Article
Ophthalmology
Jingjing Wang, Tianyu Cheng, Bo Zhang, Shuyu Xiong, Huijuan Zhao, Qiangqiang Li, Xiangui He
Summary: The study suggests that puberty may play a regulating role in the relationship between outdoor time and refractive development in Chinese children and adolescents. Factors such as having myopic parents, less outdoor time, and changes in estradiol levels were found to be associated with greater changes in axial length and spherical equivalent. The interaction between outdoor time and puberty was significantly linked to axial length changes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Hung-Da Chou, Tsung-Chieh Yao, Yu-Shu Huang, Chung-Ying Huang, Men-Ling Yang, Ming-Hui Sun, Hung-Chi Chen, Chun-Hsiu Liu, Shih-Ming Chu, Jen-Fu Hsu, Kuan-Jen Chen, Yih-Shiou Hwang, Chi-Chun Lai, Wei-Chi Wu
Summary: Among school-aged children born prematurely, more time spent outdoors is associated with a lower odds of myopia. However, serum 25-hydroxyvitamin D concentration is not significantly associated with myopia, with a high proportion of participants having insufficient levels.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Meng-Tian Kang, Catherine Jan, ShiMing Li, Mayinuer Yusufu, Xintong Liang, Kai Cao, Luo-Ru Liu, He Li, Ningli Wang, Nathan Congdon
Summary: Pseudomyopia is more common in younger, more hyperopic children. Only a small percentage of optometry stores use cycloplegia for refracting children, indicating potential need for wider adoption of this practice.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Peiyao Jin, Junjie Deng, Minzhi Lv, Sifei Sun, Jianfeng Zhu, Xun Xu, Xiangui He, Haidong Zou
Summary: The study found that the thickness of retinal layers in children decreased with age, and the central foveal ORL thickness increased more in 8-9 year old children without myopic shift. However, the thickness of parafoveal and perifoveal retinal layers in children under 9 years old with myopic shift was less increased or more decreased.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Mijie Li, Carla Lanca, Chuen-Seng Tan, Li-Lian Foo, Chen-Hsin Sun, Fabian Yap, Raymond P. Najjar, Charumathi Sabanayagam, Seang-Mei Saw
Summary: This study evaluated the association between reported time outdoors and light exposure patterns with myopia in 9-year-old Singaporean children. The findings showed that greater reported time outdoors was associated with a lower risk of myopia, while light levels and specific light measures did not have an impact.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Jingjing Wang, Ziyi Qi, Yanqing Feng, Jun Chen, Linlin Du, Jinliuxing Yang, Hui Xie, Jianfeng Zhu, Haidong Zou, Xiangui He, Xun Xu
Summary: This research aimed to generate normative values of hyperopia reserve and refractive progression as effective tools to estimate the risk of myopia. The study found age-specific normative values of hyperopia reserve and yearly myopic shift in children and adolescents aged 3-16 years, which are important for identifying and preventing myopia.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ving Fai Chan, David M. Wright, Sonia Mavi, Reshma Dabideen, Mike Smith, Alan Sherif, Nathan Congdon
Summary: In this study, we modeled the suitability of conventional ready-made spectacles (RMS) and interchangeable-lens ready-made spectacles (IRMS) based on prescribing guidelines. The results showed that the coverage delivered by these spectacles is limited, especially for children and presbyopic adults.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Jinhua Bao, Adeline Yang, Yingying Huang, Xue Li, Yiguo Pan, Chenglu Ding, Ee Woon Lim, Jingwei Zheng, Daniel P. Spiegel, Bjorn Drobe, Fan Lu, Hao Chen
Summary: The study found that spectacle lenses with aspherical lenslets can effectively slow myopia progression and reduce axial elongation compared to single-vision spectacle lenses. Myopia control efficacy increases with lenslet asphericity.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Fen Fen Li, Shi Yao Lu, Shu Min Tang, Ka Wai Kam, Tam O. S. Pancy, Wilson W. K. Yip, Alvin L. Young, Clement C. Tham, Chi Pui Pang, Jason C. Yam, Li Jia Chen
Summary: The study revealed ZC3H11B and BICC1 as genetic risk factors for moderate and high myopia, while ZC3H11B, KCNQ5, SNTB1 and GJD2 are associated with excessive axial length in children.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Sylvain El-Khoury, Sophia Strittmatter, Theophile Tuyisabe, Paul-Rolf Preussner, Youssef Abdelmassih
Summary: According to a retrospective study in a tertiary referral centre in Rwanda, 10.9% of children under 18 years old had severe visual impairment and blindness (SVI/BL) in at least one eye. The main causes of bilateral SVI/BL were cataract, refractive error, keratoconus, congenital eye anomaly, glaucoma, cortical blindness, and retinoblastoma, while trauma, cataract, keratoconus, infectious corneal disease, and retinoblastoma were the main causes of unilateral SVI/BL.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Lucinda J. Teoh, Ameenat Lola Solebo, Jugnoo S. Rahi
Summary: This study investigates the changing epidemiology of severe visual impairment (SVI) and blindness (BL) in children in the UK in the 21st century. The overall incidence rates remained stable, with higher rates in infancy. Mortality among children diagnosed in infancy declined, despite an increase in the overall proportion with non-ophthalmic impairments/disorders. The relative contribution of different groups of disorders changed over time, with an increase in cerebral visual impairment and hereditary conditions. The study highlights the increasing complexity and heterogeneity of childhood visual disability.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Sanne M. Thysen, Ane Baerent Fisker, Stine Byberg, Peter Aaby, Partho Roy, Richard White, Ulla Griffiths, Rebecca C. Harris
Summary: Disregarding the restrictive BCG vial-opening policy was estimated to reduce TB deaths by 11.0% and all-cause deaths by 8.1%, with incremental cost-effectiveness ratios of US$ 911 per discounted life-year gained for TB deaths and US$ 9 per discounted life-year gained for all-cause deaths. The results suggest that it would be cost-effective to disregard the restrictive vial-opening policy in Guinea-Bissau and other similar settings.
