How and why multiple MCMs are loaded at origins of DNA replication

Genome-wide chromatin footprinting reveals changes in replication origin architecture induced by pre-RC assembly

(2015) Jason A. Belsky et al.   GENES & DEVELOPMENT

Replication timing is regulated by the number of MCMs loaded at origins

(2015) Shankar P. Das et al.   GENOME RESEARCH

Post-licensing Specification of Eukaryotic Replication Origins by Facilitated Mcm2-7 Sliding along DNA

(2015) Julien Gros et al.   MOLECULAR CELL

Structure of the eukaryotic MCM complex at 3.8 Å

(2015) Ningning Li et al.   NATURE

Different nucleosomal architectures at early and late replicating origins in Saccharomyces cerevisiae

(2014) Ignacio Soriano et al.   BMC GENOMICS

The contribution of dormant origins to genome stability: From cell biology to human genetics

(2014) Robert C. Alver et al.   DNA REPAIR

Prereplication-complex formation: a molecular double take?

(2014) Hasan Yardimci et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Total Synthesis of a Functional Designer Eukaryotic Chromosome

(2014) N. Annaluru et al.   SCIENCE

Time to Be Versatile: Regulation of the Replication Timing Program in Budding Yeast

(2013) Kazumasa Yoshida et al.   JOURNAL OF MOLECULAR BIOLOGY

Diminished Origin-Licensing Capacity Specifically Sensitizes Tumor Cells to Replication Stress

(2013) Kristin M. Zimmerman et al.   MOLECULAR CANCER RESEARCH

DNA replication timing, genome stability and cancer

(2013) Nathan Donley et al.   SEMINARS IN CANCER BIOLOGY

DNA Replication Timing

(2013) N. Rhind et al.   Cold Spring Harbor Perspectives in Biology

A Link between ORC-Origin Binding Mechanisms and Origin Activation Time Revealed in Budding Yeast

(2013) Timothy Hoggard et al.   PLoS Genetics

Forkhead Transcription Factors Establish Origin Timing and Long-Range Clustering in S. cerevisiae

(2012) Simon R.V. Knott et al.   CELL

Quantitative Analysis of Fission Yeast Transcriptomes and Proteomes in Proliferating and Quiescent Cells

(2012) Samuel Marguerat et al.   CELL

Rif1 is a global regulator of timing of replication origin firing in fission yeast

(2012) M. Hayano et al.   GENES & DEVELOPMENT

The dynamics of replication licensing in liveCaenorhabditis elegansembryos

(2012) Remi Sonneville et al.   JOURNAL OF CELL BIOLOGY

Replication timing and its emergence from stochastic processes

(2012) John Bechhoefer et al.   TRENDS IN GENETICS

Spatio-Temporal Organization of Replication in Bacteria and Eukaryotes (Nucleoids and Nuclei)

(2012) D. Jackson et al.   Cold Spring Harbor Perspectives in Biology

Genome-wide identification and characterization of replication origins by deep sequencing

(2012) Jia Xu et al.   GENOME BIOLOGY

Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast

(2011) Davide Mantiero et al.   EMBO JOURNAL

MCM2-7 Form Double Hexamers at Licensed Origins inXenopusEgg Extract

(2011) Agnieszka Gambus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The effect of Ku on telomere replication time is mediated by telomere length but is independent of histone tail acetylation

(2011) Hui-Yong Lian et al.   MOLECULAR BIOLOGY OF THE CELL

OriDB, the DNA replication origin database updated and extended

(2011) C. C. Siow et al.   NUCLEIC ACIDS RESEARCH

Eukaryotic Chromosome DNA Replication: Where, When, and How?

(2010) Hisao Masai et al.   Annual Review of Biochemistry

Conserved nucleosome positioning defines replication origins

(2010) M. L. Eaton et al.   GENES & DEVELOPMENT

Modeling genome-wide replication kinetics reveals a mechanism for regulation of replication timing

(2010) Scott Cheng-Hsin Yang et al.   Molecular Systems Biology

Stoichiometry and Architecture of Active DNA Replication Machinery in Escherichia coli

(2010) R. Reyes-Lamothe et al.   SCIENCE

Genome-Wide Kinetics of Nucleosome Turnover Determined by Metabolic Labeling of Histones

(2010) R. B. Deal et al.   SCIENCE

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

Reconciling stochastic origin firing with defined replication timing

(2009) Nicholas Rhind et al.   CHROMOSOME RESEARCH

The Mcm Complex: Unwinding the Mechanism of a Replicative Helicase

(2009) M. L. Bochman et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Measurement of replication structures at the nanometer scale using super-resolution light microscopy

(2009) D. Baddeley et al.   NUCLEIC ACIDS RESEARCH

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

(2009) C. Evrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication

(2008) Arkaitz Ibarra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA