Safe and highly efficient adaptation of potentially explosive azide chemistry involved in the synthesis of Tamiflu using continuous-flow technology

Efficient continuous flow synthesis of ethyl shikimate: the first step in the synthesis of Tamiflu

(2019) Cloudius R. Sagandira et al.   Journal of Flow Chemistry

Taming hazardous chemistry by continuous flow technology

(2016) M. Movsisyan et al.   CHEMICAL SOCIETY REVIEWS

CHEM21 selection guide of classical- and less classical-solvents

(2016) Denis Prat et al.   GREEN CHEMISTRY

Multistep Continuous-Flow Synthesis of (–)-Oseltamivir

(2016) Yujiro Hayashi et al.   SYNTHESIS-STUTTGART

Facile method for the synthesis of oseltamivir phosphate

(2013) A. I. Kalashnikov et al.   RUSSIAN CHEMICAL BULLETIN

A novel azide-free asymmetric synthesis of oseltamivir phosphate (Tamiflu) starting from Roche’s epoxide

(2013) Liang-Deng Nie et al.   TETRAHEDRON-ASYMMETRY

Development of continuous pharmaceutical production processes supported by process systems engineering methods and tools

(2012) Krist V Gernaey et al.   Future Medicinal Chemistry

Synthesis of (-)-Oseltamivir by Using a Microreactor in the Curtius Rearrangement

(2011) Hayato Ishikawa et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Recent synthetic approaches to oseltamivir phosphate (Tamiflu™) for the treatment of influenza

(2011) Javier Magano   TETRAHEDRON

High-Yielding Synthesis of the Anti-Influenza Neuraminidase Inhibitor (−)-Oseltamivir by Two “One-Pot” Sequences

(2010) Hayato Ishikawa et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Practical and Azide-Free Synthetic Approach to Oseltamivir from Diethyld-Tartrate

(2010) Jiang Weng et al.   JOURNAL OF ORGANIC CHEMISTRY

Efficient Access to Oseltamivir Phosphate (Tamiflu) via theO-Trimesylate of Shikimic Acid Ethyl Ester

(2009) Martin Karpf et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic Approaches to the Neuraminidase Inhibitors Zanamivir (Relenza) and Oseltamivir Phosphate (Tamiflu) for the Treatment of Influenza

(2009) Javier Magano   CHEMICAL REVIEWS

A Short and Practical Synthesis of Oseltamivir Phosphate (Tamiflu) from (−)-Shikimic Acid†

(2009) Liang-Deng Nie et al.   JOURNAL OF ORGANIC CHEMISTRY

Azide-Free Synthesis of Oseltamivir from l-Methionine

(2009) Tadakatsu Mandai et al.   SYNLETT

A novel asymmetric synthesis of oseltamivir phosphate (Tamiflu) from (−)-shikimic acid

(2009) Liang-Deng Nie et al.   TETRAHEDRON-ASYMMETRY