Article
Biochemistry & Molecular Biology
Kathy K. W. Au-Yeung, Yue Shang, Charith U. B. Wijerathne, Susara Madduma Hewage, Yaw L. Siow, O. Karmin
Summary: Acute kidney injury (AKI) often leads to liver injury with increased oxidative stress, inflammatory response, and lipid accumulation. The mechanisms by which ischemia-reperfusion-induced AKI causes hepatic lipid accumulation were investigated in this study. Kidney ischemia-reperfusion resulted in kidney and liver injury, as indicated by increased plasma creatinine and transaminases. Histological and biochemical analysis revealed hepatic lipid accumulation with increased triglyceride and cholesterol levels. AMPK phosphorylation, an energy sensor for lipid metabolism, was reduced, accompanied by decreased expression of fatty acid oxidation genes and increased expression of lipogenesis genes. Oxidative stress and inhibition of AMPK phosphorylation in HepG2 cells led to cellular lipid accumulation. These findings suggest that AKI induces hepatic lipid accumulation through decreased fatty acid metabolism and increased lipogenesis, with oxidative stress playing a role in downregulating the AMPK signaling pathway.
Article
Cell Biology
Rui Wang, Wenchao Hu
Summary: The study demonstrated that asprosin induces apoptosis in beta-cells by inhibiting autophagy. High glucose and asprosin both lead to increased apoptosis and altered expression of certain proteins in MIN6 cells, affecting the AMPK-mTOR signaling pathway. Activation of the AMPK pathway by AICAR partially reverses the effects of asprosin on autophagy and apoptosis in beta-cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Zhang Jiao-jiao, Li Ya-qi, Shi Mei, Wang Yu-sha, Tang Yao, Wang Xian-zhong
Summary: This study investigated the effects of cold plasma on immune chicken Sertoli cell (SC) proliferation and the regulation mechanism. The results showed that appropriate cold plasma treatment can promote SC viability, cell growth, and cell cycle progression. This effect is regulated by increasing ATP production and respiratory enzyme activity in the mitochondria, potentially through the AMPK-mTOR signaling pathway mediated by microRNA targeting regulation and intracellular reactive oxygen species homeostasis. The findings suggest that cold plasma treatment provides a safe strategy to improve SC proliferation, which is beneficial to elevating male chicken reproductive capacity.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2022)
Article
Chemistry, Multidisciplinary
Chan-juan Zhang, Neng Zhu, Jia Long, Hong-tao Wu, Yu-xiang Wang, Bi-yuan Liu, Duan-fang Liao, Li Qin
Summary: Celastrol triggers lipophagy in ccRCC by activating LXR alpha, promotes ABCA1-mediated cholesterol efflux, suppresses EMT progress, and ultimately inhibits cell proliferation, migration, and invasion as well as tumor growth.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Cell Biology
Xiaosai Yao, Jing Han Hong, Amrita M. Nargund, Michelle Shu Wen Ng, Hong Lee Heng, Zhimei Li, Peiyong Guan, Masahiro Sugiura, Pek Lim Chu, Loo Chien Wang, Xiaofen Ye, James Qu, Xiu Yi Kwek, Jeffrey Chun Tatt Lim, Wen Fong Ooi, Joanna Koh, Zhenxun Wang, You-Fu Pan, Yan Shan Ong, Kiat-Yi Tan, Jian Yuan Goh, Sheng Rong Ng, Luca Pignata, Dachuan Huang, Alexander Lezhava, Su Ting Tay, Minghui Lee, Xun Hui Yeo, Wai Leong Tam, Sun Young Rha, Shang Li, Ernesto Guccione, Andrew Futreal, Jing Tan, Joe Poh Sheng Yeong, Wanjin Hong, Robert Yauch, Kenneth Tou-En Chang, Radoslaw M. Sobota, Patrick Tan, Bin Tean Teh
Summary: Yao et al. found that PBRM1 loss leads to the redistribution of PBAF complexes in the genome, resulting in sustained RELA occupancy by SMARCA4, activation of the NF-kB pathway, and enhanced kidney tumor formation. PBRM1 is an accessory subunit of the PBAF SWI/SNF chromatin remodeler and is frequently inactivated in kidney cancer. However, the effects of PBRM1 loss on chromatin remodeling were not well studied.
