Why Do Intravascular Schistosomes Coat Themselves in Glycolytic Enzymes?

Schistosomes can hydrolyze proinflammatory and prothrombotic polyphosphate (polyP) via tegumental alkaline phosphatase, SmAP

(2019) Manal Elzoheiry et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The blood fluke Schistosoma mansoni cleaves the coagulation protein high molecular weight kininogen (HK) but does not generate the vasodilator bradykinin

(2018) Qiang Wang et al.   Parasites & Vectors

The Essential Ectoenzyme SmNPP5 from the Human Intravascular Parasite Schistosoma mansoni is an ADPase and a Potent Inhibitor of Platelet Aggregation

(2018) Manal Elzoheiry et al.   THROMBOSIS AND HAEMOSTASIS

Intravascular Schistosoma mansoni Cleave the Host Immune and Hemostatic Signaling Molecule Sphingosine-1-Phosphate via Tegumental Alkaline Phosphatase

(2018) Manal Elzoheiry et al.   Frontiers in Immunology

Moonlighting glycolytic protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH): an evolutionarily conserved plasminogen receptor on mammalian cells

(2017) Anoop Singh Chauhan et al.   FASEB JOURNAL

Schistosoma bovis -host interplay: Proteomics for knowing and acting

(2017) Eduardo de la Torre-Escudero et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Pro-invasive stimuli and the interacting protein Hsp70 favour the route of alpha-enolase to the cell surface

(2017) Giovanni Perconti et al.   Scientific Reports

The human blood parasite Schistosoma mansoni expresses extracellular tegumental calpains that cleave the blood clotting protein fibronectin

(2017) Qiang Wang et al.   Scientific Reports

Identification and functional characterization of alpha-enolase from Taenia pisiformis metacestode

(2015) Shaohua Zhang et al.   ACTA TROPICA

Surface-displayed glyceraldehyde 3-phosphate dehydrogenase and galectin from Dirofilaria immitis enhance the activation of the fibrinolytic system of the host

(2015) Javier González-Miguel et al.   ACTA TROPICA

Network of Surface-Displayed Glycolytic Enzymes in Mycoplasma pneumoniae and Their Interactions with Human Plasminogen

(2015) Anne Gründel et al.   INFECTION AND IMMUNITY

A quantitative proteomic analysis of the tegumental proteins from Schistosoma mansoni schistosomula reveals novel potential therapeutic targets

(2015) Javier Sotillo et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

The N-terminal segment of glyceraldehyde-3-phosphate dehydrogenase ofHaemonchus contortusinteracts with complements C1q and C3

(2015) G. V. Vedamurthy et al.   PARASITE IMMUNOLOGY

Schistosomes Enhance Plasminogen Activation: The Role of Tegumental Enolase

(2015) Barbara C. Figueiredo et al.   PLoS Pathogens

Structural analysis of glyceraldehyde-3-phosphate dehydrogenase functional diversity

(2014) Michael A. Sirover   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Streptococcus pneumoniaePhosphoglycerate Kinase Is a Novel Complement Inhibitor Affecting the Membrane Attack Complex Formation

(2014) Anna M. Blom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular functions of glycolytic enzymes of parasites: Unpredicted use of ancient proteins

(2014) Amaranta Gómez-Arreaza et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Expression profiles of glyceraldehyde-3-phosphate dehydrogenase from Clonorchis sinensis: a glycolytic enzyme with plasminogen binding capacity

(2014) Yue Hu et al.   PARASITOLOGY RESEARCH

Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut

(2014) J. Vega-Rodriguez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Schistosome apyrase SmATPDase1, but not SmATPDase2, hydrolyses exogenous ATP and ADP

(2014) Akram A. Da’dara et al.   Purinergic Signalling

The Global Burden of Disease Study 2010: Interpretation and Implications for the Neglected Tropical Diseases

