Article
Biochemistry & Molecular Biology
Matej L'uptak, Zdenek Fisar, Jana Hroudova
Summary: Mitochondrial dysfunction is involved in psychiatric and neurodegenerative disorders and can be used to predict treatment responsiveness. Understanding the mitochondrial effects of antidepressants is important to connect mitochondria with therapeutic and adverse effects.
Article
Neurosciences
Matej L'uptak, Zdenek Fisar, Jana Hroudova
Summary: The study found that novel antipsychotics mainly decreased ATP production and increased ROS generation in mitochondria, but the inhibition of MAO-A may contribute to their antidepressant effect, while the MAO-B inhibition induced by brexpiprazole and loxapine may promote neuroplasticity and neuroprotection.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Engineering, Environmental
Xiangyu Wang, Hanjiang Zhao, Zhenchuan Liu, Yitong Wang, Dan Lin, Long Chen, Jiewen Dai, Kaili Lin, Steve G. Shen
Summary: PDA nanoparticles exhibit a dual antioxidative and anti-inflammatory mechanism, effectively treating temporomandibular joint osteoarthritis by improving mitochondrial respiration efficiency and reducing ROS production. This nanoplatform opens up a new avenue for osteoarthritis treatment and offers valuable insights into the design of biomaterials with multiple biomedical applications by regulating cellular energy metabolism.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Chemistry, Medicinal
Milan Urban, Veronika Slachtova, Lucie Brulikova
Summary: Mycobacterial energy metabolism, particularly the oxidative phosphorylation pathway, has become increasingly important as a molecular target for the development of new anti-TB drugs. Small organic molecules targeting this pathway have shown promising activity against latent and resistant TB strains, with FDA-approved inhibitors confirming the value of targeting mycobacterial energy metabolism.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Physiology
Sonia Dominguez-Zorita, Ines Romero-Carraminana, Jose M. Cuezva, Pau B. Esparza-Molto
Summary: IF1 plays a crucial regulatory role in maintaining tissue homeostasis, with a particular emphasis on its harmful effects on learning when genetically ablated in neurons.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Cell Biology
Shuji Wakatsuki, Toshiyuki Araki
Summary: Neurite degeneration, a self-destructive process, is a major component of neurodegenerative diseases induced by oxidative stress. The mechanism and signaling pathways of oxidative stress-induced neurite degeneration have been unknown. This review focuses on the phosphorylation-dependent regulation of the molecular interaction between ZNRF1 and the NADPH oxidase complex in reactive oxygen species-induced neurite degeneration.
NEURAL REGENERATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Alessandro Maria Morelli, Mariachiara Chiantore, Silvia Ravera, Felix Scholkmann, Isabella Panfoli
Summary: There is a striking morphological similarity between multilamellar concentric thylakoids in cyanobacteria and the myelin sheath that wraps nerve axons. Both structures play a role in conveying nutrients and producing ATP, suggesting a convergent evolution in fulfilling similar functions in Earth's life forms.
Article
Biochemistry & Molecular Biology
Matej L'uptak, Zdenek Fisar, Jana Hroudova
Summary: This study evaluates and quantifies the effects of antidepressant drugs (agomelatine, ketamine and vortioxetine) on pig brain-isolated mitochondria in vitro. The results indicate that vortioxetine is the most potent inhibitor of mitochondrial complexes and complex I-linked respiration, while agomelatine and ketamine have inhibitory effects on specific complexes. Vortioxetine may activate an antioxidant mechanism, while agomelatine may contribute to oxidative damage and adverse effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Semen Nesterov, Yury Chesnokov, Roman Kamyshinsky, Alisa Panteleeva, Konstantin Lyamzaev, Raif Vasilov, Lev Yaguzhinsky
Summary: The study revealed a new type of OXPHOS structural organization in rat heart mitochondria cristae during ATP synthesis, ensuring quickness, efficiency, and damage resistance of the system with direct proton transfer from pumps to ATP synthase along the lateral pH gradient without energy dissipation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Chenbin Bian, Zhuangzhuang Zheng, Jing Su, Huanhuan Wang, Sitong Chang, Ying Xin, Xin Jiang
Summary: Radiotherapy failure and poor tumor prognosis are mainly caused by radioresistance. The relationship and mechanisms between mitochondrial metabolism and cancer radioresistance are not fully understood. However, mitochondria play a crucial role in regulating various biological reactions and influencing the radiation effects of malignancies. Therefore, targeting mitochondrial signaling pathways for the development of novel anticancer drugs holds promise.
