Journal
CARBOHYDRATE POLYMERS
Volume 222, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.114985
Keywords
Composite membrane; Antibacterial material; Wound dressing; Wound healing
Categories
Funding
- National Natural Science Foundation of China [51773018]
- Fundamental Research Funds for the Central Universities [FRF-TP-17-001A2]
- Key Research and Development Projects of People's Liberation Army [BWS17J036]
- University of Science and Technology Beijing-National Taipei University of Technology Joint Research Project [TW2019005]
Ask authors/readers for more resources
In recent years, bacterial cellulose (BC)-based dressings or patches for skin or soft tissue repair have become investigative emphasis. However, most of the BC-based products used for biomedical applications present limitations due to their low flexibility, poor gas permeability and no inherent antibacterial activity. Herein, we proposed and designed a novel composite composed of natural bacterial cellulose (BC), polyethylene glycol (PEG) and polyhexamethylene biguanidine (PHMB) through new synthetic approaches. The composite membrane exhibited favorable physicochemical performance, especially transparency, water retention ability, flexibility as well as the characteristic of anti-adhesion. In vitro biochemical experiment results indicated that the composite had excellent biocompatibility and exhibited strong and sustained antibacterial effect. In vivo test further demonstrated that the composite could efficiently promote skin wound healing and regeneration in a rat model. This composite membrane possesses multiple mechanisms of promoting cutaneous wound healing and will provide new ideas for future development of wound dressings.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available