NATURE CELL BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Jinming Xu, Yan Wang, Jiahao Jiang, Cong Yin, Bentao Shi
Summary: ADAM12 is significantly upregulated in clear cell renal cell carcinoma (ccRCC) and is associated with poor prognosis. ADAM12 promotes ccRCC cell proliferation, migration, and invasion by activating the EGFR/ERK signaling pathway, inducing epithelial-mesenchymal transition (EMT), and upregulating target genes.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Qi Wang, Jiaju Xu, Zhiyong Xiong, Tianbo Xu, Jingchong Liu, Yuenan Liu, Jiaping Chen, Jian Shi, Yi Shou, Changjie Yue, Di Liu, Huageng Liang, Hongmei Yang, Xiong Yang, Xiaoping Zhang
Summary: This research identified that several CENP family members, especially CENPA, are highly expressed in ccRCC tissues and can serve as biomarkers for the disease. Overexpression of CENPA was found to promote ccRCC proliferation and metastasis by accelerating the cell cycle and activating the Wnt/beta-catenin signaling pathway. Targeting CENPA with selective drugs may be a promising direction for cancer treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Yanjuan Hou, Qian Wang, Baosheng Han, Yiliang Chen, Xi Qiao, Lihua Wang
Summary: In diabetic nephropathy, CD36 mediates ROS production that enhances NLRP3 inflammasome activation, leading to IL-1 beta secretion and cell apoptosis. Inhibition of CD36 protects mice from tubulointerstitial inflammation and tubular epithelial cell apoptosis.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Tao Liu, Wan Xiang, Zhizhuang Chen, Gang Wang, Rui Cao, Fenfang Zhou, Zhe Meng, Yongwen Luo, Liang Chen
Summary: This study found that hypoxia is elevated in ccRCC and may be an independent risk factor for prognosis in ccRCC patients. The study also revealed that PLOD2 is transcriptionally activated by HIF1A, interacts with EGFR, and ultimately promotes the malignant progression of ccRCC by activating the AKT signaling pathway.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Qian Zheng, Pengfei Li, Xin Zhou, Yulong Qiang, Jiachen Fan, Yan Lin, Yurou Chen, Jing Guo, Fan Wang, Haihua Xue, Jie Xiong, Feng Li
Summary: The histone demethylase gene KDM5C was found to play a crucial role in ccRCC by regulating glucose metabolism and affecting cell tolerance and survival through glycogen synthesis and glucose flux modulation.
Article
Oncology
Kun Jiang, Li-zhe Xu, Jin-zhuo Ning, Fan Cheng
Summary: This study aimed to investigate the expression of FAP and its clinical implication in ccRCC. Computational tools analysis of gene databases revealed that FAP levels were significantly elevated in ccRCC. Higher expression levels of FAP were associated with poorer prognoses in ccRCC patients, and FAP may serve as a reliable biomarker for the diagnosis and prognosis of ccRCC.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Xin Gao, Chenguang Wang, Suhaib Abdelrahman, Nermin Kady, Carlos Murga-Zamalloa, Peter Gann, Maria Sverdlov, Ashley Wolfe, Avery Polk, Noah Brown, Nathanael G. Bailey, Kedar Inamdar, Sandro Casavilca-Zambrano, Jaime Montes, Carlos Barrionuevo, Luis Taxa, John Reneau, Christian W. Siebel, Ivan Maillard, Ryan A. Wilcox
Summary: Notch signaling pathway plays a crucial role in the pathogenesis of peripheral T-cell lymphoma, and Notch1 activation is associated with proliferation. Blockade of Notch1/Notch2 and DLL1/DLL4 can inhibit the proliferation of malignant T cells and tumor progression.
