlighting its potential for future use in combating RVFV infection.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Nastiti Kaswandani, Bernie Endyarni Medise, Elcha Leonard, Hindra Irawan Satari, Julitasari Sundoro, Sri Rezeki Harun Hadinegoro, Ade Putra, Putra Fajar Angkasa
Summary: This study evaluated the incidence rate and severity of Adverse Events Following Immunization (AEFI) of inactivated SARS-CoV-2 vaccine in Indonesia from the first quarter of 2021 to the second quarter of 2022. The results showed that the Sinovac/CoronaVac vaccine used in Indonesia is safe, with most adverse events classified as unrelated to the vaccine or coincidental events.
Article
Biotechnology & Applied Microbiology
Abraham Aragones, Francesca Gany, Andrea Kaplan, Denise Bruno
Summary: This study evaluated potential opportunities for discussing the HPV vaccine during a recent primary care provider visit for Latino parents of 9-10-year-old children in New York City. The majority of parents reported not discussing or receiving a recommendation for the vaccine during that visit. Lowering the recommended age for routine HPV vaccination to 9-10 years old could be an important strategy to increase vaccination rates among Latino populations.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Review
Biotechnology & Applied Microbiology
Aneisha Collins-Fairclough, Robine Donken, Bohdan Nosyk, Simon Dobson, Gina Ogilivie, Manish Sadarangani
Summary: The study found that a 12-month interval for HPV vaccination is non-inferior to a 6-month interval, with inconclusive results for intervals of 36-96 months. This suggests that HPV immunization programs could adopt a 12-month interval to increase flexibility without compromising immunogenicity. Further evaluation is needed to confirm the effectiveness of intervals beyond 12 months.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Review
Dermatology
Farhat Fatima, Satarupa Kumar, Anupam Das
Summary: In this review, the importance of sexually transmitted infections (STI) was highlighted as a major concern for physicians. Despite progress in diagnosing and treating STIs, there is a need for the development of effective and safe vaccines. The current status, gaps, and areas for future research in STI vaccine development were summarized.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Kristen A. Clarkson, Kawsar R. Talaat, Cristina Alaimo, Patricia Martin, A. Louis Bourgeois, Anita Dreyer, Chad K. Porter, Subhra Chakraborty, Jessica Brubaker, Daniel Elwood, Rahel Frolich, Barbara DeNearing, Hailey P. Weerts, Brittany Feijoo, Jane Halpern, David Sack, Mark S. Riddle, Veronica Gambillara Fonck, Robert W. Kaminski
Summary: The Flexyn2a vaccine induces specific immune responses, such as serum IgG responses, which are associated with protection against shigellosis. Additionally, Flexyn2a increases memory B cell responses, bactericidal antibodies, and serum IgA levels in vaccinees protected against shigellosis. Flexyn2a also induces gut-homing, LPS-specific IgG and IgA secreting B cells, indicating immune effectors functioning at the site of intestinal infection.
Article
Oncology
Melissa Bersanelli, Diana Giannarelli, Ugo De Giorgi, Sandro Pignata, Massimo Di Maio, Alberto Clemente, Elena Verzoni, Raffaele Giusti, Marilena Di Napoli, Giuseppe Aprile, Paola Ermacora, Annamaria Catino, Vieri Scotti, Francesca Mazzoni, Pamela Francesca Guglielmini, Antonello Veccia, Marco Maruzzo, Ernesto Rossi, Francesco Grossi, Chiara Casadei, Corrado Ficorella, Vincenzo Montesarchio, Francesco Verderame, Mimma Rizzo, Giorgia Guaitoli, Lucia Fratino, Caterina Accettura, Manlio Mencoboni, Fable Zustovich, Cinzia Baldessari, Saverio Cinieri, Andrea Camerini, Letizia Laera, Mariella Soraru, Paolo Andrea Zucali, Valentina Guadalupi, Francesco Leonardi, Marcello Tiseo, Michele Tognetto, Francesco Di Costanzo, Carmine Pinto, Giorgia Negrini, Antonio Russo, Maria R. Migliorino, Marco Filetti, Sebastiano Buti
Summary: The study shows that influenza vaccination in patients with advanced cancer receiving immunotherapy can reduce the incidence of influenza-like illness, decrease ILI complications, and improve survival rates.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biotechnology & Applied Microbiology
Suzanne M. Garland, Manjula Anagani, Neerja Bhatla, Sukanta Chatterjee, Sanjay Lalwani, Cecil Ross, Thomas Group, Jianxin Lin, Alain Luxembourg, Anuj Walia, Yingmei Tu
Summary: The quadrivalent and 9-valent human papillomavirus vaccines have shown efficacy, immunogenicity, and safety in clinical trials conducted in India. They induced robust antibody responses and were well tolerated by the participants.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Yue-Mei Hu, Zhao-Feng Bi, Ya Zheng, Li Zhang, Feng-Zhu Zheng, Kai Chu, Ya-Fei Li, Qi Chen, Jia-Li Quan, Xiao-Wen Hu, Xing-Cheng Huang, Kong-Xin Zhu, Ya-Hui Wang-Jiang, Han -Min Jiang, Xia Zang, Dong-Lin Liu, Chang -Lin Yang, Hong-Xing Pan, Qiu-Fen Zhang, Ying-Ying Su, Shou-Jie Huang, Guang Sun, Wei-Jin Huang, Yue Huang, Ting Wu, Jun Zhang, Ning-Shao Xia
Summary: This study evaluated the immunogenicity and safety of the Escherichia coli-produced second-generation nonavalent HPV vaccine (Cecolin 9). The results showed that Cecolin 9 had good immunogenicity against all nine HPV types and was well tolerated.
