Activation of the motor protein upon attachment: Anchors weigh in on cytoplasmic dynein regulation

The dynein cortical anchor Num1 activates dynein motility by relieving Pac1/LIS1-mediated inhibition

(2015) Lindsay G. Lammers et al.   JOURNAL OF CELL BIOLOGY

Dynactin and Num1 cooperate to establish the cortical anchoring of cytoplasmic dynein in S. pombe

(2015) I. Fujita et al.   JOURNAL OF CELL SCIENCE

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structure of the dynactin complex and its interaction with dynein

(2015) L. Urnavicius et al.   SCIENCE

Structural organization of the dynein–dynactin complex bound to microtubules

(2015) Saikat Chowdhury et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynein, microtubule and cargo: a ménage à trois

(2015) Nenad Pavin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane

(2014) S. Kotak et al.   EMBO JOURNAL

In vitroreconstitution of a highly processive recombinant human dynein complex

(2014) Max A Schlager et al.   EMBO JOURNAL

A microscopy-based screen employing multiplex genome sequencing identifies cargo-specific requirements for dynein velocity

(2014) Kaeling Tan et al.   MOLECULAR BIOLOGY OF THE CELL

Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein

(2014) Takayuki Torisawa et al.   NATURE CELL BIOLOGY

Autoregulatory mechanism for dynactin control of processive and diffusive dynein transport

(2014) Suvranta K. Tripathy et al.   NATURE CELL BIOLOGY

A divide and conquer strategy for the maximum likelihood localization of low intensity objects

(2014) Alexander Krull et al.   OPTICS EXPRESS

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Reconstitution of dynein transport to the microtubule plus end by kinesin

(2014) Anthony J Roberts et al.   eLife

The influence of dynein processivity control, MAPs, and microtubule ends on directional movement of a localising mRNA

(2014) Harish Chandra Soundararajan et al.   eLife

Dynein Motion Switches from Diffusive to Directed upon Cortical Anchoring

(2013) Vaishnavi Ananthanarayanan et al.   CELL

Molecular Adaptations Allow Dynein to Generate Large Collective Forces inside Cells

(2013) Arpan K. Rai et al.   CELL

Mechanisms of spindle positioning: cortical force generators in the limelight

(2013) Sachin Kotak et al.   CURRENT OPINION IN CELL BIOLOGY

Molecular pathways regulating mitotic spindle orientation in animal cells

(2013) M. S. Lu et al.   DEVELOPMENT

NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function

(2013) Sachin Kotak et al.   EMBO JOURNAL

Cell cycle–regulated membrane binding of NuMA contributes to efficient anaphase chromosome separation

(2013) Zhen Zheng et al.   MOLECULAR BIOLOGY OF THE CELL

Cortical Dynein Controls Microtubule Dynamics to Generate Pulling Forces that Position Microtubule Asters

(2012) Liedewij Laan et al.   CELL

Lis1 Acts as a “Clutch” between the ATPase and Microtubule-Binding Domains of the Dynein Motor

(2012) Julie Huang et al.   CELL

Dynein Tethers and Stabilizes Dynamic Microtubule Plus Ends

(2012) Adam G. Hendricks et al.   CURRENT BIOLOGY

Cortical dynein is critical for proper spindle positioning in human cells

(2012) Sachin Kotak et al.   JOURNAL OF CELL BIOLOGY

A novel patch assembly domain in Num1 mediates dynein anchoring at the cortex during spindle positioning

(2012) Xianying Tang et al.   JOURNAL OF CELL BIOLOGY

Cell cycle–regulated cortical dynein/dynactin promotes symmetric cell division by differential pole motion in anaphase

(2012) Elizabeth S. Collins et al.   MOLECULAR BIOLOGY OF THE CELL

BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures

(2012) Daniël Splinter et al.   MOLECULAR BIOLOGY OF THE CELL

The 2.8 Å crystal structure of the dynein motor domain

(2012) Takahide Kon et al.   NATURE

Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation

(2012) Tomomi Kiyomitsu et al.   NATURE CELL BIOLOGY

Insights into dynein motor domain function from a 3.3-Å crystal structure

(2012) Helgo Schmidt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reconstitution of the human cytoplasmic dynein complex

(2012) M. Trokter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A CAAX motif can compensate for the PH domain of Num1 for cortical dynein attachment

(2011) Xianying Tang et al.   CELL CYCLE

An Ana2/Ctp/Mud Complex Regulates Spindle Orientation in Drosophila Neuroblasts

(2011) Cheng Wang et al.   DEVELOPMENTAL CELL

Canoe binds RanGTP to promote PinsTPR/Mud-mediated spindle orientation

(2011) Brett Wee et al.   JOURNAL OF CELL BIOLOGY

aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division

(2011) Matilde Galli et al.   NATURE CELL BIOLOGY

LIS1 and NudE Induce a Persistent Dynein Force-Producing State

(2010) Richard J. McKenney et al.   CELL

Nucleotide-dependent behavior of single molecules of cytoplasmic dynein on microtubules in vitro

(2010) Michi Miura et al.   FEBS LETTERS

Contribution of dynein light intermediate and intermediate chains to subcellular localization of the dynein-dynactin motor complex inSchizosaccharomyces pombe

(2010) Ikumi Fujita et al.   GENES TO CELLS

A cytoplasmic dynein tail mutation impairs motor processivity

(2010) Kassandra M. Ori-McKenney et al.   NATURE CELL BIOLOGY

NuMA after 30 years: the matrix revisited

(2010) Andreea E. Radulescu et al.   TRENDS IN CELL BIOLOGY

AAA+ Ring and Linker Swing Mechanism in the Dynein Motor

(2009) Anthony J. Roberts et al.   CELL

Motor- and Tail-Dependent Targeting of Dynein to Microtubule Plus Ends and the Cell Cortex

(2009) Steven M. Markus et al.   CURRENT BIOLOGY

Apical/Basal Spindle Orientation Is Required for Neuroblast Homeostasis and Neuronal Differentiation in Drosophila

(2009) Clemens Cabernard et al.   DEVELOPMENTAL CELL

Cytoplasmic dynein is not a conventional processive motor

(2009) Wilhelm J. Walter et al.   JOURNAL OF STRUCTURAL BIOLOGY

Traffic control: regulation of kinesin motors

(2009) Kristen J. Verhey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Self-Organization of Dynein Motors Generates Meiotic Nuclear Oscillations

(2009) Sven K Vogel et al.   PLOS BIOLOGY

Lis1/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts

(2008) Karsten H. Siller et al.   DEVELOPMENTAL BIOLOGY

A Casein Kinase 1 and PAR Proteins Regulate Asymmetry of a PIP2 Synthesis Enzyme for Asymmetric Spindle Positioning

(2008) Costanza Panbianco et al.   DEVELOPMENTAL CELL

Highly inclined thin illumination enables clear single-molecule imaging in cells

(2008) Makio Tokunaga et al.   NATURE METHODS