Article
Chemistry, Multidisciplinary
Shambhavi Pandey, Myungchul Lee, Jaewoon Lim, Sangbae Park, Yun-Hoon Choung, Jae Eun Kim, Pankaj Garg, Jong Hoon Chung
Summary: In this study, a therapy targeting cancer stem cells and non-stem cells in glioblastoma was developed by using CRISPR/Cas9 and siRNA to suppress key signaling pathways. The combined treatment effectively inhibited tumor growth and metastasis.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Vahideh Keyvani, Espanta Riahi, Meysam Yousefi, Seyed-Alireza Esmaeili, Rana Shafabakhsh, Amin Moradi Hasan-Abad, Maryam Mahjoubin-Tehran, Michael R. Hamblin, Samaneh Mollazadeh, Hamed Mirzaei
Summary: This article discusses the molecular mechanism of gynecologic cancer and the role of cancer stem cells (CSCs) in treatment, aiming to discover more specific therapeutic approaches to gynecologic cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Athanasios Patsalias, Zuzana Kozovska
Summary: The study examines the potential of stem cells in cancer treatment, particularly in colorectal cancer. Stem cells can serve as biomarkers, facilitate personalized treatment, and guide the development of targeted therapies. The review suggests that stem cells offer dynamic potential for improving current treatment approaches and enhancing outcomes for cancer patients, specifically in CRC.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Boyang Fan, Qian Zhang, Ning Wang, Guiyu Wang
Summary: This review evaluates the role of lncRNAs in regulating CRCSC signaling pathways and their involvement in promoting and suppressing colorectal cancer. The potential clinical applications of lncRNAs as diagnostic and prognostic biomarkers and therapeutic targets for colorectal cancer are also discussed, providing new ideas and protocols for the prevention and treatment of this disease.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wang Yin, Cuong Pham, Tao Wang, Hadi Al Shamaileh, Rocky Chowdhury, Shweta Patel, Yong Li, Lingxue Kong, Yingchu Hou, Yimin Zhu, Sunrui Chen, Huo Xu, Lee Jia, Wei Duan, Dongxi Xiang
Summary: This study aimed to overcome drug resistance in liver cancer caused by cancer stem cells by using a CD133 aptamer for targeted delivery of Doxorubicin and enhancing the treatment efficacy through autophagy inhibition. The results showed that CD133 aptamer-guided delivery of Doxorubicin resulted in a higher concentration of Doxorubicin in liver cancer stem cells. The combinatorial treatment strategy of CD133 aptamer-Doxorubicin conjugates and an autophagy inhibitor showed a significantly higher elimination of liver cancer stem cells in vitro.
Review
Oncology
Jianhui Yang, Omar Aljitawi, Peter Van Veldhuizen
Summary: This review summarizes the recent research progress on the role of CD133 in prostate cancer stem cells (PCSC), including its selective expression in undifferentiated cells, its correlation to treatment resistance, its gene regulation and functional analysis, and its targeted therapy in vitro, in vivo, and in clinical trials.
Review
Biochemistry & Molecular Biology
Mehran Pashirzad, Thozhukat Sathyapalan, Afsana Sheikh, Prashant Kesharwani, Amirhossein Sahebkar
Summary: This review summarizes the current understanding of CRC-SCs in the progression of CRC and the prognostic importance of these CSCs and their markers in colorectal cancer. Moreover, various therapeutic approaches against markers-expressing CRC SC are also discussed.