Article
Biochemistry & Molecular Biology
Gabriel Garcia-Molina, Paolo Natale, Ana M. Coito, Daniel G. Cava, Ines A. C. Pereira, Ivan Lopez-Montero, Marisela Velez, Marcos Pita, Antonio L. De Lacey
Summary: We have developed an electroenzymatic ATP regeneration system using a modified gold electrode with a floating phospholipid bilayer, which allows the coupling of two membrane-bound enzymes: NiFeSe hydrogenase from Desulfovibrio vulgaris and F1Fo-ATP synthase from Escherichia coli. This system uses H2 as a fuel to produce ATP. It has been studied as an ATP regeneration system for phosphorylation reactions catalyzed by kinases.
BIOELECTROCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Natalia Zeber-Lubecka, Michal Ciebiera, Ewa E. Hennig
Summary: Oxidative stress is closely related to polycystic ovary syndrome (PCOS). Mitochondrial mutations may contribute to the metabolic and hormonal dysregulation observed in PCOS, while excessive reactive oxygen species (ROS) can damage oocytes and granulosa cells within the follicles, impairing fertility. Additionally, impaired oxidative phosphorylation (OXPHOS) and mitochondrial dysfunction may lead to insulin resistance (IR), further exacerbating oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Yajing Zhao, Yan Lyu, Yanli Zhang, Shuixiu Li, Yishan Zhang, Yuting Liu, Chuanyan Tang, Zhanpeng Zhang, Dongmei Li, Hong Zhang
Summary: Invasive fungal infections are a major cause of human mortality due to limited antifungal drugs. The study found that the fungal-specific subunit i/j of F1FO-ATP synthase plays a critical role, while subunit k does not, in the pathogenicity of Candida albicans.
Review
Cell Biology
Pierre Eyenga, Benjamin Rey, Lilia Eyenga, Shey-Shing Sheu
Summary: The link between liver dysfunction and decreased mitochondrial oxidative phosphorylation in sepsis has been established. The efficiency of mitochondrial coupling collapses in the early stage but is expected to increase during recovery phases. Slipping reactions at the cytochrome oxidase and ATP synthase appear to be a determining element in regulating coupling efficiency.
Article
Neurosciences
Mogens Andreasen, Steen Nedergaard
Summary: The study investigated the causal link between acute mitochondrial dysfunction and increased seizure susceptibility in hyperexcitable hippocampal networks. The findings indicate that acute mitochondrial dysfunction can lead to a convulsive state within a short timeframe, and increased ROS production plays a significant role in such induction.
Article
Biochemistry & Molecular Biology
Aleksandra Markovic, Katerina Tauchmannova, Miroslava Simakova, Petr Mlejnek, Vilma Kaplanova, Petr Pecina, Alena Pecinova, Frantisek Papousek, Frantisek Liska, Jan Silhavy, Jana Mikesova, Jan Neckar, Josef Houstek, Michal Pravenec, Tomas Mracek
Summary: In this study, the efficiency of gene complementation was tested using a transgenic rescue approach in spontaneously hypertensive rats. The results showed successful complementation of ATP synthase deficiency and genetic treatment of a fatal mitochondrial disorder.
Article
Cell Biology
Silvia Magalhaes-Novais, Jan Blecha, Ravindra Naraine, Jana Mikesova, Pavel Abaffy, Alena Pecinova, Mirko Milosevic, Romana Bohuslavova, Jan Prochazka, Shawez Khan, Eliska Novotna, Radek Sindelka, Radek Machan, Mieke Dewerchin, Erik Vlcak, Joanna Kalucka, Sona Stemberkova Hubackova, Ales Benda, Jermaine Goveia, Tomas Mracek, Cyril Barinka, Peter Carmeliet, Jiri Neuzil, Katerina Rohlenova, Jakub Rohlena
Summary: Mitochondrial oxidative phosphorylation (OXPHOS) not only generates ATP, but also supports autophagy to provide resistance against oxidative stress during cell quiescence.
