Article
Nanoscience & Nanotechnology
Mohammad Akrami, Shabnam Samimi, Mohsen Alipour, Hassan Bardania, Sorour Ramezanpour, Niayesh Najafi, Saman Hosseinkhani, Mojtaba Kamankesh, Ismaeil Haririan, Fatemeh Hassanshahi
Summary: The study successfully developed a cancer-targeting nanoparticle platform with higher affinity to breast cancer cells by combining peptides with AuNPs, showing improved uptake and anti-tumor efficiency in vivo.
Article
Engineering, Biomedical
Lee-Hsin Chang, Er-Yuan Chuang, Tsai-Mu Cheng, Chi Lin, Chun-Ming Shih, Alexander T. H. Wu, Pei-Ru Jheng, Hsin-Ying Lu, Chun-Che Shih, Fwu-Long Mi
Summary: A novel photothermal theranostic nanocomposite for thrombus-targeted delivery of urokinase and near-infrared fluorescence contrast agent indocyanine green (ICG) was developed, showing potential for precise thrombus imaging and enzyme/hyperthermia combined thrombolytic therapy. The nanocomposite has multiple functions including thrombus targeting, imaging, and photothermal thrombolysis, making it an advanced platform for targeted thrombolytic therapy.
ACTA BIOMATERIALIA
(2021)
Review
Chemistry, Multidisciplinary
Guanyou Lin, Miqin Zhang
Summary: The potential of theranostic nanoparticles in tumor treatment is widely recognized due to their ability to integrate multifaceted functionalities into a single nanosystem. These nanoparticles typically consist of an inorganic core for imaging and therapeutic functions, bioinert coatings for improved biocompatibility, controlled drug-loading-release modules, and targeting ligands for specific cell uptake. The design and assembly of these functionalities require sophisticated molecular design and precise execution. Ligand chemistry plays a decisive role in translating theoretical designs into functionalized theranostic nanoparticles. This Account reviews the properties and utilities of capping ligands, drug-loading ligands, and targeting ligands in theranostic nanoparticles.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Review
Chemistry, Inorganic & Nuclear
Manoj Kumar Sarangi, Sasmita Padhi, Goutam Rath, Sitansu Sekhar Nanda, Dong Kee Yi
Summary: The emergence of nanobiotechnology offers a unique opportunity for advancements in disease diagnosis and treatment. Gold nanoparticles (AuNPs) with functionalized surfaces have gained significant attention due to their unique properties, such as optical, electrical, magnetic, and catalytical properties. AuNPs have shown great potential in various biomedical applications including sensing, targeted drug delivery, bio-imaging, immunotherapy, vaccines, cancers, and infectious diseases, thanks to their key features such as electronic, optical, surface plasmon resonance, physicochemical, and immunomodulatory effects. Additionally, the low toxicity, biocompatibility, tunability, and stability of AuNPs make them promising candidates for diagnostic and therapeutic applications.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Mukesh Kumar Meher, B. S. Unnikrishnan, Deepak Kumar Tripathi, Gopinath Packirisamy, Krishna Mohan Poluri
Summary: The study focuses on the synthesis of heparin carbon dots (HCDs) for the efficient delivery of the natural anticancer compound baicalin (BA). The surface passivation of HCDs with polyethylenimine (PEI) improves their fluorescence yield. The sustained release of BA in acidic conditions and enhanced anticancer activity of BA-loaded HCDs demonstrate the potential of this nanotheranostic agent for cancer treatment. Flow cytometry analysis and bioimaging studies confirm the effectiveness of BA-loaded HCDs in arresting cell cycle and penetrating cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Saeideh Arsalani, Yaser Hadadian, Ernesto E. Mazon, Eder J. Guidelli, Emanuel Kava, Ana Paula Ramos, Alexandre Jose Gauldi, Theo Z. Pavan, Oswaldo Baffa, Antonio A. O. Carneiro
Summary: This study successfully synthesized bare magnetite NPs and PEG-MNPs with high stability and optimized physicochemical properties through an optimized synthesis method. In vitro biological assays on Escherichia coli strains demonstrated low cytotoxicity of these nanoparticles at high concentrations. Furthermore, the MNPs showed potential as theranostic agents in magnetomotive ultrasound imaging and magnetic hyperthermia.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Rui Teixeira da Silva, Ivo F. Machado, Joao S. Teodoro, Arnau Panisello-Rosello, Joan Rosello-Catafau, Anabela P. Rolo, Carlos M. Palmeira
Summary: PEG35 preconditioning effectively ameliorates hepatic hypoxia/reoxygenation injury through the enhancement of autophagy and mitochondrial quality control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Materials Science, Multidisciplinary
Zixuan Xiao, Shujing Zhao, Xiaoyuan Zhang, Gang Wei, Zhiqiang Su
Summary: This review presents recent advances in the functionalization of PEG hydrogels with peptides for biomedical applications, including preparation methods, functional regulation, and specific applications. This work provides a systematic literature review on this promising topic and facilitates readers in the design of composite materials and functional tailoring of PEG hydrogels with biomolecules.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
Xiqi Ma, Xiaojuan Wang, Cai Liu, Baosheng Ge, Hua He, Qi Dai, Zhixiong Zhang, Jinyi Yu, Werner M. Nau, Fang Huang
Summary: HBMA is a novel heparanase degradable heparin-based microcarrier developed for specific staining, targeting, and inhibiting tumor cells with high metastatic potential. Results from various assays demonstrate that HBMA effectively suppresses the proliferation and migration of selectively targeted tumor cells, highlighting its potential as a promising cancer theranostic agent to prevent tumor metastasis.
