Article
Endocrinology & Metabolism
Dixing Liu, Jiana Zhong, Weiheng Wen, Yuting Ruan, Zhen Zhang, Jia Sun, Hong Chen
Summary: The study revealed that individuals with lower SVR values in T2DM are more likely to increase the risk of cardiovascular diseases. SVR shows a significant and inverse correlation with the estimated 10-year CVD risk in T2DM, especially in men.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Lisa Pennells, Stephen Kaptoge, Helena Bleken Ostergaard, Stephanie H. Read, Fabrizio Carinci, Josep Franch-Nadal, Carmen Petitjean, Owen Taylor, Steven H. J. Hageman, Zhe Xu, Fanchao Shi, Sarah Spackman, Stefano Gualdi, Naomi Holman, Rui Bebiano Da Providencia E Costa, Fabrice Bonnet, Hermann Brenner, Richard F. Gillum, Stefan Kiechl, Deborah A. Lawlor, Louis Potier, Ben Schoettker, Reecha Sofat, Henry Voelzke, Johann Willeit, Zane Baltane, Stephen Fava, Sandor Janos, Astrid Lavens, Santa Pildava, Tamara Poljicanin, Ivan Pristas, Peter Rossing, Reiff Sascha, Christa Scheidt-Nave, Iztok Stotl, Gail Tibor, Vilma Urbancic-Rovan, An-Sofie Vanherwegen, Dorte Vistisen, Yong Du, Matthew R. Walker, Peter Willeit, Brian Ference, Dirk De Bacquer, Martin Halle, Radu Huculeci, John William McEvoy, Adam Timmis, Panagiotis Vardas, Jannick A. N. Dorresteijn, Ian Graham, Angela Wood, Bjorn Eliasson, William Herrington, John Danesh, Didac Mauricio, Massimo Massi Benedetti, Naveed Sattar, Frank L. J. Visseren, Sarah Wild, Emanuele Di Angelantonio, Beverley Balkau, Frederic Fumeron, Hannah Stocker, Bernd Holleczek, Sabine Schipf, Carsten Oliver Schmidt, Marcus Doerr, Herbert Tilg, Christoph Leitner, Marlene Notdurfter, Julie Taylor, Caroline Dale, David Prieto-Merino, Richard F. Gillum, Tamara Buble, Pero Ivanko, Bendix Carstensen, Christin Heidemann, Tibor Gall, Janos Sandor, Jana Lepiksone, Caroline J. Magri, Joseph Azzopardi, Jordi Real, Bogdan Vlacho, Manel Mata-Cases
Summary: The study aimed to develop and validate a recalibrated prediction model (SCORE2-Diabetes) for estimating the 10-year risk of cardiovascular disease (CVD) in individuals with type 2 diabetes in Europe. The model showed good discrimination and improvement over previous models, with risk predictions varying based on individuals' diabetes-related factors. SCORE2-Diabetes enhances the identification of individuals at higher risk of CVD in Europe.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Tingting Qiao, Tao Luo, Hualian Pei, Bahegu Yimingniyazi, Dilihumaer Aili, Aliya Aimudula, Hui Zhao, Huanwen Zhang, Jianghong Dai, Duolao Wang
Summary: This study found that abdominal obesity indices are associated with an increased risk of cardiovascular events in patients with type 2 diabetes, and the Chinese visceral adiposity index (CVAI) may be a valuable indicator for identifying high-risk cardiovascular events in the Chinese population with T2D.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Gastroenterology & Hepatology
Selena Z. Kuo, Sandra Cepin, Jaclyn Bergstrom, Harris Siddiqi, Jinho Jung, Scarlett Lopez, Daniel Q. Huang, Pam Taub, Maral Amangurbanova, Rohit Loomba
Summary: This study examined the clinical utility of liver fat quantification in determining cardiovascular disease (CVD) risk among patients with type 2 diabetes mellitus (T2DM). The results showed that higher liver fat content was associated with higher CVD risk, independent of other factors such as age, gender, ethnicity, and BMI. This suggests that measuring liver fat may be useful in further stratifying patients with T2DM and identifying those at higher risk of CVD.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Haishan Huang, Xiaobin Zheng, Xiaoming Wen, Jingyi Zhong, Yanting Zhou, Lingling Xu
Summary: This study found that visceral fat affects insulin secretion and sensitivity in Chinese patients with T2DM, and the impact is more significant in overweight/obese individuals. This suggests that visceral fat plays a crucial role in diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Ningjian Wang, Ying Sun, Haojie Zhang, Chi Chen, Yuying Wang, Jihui Zhang, Fangzhen Xia, Christian Benedict, Xiao Tan, Yingli Lu
Summary: Higher total and regional fat-to-muscle mass ratios were associated with an increased risk of developing type 2 diabetes, independent of BMI. This association was particularly prominent in individuals with a BMI >= 25 kg/m(2).