Article
Ophthalmology
Yinxi Yu, Lauren A. Tomlinson, Gil Binenbaum, Gui-Shuang Ying
Summary: Type 1 ROP developed in about 6% of premature infants over wide time windows in terms of both PMA and PNA. BW and GA are the dominant risk factors for type 1 ROP, while other prenatal factors add minimal predictive power for type 1 ROP.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Hongxi Wang, Yuancun Li, Kunliang Qiu, Riping Zhang, Xuehui Lu, Li Luo, Jian-Wei Lin, Yanlin Lu, Dan Zhang, Peiting Guo, Yong Yang, Liu Jing, Yingzi Huang, Qian Ma, Ruiqing Zhou, Yunxuan Ou, Quanwen Chen, Youming Zhou, Dandan Deng, Can Li, Jason C. Yam, Li Jia Chen, Chi-Pui Pang, Mingzhi Zhang
Summary: The study investigated the prevalence and risk factors for myopia and uncorrected myopia in schoolchildren in southern China. It found a high prevalence of myopia and a significant proportion of uncorrected myopia, especially in primary schools. This highlights the importance of public education on eye care among schoolchildren, even in a municipal city.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Shengsong Xu, Zhouyue Li, Wenchen Zhao, Bingru Zheng, Jinyun Jiang, Guitong Ye, Zhibin Feng, Wen Long, Liying He, Mingguang He, Yin Hu, Xiao Yang
Summary: Combining atropine with ortho-k treatment can improve the efficacy of myopia control in children aged 8-12, with younger children benefiting more from ortho-k.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Yung-Ray Hsu, Jerry Chien-Chieh Huang, Yong Tao, Toshikatsu Kaburaki, Christopher Seungkyu Lee, Tai-Chi Lin, Chih-Chien Hsu, Shih-Hwa Chiou, De-Kuang Hwang
Article
Biochemistry & Molecular Biology
Tzu-Wei Lin, Yueh Chien, Yi-Ying Lin, Mong-Lien Wang, Aliaksandr A. Yarmishyn, Yi-Ping Yang, De-Kuang Hwang, Chi-Hsien Peng, Chih-Chien Hsu, Shih-Jen Chen, Ke-Hung Chien
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Chih-Chen Hsu, Yi-Ying Lin, Tien-Chun Yang, Aliaksandr A. Yarmishyn, Tzu-Wei Lin, Yuh-Lih Chang, De-Kuang Hwang, Chien-Ying Wang, Yung-Yang Liu, Wen-Liang Lo, Chi-Hsien Peng, Shih-Jen Chen, Yi-Ping Yang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Nursing
Valerie Holton, James E. Hinterlong, Ching-Yao Tsai, Jen-Chen Tsai, Jia Shan Wu, Yiing Mei Liou
Summary: The study found that factors such as age, parent myopia, and school district are associated with a student's myopia risk. Spending one hour or more on near work can increase the odds of myopia, while the same amount of time spent on outdoor activities or physical exercises can lower the risk.
