Intracellular evolution of mitochondrial DNA (mtDNA) and the tragedy of the cytoplasmic commons

Mitochondrial dysfunction in aging: Much progress but many unresolved questions

(2015) Brendan A.I. Payne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The evolution of sex: A new hypothesis based on mitochondrial mutational erosion

(2015) Justin C. Havird et al.   BIOESSAYS

What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research

(2015) Hanne Hoitzing et al.   BIOESSAYS

Mitochondrial membrane potential: a trait involved in organelle inheritance?

(2015) Liliana Milani   Biology Letters

Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA

(2015) Liang Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion

(2015) Christof Osman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extreme-Depth Re-sequencing of Mitochondrial DNA Finds No Evidence of Paternal Transmission in Humans

(2015) Angela Pyle et al.   PLoS Genetics

Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

(2015) Iain G Johnston et al.   eLife

What cost mitochondria? The maintenance of functional mitochondrial DNA within and across generations

(2014) D. K. Aanen et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The road to rack and ruin: selecting deleterious mitochondrial DNA variants

(2014) I. J. Holt et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Quality matters: how does mitochondrial network dynamics and quality control impact on mtDNA integrity?

(2014) K. B. Busch et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging

(2014) A. Kowald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial mutations and aging: random drift is insufficient to explain the accumulation of mitochondrial deletion mutants in short-lived animals

(2013) Axel Kowald et al.   AGING CELL

An estimation of the number of cells in the human body

(2013) Eva Bianconi et al.   ANNALS OF HUMAN BIOLOGY

Evolution of cytochrome bc complexes: From membrane-anchored dehydrogenases of ancient bacteria to triggers of apoptosis in vertebrates

(2013) Daria V. Dibrova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial fission-fusion as an emerging key regulator of cell proliferation and differentiation

(2013) Kasturi Mitra   BIOESSAYS

Disease-Causing Mitochondrial Heteroplasmy Segregated Within Induced Pluripotent Stem Cell Clones Derived from a Patient with MELAS

(2013) Clifford D.L. Folmes et al.   STEM CELLS

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease

(2013) D. C. Wallace et al.   Cold Spring Harbor Perspectives in Biology

Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations

(2012) Laura C. Greaves et al.   PLoS Genetics

Cytochrome c oxidase: Evolution of control via nuclear subunit addition

(2011) Denis Pierron et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Regulation of mitochondrial respiration and apoptosis through cell signaling: Cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation

(2011) Maik Hüttemann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitonuclear match: Optimizing fitness and fertility over generations drives ageing within generations

(2011) Nick Lane   BIOESSAYS

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

(2011) Jean-Claude Martinou et al.   DEVELOPMENTAL CELL

Evolution of the mitochondrial fusion-fission cycle and its role in aging

(2011) A. Kowald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selection for mitonuclear co-adaptation could favour the evolution of two sexes

(2011) Z. Hadjivasiliou et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Somatic Mitochondrial DNA Mutations in Mammalian Aging

(2010) Nils-Göran Larsson   Annual Review of Biochemistry

Is the mitochondrial cloud the selection machinery for preferentially transmitting wild-type mtDNA between generations? Rewinding Müller’s ratchet efficiently

(2010) Rong Rong Zhou et al.   CURRENT GENETICS

Age related changes in mitochondrial function and new approaches to study redox regulation in mammalian oocytes in response to age or maturation conditions

(2010) U. Eichenlaub-Ritter et al.   MITOCHONDRION

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

(2010) D.-F. Suen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells

(2010) Alessandro Prigione et al.   STEM CELLS

Mitochondrial ‘kiss-and-run’: interplay between mitochondrial motility and fusion–fission dynamics

(2009) Xingguo Liu et al.   EMBO JOURNAL

Ovarian Aging: Mechanisms and Clinical Consequences

(2009) F. J. Broekmans et al.   ENDOCRINE REVIEWS

mtDNA mutation pattern in tumors and human evolution are shaped by similar selective constraints

(2009) I. Zhidkov et al.   GENOME RESEARCH

A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase

(2009) K. Mitra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selection against Pathogenic mtDNA Mutations in a Stem Cell Population Leads to the Loss of the 3243A→G Mutation in Blood

(2008) Harsha Karur Rajasimha et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view

(2008) Gilad Twig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation

(2008) Mannis van Oven et al.   HUMAN MUTATION

Mitochondrial nucleoids maintain genetic autonomy but allow for functional complementation

(2008) Robert W. Gilkerson et al.   JOURNAL OF CELL BIOLOGY

Purifying selection of mtDNA and its implications for understanding evolution and mitochondrial disease

(2008) James Bruce Stewart et al.   NATURE REVIEWS GENETICS

A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations

(2008) Weiwei Fan et al.   SCIENCE

Strong Purifying Selection in Transmission of Mammalian Mitochondrial DNA

(2008) James Bruce Stewart et al.   PLOS BIOLOGY