Article
Biochemistry & Molecular Biology
Wei Li, Yufeng He, Wei Chen, Wenling Man, Qiang Fu, Hongtong Tan, Huanqing Guo, Jingnan Zhou, Po Yang
Summary: LINC00467 is upregulated in HCC and promotes proliferation and invasion, inhibits apoptosis, and contributes to Axitinib resistance through the miR-509-3p/PDGFRA pathway.
Article
Medicine, Research & Experimental
Jing Yan, Tao Fang, Ming Zhang, Quan Zhou
Summary: This study elucidated the potential carcinogenic mechanism of LINC00467 in osteosarcoma, showing that high LINC00467 expression is associated with poor prognosis in patients. LINC00467 exerts its effects through the miR-217/KPNA4 axis in osteosarcoma.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Jiwei Cheng, Haibo Ma, Ming Yan, Wenqun Xing
Summary: THAP9-AS1 is overexpressed in esophageal squamous cell carcinoma (ESCC) and is positively correlated with tumor size, TNM stage, lymph node metastasis, and prognosis. It functions as a competing endogenous RNA (ceRNA) for miR-133b, leading to the upregulation of SOX4 and promoting ESCC progression.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Clara Boces-Pascual, Aida Mata-Ventosa, Mireia Martin-Satue, Loreto Boix, Meritxell Gironella, Marcal Pastor-Anglada, Sandra Perez-Torras
Summary: Downregulation of hCNT1 protein was found in both colorectal and pancreatic ductal adenocarcinoma, potentially regulated by miR-106a and miR-17, leading to chemoresistance to fluoropyrimidine-based treatments.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Rongrong Xu, Xiaoyue Zhang, Yan Xu, Junqin Wang, Zhihui Li, Xiaoming Cui
Summary: The study revealed that lncRNA MST1P2 is significantly overexpressed in cervical cancer tissues and cells, with Si-Lnc MST1P2 inhibiting cell growth, migration, and invasion both in vivo and in vitro. Up-regulation of miR-133b inhibited cell viability and metastasis, while its inhibition decreased the anticancer effect of si-Lnc MST1P2. Overall, lncRNA MST1P2 acts as an oncogene in cervical cancer by interacting with miR-133b.
Article
Multidisciplinary Sciences
Haibing Gao, Xiangmei Wang, Huaxi Ma, Shenglong Lin, Dongqing Zhang, Wenjun Wu, Ziyuan Liao, Mengyun Chen, Hanhui Ye, Qin Li, Minghua Lin, Dongliang Li
Summary: This study found that lncRNA CCAT2 may regulate the TGF-beta 1 pathway in hepatic stellate cells (HSCs) by modulating miR-34a-5p, thus alleviating liver fibrosis.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Zhengwei Chen, Chaobo Xu, Xiaoming Pan, Guoxiong Cheng, Ming Liu, Jiaxin Li, Yijun Mei
Summary: DSCR8, upregulated in gastric cancer, promotes proliferation and invasion while inhibiting apoptosis of cancer cells. It interacts with miR-137 and Cdc42 to regulate cell cycle, providing a potential target for gastric cancer treatment.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Retraction
Chemistry, Multidisciplinary
Laura Fisher
Summary: The article has been retracted.
Article
Multidisciplinary Sciences
Xu Zhao, Jizhao Wang, Rui Zhu, Jing Zhang, Yunfeng Zhang
Summary: DLX6-AS1 regulates cisplatin sensitivity of lung squamous cell carcinoma cells through the miR-181a-5p/miR-382-5p/CELF1 axis, playing a key role in promoting secondary cisplatin resistance. Targeting DLX6-AS1 may be a novel approach to overcome cisplatin resistance in lung squamous cell carcinoma.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Fengyu Xu, Mengqi Huang, Qingyong Chen, Yi Niu, Yuhang Hu, Ping Hu, Ding Chen, Chi He, Kang Huang, Zhu Zeng, Jiang Tang, Fan Wang, Yong Zhao, Chunyou Wang, Gang Zhao
Summary: The reciprocal feedback loop between HIF1A-AS1 and HIF1 alpha promotes gemcitabine resistance in pancreatic cancer, highlighting a potential therapeutic target.
Article
Medicine, Research & Experimental
Chen Luo, Kang Lin, Cegui Hu, Xiaojian Zhu, Jinfeng Zhu, Zhengming Zhu
Summary: The study reveals that LINC01094 is significantly overexpressed in pancreatic cancer tissues and promotes cell proliferation and metastasis by acting as an endogenous miR-577 sponge to upregulate LIN28B expression through the PI3K/AKT pathway.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Wen Li, Shan-Shan Wang, Bo-Quan Shan, Jian-Bing Qin, He-Yan Zhao, Mei-Ling Tian, Hui He, Xiang Cheng, Xin-Hua Zhang, Guo-Hua Jin
Summary: This study showed that miR-103-3p suppresses the proliferation and promotes the apoptosis and differentiation of neural stem cells, and Ndel1 is identified as a target of miR-103-3p, and its overexpression can reverse these effects.
NEURAL REGENERATION RESEARCH
(2022)
Article
Oncology
Michelle Xin Liu, Kent-Man Chu
Summary: This study aims to investigate the functional roles of miR-410-3p in primary gastric cancer and the roles of exosomes in regulating miR-410-3p expression. It was found that miR-410-3p was downregulated in gastric cancer and its overexpression inhibited cancer cell proliferation, migration, and invasion. Exosomal miR-410-3p expression was significantly higher than its endogenous expression and exosomes from gastric cancer cells regulated miR-410-3p expression in other cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Cell Biology
Yanling Tao, Jingjing Zhang, Lulu Chen, Xin Liu, Mingkang Yao, Hao Zhang
Summary: High expression of CD27-AS1 in AML is associated with shorter overall survival time, its downregulation can inhibit the proliferation and induce apoptosis of AML cells, while overexpression enhances the malignant phenotype. CD27-AS1 regulates the growth of AML cells through the miR-224-5p/PBX3/MAPK signaling pathway.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Zhaoping Liu, Pan Wang, Shunling Yuan, Yanyan Wang, Pengfei Cao, Feng Wen, Hui Li, Lin Zhu, Long Liang, Zi Wang, Bin Hu, Fuxiang Zheng, Jing Liu, Xiaojuan Xiao, Ji Zhang
Summary: In this study, BC200 was found to be highly expressed in MDS patients and promoted the malignant proliferation of MDS cells through the miR-150-5p/MYB positive feedback loop. This provides evidence for BC200 as a potential therapeutic target in MDS.
CELL DEATH & DISEASE
(2022)