Review
Biochemistry & Molecular Biology
Eugenia D. Namiot, Jenni Viivi Linnea Niemi, Vladimir N. Chubarev, Vadim V. Tarasov, Helgi B. Schioth
Summary: Neurological diseases can significantly impact quality of life and lifespan. Stem cells show promise in treating these diseases due to their regenerative properties, as well as their ability to reduce inflammation and promote angiogenesis. A study analyzing 492 clinical trials found that the most common neurological disorders treated with stem cells were brain, spinal cord, and peripheral nerve injuries, stroke, multiple sclerosis, and brain tumors. The majority of trials were in phases 1 or 2, with only two trials in phase 4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Yanina Bogliotti, Mark Vander Roest, Aras N. Mattis, Robert G. Gish, Gary Peltz, Robin Anwyl, Salah Kivlighn, Eric R. Schuur
Summary: Liver disease is a major cause of global mortality, with late-stage liver disease being characterized by hepatocyte injury, inflammation, and aberrant tissue healing. Treatment options for liver disease are limited, but cell replacement therapy using hepatocyte-like cells shows promise as a safe and effective treatment option.
Review
Cell & Tissue Engineering
Maryam Ghasemi, Elham Roshandel, Mozhdeh Mohammadian, Behrouz Farhadihosseinabadi, Parvin Akbarzadehlaleh, Karim Shamsasenjan
Summary: In recent years, mesenchymal stromal cells (MSCs) have gained scientific attention for their potential in treating incurable diseases. However, concerns about side effects and limitations of direct cell transplantation have led to the exploration of MSC secretome, which consists of bioactive molecules involved in neuro-regeneration. This study reviews the therapeutic effects and mechanisms of MSC secretome in central nervous system disorders, such as Alzheimer's disease, multiple sclerosis, and Parkinson's disease, with the aim of discovering new treatment options.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Cell Biology
Magdalena Kulus, Rafal Sibiak, Katarzyna Stefanska, Maciej Zdun, Maria Wieczorkiewicz, Hanna Piotrowska-Kempisty, Jedrzej M. Jaskowski, Dorota Bukowska, Kornel Ratajczak, Maciej Zabel, Paul Mozdziak, Bartosz Kempisty
Summary: Mesenchymal stem/stromal cells (MSCs) are extensively researched for regenerative medicine, with perinatal MSCs emerging as a valuable source devoid of ethical conflicts compared to embryonic stem cells, showing better self-renewal and differentiation properties. Understanding the anatomy of perinatal tissues and the signaling pathways involved in MSC differentiation is essential for their clinical applications.
Article
Oncology
Yolanda Aguilera, Nuria Mellado-Damas, Laura Olmedo-Moreno, Victor Lopez, Concepcion Panadero-Moron, Marina Benito, Hugo Guerrero-Cazares, Catalina Marquez-Vega, Alejandro Martin-Montalvo, Vivian Capilla-Gonzalez
Summary: Utilizing mesenchymal stem cells through intranasal application is a safe and non-invasive strategy for treating neurological disorders, as evidenced by studies conducted on mice. The repeated doses of cells administered through the nostrils did not cause any serious adverse events or tumor formation, demonstrating the potential for future clinical trials. These findings support the use of intranasal MSC therapy for managing central nervous system diseases.
Article
Medicine, General & Internal
Aishwarya Balasankar, Shu-Yi Claire Chan, Venkata Pakala Sudheer Babu, Gary Yam, Goh Bee Tin, Shweta Singhal
Summary: Dental pulp stem cells (DPSCs) derived from the neural crest are easily accessible MSCs that have potential for retinal therapy. This study shows that DPSCs maintain their mesenchymal phenotype and upregulate retinal markers under differentiation conditions. However, current markers are inadequate for isolating neural crest cells in DPSCs, highlighting the need for more specific markers.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Mehdi Farokhi, Fatemeh Mottaghitalab, Mohammad Reza Saeb, Shahrokh Shojaei, Negin Khaneh Zarrin, Sabu Thomas, Seeram Ramakrishna
Summary: Currently, there are no clinically available methods to enhance neural structural regeneration and functional recovery of nerve injuries. Conductive materials, such as polypyrrole and graphene, have been considered as one of the best choices for nerve regeneration due to their capacity to control the growth and differentiation of neural stem cells.