Article
Pharmacology & Pharmacy
Yanqing Zhang, Zhenzhen Zhang, Yiwei Zhang, Leiming Wu, Lu Gao, Rui Yao, Yanzhou Zhang
Summary: The study demonstrates that baicalin (BAI) can limit weight gain, improve glucose tolerance, enhance cold tolerance, and promote brown-like tissue formation in diet-induced obesity mice. BAI increases mitochondrial copy number and activates the AMPK/PGC1 alpha pathway, leading to the upregulation of UCP1 and other browning-related genes in brown adipose tissue and white adipose tissue.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yusuke Takahashi, Satoshi Serada, Tomoharu Ohkawara, Minoru Fujimoto, Kosuke Hiramatsu, Yutaka Ueda, Tadashi Kimura, Hiroshi Takemori, Tetsuji Naka
Summary: The study found that LSR promotes EOC cell survival and tumor growth through the LKB1-AMPK pathway, regulating the activity of AMPK and ACC under glucose deprivation conditions.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Plant Sciences
Xiaoye Fan, Min Xie, Feijie Zhao, Jiajia Li, Changqing Fan, Hao Zheng, Zhentong Wei, Xinxin Ci, Songling Zhang
Summary: The study demonstrates that Daph induces ROS-dependent apoptosis in ovarian cancer cells and triggers cytoprotective autophagy through the modulation of the AMPK/Akt/mTOR pathway. Combination therapy of Daph and an autophagy inhibitor shows synergistic effects on inhibiting cell viability and promoting apoptosis in ovarian cancer cells, suggesting a potential therapeutic strategy.
Article
Medicine, General & Internal
Xi Tian, Wen-Hao Xu, Fu-Jiang Xu, Hui Li, Aihetaimujiang Anwaier, Hong-Kai Wang, Fang-Ning Wan, Yu-Zhu, Da-Long Cao, Yi-Ping Zhu, Guo-Hai Shi, Yuan-Yuan Qu, Hai-Liang Zhang, Ding-Wei Ye
Summary: This study identifies 8 genes associated with the prognosis of pRCC patients, including BUB1B, CCNB1, CCNB2, MAD2L1, TTK, CDC20, PTTG1, and MCM. The expression level of PTTG1 is significantly correlated with lymphocytes, immunomodulators, and chemokines in the tumor microenvironment. In the FUSCC cohort, higher expression of PTTG1 predicts worse progression-free survival and overall survival, and is also associated with a response to immune checkpoint blockade.
ANNALS OF MEDICINE
(2022)
Article
Genetics & Heredity
Weicheng Chen, Yuan Zhang, Libing Shen, Jialiang Zhu, Ke Cai, Zhouping Lu, Weijia Zeng, Jianyuan Zhao, Xiangyu Zhou
Summary: This study identified recessive DNAH9 mutations in Chinese patients with cardiac abnormalities and defective left-right patterning. Whole exome sequencing and transmission electron microscopy were used to confirm the presence and effects of these mutations.
Article
Multidisciplinary Sciences
Wen-Jie Zhou, Hui-Li Yang, Jie Mei, Kai-Kai Chang, Han Lu, Zhen-Zhen Lai, Jia-Wei Shi, Xiao-Hui Wang, Ke Wu, Tao Zhang, Jian Wang, Jian-Song Sun, Jiang-Feng Ye, Da-Jin Li, Jian-Yuan Zhao, Li-Ping Jin, Ming-Qing Li
Summary: This study reveals the role of fructose-1,6-bisphosphate (FBP) in the decidualization process and its impact on IL-27 secretion and COX-2(+) macrophage differentiation. Supplementation of FBP can improve embryo loss and potentially serve as a therapeutic strategy to prevent pregnancy loss.
Article
Cell Biology
Hui-Li Yang, Zhen-Zhen Lai, Jia-Wei Shi, Wen-Jie Zhou, Jie Mei, Jiang-Feng Ye, Tao Zhang, Jian Wang, Jian-Yuan Zhao, Da-Jin Li, Ming-Qing Li
Summary: Decidual macrophages (dMφ), important regulators of maternal-fetal immune tolerance and trophoblast invasion during pregnancy, display an active glycerophospholipid metabolism and their adhesion and retention, as well as M2 differentiation, are facilitated by the activation of ENPP2-lysophosphatidic acid (LPA). This process involves the activation of LPA receptors, mediated through the DDIT4-macroautophagy/autophagy axis, leading to upregulation of multiple adhesion factors and poor trophoblast invasion. Supplementation with LPA or autophagy inducer rapamycin improves dMφ autophagy and cell residence, preventing spontaneous abortion.
