Article
Immunology
Qing Zhang, Hu-Xinyue Duan, Ruo-Lan Li, Jia-Yi Sun, Jia Liu, Wei Peng, Chun-Jie Wu, Yong-Xiang Gao
Summary: By using bioinformatic analysis and experimental verification, this study uncovered the overall mechanism of Guizhi-Shaoyao-Zhimu decoction (GSZD) against rheumatoid arthritis (RA), including its anti-inflammatory and proapoptotic effects. GSZD was found to induce synovial fibroblast apoptosis and inhibit inflammatory response as important ways to treat RA.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Computer Science, Interdisciplinary Applications
Yongyu Xu, Zebin Huang, Guangping Wu, Fujun Jin, Shuojia Lin, Chuang Zhang, Jie Zheng, Wenjie Liu, Jinqiang Hou, Yu-Jing Lu
Summary: This study explored the potential mechanism of Guizhi-Shaoyao-Zhimu decoction (GSZD) in treating rheumatoid arthritis (RA) patients with mild-to-moderate COVID-19. The results showed that GSZD intervened in RA and mild-to-moderate COVID-19 by regulating inflammation-related signaling pathways and oxidative stress. The active compounds in GSZD had good binding potential to SARS-CoV-2 related proteins, suggesting its potential therapeutic option for RA patients against mild-to-moderate COVID-19.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Plant Sciences
Shu-jun Wei, Qing Zhang, Yong-jing Xiang, Lan-yu Peng, Wei Peng, Qiang Ren, Yong-xiang Gao
Summary: Guizhi-Shaoyao-Zhimu decoction has shown anti-rheumatoid arthritis effects in CII-induced arthritis rats, suggesting its potential use as a supplement and alternative drug therapy for RA.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Plant Sciences
Guo-Qing Zhou, Gang Chen, Juan Yang, Wen-Yi Qin, Jia Ping
Summary: The study demonstrates that Guizhi-Shaoyao-Zhimu decoction (GSZD) alleviates MSU-induced inflammation by inhibiting the activations of NF-Kappa B and NLRP3 inflammasome.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Jing Ye, Renliang Li, Ziyi Hu, Ping Zhang, Liangji Liu
Summary: This study aims to investigate the efficacy and safety of Guizhi-Shaoyao-Zhimu decoction (GSZD) in the treatment of rheumatoid arthritis (RA). By screening literature, collecting data, and using statistical analysis software, the results will be published in a peer-reviewed journal.
Article
Integrative & Complementary Medicine
Lin Li, Xiang-Yu Kong, Wu Chen, Mei-Jian Wang, Zhi-Xing He, Yun Zhang, Cheng-Ping Wen, Qiao Wang, Lin Huang
Summary: This study investigated the prophylactic treatment with Guizhi-Shaoyao-Zhimu decoction (GSZ) in delaying the onset of rheumatoid arthritis by targeting mast cells. The results showed that GSZ could reduce inflammation, maintain cartilage structure, block mast cell degranulation, and inhibit the TLR4/MyD88/NF-KB p65 pathway.
TRADITIONAL MEDICINE RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Chenxi Feng, Rongrong Chen, Keer Wang, Chengping Wen, Zhenghao Xu
Summary: Combining GuiZhi-ShaoYao-ZhiMu decoction with methotrexate for treating rheumatoid arthritis may improve efficacy and reduce adverse events. This combination therapy can alleviate symptoms like joint swelling and morning stiffness, while also reducing inflammatory markers.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Article
Plant Sciences
Huan Yao, Li Xiang, Yucheng Huang, Jin Tan, Yongmei Shen, Fangqiong Li, Funeng Geng, Weiwei Liu, Xueping Li, Yongxiang Gao
Summary: This study examines the effects and mechanisms of Guizhi Shaoyao Zhimu granules (GSZGs) on bone destruction in rheumatoid arthritis (RA). The results demonstrate that medium and high doses of GSZGs significantly reduce paw volume and bone erosion in mice. The treatment also inhibits the generation of osteoclasts through the promotion of PINK1/Parkin-mediated mitochondrial autophagy.
Article
Biotechnology & Applied Microbiology
Qilin Yang, Jikong Zhang, Jiuwei Li
Summary: This study explores the clinical effectiveness of the traditional Chinese medicine Guizhi Shaoyao Zhimu Decoction in treating hyperuricemia. The results show that this herbal formula effectively lowers blood uric acid levels, improves vascular endothelial function, reduces inflammatory response, and has no significant adverse reactions.
BIOMED RESEARCH INTERNATIONAL
(2022)
Review
Integrative & Complementary Medicine
Lian Zhong, Qing Zhang, Wei Peng, Yongxiang Gao, Daneng Wei, Xufeng Pu, Huan Xu, Chunjie Wu
Summary: This systematic review and meta-analysis evaluated the effect and safety of Guizhi-Shaoyao-Zhimu decoction (GSZD) for treating rheumatoid arthritis (RA). The results showed that GSZD was more likely to achieve clinical efficacy and significantly improve physical signs compared to conventional drugs. Additionally, GSZD exhibited a reduced incidence of adverse events compared to the control group.