(2014) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

Schistosome Feeding and Regurgitation

(2014) Patrick J. Skelly et al.   PLoS Pathogens

Schistosome tegumental ecto-apyrase (SmATPDase1) degrades exogenous pro-inflammatory and pro-thrombotic nucleotides

(2014) Akram A. Da’dara et al.   PeerJ

Triose phosphate isomerase from the blood flukeSchistosoma mansoni: Biochemical characterisation of a potential drug and vaccine target

(2013) Veronika L. Zinsser et al.   FEBS LETTERS

Proteomic Analysis of Tegument-Exposed Proteins of Female and Male Schistosoma japonicum Worms

(2013) Min Zhang et al.   JOURNAL OF PROTEOME RESEARCH

In vivo intravascular biotinylation of Schistosoma bovis adult worms and proteomic analysis of tegumental surface proteins

(2013) Eduardo de la Torre-Escudero et al.   Journal of Proteomics

The Cell Surface Proteome ofEntamoeba histolytica

(2013) Laura Biller et al.   MOLECULAR & CELLULAR PROTEOMICS

Glyceraldehyde-3-phosphate dehydrogenase of the parasitic nematodeHaemonchus contortusbinds to complement C3 and inhibits its activity

(2013) S. Sahoo et al.   PARASITE IMMUNOLOGY

Surface associated antigens of Dirofilaria immitis adult worms activate the host fibrinolytic system

(2013) Javier González-Miguel et al.   VETERINARY PARASITOLOGY

Group B Streptococcus GAPDH Is Released upon Cell Lysis, Associates with Bacterial Surface, and Induces Apoptosis in Murine Macrophages

(2012) Liliana Oliveira et al.   PLoS One

Surface Export of GAPDH/SDH, a Glycolytic Enzyme, Is Essential for Streptococcus pyogenes Virulence

(2011) H. Jin et al.   mBio

Enzymatic Shaving of the Tegument Surface of Live Schistosomes for Proteomic Analysis: A Rational Approach to Select Vaccine Candidates

(2011) William Castro-Borges et al.   PLoS Neglected Tropical Diseases

Metabolic genes in cancer: Their roles in tumor progression and clinical implications

(2010) Eiji Furuta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Echinococcus multilocularis phosphoglucose isomerase (EmPGI): A glycolytic enzyme involved in metacestode growth and parasite–host cell interactions

(2010) Britta Stadelmann et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Molecular cloning and functional characterization of Schistosoma japonicum enolase which is highly expressed at the schistosomulum stage

(2010) Jianmei Yang et al.   PARASITOLOGY RESEARCH

Cloning and characterization of a plasminogen-binding surface-associated enolase from Schistosoma bovis

(2010) Eduardo de la Torre-Escudero et al.   VETERINARY PARASITOLOGY

Suppressing Glucose Transporter Gene Expression in Schistosomes Impairs Parasite Feeding and Decreases Survival in the Mammalian Host

(2010) Greice Krautz-Peterson et al.   PLoS Pathogens

The role of tegumental aquaporin from the human parasitic worm, Schistosoma mansoni, in osmoregulation and drug uptake

(2009) Zahra Faghiri et al.   FASEB JOURNAL

Exposed proteins of the Schistosoma japonicum tegument

(2009) Jason Mulvenna et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Purinergic signaling and immune modulation at the schistosome surface?

(2009) Rita Bhardwaj et al.   TRENDS IN PARASITOLOGY

Immunoproteomic assay of surface proteins ofStreptococcus suisserotype 9

(2008) Zongfu Wu et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

A proteomic approach to the identification of tegumental proteins of male and female Schistosoma bovis worms

(2008) Ricardo Pérez-Sánchez et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Protective effect and granuloma down-modulation promoted by RP44 antigen a fructose 1,6 bisphosphate aldolase of Schistosoma mansoni

(2007) Heloisa H. Marques et al.   IMMUNOBIOLOGY