Review
Biochemistry & Molecular Biology
Su Woong Yoo, Gyungseok Oh, Jin Chul Ahn, Euiheon Chung
Summary: Phototherapy is widely used in various human diseases, and nanomedicine-based phototherapy can be classified into PDT and PTT. While PDT has been tried in dermatologic, ophthalmologic, cardiovascular, and dental diseases, PTT has been tested in atherosclerosis and dry eye syndrome. Despite promising results, there are still limitations in specificity, targeting efficiency, and tissue penetration using phototherapy, which nanomaterials are showing potential to overcome.
Review
Pharmacology & Pharmacy
Sherif Ashraf Fahmy, Hassan Mohamed El-Said Azzazy, Jens Schaefer
Summary: Photodynamic therapy is a promising cancer treatment strategy that utilizes highly reactive oxygen species to kill cancer cells. However, it has shortcomings, leading researchers to develop various nanoplatforms to enhance treatment effectiveness.
Article
Biophysics
Thais P. Pivetta, Quirina Ferreira, Tania Vieira, Jorge C. Silva, Sandra Simo, Paulo A. Ribeiro, Maria Raposo
Summary: Photodynamic therapy utilizes photosensitizer molecules for the treatment of diseases, but stability and encapsulation efficiency are influenced by lipid composition. Some lipid compositions can enhance stability of liposomes, while Acridine Orange has greater affinity for vesicles. Different liposomes have varied effects on cytotoxicity and phototoxicity in tumor cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Xin-Yue Ma, Wen Zhang, Rong-Bin Que, Chao Wang, Wen-Wen Shang, Yuan-Yuan Zhu, Bi-Yuan Zheng, Yu Chen, Mei-Rong Ke, Jian-Dong Huang
Summary: This work presents the development of a multifunctional thermosensitive liposomal nanoplatform that exhibits both photodynamic and photothermal effects. The nanoplatform enables fluorescence imaging-guided combined cancer treatment and demonstrates significant anticancer efficacy in vivo.
Article
Chemistry, Medicinal
Kotaro Nishimura, Risako Shimada, Keita Yamana, Riku Kawasaki, Toshimi Nakaya, Atsushi Ikeda
Summary: In this study, lipid-membrane incorporated porphyrins were prepared as aqueous solutions. Porphyrins with proton-donor groups at the meso position formed stable aqueous solutions, while tetrakis(carboxyphenyl)porphyrin was soluble in water. The photodynamic activity of tetrakis(hydroxyphenyl)porphyrin was higher than that of tetrakis(aminophenyl)porphyrin, attributed to the self-aggregation of the latter in liposomes.
Article
Chemistry, Inorganic & Nuclear
Xuwen Da, Fei-Hu Yu, Chao Zhang, Zhanhua Wang, Yao Jian, Yuanjun Hou, Yong Chen, Xuesong Wang, Qianxiong Zhou
Summary: This work proposes a bioorthogonal assembly based on d(10)MIDLINE HORIZONTAL ELLIPSISd(10) metallophilic interactions for precise cancer cell imaging and photodynamic therapy (PDT). The assembly exhibits luminescence turn-on and singlet oxygen generation upon irradiation, demonstrating the potential of using supramolecular interaction for bioorthogonal chemistry.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Bing Lu, Hui Quan, Zhecheng Zhang, Tengfei Li, Jin Wang, Yue Ding, Yang Wang, Yong Yao, Xiaowei Zhan
Summary: Enhancing the phototherapy efficacy of organic photosensitizers through molecular design is a challenging task. This study proposes a simple design strategy to generate superoxide anion radical using A-D-A fused-ring photosensitizers. By replacing one cyano group with an ester group, a novel nonplanar end group (A unit) was synthesized to design the A-D-A photosensitizer F8CA. F8CA nanoparticles showed higher photodynamic activities with the generation of singlet oxygen, hydroxyl radical, and superoxide anion radical compared to F8CN nanoparticles. Additionally, F8CA nanoparticles displayed high photothermal conversion efficiency. This study provides an effective design approach for A-D-A photosensitizers.
Article
Chemistry, Multidisciplinary
Weiwei Wu, Yan Yang, Zhuoying Liang, Xiling Song, Yadong Huang, Lin Qiu, Xiaozhong Qiu, Siming Yu, Wei Xue
Summary: This study demonstrated the effective strategy of utilizing near-infrared laser-induced simultaneous release of NO and alkyl radicals to inhibit tumor growth, achieved through the elaborately fabricated biocompatible free radical nanogenerator. Under NIR II laser irradiation, the nanogenerator can precisely control the release profiles of NO and alkyl radicals, displaying synergistic anticancer effects on breast tumors.