JOURNAL OF HERBAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Tingna Li, Hairong Zeng, Yijia Zeng, Xiaorui Zhang, Yuanyuan Ren, Yongxiang Gao, Qinwan Huang, Jin Tan
Summary: This study explored the mechanism of Guizhi Shaoyao Zhimu Decoction in treating gouty arthritis using a combination of UHPLC-Q-Orbitrap HRMS and network pharmacology. The potential key active compounds identified in the decoction may exert their effects against gouty arthritis by interacting with multiple inflammatory factors and pathways.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Bin Zhao, Lingting Zeng, Danyang Chen, Songqing Xie, Zhaokui Jin, Guanglin Li, Wei Tang, Qianjun He
Summary: This study proposes a concept of photocatalytic regulation of the synovial microenvironment (SME) for arthritis treatment. Monodispersive hydrogen-doped titanium dioxide nanorods with a rutile single-crystal structure are developed to achieve near infrared-photocatalytic generation of hydrogen molecules and depletion of lactic acid (LA) in a collagen-induced mouse model of rheumatoid arthritis. The results show that locally produced hydrogen molecules scavenge reactive oxygen species and regulate the synovial microenvironment, thereby preventing synovial pannus formation and cartilage destruction.
Article
Medicine, Research & Experimental
Jiaying Shen, Qianwen Chen, Guanghui Yang, Yikun He
Summary: This study aims to evaluate the safety and efficacy of Guizhi-Shaoyao-Zhimu decoction in treating early-stage RA patients through a double-blinded randomized controlled clinical trial. The results may provide insights on improving clinical symptoms and delaying joint destruction.
Article
Rheumatology
Raphael Micheroli, Muriel Elhai, Sam Edalat, Mojca Frank-Bertoncelj, Kristina Buerki, Adrian Ciurea, Lucy MacDonald, Mariola Kurowska-Stolarska, Myles J. Lewis, Katriona Goldmann, Cankut Cubuk, Tadeja Kuret, Oliver Distler, Costantino Pitzalis, Caroline Ospelt
Summary: This study integrated single-cell RNA sequencing data to assess the contribution of synovial fibroblast subsets to synovial pathotypes and clinical characteristics in treatment-naive early arthritis. The findings revealed a previously unexplored association between specific synovial pathologies and subtypes of synovial fibroblasts.
Article
Plant Sciences
Qi Chen, Jinming Yang, Huan Chen, Ting Pan, Panwang Liu, Shi-jun Xu
Summary: Baihu Jia Guizhi Decoction (BHJGZ), a classic prescription with a good anti-inflammatory action, has been widely used for treating rheumatoid arthritis (RA). However, its underlying molecular mechanisms are still unclear. This study aimed to investigate the potential mechanism of BHJGZ against RA, focusing on the Ras/MEK/ERK pathway. The results showed that the inhibition of the Ras/MEK/ERK pathway is a crucial mechanism of BHJGZ for alleviating synovitis in RA.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wei Peng, Yunhui Chen, Steve Tumilty, Lizhou Liu, Ling Luo, Haiyan Yin, Yongmei Xie
Summary: Neurodegenerative diseases (NDDs) are neurological disorders characterized by neuronal degeneration and apoptosis. Paeoniflorin, a natural compound extracted from the root of Paeonia lactiflora pall, has been found to have potential therapeutic effects on NDDs by modulating cellular Ca2+/ROS homeostasis.
CURRENT OPINION IN PHARMACOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Ruolan Li, Feng Lu, Xue Sun, Liying He, HuXinyue Duan, Wei Peng, ChunJie Wu
Summary: The study successfully developed hydroxy-alpha-sanshool liposomes (HAS-LPs) that can improve learning and memory disorders in an Alzheimer's disease (AD) model, suggesting potential clinical applications for these nanoparticles.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Cell Biology
Dandan Tang, Qing Zhang, Huxinyue Duan, Xun Ye, Jia Liu, Wei Peng, Chunjie Wu
Summary: This article comprehensively summarizes the pharmacological effects and potential molecular mechanisms of polydatin in protecting and treating liver disorders through regulation of oxidative stress. Polydatin has shown significant protective and curative effects on liver diseases associated with oxidative stress through various molecular mechanisms. However, further clinical investigations are needed to confirm the clinical treatment effect of polydatin in liver diseases related to regulation of oxidative stress.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Multidisciplinary Sciences
Bingke Bai, Chang Liu, Chengzhong Zhang, Xuhui He, Hongrui Wang, Wei Peng, Chengjian Zheng
Summary: This review summarizes the structural diversities, biological activities, and promising biosynthetic potentials of terpenoids isolated from Trichoderma species. Trichoderma terpenoids exhibit important antibacterial, antifungal, inhibitory, and cytotoxic activities, making Trichoderma species valuable microbial resources for drug discovery and environmentally friendly agrochemicals development. The abundance of novel skeletons, bioactivities, and biosynthetic potentials present new opportunities for drug and agrochemicals discovery, genome mining, and enzymology exploration from Trichoderma species.