Article
Immunology
Jamiyah Hassan, Teck-Hock Toh, Selva Kumar Sivapunniam, Ruziaton Hasim, Nor Faizah Ghazali, Sofiah Sulaiman, Mia Tuang Koh, Stephanie Meyer, Myew-Ling Toh, Celine Zocchetti, Claire Vigne, Cesar Mascarenas
Summary: The study conducted in Malaysia among healthy children aged 9-13 found that the immunogenicity and safety profiles of CYD-TDV and quadrivalent HPV vaccines were unaffected when administered concomitantly or sequentially in dengue-seropositive participants. There were no safety concerns identified, and antibody titers for both HPV and dengue were similar between treatment groups.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Immunology
Frederik Schaltz-Buchholzer, Peter Aaby, Isaquel Silva, Ivan Monteiro, Tobias R. Kollmann, Nelly Amenyogbe, Morten Bjerregaard-Andersen, Christine Stabell Benn
Summary: This study suggests that maternal BCG vaccine may be associated with reduced overall NICU mortality rate in newborns.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Clinical Neurology
Carmen Yea, Michelle Barton, Ari Bitnun, Shaun K. Morris, Tala El Tal, Rolando Ulloa-Gutierrez, Helena Brenes-Chacon, Adriana Yock-Corrales, Gabriela Ivankovich-Escoto, Alejandra Soriano-Fallas, Marcela Hernandez-de Mezerville, Peter Gill, Alireza Nateghian, Behzad Haghighi Aski, Ali Anari Manafi, Rachel Dwilow, Jared Bullard, Jesse Papenburg, Rosie Scuccimarri, Marie-Astrid Lefebvre, Suzette Cooke, Tammie Dewan, Lea Restivo, Alison Lopez, Manish Sadarangani, Ashley Roberts, Jacqueline Wong, Nicole Le Saux, Jennifer Bowes, Rupeena Purewal, Janell Lautermilch, Cheryl Foo, Joanna Merckx, Joan Robinson, E. Ann Yeh
Summary: This multicenter observational study aimed to describe the characteristics and prevalence of neurological involvement in hospitalized pediatric patients with SARS-CoV-2. The results showed that approximately 21% of hospitalized children had neurological signs/symptoms, with headache, encephalopathy, and seizures being the most reported. Factors associated with neurological involvement included ICU admission, satisfaction of MIS-C criteria, fever during hospitalization, and gastrointestinal involvement.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Review
Parasitology
Wenna Lee, Amanda D. Barbosa, Peter J. Irwin, Andrew Currie, Tobias R. Kollmann, Miles Beaman, Amy H. Lee, Charlotte L. Oskam
Summary: Tick-borne diseases pose a growing global health concern, and the immunological responses and inter-individual variations after tick bite remain unclear. By integrating clinical metadata and biological host data using advanced computational tools, we can gain a better understanding of tick-associated illnesses. This review emphasizes the importance of integrative system biology approaches for comprehending the complex pathobiology of tick-borne diseases.
TRENDS IN PARASITOLOGY
(2023)
Article
Immunology
Benjamin Malo, Fabienne Labbe, Samantha B. Meyer, Eric Filice, Janice E. Graham, Noni E. MacDonald, Julie A. Bettinger, Devon Greyson, Shannon E. MacDonald, S. Michelle Driedger, Gregory Kawchuk, Eve Dube
Summary: This study examined the vaccination perspectives of naturopathy practitioners in Quebec, Canada. The findings showed that naturopaths discuss vaccination in their practice only when clients ask questions or seek advice. They refrain from explicitly recommending for or against vaccination and instead focus on empowering clients to make their own informed decision. Discussions with clients about vaccination include discussing risks and benefits in a personalized and individual approach.