Article
Oncology
Ning Xu, Zhenmei Yao, Guoguo Shang, Dingwei Ye, Haixing Wang, Hailiang Zhang, Yuanyuan Qu, Fujiang Xu, Yunzhi Wang, Zhaoyu Qin, Jiajun Zhu, Fan Zhang, Jinwen Feng, Sha Tian, Yang Liu, Jianyuan Zhao, Jun Hou, Jianming Guo, Yingyong Hou, Chen Ding
Summary: This study provides an integrated multi-omics analysis of Chinese UC patients, revealing the association between SND1 and CDK5 amplifications and the activation of STAT3 in tumor proliferation. It also identifies chromosome 5p gain as a high-risk factor in NMIBC patients through actin cytoskeleton modulation. Phosphoproteomic analysis identifies UC-associated activated kinases, and proteomic analysis groups UC patients into distinct prognostic and molecular signature categories. Immune subtypes of UC tumors demonstrate a complex immune landscape with the amplification of TRAF2 related to increased PD-L1 expression. Lastly, GARS is validated to promote the pentose phosphate pathway by inhibiting activities of PGK1 and PKM2 in U-II subtype.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuanyuan Qu, Jinwen Feng, Xiaohui Wu, Lin Bai, Wenhao Xu, Lingli Zhu, Yang Liu, Fujiang Xu, Xuan Zhang, Guojian Yang, Jiacheng Lv, Xiuping Chen, Guo-Hai Shi, Hong-Kai Wang, Da-Long Cao, Hang Xiang, Lingling Li, Subei Tan, Hua-Lei Gan, Meng-Hong Sun, Jiange Qiu, Hailiang Zhang, Jian-Yuan Zhao, Dingwei Ye, Chen Ding
Summary: This study provides insights into the biological underpinnings and prognosis assessment of ccRCC, revealing targetable metabolic vulnerabilities.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Song-Hua Hu, Xia-Di He, Ji Nie, Jun-Li Hou, Jiang Wu, Xiao-Yan Liu, Yun Wei, Hui-Ru Tang, Wen-Xing Sun, Shu-Xian Zhou, Yi-Yuan Yuan, Yan-Peng An, Guo-Quan Yan, Yan Lin, Peng-Cheng Lin, Jean J. Zhao, Ming-Liang Ye, Jian-Yuan Zhao, Wei Xu, Shi-Min Zhao
Summary: This study reveals that docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) regulate cell signaling pathways by modifying specific proteins, and identifies the underlying mechanisms of their effects on the PI3K-AKT signaling pathway.
Article
Chemistry, Multidisciplinary
Xuan Zhang, Lian Liu, Wei-Cheng Chen, Feng Wang, Yi-Rong Cheng, Yi-Meng Liu, Yang-Fan Lai, Rui-Jia Zhang, Ya-Nan Qiao, Yi-Yuan Yuan, Yan Lin, Wei Xu, Jing Cao, Yong-Hao Gui, Jian-Yuan Zhao
Summary: Elevated maternal leucine levels are associated with an increased risk of congenital heart disease (CHD) in offspring. Increased leucine levels lead to embryonic lysine leucylation, inhibiting TBX5 signaling and contributing to CHD development.