PROCESS BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Zhiwei Chen, Heyan Chen, Lihui Huang, Baiqun Duan, Sheng Dai, Wenjing Cai, Meng Sun, Zhikai Jiang, Ruijie Lu, Yiling Jiang, Xinyu Jiang, Hailun Zheng, Qing Yao, Kwonseop Kim, Guangyong Lin, Congying Xie, Maoping Chu, Ruijie Chen, Longfa Kou
Summary: Oxaliplatin resistance is a major obstacle in the chemotherapy of colorectal cancer. In this study, oxaliplatin/berbamine-co-loaded nanoparticles were designed to target SLC6A14 (ATB0,+) and inhibit cancer proliferation. The nanoparticles significantly inhibited the proliferation and decreased the drug resistance of resistant colorectal cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Julia Pospieszna, Hanna Dams-Kozlowska, Wachirawit Udomsak, Marek Murias, Malgorzata Kucinska
Summary: Cancer, a leading cause of death globally, poses a significant challenge to effective treatment due to its complexity. Cancer stem cells and their markers, such as CD133, play a crucial role in tumor growth and progression. This article explores the potential of CD133 as a therapeutic target in cancer treatment, including its structure, functions, occurrence in different cancer types, and approaches to affect CD133 expression. Nanoparticles, such as gold nanoparticles and nanoliposomes, are also discussed in the context of CD133-targeted therapy. Overall, CD133 shows promise as a therapeutic target, offering new treatment options for cancer patients in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Isis Wolf, Christian Gratzke, Philipp Wolf
Summary: Despite research and improvements in diagnosis and therapy, prostate cancer (PC) remains a major challenge. Recent findings have highlighted the role of PC stem cells (PCSCs) in tumorigenesis, relapse, metastasis, and treatment resistance. This review discusses the impact of PCSCs in clinical practice and presents new therapeutic approaches to improve outcomes for PC patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tomokazu Ohishi, Mika K. Kaneko, Yukihiro Yoshida, Atsuo Takashima, Yukinari Kato, Manabu Kawada
Summary: Colorectal cancer (CRC) is one of the most common and deadly types of cancer worldwide. Traditional treatment options for metastatic CRC (mCRC) were surgery or surgery combined with radiation and/or chemotherapy. However, the development of targeted drugs like cetuximab and bevacizumab has significantly improved patients' overall survival. This review discusses the latest molecular evidence and FDA-approved targeted drugs for mCRC, as well as their mechanisms of action and implications for treatment selection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Rui Wang, Yijing Yao, Yihui Gao, Mengyao Liu, Qian Yu, Xuejiao Song, Xiao Han, Dechao Niu, Lixin Jiang
Summary: This study aims to improve therapeutic efficiency and minimize side effects by delivering cancer stem cells antibody and synergist to pancreatic cancer using an effective and visualized nanocarrier. The results showed that CD133-grafted nanovesicles aggregated around pancreatic cancer stem cells, and the combination of CD133-grafted nanovesicles and HIFU irradiation demonstrated obvious synergistic efficacy in tumor treatment. Therefore, CD133-grafted nanovesicles combined with HIFU irradiation can effectively treat pancreatic cancer.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Medicine, Research & Experimental
Jiaqi Shen, Wei Zhu
Summary: This review discusses the important role of mesenchymal stem cells (MSCs) in gastric cancer (GC) and their impact on tumor progression, treatment response, and immune evasion in the tumor microenvironment. Research on GC-MSCs may contribute to the development of novel therapeutic strategies against gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biology
Gerard Cantero-Recasens, Josune Alonso-Maranon, Teresa Lobo-Jarne, Marta Garrido, Mar Iglesias, Lluis Espinosa, Vivek Malhotra, Kelly G. Ten Hagen
Summary: Colorectal cancer cells build a barrier to chemotherapy by increasing mucins' secretion, and low levels of KChIP3 are associated with relapse risk and drug resistance in CRC patients. Inhibiting mucin secretion significantly enhances sensitivity to chemotherapy.
Article
Medicine, Research & Experimental
Kun Zhang, Tao Zhang, Yuhan Yang, Wenling Tu, Hongbin Huang, Yujun Wang, Yuzhuo Chen, Kejian Pan, Zhuojia Chen
Summary: The study reveals that the METTL3/LDHA axis-induced glucose metabolism could be a potential therapeutic target to overcome 5-FU resistance in CRC cells.
Article
Food Science & Technology
Hasan Nasiri, Hamed Baghban, Reza Teimuri-Mofrad, Ahad Mokhtarzadeh
Summary: Graphitic carbon nitride supported on magnetic chitosan was synthesized and used as a support for cellobiose dehydrogenase immobilization and as a modifier for glassy carbon electrode in the fabrication of an electrochemical lactose sensor. The composite exhibited excellent electrochemical performance and was successfully applied in lactose quantification in dairy products.
INTERNATIONAL DAIRY JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Fahimeh Zahednezhad, Parvin Zakeri-Milani, Javid Shahbazi Mojarrad, Muhammad Sarfraz, Mohammad Mahmoudian, Behzad Baradaran, Hadi Valizadeh
Summary: This study investigates the cellular uptake and cytotoxicity of surface-modified cisplatin (CisP) loaded liposomes in macrophage and cancer cells. Modified/un-modified liposomes were prepared and characterized for various properties. The results show that the modified liposomes demonstrate higher cellular uptake and increased cytotoxicity in the studied cells. Acetyl carnitine modification of CisP-liposomes can be considered an effective approach for increasing cellular uptake and cytotoxicity in cancer and macrophage cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mahsa Mashayekhi, Milad Asadi, Shahriar Hashemzadeh, Amir Vahedi, Dariush Shanehbandi, Ahmad Faris Al-Omar, Morteza Akbari, Mortaza Raeisi
Summary: The study aimed to evaluate the role of methylation status in the promoter of RASSF1 and ATIC genes in Iranian lung cancer patients. Methylation of the RASSF1 gene promoter was significantly higher in lung tumor tissues, while promoter methylation levels of the ATIC gene were significantly lower. These findings were further validated by analysis of the TCGA dataset. Promoter methylation of both RASSF1 and ATIC genes was significantly associated with lymph node metastasis and clinical stage of lung cancer, suggesting their potential as diagnostic biomarkers.
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
(2023)
Review
Biochemistry & Molecular Biology
Pouriya Sameti, Mohammad Amini, Fatemeh Oroojalian, Yalda Baghay Esfandyari, Maryam Tohidast, Seyed Ali Rahmani, Shirin Azarbarzin, Ahad Mokhtarzadeh, Behzad Baradaran
Summary: MicroRNAs (miRNAs), dysregulated in a wide range of human cancers, play critical roles in cancer progression and can be potential targets for cancer detection and treatment. Specifically, miR-425, dysregulated in various human malignancies, participates in the regulation of cellular processes, such as metastasis, invasion, and cell proliferation, by modulating multiple signaling pathways. Therefore, miR-425 has high therapeutic potential.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Oncology
Neda Rajabi, Fateme Mohammadnejad, Mohammad Amin Doustvandi, Mahdi Abdoli Shadbad, Mohammad Amini, Habib Tajalli, Ahad Mokhtarzadeh, Elham Baghbani, Nicola Silvestris, Behzad Baradaran
Summary: Photodynamic therapy (PDT) combined with tamoxifen (TA) has shown promising anti-cancer effects on MDA-MB-231 cells. The combination treatment increased cytotoxicity, induced apoptosis, inhibited migration, and suppressed clonogenicity. Furthermore, the synergy between ZnPc-PDT and TA enhanced the cytotoxicity and modulated gene expression.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Chemistry, Analytical
Maryam Hejazi, Sina Arshadi, Mohammad Amini, Behzad Baradaran, Payam Shahbazi-Derakhshi, Pouriya Sameti, Jafar Soleymani, Ahad Mokhtarzadeh, Seyed Mohammad Tavangar
Summary: A nanomaterial-based bioimaging method using AuNPs/PEI/RhB-HA was developed for detecting MCF-7 cancer cells. The materials showed low toxicity and specifically attached to CD44-overexerted cancer cells. The bioimaging of the nanoparticles was evaluated and showed high physical stability and quantum yield, making it a promising material for in vivo cancer diagnosis.
MICROCHEMICAL JOURNAL
(2023)
Article
Engineering, Electrical & Electronic
Hassan Nasiri, Hamed Baghban, Reza Teimuri-Mofrad, Ahad Mokhtarzadeh
Summary: This study aims to develop a surface plasmon resonance (SPR) sensor using a Chitosan/Polyaniline/Graphene oxide-Ferrocene (CS/PANI/GOFc) composite thin film for glucose detection. The optimal composite formulation was determined based on experimental refractive index data and the effective medium theory (EMT). The prepared CS 25%/PANI 25%/GOFc 50% composite was evaluated in the design of the glucose sensor by modifying the SPR gold chip. The results show that the SPR sensor exhibits a linear response in the glucose concentration range of 0.5-100 μM with a sensitivity of 0.0202 μM-1. The binding affinity analysis using Langmuir and Sips models indicates that the composite film has a higher affinity constant compared to the bare gold chip.