JOURNAL OF SCHOOL NURSING
(2021)
Article
Engineering, Biomedical
Zhengbing Zhou, Da Long, Chih-Chien Hsu, Huanhuan Liu, Long Chen, Benjamin Slavin, Hui Lin, Xiaowei Li, Juyu Tang, Samuel Yiu, Sami Tuffaha, Hai-Quan Mao
ACTA BIOMATERIALIA
(2019)
Article
Engineering, Biomedical
Tien-Chun Yang, Chia-Yu Chang, Aliaksandr A. Yarmishyn, Yen-Shiang Mao, Yi-Ping Yang, Mong-Lien Wang, Chih-Chien Hsu, Hsin-Yu Yang, De-Kuang Hwang, Shih-Jen Chen, Ming-Long Tsai, Yun-Hsien Lai, Yonhua Tzeng, Chia-Ching Chang, Shih-Hwa Chiou
ACTA BIOMATERIALIA
(2020)
Article
Sport Sciences
Stanley Sai-chuen Hui, Ru Zhang, Koya Suzuki, Hisashi Naito, Govindasamy Balasekaran, Jong Kook Song, Soo Yeon Park, Yiing Mei Liou, Dajiang Lu, Bee Koon Poh, Kallaya Kijboonchoo, Wiyada Thasanasuwan
Summary: Compliance with 24-hour movement guidelines varied among Asian adolescents in eight cities, and a negative association was found between the number of guidelines followed and body fat percentage. Meeting only the sleep guideline or both the physical activity and sleep guidelines showed negative associations with body fat percentage compared to not meeting any guidelines.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Article
Biochemistry & Molecular Biology
Henkie Isahwan Ahmad Mulyadi Lai, Shih-Jie Chou, Yueh Chien, Ping-Hsing Tsai, Chian-Shiu Chien, Chih-Chien Hsu, Ying-Chun Jheng, Mong-Lien Wang, Shih-Hwa Chiou, Yu-Bai Chou, De-Kuang Hwang, Tai-Chi Lin, Shih-Jen Chen, Yi-Ping Yang
Summary: This study identified the expression of ACE2 and TMPRSS2 in human induced pluripotent stem cell (hiPSC)-derived retinal organoids, and demonstrated the potential infection of SARS-CoV-2 pseudovirus in retinal organoids and monolayer cultures. These findings highlight the potential of iPSC-derived retinal organoids as models for ACE2 receptor-based SARS-CoV-2 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Wei Chiu, Ting-Yi Lin, Yun-Chia Chang, Henkie Isahwan-Ahmad Mulyadi Lai, Shen-Che Lin, Chun Ma, Aliaksandr A. Yarmishyn, Shiuan-Chen Lin, Kao-Jung Chang, Yu-Bai Chou, Chih-Chien Hsu, Tai-Chi Lin, Shih-Jen Chen, Yueh Chien, Yi-Ping Yang, De-Kuang Hwang
Summary: Inherited retinal dystrophies (IRDs) are rare eye diseases caused by gene mutations, and gene therapy has shown promising prospects in treating these diseases. Gene therapy for patients with confirmed biallelic RPE65 mutation-associated Leber Congenital Amaurosis (LCA) has been approved by the FDA, marking a significant advancement in the field of genetic treatments for eye diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ting-Yi Lin, Yun-Chia Chang, Yu-Jer Hsiao, Yueh Chien, Ying-Chun Jheng, Jing-Rong Wu, Lo-Jei Ching, De-Kuang Hwang, Chih-Chien Hsu, Tai-Chi Lin, Yu-Bai Chou, Yi-Ming Huang, Shih-Jen Chen, Yi-Ping Yang, Ping-Hsing Tsai
Summary: This study identified five potentially pathogenic variants, including a novel variant that has not been reported previously, through whole-exome sequencing. Further research is needed to clarify the precise roles of these variants in the pathogenesis of retinitis pigmentosa. These findings may contribute to exploring risk variants and upgrading variant annotation databases, potentially aiding in the detection of specific eye diseases in East Asia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Health Care Sciences & Services
Yu-Jer Hsiao, Hao-Kai Chuang, Sheng-Chu Chi, Yung-Yu Wang, Pin-Hsuan Chiang, Pai-Chi Teng, Tung-Mei Kuang, Aliaksandr A. Yarmishyn, Tai-Chi Lin, De-Kuang Hwang, Shih-Jen Chen, Shih-Hwa Chiou, Mei-Ju Chen, Ai-Ru Hsieh, Chih-Chien Hsu
Summary: This study conducted a GWAS based on the Taiwan Biobank, identifying 138 independent glaucoma-associated SNPs. A polygenic risk score model was successfully constructed to predict the risk of glaucoma in individuals, and its effectiveness was validated in the Han Chinese population.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Chih-Chien Hsu, Hao-Kai Chuang, Yu-Jer Hsiao, Yuan-Chi Teng, Pin-Hsuan Chiang, Yu-Jun Wang, Ting-Yi Lin, Ping-Hsing Tsai, Chang-Chi Weng, Tai-Chi Lin, De-Kuang Hwang, Ai-Ru Hsieh
Summary: In this study, a genome-wide association study was conducted on the largest Han population to date, leading to the identification of cataract-associated SNPs. Additionally, a polygenic risk score was developed to predict high-risk cataract individuals. These findings are of great significance for understanding the genetic basis of cataracts and predicting individual risk of developing cataracts.
Article
Chemistry, Multidisciplinary
Lan-Sheng Yang, Hsin-Fei Meng, Yu-Chiang Chao, Hu-Chi Huang, Chih-Wei Luo, Hsiao-Wen Zan, Sheng-Fu Horng, Heh-Lung Huang, Cheng-Chang Lai, Yiing-Mei Liou