Review
Medicine, Research & Experimental
Nuo Cheng, Yunxiu Wang, Zhaowei Gu
Summary: Allergic rhinitis (AR) is a chronic inflammatory disease caused by immunoglobulin E-mediated immune response, which has been increasing in incidence and significantly impacting individuals' wellbeing. Due to the complex pathogenesis of AR, treatment outcomes are still not ideal. Recent studies have found that NLRP3 inflammasome-mediated pyroptosis is widely involved in the occurrence and development of AR through various pathways. This article reviews the mechanism of pyroptosis and its research progress in AR, proposing potential therapeutic targets for innovative management approaches.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Huiqin Zhou, Wei Zhang, Danxue Qin, Peiqiang Liu, Wenjun Fan, Hao Lv, Lu Tan, Ziang Gao, Yu Xu
Summary: NLRP3 inflammasome activation plays an important role in allergic rhinitis by inducing macrophage pyroptosis and releasing inflammatory mediators to local tissues.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Applied
Xinyu Bai, Ping Liu, Hengyan Shen, Qiaoyue Zhang, Tao Zhang, Xuejun Jin
Summary: WLJP was found to improve allergic rhinitis through various mechanisms, such as reducing inflammation levels, modulating immune responses, maintaining gut microbiota balance, repairing damaged barriers, and alleviating AR symptoms. Additionally, significant interaction between WLJP and the NLRP3 inhibitor CY-09 was observed.
CARBOHYDRATE POLYMERS
(2022)
Article
Immunology
Nini Chen, Peiyu Chen, Yanhe Zhou, Sidong Chen, Sitang Gong, Ming Fu, Lanlan Geng
Summary: Norovirus infection is the leading cause of foodborne gastroenteritis worldwide, causing more than 200,000 deaths each year. However, the pathogenesis of human norovirus (HuNoV) is still poorly understood due to the lack of reproducible in vitro culture systems and suitable animal models. In this study, researchers successfully constructed human intestinal enteroids (HIEs) which supported the replication of HuNoV. They found that HuNoV activated the NLRP3 inflammasome and induced cell death. Furthermore, they discovered that berberine (BBR) could inhibit NLRP3 inflammasome activation and ameliorate the cell death caused by HuNoV.
Article
Medicine, Research & Experimental
Li-Chun Ho, Yu-Hsin Chen, Ting-Yun Wu, Ling-Zhen Kao, Shih-Yuan Hung, Hung-Hsiang Liou, Pei-Chun Chen, Pei-Jane Tsai, Hui-Kuan Lin, Yi-Che Lee, Hsi-Hao Wang, Yau-Sheng Tsai
Summary: In this study, a potassium efflux-triggered NLRP3-caspase-1-mediated pyroptotic pathway for VSMC calcification was identified that is unique and different from the canonical NLRP3 inflammasome activation.
Article
Environmental Sciences
Juan Li, Ying Zhang, Lin Zhang, Zhen An, Jie Song, Chunzhi Wang, Yanmei Ma, Qi Gu, Qizhan Luo, Weiling Yang, Yue Du, Weidong Wu
Summary: This study revealed that exposure to PM2.5 can exacerbate allergic rhinitis symptoms, increase serum IgE levels, disrupt nasal mucosa ultrastructure, and lead to NLRP3/Caspase-1/GSDMD-mediated cell pyroptosis in the process of allergic rhinitis aggravation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Multidisciplinary Sciences
Hsing- Huang, Chi-Chong Chio, Jhao-Yin Lin, Chia-Jung Chou, Chia-Chen Lin, Shih-Hsiang Chen, Liang-Sheng Yu
Summary: This study found that pattern recognition receptors, including RIG-I, TLR3, and TLR8, are involved in the release of IL-1 beta in EV-A71-infected human macrophages. EV-A71 infection leads to an increase in caspase-1 and caspase-8, which regulate the activation of NLRP3 and RIG-I inflammasomes. Knockdown of TLR3 and TLR8 reduces IL-1 beta release in an NLRP3-dependent manner.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Junjun Guo, Meijuan Zhou, Man Zhao, Shuxian Li, Zhenya Fang, Anna Li, Meihua Zhang