MACROMOLECULAR BIOSCIENCE
(2021)
Review
Cell Biology
Maciej Checinski, Kamila Checinska, Natalia Turosz, Monika Kaminska, Zuzanna Nowak, Maciej Sikora, Dariusz Chlubek
Summary: This systematic review analyzed the outcomes of intra-articular administration of mesenchymal stem cells (MSCs) for the treatment of temporomandibular joint (TMJ) articular pain (AP) and restricted maximum mouth opening (MMO). The results suggest that intra-articular administration of MSCs may be highly effective in reducing AP and improving MMO.
Article
Biotechnology & Applied Microbiology
Sonali Rawat, Krishan Gopal Jain, Deepika Gupta, Pawan Kumar Raghav, Rituparna Chaudhuri, Pinky, Adeeba Shakeel, Varun Arora, Harshita Sharma, Debika Debnath, Ankarao Kalluri, Ashwini K. Agrawal, Manjeet Jassal, Amit K. Dinda, Prabir Patra, Sujata Mohanty
Summary: The study successfully differentiated mesenchymal stem cells into dopaminergic neurons using PCL-G nanocomposites, showing promising potential. The newly differentiated neurons exhibited unique features, including enhanced neuronal arborization, intracellular Ca2+ influx, and dopamine secretion.
Article
Multidisciplinary Sciences
Nidaa A. Ababneh, Ban Al-Kurdi, Fatima Jamali, Abdalla Awidi
Summary: This study compared the differentiation abilities of MSCs isolated from different human tissue sources, and found that WJ-MSCs had a higher potential to differentiate into NSC and dopaminergic-like cells. This could provide an additional or alternative source of cells for neurological cell-based therapies.
Article
Chemistry, Medicinal
Shengying Lou, Ting Huang, Jifeng Qi, Tianyuan Zhang, Jianqing Gao, Sunliang Cui
Summary: The lack of suitable stem cells is currently a limiting factor in the success of stem cell therapy for neurodegenerative diseases, but utilizing mesenchymal stem cells shows potential for treating these diseases. Enhancing the neuronal differentiation capacity of MSCs through bioengineering with small molecules is a promising strategy.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Cell Biology
Raquel M. Alves-Paiva, Sabrina do Nascimento, Denise De Oliveira, Larissa Coa, Kelen Alvarez, Nelson Hamerschlak, Oswaldo Keith Okamoto, Luciana C. Marti, Andrea T. Kondo, Jose Mauro Kutner, Maria Augusta Tezelli Bortolini, Rodrigo Castro, Juliana A. Preto de Godoy
Summary: This study reports a case where MSCs derived from an elderly donor entered a senescence state after three passages. MSCs cultured with AS displayed an early senescence state, and there were more senescence cells and altered gene expression compared to cells cultured with FBS.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Biomedical
Yifan Wang, Tengfei Zhao, Yiren Jiao, Hanxu Huang, Yongxiang Zhang, Ao Fang, Xuhua Wang, Yanling Zhou, Haochen Gu, Qionghua Wu, Jiang Chang, Fangcai Li, Kan Xu
Summary: This study investigates the effect of Laponite nanoplatelets on stem cell therapy. The results show that Laponite nanoplatelets can induce the neuronal differentiation of neural stem cells within five days in vitro, and the NF-kappa B pathway is involved in this process. Moreover, Laponite nanoplatelets can increase the survival rate of transplanted neural stem cells and promote their differentiation into mature neurons. The formation of connections between transplanted cells and host cells is confirmed by axon tracing. Therefore, Laponite nanoplatelets can be considered a convenient and practical biomaterial to enhance the efficacy of neural stem cell transplantation and promote repair of the injured spinal cord.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Neurosciences
Charlotte Jaloux, Maxime Bonnet, Marie Vogtensperger, Marie Witters, Julie Veran, Laurent Giraudo, Florence Sabatier, Justin Michel, Regis Legre, Gaelle Guiraudie-Capraz, Francois Feron
Summary: A safer and more efficient manufacturing process for clinical grade olfactory stem cells has been developed and is expected to be used in a Phase I clinical trial involving autologous transplantation in digital nerves with neglected injury.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Martha G. Castillo, Tomas M. Peralta, Paola Locatelli, Candela Velazquez, Yamila Herrero, Alberto J. Crottogini, Fernanda D. Olea, Luis A. Cuniberti
Summary: BM-Muse cells have shown potential in reducing myocardial infarct size and improving cardiac function, but their ability to promote new blood-vessel formation needs further investigation. The present study examined the neovascularization capacity of AT-Muse cells in vitro and in vivo using an ovine model of acute myocardial infarction. The results demonstrated that intramyocardially administered AT-Muse cells displayed significant neovascularization activity and survival capacity in the animal model.
