Review
Oncology
David Johnson, Brigette B. Y. Ma
Summary: The upregulation of the PD-1/PD-L1 pathway is a possible immune-evasion mechanism in Epstein-Barr virus-associated nasopharyngeal cancer (NPC). Therapeutic targeting of this pathway is actively researched in NPC, with multiple monoclonal antibodies currently under evaluation in clinical settings. Combinatorial strategies involving cytotoxic chemotherapy, radiotherapy, and other immunotherapeutic agents are also being explored in clinical trials for NPC.
Article
Oncology
Xi Zhong, Li Li, Jinxue Yin, Yuanlin Chen, Xin Xin, Lanlan Yu, Yongfang Tang, Jiangyu Zhang, Jiansheng Li
Summary: This study investigated the feasibility and usefulness of quantitative ADC measurements in predicting the expression status of PD-L1 in NPC. The results showed that ADC measurements were negatively correlated with PD-L1 expression status and could predict high PD-L1 expression status.
Review
Immunology
Quanqing Tang, Shihao Li, Gaozhen Huang, Hongwei Liu
Summary: Urothelial carcinoma (UC) is a common malignant tumor. Platinum-based chemotherapy has been the standard treatment for metastatic UC, but immune checkpoint inhibitors (ICIs) offer hope for patients unfit for platinum therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Anna Makowska, Nora Lelabi, Christina Nothbaum, Lian Shen, Pierre Busson, Tram Thi Bao Tran, Michael Eble, Udo Kontny
Summary: Radiation enhances the killing of NPC cells by NK cells, and further augmentation of killing can be achieved by blocking the PD-L1/PD-1 checkpoint. The combination of radiotherapy with PD-L1/PD-1 checkpoint blockade may increase the efficacy of radiotherapy in NPC tumors.
Review
Medicine, General & Internal
Jun Xu, Jianguo Zhao, Jianfang Wang, Caiping Sun, Xiaoling Zhu
Summary: This meta-analysis suggests that a higher pretreatment LDH level is significantly associated with worse overall survival and shorter progression-free survival in melanoma patients receiving anti-PD1/PD-L1 monotherapy.
Article
Oncology
Hanqun Zhang, Shisheng Tan, Chunju Fang, Qi Zhang, Xue Cao, Yuncong Liu
Summary: This study explores the role of PD-1/PD-L1 in the evaluation of concurrent chemoradiotherapy efficacy and prognosis in cervical cancer patients. The results suggest that PD-1/PD-L1 may be a potential indicator for evaluating the efficacy and prognosis of CCRT in cervical cancer, providing potential targets for its treatment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Chen Zhang, Qing Yang
Summary: Our meta-analysis of 55 studies found that high PD-L1 expression is not significantly associated with overall survival, progression-free survival, recurrence-free survival, cancer-specific survival, and disease-free survival in gynecological cancers. However, subgroup analysis revealed that high PD-L1 expression may be correlated with a shorter overall survival in some cases. Additionally, PD-L1 positivity was associated with certain clinical parameters and could potentially predict response to anti-PD-1/PD-L1 treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Kiyohiro Ando, Kazuyuki Hamada, Midori Shida, Ryotaro Ohkuma, Yutaro Kubota, Atsushi Horiike, Hiroto Matsui, Tomoyuki Ishiguro, Yuya Hirasawa, Hirotsugu Ariizumi, Makoto Watanabe, Rie Onoue, Junji Tsurutani, Kiyoshi Yoshimura, Takuya Tsunoda, Shinichi Kobayashi, Satoshi Wada
Summary: The study investigated the prognostic impact of pretreatment PD-L1 expression levels in PBMC subsets in patients receiving anti-PD-1 blockade therapy. It was found that an increase in PD-L1 expression levels on CD14(+)monocytes was significantly associated with overall survival, suggesting a potential predictive role of PBMC in patients treated with immune checkpoint inhibitors.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Oncology
