Article
Medicine, Research & Experimental
Hengcheng Zhang, Cecilia B. Cavazzoni, Manuel A. Podesta, Elsa D. Bechu, Garyfallia Ralli, Pragya Chandrakar, Jeong-Mi Lee, Ismail Sayin, Stefan G. Tullius, Reza Abdi, Anita S. Chong, Bruce R. Blazar, Peter T. Sage
Summary: This study found that a specific subset of effector Tfh cells was activated during allogeneic kidney transplantation, and these cells played a crucial role in transplant rejection by regulating the clonal dynamics of donor-specific germinal center B cells.
Article
Multidisciplinary Sciences
Kaitlin A. Read, Devin M. Jones, Srijana Pokhrel, Emily D. S. Hales, Aditi Varkey, Jasmine A. Tuazon, Caprice D. Eisele, Omar Abdouni, Abbey Saadey, Melissa R. Leonard, Robert T. Warren, Michael D. Powell, Jeremy M. Boss, Emily A. Hemann, Jacob S. Yount, Gang Xin, Hazem E. Ghoneim, Chan-Wang J. Lio, Aharon G. Freud, Patrick L. Collins, Kenneth J. Oestreich
Summary: During intracellular infection, T follicular helper (T-FH) and T helper 1 (T(H)1) cells have different roles in promoting immune responses. This study identifies Aiolos as a crucial regulator of T-FH and CD4-CTL programming. Aiolos deficiency leads to reduced T-FH differentiation and antibody production, while increasing CD4-CTL programming and cytolytic molecule expression.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Sean Turner, Brent Raisley, Kimberly Roach, Sandra Bajana, Melissa E. Munroe, Judith A. James, K. Mark Coggeshall, Susan Kovats
Summary: Gram-positive bacterial infections can cause organ failure and death in sepsis. Bacillus anthracis PGN, a component shed during bacterial replication, can promote sepsis-like pathology. This study found that purified Bacillus anthracis PGN can activate human dendritic cells (DCs), promote the production of proinflammatory cytokines, and induce the differentiation of T(H)17 cells.
Article
Multidisciplinary Sciences
Anusha Kalbasi, Mikko Siurala, Leon L. Su, Mito Tariveranmoshabad, Lora K. Picton, Pranali Ravikumar, Peng Li, Jian-Xin Lin, Helena Escuin-Ordinas, Tong Da, Sarah V. Kremer, Amy L. Sun, Sofia Castelli, Sangya Agarwal, John Scholler, Decheng Song, Philipp C. Rommel, Enrico Radaelli, Regina M. Young, Warren J. Leonard, Antoni Ribas, Carl H. June, K. Christopher Garcia
Summary: Synthetic receptor signaling has the potential to enhance the functions of adoptively transferred T cells, improving their ability to treat solid tumors. By designing chimeric receptors with an orthogonal IL-2 receptor extracellular domain fused with the intracellular domain of receptors for common gamma-chain cytokines IL-4, IL-7, IL-9, and IL-21, T cells can be activated to elicit corresponding gamma(e) cytokine signals. This activation leads to improved anti-tumor efficacy in challenging mouse models of melanoma and pancreatic cancer.
Article
Medicine, Research & Experimental
Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee, Hae-Rim Kim
Summary: Patients with rheumatoid arthritis (RA) have higher levels of interleukin-18 (IL-18) and lower levels of IL-18 binding protein (IL-18BP) in their serum and synovial fluid compared to those with osteoarthritis (OA) or healthy controls. In vitro studies show that IL-18BP can correct the Th17/Treg imbalance in CD4(+) T cells of RA patients and reduce IL-17-induced osteoclastogenesis, suggesting therapeutic potential for RA treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Allergy
Sunil Tomar, Varsha Ganesan, Ankit Sharma, Chang Zeng, Lisa Waggoner, Andrew Smith, Chang H. Kim, Paula Licona-Limon, Richard L. Reinhardt, Richard A. Flavell, Yui-Hsi Wang, Simon P. Hogan
Summary: This study found that IL-4Ra signaling directly modulates MMC9 function and exacerbates experimental IgE-mediated food allergic reactions. IL-4Ra regulation of MMC9s is partly BATF-dependent and occurs via modulation of metabolic transcriptional programs.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Oncology
Haijing Wu, Yaxiong Deng, Di Long, Ming Yang, Qianwen Li, Yu Feng, Yongjian Chen, Hong Qiu, Xin Huang, Zhenghao He, Longyuan Hu, Heng Yin, Guangdi Li, Yunkai Guo, Wenhan Du, Ming Zhao, Liwei Lu, Qianjin Lu
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the involvement of T follicular helper (T-FH) cells. This study found that AIM2 expression was upregulated in SLE patients, especially in T-FH-like cells. Knocking out AIM2 significantly reduced T-FH cell response and decreased levels of serum autoantibodies and proteinuria in lupus mice.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