Article
Health Care Sciences & Services
Marian Orhierhor, Wendy Pringle, Donna Halperin, Janet Parsons, Scott A. Halperin, Julie A. Bettinger
Summary: This study examines the impact of COVID-19 on healthcare workers in British Columbia and summarizes effective measures and strategies for pandemic management.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Infectious Diseases
Tilmann Schober, Shaun K. Morris, Julie A. Bettinger, Catherine Burton, Scott A. Halperin, Taj Jadavji, Kescha Kazmi, Jacqueline Modler, Manish Sadarangani, Jesse Papenburg
Summary: The aim of this study was to determine the characteristics associated with inappropriate antibiotic use among children hospitalized for influenza. The results showed that over two-thirds of hospitalized children received antibiotics, including over half of those without an appropriate indication for antibiotic treatment. Differences among study centers suggest the importance of contextual determinants of antibiotic use.
Article
Public, Environmental & Occupational Health
Marilou Kiely, Fazia Tadount, Ernest Lo, Manish Sadarangani, Shu Qin Wei, Ellen Rafferty, Caroline Quach, Shannon E. Macdonald
Summary: This study found that females have a higher risk of adverse reactions following influenza vaccines compared to males, regardless of age and vaccine type. Transparent communication of this risk could increase trust in vaccines and reduce vaccine hesitancy.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Bahaa Abu-Raya, Mirjam J. Esser, Eve Nakabembe, Jesus Reine, Kyle Amaral, Annieck M. Diks, Esther Imede, Sing Sing Way, Ali M. Harandi, Andrew Gorringe, Kirsty Le Doare, Scott A. Halperin, Magdalena A. Berkowska, Manish Sadarangani
Summary: Neither immunization nor recovery from natural infection provides life-long protection against Bordetella pertussis. Replacement of a whole-cell pertussis (wP) vaccine with an acellular pertussis (aP) vaccine, mutations in B. pertussis strains, and better diagnostic techniques contribute to the resurgence of the number of cases especially in young infants. Development of new immunization strategies relies on a comprehensive understanding of the immune system responses to infection and immunization and how triggering these immune components would ensure protective immunity.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Pediatrics
Brian Condran, Melissa Kervin, Catherine Burton, Tom D. Blydt-Hanson, Shaun K. Morris, Manish Sadarangani, Anthony Otley, Elaine Yong, Hana Mitchell, Julie A. Bettinger, Karina A. Top
Summary: The study found that while some parents were still confused by the previously believed absolute contraindication of live attenuated varicella vaccine, they also demonstrated adaptive leadership skills in protecting their children from infectious diseases.
PEDIATRIC TRANSPLANTATION
(2023)
Article
Immunology
Caroline E. Munoz, Anne Pham-Huy, Jeffrey M. Pernica, Gaston De Serres, Wendy Vaudry, Cora Constantinescu, Manish Sadarangani, Julie A. Bettinger, Bruce Tapiero, Shaun K. Morris, Athena McConnell, Francisco Noya, Scott A. Halperin, Karina A. Top
Summary: This study examined the factors associated with physician recommendation for revaccination and participant intention to be revaccinated among patients with adverse events following immunization (AEFIs). The type and impact of the AEFI were found to influence physician recommendation and participant intention for revaccination. The findings can provide valuable guidance for counseling patients with AEFIs.
Article
Medicine, General & Internal
Malou Bourdeau, Nirma Khatri Vadlamudi, Nathalie Bastien, Joanne Embree, Scott A. Halperin, Taj Jadavji, Kescha Kazmi, Joanne M. Langley, Marc H. Lebel, Nicole Le Saux, Dorothy Moore, Shaun K. Morris, Jeffrey M. Pernica, Joan Robinson, Manish Sadarangani, Julie A. Bettinger, Jesse Papenburg
Summary: This study provides an overview of the epidemiology and burden of RSV-associated hospitalizations among children and adolescents in Canadian tertiary pediatric hospitals from 2017 to 2022. The findings show that the number of RSV hospitalizations increased during this period, particularly during the COVID-19 pandemic. However, the severity of illness did not change compared to the prepandemic period.
Article
Medicine, General & Internal
Laure F. Pittet, Cecilia L. Moore, Ellie McDonald, Simone Barry, Marc Bonten, John Campbell, Julio Croda, Margareth Dalcolmo, Andrew Davidson, Mark W. Douglas, Kaya Gardiner, Amanda Gwee, Bruno Jardim, Marcus V. G. Lacerda, Michaela Lucas, David J. Lynn, Laurens Manning, Roberto D. de Oliveira, Kirsten P. Perrett, Cristina Prat-Aymerich, Peter C. Richmond, Jorge L. Rocha, Jesus Rodriguez-Bano, Adilia Warris, Nicholas J. Woods, Nicole L. Messina, Nigel Curtis
Summary: This study aimed to investigate the impact of the bacille Calmette-Guerin (BCG) vaccine on cold sore recurrences. The results showed that BCG vaccination could delay the recurrence of cold sores, especially in males with frequent recurrences. However, BCG vaccination also increased the risk of a first episode of cold sore.