MATERIALS & DESIGN
(2021)
Article
Chemistry, Inorganic & Nuclear
Yafang Qin, Xingguo Tang, Jintai Chen, Jingcong Huang, Dingding Wang, Xianhuan Zhang, Yangli Zhang, Fenglin Wu, Jinquan Wang
Summary: In this study, a tumor-targeting ruthenium(II) complex, Ru1-LHRH, conjugated with LHRH peptide was synthesized and characterized. Ru1-LHRH selectively targeted the mitochondria of A2780 tumor cells overexpressing LHRH receptor, showing approximately 8 times higher cytotoxicity against A2780 cells compared to non-targeted L02 cells. Moreover, Ru1-LHRH exhibited theranostic functions by simultaneously imaging and killing targeted tumor cells. Further analysis revealed that Ru1-LHRH induced apoptosis by promoting the generation of reactive oxygen species (ROS) and activating the Caspase3/7 protein family. These findings suggest that Ru1-LHRH has potential as a multifunctional tumor-targeted theranostic anticancer agent.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Riku Kawasaki, Kosuke Kondo, Risako Miura, Keita Yamana, Hinata Isozaki, Risako Shimada, Shogo Kawamura, Hidetoshi Hirano, Tomoki Nishimura, Naoki Tarutani, Kiyofumi Katagiri, Alexandra Stubelius, Shin-ichi Sawada, Yoshihiro Sasaki, Kazunari Akiyoshi, Atsushi Ikeda
Summary: In this study, a theranostic agent based on a hybrid nanoparticle comprising fullerene nanocrystals and gold nanoparticles was developed for cancer diagnosis and therapy. The nanoparticle exhibited stronger photoacoustic signals and photothermal heating characteristics, and showed promise for killing cancer cells and visualizing tumor tissue in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Ceramics
Mohammad Poorhossein, Fatemehsadat Pishbin, Abolghasem Ataie, Mohammad Akrami
Summary: Magnetic nanoparticles can improve the delivery of anticancer drugs to tumor sites while reducing side effects. This research examined the effects of polyethylene glycol (PEG) on the structure, size, morphology, magnetic properties, and coating of cobalt ferrite nanoparticles (CFO). The results showed that higher molecular weight PEG created a thicker coating on the nanoparticles, resulting in higher drug loading efficiency.
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Applied
Vahid Zeyni, Soheyla Karimi, Hassan Namazi
Summary: In this study, a zinc-based metal-organic framework/magnetic hydroxyapatite nanocomposite was synthesized and coated with a biocompatible layer of polyethylene glycol as a targeting drug delivery system. The nanocomposites were characterized and utilized as carriers to encapsulate the anticancer drug doxorubicin. Both nanocomposites showed pH-dependent drug release and the Korsmeyer-Peppas model was the best fit to describe the release mechanism. The synthesized systems showed no significant toxicity and exhibited higher toxicity against lung cancer cell lines. Additionally, the nanocomposites demonstrated excellent antioxidant activity. These findings suggest that the prepared drug systems have potential for targeted drug delivery applications.
MICROPOROUS AND MESOPOROUS MATERIALS
(2023)
Article
Polymer Science
Zhenzhen Pi, Changyu Deng, Hongmei Pan, Kemei Pei
Summary: Polyethylene glycol 1000 (PEG1000) and epoxy resin E20 were used to synthesize the E20/PEG1000 polymer (EP1K), which was later transformed into a self-emulsifying water-based epoxy curing agent by reacting with m-Xylylenediamine (MXDA). The effects of various factors on the properties of the curing agent were analyzed, and the coating properties of the waterborne epoxy varnish were tested. The results showed excellent anti-corrosion performance and mechanical properties for the prepared varnish under specific conditions.
Article
Biochemistry & Molecular Biology
Chiung-Chyi Shen, Shan-hui Hsu, Kai-Bo Chang, Chun-An Yeh, Hsiang-Chun Chang, Cheng-Ming Tang, Yi-Chin Yang, Hsien-Hsu Hsieh, Huey-Shan Hung
Summary: This study demonstrates the superior biological properties and biocompatibility of PEG-HA-AuNP nanocomposites for cell behavior in both MC3T3-E1 cells and MSCs, as well as their potential in promoting anti-inflammatory response and endothelialization when implanted into rats subcutaneously for a period of 1 month.