Wen Wen, Yong Zhang, Hua Zhang, Yingshuang Chen
Summary: PD-L1/PD-1 inhibitors have shown effective and tolerable outcomes in advanced hepatocellular carcinoma patients. Additionally, the combination of PD-L1/PD-1 inhibitors with anti-VEGF agents leads to more clinical improvements compared to monotherapy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Anna Makowska, Selina Meier, Lian Shen, Pierre Busson, Valentin Baloche, Udo Kontny
Summary: NK cells exhibit cytotoxicity against NPC cells in the context of chemotherapy, and the inhibition of the PD-L1/PD-1 checkpoint can enhance NK cell cytotoxicity towards NPC cells. Therefore, the addition of an anti-PD-1 antibody to chemotherapy in patients with NPC may improve the efficacy of induction chemotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Topias Karjula, Hanna Elomaa, Anne Niskakangas, Olli Mustonen, Iiris Puro, Teijo Kuopio, Maarit Ahtiainen, Jukka-Pekka Mecklin, Toni T. Seppala, Erkki-Ville Wirta, Eero Sihvo, Juha P. Vayrynen, Fredrik Yannopoulos, Olli Helminen
Summary: The study found that CD3(+) and CD8(+) T-cell density and PD-1/PD-L1 expression have prognostic value in pulmonary metastases of colorectal cancer. T-cell infiltration is higher in pulmonary metastases compared to primary tumors. High CD3(+) and CD8(+) cell density are associated with better survival, while high PD-L1 expression is associated with favorable prognosis.
Article
Oncology
Pei Huang, Wei Hu, Ying Zhu, Yushen Wu, Huapeng Lin
Summary: This meta-analysis found that high levels of sPD-L1 in cancer patients were associated with worse survival prognosis, suggesting that sPD-L1 may serve as a potential prognostic, non-invasive, and dynamic monitoring biomarker for cancers in the future.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Fengze Sun, Dawei Wang, Aina Liu, Tianqi Wang, Dongxu Zhang, Huibao Yao, Kai Sun, Zhongbao Zhou, Guoliang Lu, Jitao Wu
Summary: PD-1 inhibitors demonstrate promising tolerance and efficacy in advanced urothelial carcinoma, but combination therapy with chemotherapy leads to more grade 3-4 adverse events.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Lin Zhang, Bo Hao, Zhihua Geng, Qing Geng
Summary: Toripalimab, a selective anti-PD-1 monoclonal antibody, has shown anti-tumor effects in melanoma, nasopharyngeal carcinoma, and urothelial carcinoma, and could be a valuable choice for future tumor treatment decision-making.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Feng Xian, Dacheng Ren, Jun Bie, Guohui Xu
Summary: This meta-analysis demonstrates that high PD-L1/PD1 expression is associated with poor survival in patients with intrahepatic cholangiocarcinoma (ICC). PD-L1/PD1 may serve as a valuable prognostic and predictive biomarker, as well as a potential therapeutic target, for ICC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yabing Cao, Xibin Qiu, Guangli Xiao, Hao Hu, Tongyu Lin
Article
Oncology
Lili Mao, Jie Dai, Yabin Cao, Xue Bai, Xinan Sheng, Zhihong Chi, Chuanliang Cui, Yan Kong, Yanxiang Zhang, Lin Wu, Xuan Wang, Bixia Tang, Bin Lian, Xieqiao Yan, Siming Li, Li Zhou, Xiaoting Wei, Caili Li, Zhonghui Qi, Lu Si, Jun Guo
Summary: This study evaluated the anti-tumour activity of palbociclib in patients with advanced AM with CDK4 pathway gene aberrations. The results showed that palbociclib monotherapy demonstrated preliminary efficacy in some patients, with MCM7 amplification or high protein levels associated with treatment benefit. The JAK-STAT pathway might play a role in the mechanism of action of palbociclib in AM.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Yabing Cao, Hongtao Chen, Yaobin Huang, Hao Hu