A Chemical Biology Approach to Understanding Molecular Recognition of Lipid II by Nisin(1–12): Synthesis and NMR Ensemble Analysis of Nisin(1–12) and Analogues

Molecular Recognition of Lipid II by Lantibiotics: Synthesis and Conformational Studies of Analogues of Nisin and Mutacin Rings A and B

(2019) Rachael Dickman et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Antibacterial Nisin–Peptoid Hybrids Using Click Methodology

(2018) Hannah Bolt et al.   MOLECULES

High-resolution NMR studies of antibiotics in cellular membranes

(2018) João Medeiros-Silva et al.   Nature Communications

Simplified lipid II-binding antimicrobial peptides: Design, synthesis and antimicrobial activity of bioconjugates of nisin rings A and B with pore-forming peptides

(2018) Serena A. Mitchell et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Insights into the Mechanism of Action of the Two-Peptide Lantibiotic Lacticin 3147

(2017) Alireza Bakhtiary et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7

(2017) Zoë V. F. Wright et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solid-phase peptide synthesis of analogues of the N -terminus A-ring fragment of the lantibiotic nisin: Replacements for the dehydroalanine (Dha) residue at position 5 and the first incorporation of a thioamide residue

(2017) Kim Manzor et al.   TETRAHEDRON LETTERS

The road to the synthesis of “difficult peptides”

(2016) Marta Paradís-Bas et al.   CHEMICAL SOCIETY REVIEWS

Synthesis and Bioactivity of Diastereomers of the Virulence Lanthipeptide Cytolysin

(2016) Subha Mukherjee et al.   ORGANIC LETTERS

New Insights into Nisin’s Antibacterial Mechanism Revealed by Binding Studies with Synthetic Lipid II Analogues

(2015) Peter ‘t Hart et al.   BIOCHEMISTRY

The Lantibiotic Nisin Induces Lipid II Aggregation, Causing Membrane Instability and Vesicle Budding

(2015) Katharina M. Scherer et al.   BIOPHYSICAL JOURNAL

Semisynthetic Lipopeptides Derived from Nisin Display Antibacterial Activity and Lipid II Binding on Par with That of the Parent Compound

(2015) Timo Koopmans et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of nisin AB dicarba analogs using ring-closing metathesis: influence of sp3versus sp2 hybridization of the α-carbon atom of residues dehydrobutyrine-2 and dehydroalanine-5 on the lipid II binding affinity

(2015) Jack C. Slootweg et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Recent advances in synthetic analogues of lantibiotics: What can we learn from these?

(2014) Alethea B. Tabor   BIOORGANIC CHEMISTRY

Cysteine Pseudoprolines for Thiol Protection and Peptide Macrocyclization Enhancement in Fmoc-Based Solid-Phase Peptide Synthesis

(2014) Tobias M. Postma et al.   ORGANIC LETTERS

A conformationally constrained fused tricyclic nisin AB-ring system mimic toward an improved pyrophosphate binder of lipid II

(2014) Rianne A.G. Harmsen et al.   TETRAHEDRON

Scalable purification of the lantibiotic nisin and isolation of chemical/enzymatic cleavage fragments suitable for semi-synthesis

(2013) Jack C. Slootweg et al.   JOURNAL OF PEPTIDE SCIENCE

Chemical Synthesis of the Lantibiotic Lacticin 481 Reveals the Importance of Lanthionine Stereochemistry

(2013) Patrick J. Knerr et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The true cost of antimicrobial resistance

(2013) R. Smith et al.   BMJ-British Medical Journal

In vitro Activities of Nisin Alone or in Combination with Vancomycin and Ciprofloxacin against Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Strains

(2012) Sibel Dosler et al.   CHEMOTHERAPY

Solid Supported Chemical Syntheses of Both Components of the Lantibiotic Lacticin 3147

(2011) Wei Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The challenge of the lantibiotics: synthetic approaches to thioether-bridged peptides

(2011) Alethea B. Tabor   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of Peptides Containing Overlapping Lanthionine Bridges on the Solid Phase: An Analogue of Rings D and E of the Lantibiotic Nisin

(2011) Begum Mothia et al.   ORGANIC LETTERS

Synthesis of Cyclogossine B Using a Traceless Pseudoproline Turn-Inducer

(2010) Michelle S. Y. Wong et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Conformational ensembles of flexible β-turn mimetics in DMSO-d6

(2010) Jari J. Koivisto et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of All-lCyclic Tetrapeptides Using Pseudoprolines as Removable Turn Inducers

(2010) Kelly A. Fairweather et al.   ORGANIC LETTERS

Synthesis of the Lantibiotic Lactocin S Using Peptide Cyclizations on Solid Phase

(2009) Avena C. Ross et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of the cyclic heptapeptide axinellin A

(2009) Kelly A. Fairweather et al.   TETRAHEDRON

The Vancomycin−Nisin(1−12) Hybrid Restores Activity against Vancomycin Resistant Enterococci†

(2008) Christopher J. Arnusch et al.   BIOCHEMISTRY

Conformational Preferences of Natural and C3-Modified Epothilones in Aqueous Solution

(2008) Máté Erdélyi et al.   JOURNAL OF MEDICINAL CHEMISTRY