Article
Chemistry, Analytical
Hulya Yilmaz Ortak, Ebru Cubuk Demiralay
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2019)
Article
Chemistry, Analytical
Hulya Yilmaz, Zehra Cobandede, Deniz Yilmaz, Ayse Cinkilic, Mustafa Culha, Ebru Cubuk Demiralay
Article
Biochemistry & Molecular Biology
Aysegul Demiral, Nihan Verimli, S. Irem Gorali, Hulya Yilmaz, Mustafa Culha, S. Sibel Erdem
Summary: Development of nanocarrier systems, specifically using gold nanoparticles (AuNPs) and photodynamic therapy (PDT), is crucial for preventing cancer recurrence and metastasis. The functionalized AuNPs with FDA-Approved photosensitizer, Verteporfin (BPD-MA), show potential as a theranostic agent with on-off switchable system, enhancing photodynamic therapy efficacy.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hulya Yilmaz, Mustafa Culha
Summary: Pharmaceutical product quality is crucial for patient safety, and impurities and degradation products can have a significant impact on product quality and safety. This study used surface-enhanced Raman spectroscopy (SERS) to investigate the degradation mechanisms and degradation products of pemetrexed (PMT), an antifolate chemotherapy drug, under different conditions.
APPLIED SCIENCES-BASEL
(2022)
Review
Pharmacology & Pharmacy
Hulya Yilmaz, Deniz Yilmaz, Irem Culha Taskin, Mustafa Culha
Summary: Surface-enhanced Raman spectroscopy (SERS) is a highly sensitive technique that can detect and identify molecules and molecular structures in low concentrations and complex sample matrices. This review provides an introduction to Raman spectroscopy, compares it to other techniques, and discusses the mechanisms, substrates, and parameters of SERS experiments. The review also summarizes the applications of SERS in pharmaceuticals, including drug discovery, drug metabolism, chemo-photothermal-therapy-delivery-release-imaging, drug stability, and drug/metabolite detection in complex biological samples.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Spectroscopy
Hulya Yilmaz, Shyam S. Mohapatra, Mustafa Culha
Summary: The study compared SERS and SEIRAS for microbial identification, showing that SEIRAS provides rich molecular information and improved discrimination power compared to FTIR, making it a potential technique for microbial analysis.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Pharmacology & Pharmacy
Aysegul Demiral, S. Irem Gorali, Hulya Yilmaz, Nihan Verimli, Mustafa Culha, S. Sibel Erdem
Summary: Innovative theranostic nanosystems utilizing gold nanoparticles have the potential to make drug-resistant micro-tumors visible to clinicians through multimodal imaging and combination therapy. A highly specific hybrid theranostic agent was developed in this study, which is activated only in the presence of stimuli at the target site. This system demonstrated high specificity and promising results for multimodal imaging and dual treatment of micro-tumors.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Jeaphianne van Rijn, Antreas Afantitis, Mustafa Culha, Maria Dusinska, Thomas E. Exner, Nina Jeliazkova, Eleonora Marta Longhin, Iseult Lynch, Georgia Melagraki, Penny Nymark, Anastasios G. Papadiamantis, David A. Winkler, Hulya Yilmaz, Egon Willighagen
Summary: Management of nanomaterials and nanosafety data requires a unique identifier for each nanomaterial, which is provided by the European Registry of Materials Identifier. This identifier ensures the linking of internal project documentation with publicly released data and knowledge for specific nanomaterials, and has been applied in H2020-funded nanosafety projects.
JOURNAL OF CHEMINFORMATICS
(2022)
Article
Oncology
Ertug Avci, Hulya Yilmaz, Nurettin Sahiner, Bilge Guvenc Tuna, Munevver Burcu Cicekdal, Mehmet Eser, Kayhan Basak, Fatih Altintoprak, Ismail Zengin, Soner Dogan, Mustafa Culha
Summary: This study investigates the reliability of surface-enhanced Raman scattering (SERS) for cancer diagnosis by varying several parameters. The results demonstrate the potential of this technique to accurately differentiate blood samples from cancer patients, healthy individuals, and patients with chronic diseases.
Article
Polymer Science
Saltuk B. Hanay, Ali Fallah, Efsun Senturk, Zeliha Yetim, Ferdows Afghah, Hulya Yilmaz, Mustafa Culha, Bahattin Koc, Ali Zarrabi, Rajender S. Varma
Summary: The acidity of urazole was utilized to fabricate a hydrogel in two simple steps, with commercial poly(hexamethylene)diisocyanate as the precursor. The formed hydrogel was highly porous with good biocompatibility, and a general strategy for embedding urazole groups into crosslinked materials was demonstrated.