OPTICAL AND QUANTUM ELECTRONICS
(2023)
Review
Pathology
Vahid Asghariazar, Mahtab Kadkhodayi, Mehdi Sarailoo, Amir Ghaffari Jolfayi, Behzad Baradaran
Summary: This review outlines the impact of miR-143 expression levels on cancer progression, discussing its roles as a tumor suppressor or an oncogene, and explores its target genes and relevant signaling pathways.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Navid Shomali, Amin Kamrani, Javad Ahmadian Heris, Parviz Shahabi, Hadi Nasiri, Shahram Sadeghvand, Kazem Ghahremanzadeh, Morteza Akbari
Summary: Breast cancer is a prevalent cancer in women worldwide, and the function of the p53 gene has drawn significant attention. Mutations in this gene can result in loss of function, leading to uncontrolled cell division and the onset of breast cancer. Focusing on p53 mutations holds promise for developing individualized treatments for breast cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Seyed Hossein Kiaie, Zahra Hatami, Mohammad Sadegh Nasr, Pouya Pazooki, Salar Hemmati, Behzad Baradaran, Hadi Valizadeh
Summary: This article discusses the crucial role of purinergic signaling in regulating energy homeostasis and modulating metabolic alterations in tumor cells. It emphasizes the importance of pharmacological targeting of purinergic receptors and explores the regulation of immune and inflammatory responses by purinergic inhibitors.
PURINERGIC SIGNALLING
(2023)
Review
Oncology
Zanyar HajiEsmailpoor, Peyman Tabnak, Behzad Baradaran, Fariba Pashazadeh, Leili Aghebati-Maleki
Summary: The purpose of this study was to evaluate the diagnostic performance of computed tomography (CT) scan-based radiomics in predicting lymph node metastasis (LNM) in gastric cancer (GC) patients. The results showed that there were differences in sensitivity, specificity, diagnostic odds ratio (DOR), and area under the curve (AUC) between radiomics models and combined models. Subgroup analysis also found that different CT scan phases, regions of interest (ROIs), and segmentation methods had an impact on diagnostic accuracy. In conclusion, CT scan-based radiomics approach has the potential to predict LNM in GC patients preoperatively as a non-invasive diagnostic tool.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Monireh Khordadmehr, Reyhaneh Matin, Behzad Baradaran, Elham Baghbani, Farinaz Jigari-Asl, Saeed Noorolyai
Summary: This study investigated the effect of miR-4800 restoration on the growth and migration inhibition of human breast cancer cells. The restoration of miR-4800 resulted in decreased expression levels of CXCR4, ROCK1, CD44, and vimentin genes, as well as reduced cell viability and migration ability. Therefore, miR-4800 can act as a tumor suppressor miRNA in breast cancer and may serve as a potential therapeutic target.
ADVANCED PHARMACEUTICAL BULLETIN
(2023)
Review
Pharmacology & Pharmacy
Mina Afrashteh Nour, Farid Ghorbaninezhad, Zahra Asadzadeh, Amir Baghbanzadeh, Hamidreza Hassanian, Patrizia Leone, Mahdi Jafarlou, Nazila Alizadeh, Vito Racanelli, Behzad Baradaran
Summary: Auto-immune diseases are chronic disorders where the immune system destroys the body's cells due to a loss of tolerance to self-antigens. Systemic lupus erythematosus (SLE) is an example of these diseases and is characterized by the production of autoantibodies in different body parts. Genetic and epigenetic factors, including alterations in noncoding RNAs (ncRNAs), play a crucial role in the pathogenesis of SLE.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2023)
Article
Immunology
Ali Sayadmanesh, Vahid Yekehfallah, Amir Valizadeh, Ali Abedelahi, Hajar Shafaei, Dariush Shanehbandi, Mohsen Basiri, Behzad Baradaran
Summary: CAR T cell therapy has shown promising efficacy in patients with hematologic malignancies, but it also presents potential toxicity and adverse effects. This study focuses on the unexpected side effects of targeting normal host tissues and discusses recent safety strategies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Farid Mostafaei, Somayeh Mahdinloo, Hadi Valizadeh, Salar Hemmati, Mahdieh Abdi, Muhammad Sarfraz, Behzad Baradaran, Parvin Zakeri-Milani
Summary: Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, usually diagnosed in advanced stages. Chemotherapy is commonly used to treat advanced liver cancer but faces challenges that reduce its effectiveness. This review discusses the prevalence, staging, and treatment methods for liver cancer. It also explores recent studies on smart drug- and gene-delivery systems designed specifically for HCC, aiming to improve treatment efficacy.