JOURNAL OF ADVANCED RESEARCH
(2023)
Editorial Material
Pharmacology & Pharmacy
Yunhui Chen, Charles Hsu, Xiuping Chen, Heng Zhang, Wei Peng
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Lijie Wang, Xiaoling Gou, Yin Ding, Jingye Liu, Yue Wang, Yaqian Wang, Jing Zhang, Leilei Du, Wei Peng, Gang Fan
Summary: Globally, metabolic diseases are a significant public health issue, and herbal medicines derived from plants are widely used in their treatment due to their efficacy and minimal side effects. Recent research has shown that the gut microbiota plays a key role in the therapeutic effects of herbal medicines on metabolic diseases. Mechanisms involved include effects on gut microbial composition, intestinal barrier, inflammation, and microbial metabolites. These findings highlight the importance of the interaction between herbal medicines and gut microbiota in the treatment of metabolic diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qi Liang, Jing-Wen Wang, Yu-Ru Bai, Ruo-Lan Li, Chun-Jie Wu, Wei Peng
Summary: TRPV1 and TRPA1 channels have beneficial effects in ameliorating postoperative ileus, making natural herbs a potential therapeutic option. Activation of these channels enhances gastrointestinal motility and relieves pain.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Ruo-Lan Li, Hu-Xinyue Duan, Ling-Yu Wang, Qi Liang, Chunjie Wu, Wei Peng
Summary: Neurodegenerative diseases are a global threat and burden on the social economy due to neuronal degeneration and apoptosis. The current drugs for these diseases have side effects, necessitating the urgent discovery of safe and effective alternatives. Zanthoxylum bungeanum Maxim. (ZBM) has a long medicinal history in China and is rich in amides. This review highlights the potential therapeutic role of amides from ZBM in neurodegenerative diseases, specifically in Alzheimer's, Parkinson's, and depression, through antioxidant and anti-inflammatory effects on the TRPV1, TRPA1, and PI3K/AKT signaling pathways. The review also discusses the physical and chemical properties of these amides.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Review
Integrative & Complementary Medicine
Lian Zhong, Qing Zhang, Wei Peng, Yongxiang Gao, Daneng Wei, Xufeng Pu, Huan Xu, Chunjie Wu
Summary: This systematic review and meta-analysis evaluated the effect and safety of Guizhi-Shaoyao-Zhimu decoction (GSZD) for treating rheumatoid arthritis (RA). The results showed that GSZD was more likely to achieve clinical efficacy and significantly improve physical signs compared to conventional drugs. Additionally, GSZD exhibited a reduced incidence of adverse events compared to the control group.
JOURNAL OF HERBAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Chengxun He, Ke Wang, Jun Xia, Die Qian, Juan Guo, Lian Zhong, Dandan Tang, Xiuping Chen, Wei Peng, Yunhui Chen, Yong Tang
Summary: MELNs can mitigate the progression of type 2 diabetes in the HFD/STZ mouse model. The underlying molecular mechanism is related to the PI3K/Akt/GLUT4/GSK-3 beta signaling pathway.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Editorial Material
Pharmacology & Pharmacy
Yunhui Chen, Yongmei Xie, Cailu Lin, Wei Peng
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Qi Liang, Ruo-Lan Li, Dan-Dan Tang, Ting Zhang, Lian Zhong, Chun-Jie Wu, Wei Peng
Summary: This review summarizes the potential roles of targeting T2Rs with bitter compounds for the treatment of respiratory diseases. It also discusses the potential of ABC transmembrane transporter proteins in delivering bitter compounds to combat drug resistance. The findings provide a reference for future studies on bitter receptor therapy for respiratory diseases.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Biochemical Research Methods
Meiyan Li, Dandan Tang, Runchun Xu, Sirong Zhang, Yu Chen, Wei Peng
Summary: This study aims to investigate the quality markers of Yiqi Tongluo capsule (YTC) and optimize its extraction process based on these markers. The results identified 8 compounds with protective effects on cardiomyocytes, which were considered as the quality markers of YTC. The optimized extraction process was established and the HPLC fingerprint of optimized YTC was successfully developed.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Plant Sciences
Qing Zhang, Cheng-Xun He, Ling-Yu Wang, Die Qian, Dan-Dan Tang, Sheng-Nan Jiang, Wen-Wen Chen, Chun-Jie Wu, Wei Peng
Summary: The study found that hydroxy-alpha-sanshool (HAS) can promote browning of white adipose tissue (WAT) through the regulation of the AMPK/SIRT-1/PPAR gamma signaling pathway, which helps combat obesity.
Review
Biochemistry & Molecular Biology
Qing Zhang, Wen Wen Chen, Xue Sun, Die Qian, Dan Dan Tang, Li Lin Zhang, Mei Yan Li, Lin Yu Wang, Chun-Jie Wu, Wei Peng
Summary: Cancers are the leading cause of death globally, and emodin, a natural compound derived from plants, has shown reliable anticancer effects on various types of cancer. This review summarizes the sources, anticancer properties, molecular mechanisms, and toxicities of emodin, while also discussing the limitations and future prospects of its research.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)