Article
Chemistry, Medicinal
Risako Shimada, Shodai Hino, Keita Yamana, Riku Kawasaki, Toshifumi Konishi, Atsushi Ikeda
Summary: This study investigates the photodynamic activity of a dyad system composed of a lipid membrane-incorporated fullerene derivative and a photoantenna molecule in liposomes. It is found that the release of the fullerene derivative from the liposomes can disrupt the dyad system and reduce its photodynamic activity. The hydrophobicity/hydrophilicity balance of the substituent in the fullerene derivatives is shown to be crucial for obtaining a dyad system with high photodynamic activity.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Review
Chemistry, Inorganic & Nuclear
Zhiheng Li, Zhenwu Zhou, Yarui Wang, Jie Wang, Liming Zhou, Hong-Bo Cheng, Juyoung Yoon
Summary: Due to deficiencies in specific accumulation at tumors and undesired activation in normal tissues, many photodynamic therapy (PDT) agents show off-target phototoxicity. To address this issue, activatable photodynamic nano-photosensitizers (nanoPSs) that generate reactive oxygen species (ROS) in response to tumor-associated or external stimuli have been developed. These nanoPSs are in an off-state during delivery and are only activated in targeted lesions, enhancing the accuracy and minimizing side effects. This review discusses the design, work principle, and therapeutic performance of PDT using activatable nanoPSs, categorized by different stimuli and composite materials.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Daniel Obitz, Karmel S. Gkika, Marvin Heller, Tia E. Keyes, Nils Metzler-Nolte
Summary: A lanthanide(iii) complex connected to a light harvesting antenna was synthesized and tested as a potential photosensitizer in photodynamic therapy. The complex showed significant phototoxic activity on cancer cells upon irradiation, with ROS production identified as the compound's phototoxic mode of action. In cell viability assays, a 10-fold decrease in IC50 value was observed compared to the dark control.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Wenwen Cao, Yu Zhu, Fapu Wu, Yang Tian, Zhaoming Chen, Weijia Xu, Senyao Liu, Tingting Liu, Hu Xiong
Summary: This study reports a heavy-atom-free NIR photosensitizer BHcy for synergistic PDT/PTT therapy. BHcy-NPs show efficient singlet oxygen generation and photothermal effect, resulting in significant cancer cell death and tumor growth inhibition.
Article
Chemistry, Organic
Zilin Zhu, Li Wei, Ashish Kumar Yadav, Zhongxian Fan, Ashish Kumar, Mengzhao Miao, Samya Banerjee, Huaiyi Huang
Summary: Recently, there has been interest in developing photo catalytic anticancer drugs, mainly in the form of metal complexes. In this study, we introduce lysosome/mitochondria targeting cyanine appended bipyridine compounds as potential organic photocatalytic anticancer agents. The organocatalyst (bpyPCN) not only induces light-induced NADH oxidation but also generates intracellular ROS, showcasing its anticancer activity. This is the first example of an organic compound inducing catalytic NADH photo-oxidation in both aqueous solutions and cancer cells.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Qiang Wang, Chunbin Li, Yuchen Song, Qiankun Shi, Heng Li, Hua Zhong, Jianguo Wang, Fang Hu
Summary: In this study, a new donor was developed to improve the overall performance of aggregation-induced emission photosensitizers. By expanding the pi extension of aromatic rings, the new photosensitizer exhibited red-shifted absorption and fluorescence peaks, enhanced photosensitization efficiency, and demonstrated excellent imaging and cancer cell ablation capabilities.
Review
Chemistry, Multidisciplinary
Yi Zhang, Xiangqian Zhang, Huocheng Yang, Le Yu, Yunjie Xu, Amit Sharma, Peng Yin, Xiangyang Li, Jong Seung Kim, Yao Sun
Summary: The article discusses the advantages and potential of photodynamic therapy and sonodynamic therapy in the treatment of deep-seated tumors, as well as imaging-guided precise SDT and recent clinical trials. It also summarizes the strategies for designing sonosensitizers based on tumor environment and structure modifications, as well as the approach of SDT combination therapy.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
