4.7 Meeting Abstract

Interim Results of a First in Man Study with the Fc-Optimized FLT3 Antibody Flysyn for Treatment of Acute Myeloid Leukemia with Minimal Residual Disease

Journal

BLOOD
Volume 134, Issue -, Pages -

Publisher

AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2019-125327

Keywords

-

Categories

Ask authors/readers for more resources

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Hematology

Identification of CD318 (CDCP1) as novel prognostic marker in AML

Jonas S. Heitmann, Ilona Hagelstein, Clemens Hinterleitner, Malte Roerden, Gundram Jung, Helmut R. Salih, Melanie Maerklin, Joseph Kauer

ANNALS OF HEMATOLOGY (2020)

Article Cell Biology

Genetic loss of NFAT2 (NFATc1) impairs B cell development of B1 and B2 B cells

Melanie Maerklin, Jonas S. Heitmann, Joseph Kauer, Stefan Wirths, Martin R. Mueller

CELLULAR IMMUNOLOGY (2020)

Article Hematology

CD105 (endoglin) as risk marker in AML patients undergoing stem cell transplantation

Melanie Maerklin, Ilona Hagelstein, Clemens Hinterleitner, Helmut R. Salih, Joseph Kauer, Jonas S. Heitmann

INTERNATIONAL JOURNAL OF HEMATOLOGY (2020)

Article Cell Biology

A novel flow cytometry-based assay to measure compromised B cell receptor signaling as a prognostic factor in chronic lymphocytic leukemia

Jonas S. Heitmann, Melanie Maerklin, Felicia M. Truckenmueller, Clemens Hinterleitner, Daniela Doerfel, Michael Haap, Hans-Georg Kopp, Stefan Wirths, Martin R. Mueller

JOURNAL OF LEUKOCYTE BIOLOGY (2020)

Article Oncology

Tocilizumab, but not dexamethasone, prevents CRS without affecting antitumor activity of bispecific antibodies

Joseph Kauer, Sebastian Hoerner, Lukas Osburg, Stefanie Mueller, Melanie Maerklin, Jonas S. Heitmann, Latifa Zekri, Hans-Georg Rammensee, Helmut R. Salih, Gundram Jung

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Article Medicine, Research & Experimental

Oral intake of lipopolysaccharide regulates toll-like receptor 4-dependent granulopoiesis

Melanie Maerklin, Stefanie Bugl, Stefan Wirths, Julia-Stefanie Frick, Martin R. Mueller, Hans-Georg Kopp, Dominik Schneidawind

EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

Article Oncology

Fc gamma receptor expression serves as prognostic and diagnostic factor in AML

Jonas S. Heitmann, Ilona Hagelstein, Clemens Hinterleitner, Lukas Osburg, Helmut R. Salih, Joseph Kauer, Melanie Maerklin

LEUKEMIA & LYMPHOMA (2020)

Article Cell Biology

C-Cbl regulates c-MPL receptor trafficking and its internalization

Melanie Maerklin, Claudia Tandler, Hans-Georg Kopp, Kyle L. Hoehn, Leticia Quintanilla-Martinez, Oliver Borst, Martin R. Mueller, Sebastian J. Saur

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Article Immunology

SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition

Annika Nelde, Tatjana Bilich, Jonas S. Heitmann, Yacine Maringer, Helmut R. Salih, Malte Roerden, Maren Luebke, Jens Bauer, Jonas Rieth, Marcel Wacker, Andreas Peter, Sebastian Hoerber, Bjoern Traenkle, Philipp D. Kaiser, Ulrich Rothbauer, Matthias Becker, Daniel Junker, Gerard Krause, Monika Strengert, Nicole Schneiderhan-Marra, Markus F. Templin, Thomas O. Joos, Daniel J. Kowalewski, Vlatka Stos-Zweifel, Michael Fehr, Armin Rabsteyn, Valbona Mirakaj, Julia Karbach, Elke Jaeger, Michael Graf, Lena-Christin Gruber, David Rachfalski, Beate Preuss, Ilona Hagelstein, Melanie Maerklin, Tamam Bakchoul, Cecile Gouttefangeas, Oliver Kohlbacher, Reinhild Klein, Stefan Stevanovic, Hans-Georg Rammensee, Juliane S. Walz

Summary: SARS-CoV-2-specific T cell epitopes were identified in convalescent and unexposed individuals, showing cross-reactivity with common cold coronaviruses. The diversity of SARS-CoV-2 T cell responses may be associated with mild symptoms of COVID-19.