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Endocrinology & Metabolism
Li Ding, Yuxin Fan, Jing He, Ruodan Wang, Qing He, Jingqiu Cui, Zhongshu Ma, Fangqiu Zheng, Hua Gao, Chenlin Dai, Hongyan Wei, Jun Li, Yuming Cao, Gang Hu, Ming Liu
Summary: This study evaluated the impact of adiposity and fat distribution on cardiovascular risk factors in adults with type 2 diabetes mellitus. It found that increased leg fat mass was associated with better glycemic control, while increased android fat mass was linked to higher risks of hypertension. Increasing BMI, trunk-to-leg fat ratio, and android-to-gynoid fat ratio were all significantly associated with elevated risks of cardiovascular risk factors.
Article
Endocrinology & Metabolism
Toshiaki Ohkuma, Masanori Iwase, Hiroki Fujii, Takanari Kitazono
Summary: This study found sex differences in Japanese patients with type 2 diabetes, with women being less likely to achieve recommended cardiovascular risk factor levels, and more likely to have unhealthy lifestyle and psychological factors.
BIOLOGY OF SEX DIFFERENCES
(2023)
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Editorial Material
Gastroenterology & Hepatology
Sherlot Juan Song, Terry Cheuk-Fung Yip, Grace Lai-Hung Wong, Vincent Wai-Sun Wong, Ken Liu
Summary: This article discusses the connection to Kuo et al papers.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Xiu Li Guo, Mei Tu, Yang Chen, Wei Wang
Summary: The study found a significant association between perirenal fat thickness and metabolic syndrome in Chinese newly diagnosed type 2 diabetes patients, with good predictive value. Thus, perirenal fat thickness may serve as an applicable surrogate marker for metabolic syndrome in Chinese individuals newly diagnosed with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Debby Ngo, Mark D. Benson, Jonathan Z. Long, Zsu-Zsu Chen, Ruiqi Wang, Anjali K. Nath, Michelle J. Keyes, Dongxiao Shen, Sumita Sinha, Eric Kuhn, Jordan E. Morningstar, Xu Shi, Bennet D. Peterson, Christopher Chan, Daniel H. Katz, Usman A. Tahir, Laurie A. Farrell, Olle Melander, Jonathan D. Mosley, Steven A. Carr, Ramachandran S. Vasan, Martin G. Larson, J. Gustav Smith, Thomas J. Wang, Qiong Yang, Robert E. Gerszten
Summary: The recent advancements in proteomic technologies have enabled the identification of biomarkers associated with future development of type 2 diabetes (T2DM) beyond known risk factors. By analyzing large longitudinal cohorts, the researchers identified specific markers with significant associations with future T2DM and explored potential causal relationships. Additionally, functional effects of a top protein association, aminoacylase 1 (ACY1), on amino acid metabolism and insulin homeostasis were discovered, highlighting potential novel disease markers and pathways in T2DM.
Article
Endocrinology & Metabolism
Shuo Zhao, Ming-Li Liu, Bing Huang, Fu-Rong Zhao, Ying Li, Xue-Ting Cui, Rong Lin
Summary: This study found that elevated levels of short-chain acylcarnitine C2 were associated with increased risk of cardiovascular disease in patients with type 2 diabetes mellitus and this association remained significant even after adjusting for potential confounders.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Yifei Feng, Xingjin Yang, Yang Li, Yuying Wu, Minghui Han, Ranran Qie, Shengbing Huang, Xiaoyan Wu, Yanyan Zhang, Jinli Zhang, Huifang Hu, Lijun Yuan, Tianze Li, Dechen Liu, Fulan Hu, Ming Zhang, Yunhong Zeng, Xinping Luo, Jie Lu, Liang Sun, Dongsheng Hu, Yang Zhao
Summary: The study found a positive association between baseline METS-VF and T2DM risk in Chinese individuals, with METS-VF demonstrating the best predictive value for T2DM incidence among six indices. A significant nonlinear dose-response association between METS-VF and T2DM risk was also observed in the study.
BRITISH JOURNAL OF NUTRITION
(2022)
Review
Nutrition & Dietetics
Ursula Schwab, Andrew N. Reynolds, Taisa Sallinen, Angela Albarosa Rivellese, Ulf Riserus
Summary: Limited data suggest that replacing saturated fats with other macronutrients, such as polyunsaturated fats, may reduce cardiovascular disease occurrence in adults with type 2 diabetes. Further research is needed to confirm these findings and provide more guidance on dietary fat intake for this population.
EUROPEAN JOURNAL OF NUTRITION
(2021)