Review
Gastroenterology & Hepatology
Cristina Jimenez-Luna, Jose Prados, Raul Ortiz, Consolacion Melguizo, Carolina Torres, Octavio Caba
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2016)
Meeting Abstract
Oncology
A. R. Rama, R. Hernandez, J. Jimenez, M. D. C. Leiva, C. Jimenez-Luna, L. Cabeza, G. Perazzoli, J. C. Prados
JOURNAL OF THORACIC ONCOLOGY
(2016)
Article
Biochemical Research Methods
Sandra Rios Peces, Caridad Diaz Navarro, Cristina Marquez Lopez, Octavio Caba, Cristina Jimenez-Luna, Consolacion Melguizo, Jose Carlos Prados, Olga Genilloud, Francisca Vicente Perez, Jose Perez del Palacio
Article
Multidisciplinary Sciences
Antonio Irigoyen, Cristina Jimenez-Luna, Manuel Benavides, Octavio Caba, Javier Gallego, Francisco Manuel Ortuno, Carmen Guillen-Ponce, Ignacio Rojas, Enrique Arande, Carolina Torres, Jose Prados
Article
Microbiology
Jesus Perales-Adan, Susana Rubino, Manuel Martinez-Bueno, Eva Valdivia, Manuel Montalban-Lopez, Ruben Cebrian, Mercedes Maqueda
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Medicine, General & Internal
Jaime A. Oliver, Jaime Gomez-Millan, Jose A. Medina, Laura Cabeza, Gloria Perazzoli, Cristina Jimenez-Luna, Kevin Doello, Raul Ortiz
BALKAN MEDICAL JOURNAL
(2019)
Article
Multidisciplinary Sciences
Ariadna Martin-Blazquez, Caridad Diaz, Encarnacion Gonzalez-Flores, Daniel Franco-Rivas, Cristina Jimenez-Luna, Consolacion Melguizo, Jose Prados, Olga Genilloud, Francisca Vicente, Octavio Caba, Jose Perez del Palacio
SCIENTIFIC REPORTS
(2019)
Article
Oncology
Ariadna Martin-Blazquez, Cristina Jimenez-Luna, Caridad Diaz, Joaquina Martinez-Galan, Jose Prados, Francisca Vicente, Consolacion Melguizo, Olga Genilloud, Jose Perez del Palacio, Octavio Caba
Review
Pharmacology & Pharmacy
Laura Cabeza, Gloria Perazzoli, Cristina Mesas, Cristina Jimenez-Luna, Jose Prados, Ana Rosa Rama, Consolacion Melguizo
Article
Biology
Jaime A. Oliver, Raul Ortiz, Cristina Jimenez-Luna, Laura Cabeza, Gloria Perazzoli, Octavio Caba, Cristina Mesas, Consolacion Melguizo, Jose Prados
JOURNAL OF BIOSCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Cristina Jimenez-Luna, Ariadna Martin-Blazquez, Carmelo Dieguez-Castillo, Caridad Diaz, Jose Luis Martin-Ruiz, Olga Genilloud, Francisca Vicente, Jose Perez del Palacio, Jose Prados, Octavio Caba
Article
Medicine, General & Internal
Caridad Diaz, Cristina Jimenez-Luna, Carmelo Dieguez-Castillo, Ariadna Martin, Jose Prados, Jose Luis Martin-Ruiz, Olga Genilloud, Francisca Vicente, Jose Perez del Palacio, Octavio Caba
Summary: This metabolomic study identified novel biomarkers for diagnosing EPI in CP patients and confirmed the effectiveness of metabolomics in differentiating between the presence and absence of EPI.
MEDICINA-LITHUANIA
(2021)
Review
Oncology
Francisco Quinonero, Cristina Mesas, Kevin Doello, Laura Cabeza, Gloria Perazzoli, Cristina Jimenez-Luna, Ana Rosa Rama, Consolacion Melguizo, Jose Prados
CANCER BIOLOGY & MEDICINE
(2019)