Article
Biochemical Research Methods
Dipankar Kundu, S. Bhattacharyya, Partha P. Gopmandal, H. Ohshima
Summary: The study investigates the hindrance created by the induced electric field on the sedimentation of a charged colloid in an aqueous media. It is found that the sedimentation velocity is governed by the balance of an electric force, hydrodynamic drag, and gravitational force, with the deviation magnifying as the charge density and particle slip length increase.
Article
Chemistry, Analytical
Minoru Suga, Ryutaro Inaba, Kenta Ookami, Hiroaki Shinohara
Summary: Rapid and easy viability assays of microorganisms are crucial for efficient control of fermentation processes. This study developed a simple optical analysis system that accurately measures the transmittance changes of cylindrical fission yeast cells in an alternating current electric field without a microscope. The transmittance of living and dead cells at different frequencies can be used to estimate the survival rate. This EO-optical method provides a rapid and easy process for viability assessment of non-spherical cells without requiring a calibration curve.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Oncology
Raphaela Schwappacher, Walburga Dieterich, Dejan Reljic, Christian Pilarsky, Debabrata Mukhopadhyay, David K. Chang, Andrew Biankin, Juergen Siebler, Hans J. Herrmann, Markus F. Neurath, Yurdagul Zopf
Summary: Exercise-induced cytokines in serum from advanced-stage pancreatic cancer patients inhibit cancer cell growth and migration, and induce cancer cell death. This study provides new insights into the cancer-protective function of exercise in pancreatic cancer and supports the use of sport therapies for cancer patients.
Article
Physics, Fluids & Plasmas
V. A. Ivanov
Summary: An analytical solution of the Poisson's equation is derived for the electric field on the surface of an electrode in a non-isothermal collisionless plasma. The plasma layer near the high-potential electrode with violated quasi neutrality increases in proportion to the parameter [eΨ/2Te](3/4), given the condition eΨ/Te >> 1. The electric field calculated by the obtained formula E = Ψ/L is significantly lower than the fields calculated by the classical formula E = Ψ/r(D) at high potential and for the parameter eΨ/Te >> 1, in the range of densities and electron temperatures considered.
PLASMA PHYSICS REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Jorge Morgado, Laura Sordini, Federico Castelo Ferreira
Summary: This study measured the potential of the electrical double layer (EDL) and found that applying a voltage to the PEDOT:PSS substrate can modify the EDL and affect the response of neural stem cells to the electric field.
BIOELECTROCHEMISTRY
(2022)
Article
Biophysics
Istvan P. Sugar
Summary: Based on the generalized version of Newton's Shell Theorem, the electric field energy density around two surface-charged spheres surrounded by electrolyte is calculated. It is found that when the surfaces of the spheres are farther from each other than four times of the Debye length, the field energy density around and inside the smaller sphere is independent of the presence of the larger sphere. The maximum electric field energy density occurs when the smaller sphere touches the inner surface of the larger sphere, specifically at the touching point on the outer surface of the larger sphere.
Article
Engineering, Electrical & Electronic
Amirabbas Mir, Mehdi Shabani-Nooshabadi
Summary: This study investigates the electrochemical behavior of a modified carbon paste electrode with gold nanoparticles for the measurement of imatinib. The modified electrode shows good performance in the presence of gold nanoparticles. Optimized parameters allow for quantitative measurements and low detection limit. The electrode also demonstrates high efficiency and anti-interference performance in plasma samples.
IEEE SENSORS JOURNAL
(2023)
Article
Biophysics
Istvan P. Sugar
Summary: Based on the generalized version of Newton's Shell Theorem, the electric field energy density around two separated surface-charged spheres in the presence of an electrolyte was calculated. The results showed that when the distance between the spheres was greater than four times the Debye length, the energy density around one sphere was independent of the other sphere. At low electrolyte ion concentration, the energy density inside and outside the spheres was zero, and it decreased with increasing distance from the sphere's surface. At high electrolyte ion concentration, the energy density decreased rapidly with increasing distance from the sphere's surface. The electric interaction between the charged spheres influenced the field energy density, especially when the surfaces of the spheres were close to each other. Analytical equations were also derived to model the interaction energy and electric field energy density between a charged flat surface and a charged sphere surrounded by neutral electrolyte in the context of electrophoresis.
Article
Engineering, Electrical & Electronic
Sergey Kutsaev, Marcos Ruelas, Vladimir Goncharik, Hoson To, Alex Murokh
Summary: This article presents the design of a pulse-to-pulse THz spectrometer for diagnostics of accelerating structures and THz radiation sources, and validates its effectiveness through numerical simulations and test results.
IEEE TRANSACTIONS ON TERAHERTZ SCIENCE AND TECHNOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Lien-Sing Tseng, Po-Hsuan Lai, Chia-Min Yang, Michael S. -C. Lu
Summary: This letter presents a large-scale DNA array based on complementary metal-oxide-semiconductor technology, consisting of over 1000 sensors. The array achieved sensitive and wide-range detection under strong Debye charge screening. By modulating the extended-gate field effect transistors (FETs), the Debye length was extended and the results were compared at different frequencies. The higher frequency operation showed superior DNA sensitivity compared to the lower frequencies, with a pH sensitivity of 38 mV/pH and a detection sensitivity of 19 mV/log(10)[DNA] from 0.1 fM to 10 nM in 1x phosphate buffered saline at 15 MHz.
IEEE SENSORS LETTERS
(2023)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)