Summary: Through the study, it was found that TIGAR is up-regulated under high glucose conditions in vivo and in vitro, and loss of TIGAR increases ROS levels in trophoblast cells, leading to phenotypic changes and inhibition of migration, invasion, and tube formation. This switch is caused by the activation of the NLRP3-ASC-caspase-1 signaling pathway, resulting in pyroptosis. These findings can be reversed by antioxidant treatment and receptor blockage. In conclusion, trophoblast pyroptosis is an upstream event of TIGAR deficiency-induced inflammation, which is promoted by ROS accumulation through NLRP3-ASC inflammasome.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Manas Kinra, Alex Joseph, Madhavan Nampoothiri, Devinder Arora, Jayesh Mudgal
Summary: The study revealed that phenylpropanoic acid derivatives have the potential to inhibit the NLRP3 inflammasome pathway and IL-1 beta release. Molecular docking and cell experiments confirmed the effectiveness of these derivatives in inhibiting inflammation.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Immunology
Ting-Yi Lin, Meng-Chun Tsai, Wei Tu, Hsin-Chih Yeh, Shu-Chi Wang, Shu-Pin Huang, Chia-Yang Li
Summary: The role of inflammasomes in cancer biology is not well understood, but research on NLRP3 could provide opportunities for discovering new therapeutic targets to prevent tumor expansion and achieve metastatic control.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Pei Gao, Shiyuan Zhang, Xinxin Zhang, Chenggang Xu, Libin Chen, Lei Fan, Jinlian Ren, Qiuyan Lin, Bin Xiang, Tao Ren
Summary: This study investigates the expression and tissue distribution of S1PR1 after NDV infection and demonstrates that S1PR1 regulates IL-1 beta expression mainly through the NLRP3/caspase-1 inflammasome. The findings reveal the molecular mechanism underlying the inflammatory response induced by NDV infection.
VETERINARY RESEARCH
(2022)
Article
Immunology
Dan Xu, Xin Zhou, Jiying Chen, Na Li, Shiyan Ruan, Anju Zuo, Shengyun Lei, Linxi Li, Yuan Guo
Summary: The study reveals that CTRP9 promotes the activation of NLRP3 inflammasome through the NOX2/ROS pathway, exacerbating inflammation. CTRP9 could be a potential target for treating NLRP3 inflammasome-driven inflammatory diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuanyuan Liu, Nianyu Xue, Boxi Zhang, Hongming Lv, Shize Li
Summary: This study investigates the effects of chronic cold exposure on liver function, apoptosis, oxidative stress, and inflammation in mice. The results suggest that cold stress can lead to liver injury and activate apoptosis, oxidative stress, and pyroptosis. The findings provide new insights into the underlying mechanisms of the cold stress response.
Article
Immunology
Shujun Ran, Jing Huang, Bin Liu, Shensheng Gu, Wei Jiang, Jingping Liang
Summary: This study aimed to investigate the pathogenicity of Enterococcus faecalis and the molecular mechanisms of IL-1 beta secretion by THP-1 macrophages infected with E. faecalis. The results showed that E. faecalis infection activated caspase-1 and the NLRP3 inflammasome to induce IL-1 beta secretion and inflammatory cell death (pyroptosis). Furthermore, the activation and expression of NLRP3 induced by E. faecalis required P2X7R and K+ efflux, suggesting NLRP3 may be a potential target for treatment and prevention of persistent periodontitis caused by E. faecalis.
MICROBIAL PATHOGENESIS
(2021)
Article
Chemistry, Medicinal
Sheng-jing Liu, Bo-da Guo, Qing-he Gao, Ying-jun Deng, Bin Yan, Yin Zeng, Ming Zhao, Kai Ren, Fu Wang, Jun Guo
Summary: This study found that ursolic acid (UA) improves chronic prostatitis (CP) by inhibiting inflammation and regulating cell death processes. UA can alleviate pathological damage, reduce levels of inflammatory cytokines, and improve CP pathology by regulating the NLRP3 inflammasome-mediated Caspase-1/GSDMD pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)