Meeting Abstract
Biochemistry & Molecular Biology
Lukas Alan, Aleksandra Markovic, Katerina Tauchmannova, Miroslava Simakova, Petr Mlejnek, Vilma Kaplanova, Petr Pecina, Alena Pecinova, Jan Silhavy, Josef Houstek, Michal Pravenec, Tomas Mracek
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Tomas Mracek, Aleksandra Markovic, Jana Mikesova, Petr Pecina, Alena Pecinova, Marek Vrbacky, Katerina Tauchmannova, Nivasini Shekhar, Miroslava Simakova, Otto Kucera, Zuzana Cervinkova, Michal Pravenec, Josef Houstek
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Guillermo Puertas-Frias, Kristyna Cunatova, Petr Pecina, Marek Vrbacky, Jan Elias, Josef Houstek, Tomas Mracek, Alena Pecinova
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Alena Pecinova, Guillermo Puertas-Frias, Kristyna Cunatova, Marek Vrbacky, Tomas Cajka, Josef Houstek, Petr Pecina, Tomas Mracek
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Kristyna Cunatova, Marek Vrbacky, Guillermo Puertas-Frias, Jan Elias, Josef Houstek, Alena Pecinova, Petr Pecina, Tomas Mracek
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Zuzana Korandova, Eliska Konarikova, Petr Pecina, Alena Pecinova, Josef Houstek, Hana Hansikova, Tomas Honzik, Tomas Mracek
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Maria Jose Saucedo Rodriguez, Petr Pecina, Kristyna Cunatova, Marek Vrbacky, Alena Pecinova, Roman Sobotka, Carlo Viscomi, Massimo Zeviani, Tomas Mracek, Josef Houstek
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2022)
Article
Endocrinology & Metabolism
Andrea Benova, Michaela Ferencakova, Kristina Bardova, Jiri Funda, Jan Prochazka, Frantisek Spoutil, Tomas Cajka, Martina Dzubanova, Tim Balcaen, Greet Kerckhofs, Wouter Willekens, G. Harry van Lenthe, Glenda Alquicer, Alena Pecinova, Tomas Mracek, Olga Horakova, Martin Rossmeisl, Jan Kopecky, Michaela Tencerova
Summary: The novel TZD analog MSDC-0602K showed improved bone parameters and reduced detrimental effects on bone marrow mesenchymal stem cell metabolism in obese mice compared to traditional TZDs, suggesting potential therapeutic use in both metabolic and bone diseases.
MOLECULAR METABOLISM
(2022)
Article
Endocrinology & Metabolism
Petra Janovska, Petr Zouhar, Kristina Bardova, Jakub Otahal, Marek Vrbacky, Tomas Mracek, Katerina Adamcova, Lucie Lenkova, Jiri Funda, Tomas Cajka, Zdenek Drahota, Sara Stanic, Arild C. Rustan, Olga Horakova, Josef Houstek, Martin Rossmeisl, Jan Kopecky
Summary: This study investigates the relative contribution of adrenergic non-shivering thermogenesis (NST) in brown adipose tissue (BAT) and lipid oxidation in skeletal muscle for thermoregulation and energy homeostasis. The results suggest that in the face of inadequate adrenergic NST in BAT, adaptive augmentation of NST in skeletal muscle occurs, providing protection against cold and resistance to obesity.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Jan Silhavy, Petr Mlejnek, Miroslava Simakova, Hana Malinska, Irena Markova, Martina Huttl, Denisa Miklankova, Ludmila Kazdova, Marek Vrbacky, Alena Pecinova, Tomas Mracek, Michal Pravenec
Summary: Recently, red beetroot has gained attention for its health benefits. Studies have shown that beetroot can lower blood pressure and improve glucose and lipid metabolism; however, the mechanisms behind these effects are not fully understood.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)