James A. Harker, Trever T. Greene, Burton E. Barnett, Phuc Bao, Aleksandr Dolgoter, Elina I. Zuniga
Summary: The IL-6 cytokine family signals through gp130 combined with a cytokine-specific receptor. Gp130 signaling on CD4 T cells is vital in controlling chronic infection of mice with LCMV Cl13. IL-6 and IL-27 signaling have distinct and overlapping roles, with IL-6 regulating Tfh differentiation, IL-27 regulating CD4 T cell survival, and both promoting IL-21.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Shate Xiang, Jingjing Zhang, Mengge Zhang, Suhai Qian, Rongyun Wang, Yao Wang, Yingshi Xiang, Xinghong Ding
Summary: This meta-analysis found that SLE patients had lower percentage of Th1 cells and higher percentage of Th2 cells, with treatments normalizing some indicators. Gender and age affected the levels of Th1 and Th2 cells in SLE patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Srikanth Sadhu, Rajdeep Dalal, Jyotsna Dandotiya, Akshay Binayke, Virendra Singh, Manas Ranjan Tripathy, Vinayaka Das, Sandeep Goswami, Shakti Kumar, Zaigham Abbas Rizvi, Amit Awasthi
Summary: IL-9, primarily produced by helper T cells, plays a critical role in COVID-19 by promoting viral spread and airway inflammation. This study demonstrates that blocking IL-9 can reduce airway inflammation, suggesting IL-9 as a potential therapeutic target for mitigating disease severity in COVID-19.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Hilal Ozturk, Devrim Saribal, Yusuf Metin Gelmez, Gunnur Deniz, Abdullah Yilmaz, Asli Kirectepe, Alev Meltem Ercan
Summary: This study investigated the potential effects of ELF-EMF exposure during the gestational and lactational period on immune system parameters. The results showed significant changes in white blood cell and lymphocyte counts, with an increase in CD4(+) cells and IL-17A and IFN-gamma levels.
ELECTROMAGNETIC BIOLOGY AND MEDICINE
(2022)
Article
Immunology
Enrique Huanosta-Murillo, Marcela Alcantara-Hernandez, Brenda Hernandez-Rico, Georgina Victoria-Acosta, Patricia Miranda-Cruz, Maria Antonieta Dominguez-Gomez, Fermin Jurado-Santacruz, Genaro Patino-Lopez, Vadim Perez-Koldenkova, Alam Palma-Guzman, Paula Licona-Limon, Ezequiel M. Fuentes-Panana, Alicia Lemini-Lopez, Laura C. Bonifaz
Summary: In cutaneous T cell lymphoma (CTCL), a dominant Th2 profile associated with disease progression has been proposed, with TOX+ CD4(+) T cells producing IL-4(+) in early-stage skin lesions. The NLRP3 receptor plays a role in promoting a Th2 response by controlling IL-4 production, which may have significant implications in disease progression. This mechanism of IL-4 regulation mediated by NLRP3 is amplified in late-stage CTCL, indicating its importance in disease progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jiawei Huang, Kai Xu, Linling Yu, Yunqiu Pu, Tong Wang, Rongli Sun, Geyu Liang, Lihong Yin, Juan Zhang, Yuepu Pu
Summary: Benzene is a typical hematopoietic toxic substance that affects the immune system, particularly T helper cell subsets. The study showed that Treg cells and secreted IL-10 may play a key role in immunosuppression in benzene-induced hematopoietic toxicity model mice.
Article
Immunology
Matthew T. T. Ollerton, Joy M. M. Folkvord, Andriana La Mantia, David A. A. Parry, Amie L. L. Meditz, Martin D. D. McCarter, Richard T. D'Aquila, Elizabeth Connick
Summary: Follicular helper CD4(+) T cells (TFH) are major sites of HIV replication, but follicular regulatory CD4(+) T cells (TFR) limit HIV replication by suppressing TFH through IL-2 restriction. TFR reduce TFH viability and HIV infected TFH, and IL-2 enhances TFH viability but decreases HIV replication in the presence of TFR.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Food Science & Technology
Astri Dewayani, Kartika Afrida Fauzia, Ricky Indra Alfaray, Langgeng Agung Waskito, Dalla Doohan, Yudith Annisa Ayu Rezkitha, Abdurachman Abdurachman, Takashi Kobayashi, Reny I'tishom, Yoshio Yamaoka, Muhammad Miftahussurur
Summary: The development of Helicobacter pylori-related diseases is closely linked to chronic inflammation, which is significantly impacted by immune responses. Key cytokines such as IL-17, IL-21, and IL-23 play crucial roles in antimicrobial activity and pathogenic immune response, maintaining Th17 cells and accommodating humoral immune cells in the gut environment.