Journal
BIORESOURCE TECHNOLOGY
Volume 289, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biortech.2019.121724
Keywords
QSTR; Combined toxic effects; Lignocellulose-derived inhibitors; Ferulic acid
Funding
- National Key R&D Program of China [2018YFC1901005]
- Shanghai Science and Technology Committee [17295810603, 17DZ1202804, 18295810400, ECNU-IEC-201901]
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This study performed a Quantitative Structure-Toxicity Relationship (QSTR) model to evaluate the combined toxicity of lignocellulose-derived inhibitors on bioethanol production. Compared with all the control groups, the combined systems exhibited lower conductivity values, higher oxidation-reduction potential values, as well as maximum inhibition rates. These results indicated that the presence of combined inhibitors had a negative effect on the bioethanol fermentation process. Meanwhile, QSTR model was excellent for evaluating the combined toxic effects at lower ferulic acid concentration (([1: 4] x IC50)) and (([1: 1] x IC50)), due to higher R-2 values (0.994 and 0.762), lower P values (0.000 and 0.023) and relative error values (less than 30%). The obtained results also showed that the combined toxic effects of ferulic acid and representative lignocellulose-derived inhibitors were relevant to different molecular descriptors. Meanwhile, the interactions of combined inhibitors were weaker when ferulic acid was at low concentration ([1:4] x IC50).
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