NATURE IMMUNOLOGY (2021)

Article Immunology

Genetic Loss of LCK Kinase Leads to Acceleration of Chronic Lymphocytic Leukemia

Melanie Maerklin, Alexander R. Fuchs, Claudia Tandler, Jonas S. Heitmann, Helmut R. Salih, Joseph Kauer, Leticia Quintanilla-Martinez, Stefan Wirths, Hans-Georg Kopp, Martin R. Mueller

FRONTIERS IN IMMUNOLOGY (2020)

Article Medicine, Research & Experimental

An IgG-based bispecific antibody for improved dual targeting in PSMA-positive cancer

Latifa Zekri, Fabian Vogt, Lukas Osburg, Stefanie Mueller, Joseph Kauer, Timo Manz, Martin Pfluegler, Andreas Maurer, Jonas S. Heitmann, Ilona Hagelstein, Melanie Maerklin, Sebastian Hoerner, Tilmann Todenhoefer, Carsten Calaminus, Arnulf Stenzl, Bernd Pichler, Christian laFougere, Marc A. Schneider, Hans-Georg Rammensee, Lars Zender, Bence Sipos, Helmut R. Salih, Gundram Jung

Summary: The PSMA antibody 10B3 exhibits superior dual reactivity on prostate carcinoma and squamous cell carcinoma tissues, and is used to construct T-cell recruiting bispecific antibodies IgGsc, which show better efficacy in eliminating tumors. Treatment with IgGsc in three patients with metastasized prostate carcinoma resulted in significant T-cell activation and rapid reduction of elevated PSA levels.

EMBO MOLECULAR MEDICINE (2021)

Article Oncology

Expression levels of HLA-DR in acute myeloid leukemia: implications for antigenicity and clinical outcome

Malte Roerden, Melanie Maerklin, Helmut R. Salih, Wolfgang A. Bethge, Reinhild Klein, Hans-Georg Rammensee, Annika Nelde, Juliane S. Walz

Summary: Low human leukocyte antigen (HLA)-DR expression does not affect the diversity of antigen presentation in non-promyelocytic acute myeloid leukemia (AML) patients, and is not associated with survival rates.

LEUKEMIA & LYMPHOMA (2021)

Article Multidisciplinary Sciences

Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross-reactivity

Matthias Becker, Monika Strengert, Daniel Junker, Philipp D. Kaiser, Tobias Kerrinnes, Bjoern Traenkle, Heiko Dinter, Julia Haering, Stephane Ghozzi, Anne Zeck, Frank Weise, Andreas Peter, Sebastian Hoerber, Simon Fink, Felix Ruoff, Alex Dulovic, Tamam Bakchoul, Armin Baillot, Stefan Lohse, Markus Cornberg, Thomas Illig, Jens Gottlieb, Sigrun Smola, Andre Karch, Klaus Berger, Hans-Georg Rammensee, Katja Schenke-Layland, Annika Nelde, Melanie Maerklin, Jonas S. Heitmann, Juliane S. Walz, Markus Templin, Thomas O. Joos, Ulrich Rothbauer, Gerard Krause, Nicole Schneiderhan-Marra

Summary: The humoral immune response to SARS-CoV-2 is crucial for understanding COVID-19 progression, monitoring seroconversion, and supporting vaccine development. A multiplex immunoassay has been developed, including spike and nucleocapsid proteins of SARS-CoV-2 and endemic human coronaviruses, with high specificity and sensitivity.

NATURE COMMUNICATIONS (2021)

Article Oncology

An Fc-Optimized CD133 Antibody for Induction of NK Cell Reactivity against B Cell Acute Lymphoblastic Leukemia

Fabian Riegg, Martina S. Lutz, Bastian J. Schmied, Jonas S. Heitmann, Manon Queudeville, Peter Lang, Gundram Jung, Helmut R. Salih, Melanie Maerklin

Summary: B cell acute lymphoblastic leukemia (B-ALL) is characterized by malignant B cells and new therapeutic option like 293C3-SDIE, which targets CD133 on B-ALL cells, activates natural killer cells, leading to B-ALL cell lysis. CD133 could serve as a separate target in B-ALL therapy, providing a promising treatment option.

CANCERS (2021)

Meeting Abstract Hematology

First-in-Human Phase I Dose Escalation and Expansion Study Evaluating the Fc Optimized FLT3 Antibody Flysyn in Acute Myeloid Leukemia Patients with Minimal Residual Disease

Jonas S. Heitmann, Daniela Dorfel, Sabine Kayser, Michael Heuser, Felicitas Thol, Silke Kapp-Schwoerer, Wolfgang Bethge, Ludger Grosse-Hovest, Martin Steiner, Melanie Marklin, Juliane S. Walz, Richard F. Schlenk, Gundram Jung, Helmut R. Salih

BLOOD (2020)

No Data Available