Article
Multidisciplinary Sciences
Yan Li, Chen Xu, Bing Wang, Fujiang Xu, Fahan Ma, Yuanyuan Qu, Dongxian Jiang, Kai Li, Jinwen Feng, Sha Tian, Xiaohui Wu, Yunzhi Wang, Yang Liu, Zhaoyu Qin, Yalan Liu, Jing Qin, Qi Song, Xiaolei Zhang, Akesu Sujie, Jie Huang, Tianshu Liu, Kuntang Shen, Jian-Yuan Zhao, Yingyong Hou, Chen Ding
Summary: Proteomic profiling of gastric cancer patients undergoing chemotherapy and anti-HER2-based therapy identified four molecular subtypes and developed prognostic models. Further exploration of therapy resistance mechanisms in gastric cancer is needed.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Yuanyuan Qu, Xiaohui Wu, Aihetaimujiang Anwaier, Jinwen Feng, Wenhao Xu, Xiaoru Pei, Yu Zhu, Yang Liu, Lin Bai, Guojian Yang, Xi Tian, Jiaqi Su, Guo-Hai Shi, Da-Long Cao, Fujiang Xu, Yue Wang, Hua-Lei Gan, Shujuan Ni, Meng-Hong Sun, Jian-Yuan Zhao, Hailiang Zhang, Dingwei Ye, Chen Ding
Summary: This study provides a comprehensive understanding of the molecular landscape of tRCC through proteogenomic analysis. Dysregulation of DNA repair, mTOR signaling, and metabolic processes were identified as important factors in the development of tRCC.
NATURE COMMUNICATIONS
(2022)
Correction
Multidisciplinary Sciences
Yan Li, Chen Xu, Bing Wang, Fujiang Xu, Fahan Ma, Yuanyuan Qu, Dongxian Jiang, Kai Li, Jinwen Feng, Sha Tian, Xiaohui Wu, Yunzhi Wang, Yang Liu, Zhaoyu Qin, Yalan Liu, Jing Qin, Qi Song, Xiaolei Zhang, Akesu Sujie, Jie Huang, Tianshu Liu, Kuntang Shen, Jian-Yuan Zhao, Yingyong Hou, Chen Ding
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Kun Chang, Fujiang Xu, Xuanzhi Zhang, Bohan Zeng, Wei Zhang, Guohai Shi, Dingwei Ye
Summary: This research found that a higher immune escape score was significantly correlated with a shorter survival time. Meanwhile, through the validation of the external cohort and the correlation analysis of the immune microenvironment, we proved that IFNAR1 is the key gene regulating immune escape in ccRCC, and we also found that the function of IFNAR1 in promoting immune activation is achieved by facilitating the infiltration of CD4(+) T cells and CD8(+) T cells. Our research found a new key molecule that regulates the immune microenvironment of ccRCC, which could accurately predict the efficacy of ccRCC immunotherapy, thus providing a new idea for immunotherapy in ccRCC.
Article
Biotechnology & Applied Microbiology
Xin-Qiang Wu, Xi Tian, Fu-Jiang Xu, Yue Wang, Wen-Hao Xu, Jia-Qi Su, Yuan-Yuan Qu, Jian-Yuan Zhao, Hai-Liang Zhang, Ding-Wei Ye
Summary: This study reveals that TRIB3 overexpression is associated with increased malignancy and invasiveness of ccRCC, and is an independent risk factor for overall survival. TRIB3-related genes are mainly involved in humoral immune responses, collagen-containing extracellular matrix, and serine hydrolase activity. The expression of TRIB3 is negatively correlated with CD8(+) T cells and hematopoietic stem cells, but positively correlated with NK T cells and macrophage M1 cells. Single-cell sequencing shows that TRIB3 mainly interacts with monocytes/macrophages and CD4(+) and CD8(+) T cells.
Article
Oncology
Haijia Tang, Xiaoxin Hu, Fujiang Xu, Kefei Lin, Wenhao Xu, Haineng Huang, Hailiang Zhang, Yu Xiao, Dongdong Sun, Wangrui Liu, Shiyin Wei
Summary: This study explores the significance of POLE in HCC prognosis, clinical treatment, and tumor immune microenvironment and suggests that it could serve as a predictive biomarker for HCC.
Letter
Biochemistry & Molecular Biology
Chao Li, Hongdou Li, Xiaoying Yao, Dong Liu, Yongming Wang, Xinyi Huang, Zhongzhou Yang, Wufan Tao, Jian-Yuan Zhao, Hongyan Wang
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)