Article
Biochemistry & Molecular Biology
David S. Hong, Brian A. Van Tine, Swethajit Biswas, Cheryl McAlpine, Melissa L. Johnson, Anthony J. Olszanski, Jeffrey M. Clarke, Dejka Araujo, George R. Blumenschein, Partow Kebriaei, Quan Lin, Alex J. Tipping, Joseph P. Sanderson, Ruoxi Wang, Trupti Trivedi, Thejo Annareddy, Jane Bai, Stavros Rafail, Amy Sun, Lilliam Fernandes, Jean-Marc Navenot, Frederic D. Bushman, John K. Everett, Derin Karadeniz, Robyn Broad, Martin Isabelle, Revashnee Naidoo, Natalie Bath, Gareth Betts, Zohar Wolchinsky, Dzmitry G. Batrakou, Erin Van Winkle, Erica Elefant, Armin Ghobadi, Amanda Cashen, Anne Grand'Maison, Philip McCarthy, Paula M. Fracasso, Elliot Norry, Dennis Williams, Mihaela Druta, David A. Liebner, Kunle Odunsi, Marcus O. Butler
Summary: Affinity-optimized T cell receptors can enhance the effectiveness of adoptive T cell therapy. The trial of afamitresgene autoleucel (afami-cel) in patients with solid tumors expressing MAGE-A4 showed promising results, with an overall response rate of 24% and a median duration of response of 25.6 weeks. Afami-cel demonstrated tumor infiltration, interferon-gamma-driven mechanism of action, and triggered adaptive immune responses. Further larger studies are warranted to validate these findings.
Article
Biochemistry & Molecular Biology
Alaa Alsalloum, Julia Shevchenko, Marina Fisher, Julia Philippova, Roman Perik-Zavodskii, Olga Perik-Zavodskaia, Saleh Alrhmoun, Julia Lopatnikova, Kurilin Vasily, Marina Volynets, Evgenii Zavjalov, Olga Solovjeva, Yasushi Akahori, Hiroshi Shiku, Alexander Silkov, Sergey Sennikov
Summary: This study investigated the cytotoxicity and functional attributes of TCR-like CAR-T cells targeting MAGE-A4 antigen. The results showed that TCR-like CAR-T cells exhibited robust T-cell activation and cytotoxicity upon encountering tumor cells expressing MAGE-A4, leading to a significant deceleration in tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Kazuhiko Hashimoto, Shunji Nishimura, Tomohiko Ito, Masao Akagi
Summary: The clinical significance of NY-ESO-1 and MAGEA4 expression in soft tissue sarcoma (STS) was investigated. Results showed that their expression levels were correlated with tumor size and histological grade, but there was no significant difference between patients in remission and those who were not in remission.
Article
Multidisciplinary Sciences
Alexandra Gyurdieva, Stefan Zajic, Ya-Fang Chang, E. Andres Houseman, Shan Zhong, Jaegil Kim, Michael Nathenson, Thomas Faitg, Mary Woessner, David C. Turner, Aisha N. Hasan, John Glod, Rosandra N. Kaplan, Sandra P. D'Angelo, Dejka M. Araujo, Warren A. Chow, Mihaela Druta, George D. Demetri, Brian A. Van Tine, Stephan A. Grupp, Gregg D. Fine, Ioanna Eleftheriadou
Summary: This study identifies potential predictive and pharmacodynamic markers of response to NY-ESO-1 T-cell therapy in a solid tumor, which may inform lymphodepletion, cell dose, and strategies to enhance anticancer efficacy.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Sandra N. Freiberger, David Holzmann, Gregoire B. Morand, Martin Huellner, Mitchell P. Levesque, Reinhard Dummer, Viktor H. Koelzer, Niels J. Rupp
Summary: This study investigates novel biomarkers in mucosal melanoma that predict response to combined ipilimumab and nivolumab immunotherapy. The results suggest that the testis antigens CTAG1B (NY-ESO-1), MAGE-A3, and MAGE-A4 are predominantly expressed in responding tumors, and could potentially be used for future routine diagnostics to predict treatment outcomes.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Chemistry, Medicinal
Matthew C. Fleming, Lilly F. Chiou, Percy P. Tumbale, Gaith N. Droby, Jiwoong Lim, Jacqueline L. Norris-Drouin, Jason G. Williams, Kenneth H. Pearce, R. Scott Williams, Cyrus Vaziri, Albert A. Bowers
Summary: MAGE-A4 proteins play a crucial role in promoting aggressive cancers by increasing tolerance to DNA damage and resistance to chemotherapy. This study identifies a series of highly selective inhibitors of the MAGE-A4:RAD18 interaction and provides valuable tools and structural insights for the development of cellular probes targeting MAGE-A4.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Sang T. Kim, Jean Tayar, Siqing Fu, Danxia Ke, Elliot Norry, Amy Sun, Juli Miller, David S. Hong
Summary: Genetically modified cell therapies are effective in various cancers, but can lead to toxicities, including pseudogout arthritis. A patient with fallopian tube cancer developed pseudogout arthritis after receiving T cell therapy, which was successfully treated with tocilizumab. The case highlights the importance for clinicians to be aware of potential complications associated with cell therapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Oncology
Geoffrey Mitchell, Seth M. Pollack, Michael J. Wagner
Summary: Synovial sarcoma is a rare cancer that mainly affects children and young adults, with Cancer testis antigens (CTAs) being expressed at high levels in this type of cancer, making them an ideal therapeutic target for immunotherapies. Targeting CTAs in treatment has the potential to significantly alter the current landscape of synovial sarcoma management and treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Endocrinology & Metabolism
Zhengqing Song, Lisha Cheng, Lili Lu, Weiqi Lu, Yuhong Zhou, Zhiming Wang
Summary: This study aimed to develop and validate practical nomograms for predicting overall survival (OS) and cancer-specific survival (CSS) in synovial sarcoma (SyS) patients. The nomograms demonstrated higher predictive accuracy and clinical value than the AJCC staging system.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Dylan Neel, Clement Ma, Natalie B. Collins, Jason L. Hornick, George D. Demetri, David S. Shulman
Summary: This study used a retrospective cohort design to construct a recursive partitioning model for overall survival of synovial sarcoma patients. The model identified three risk groups with significantly different survival outcomes. This model may have implications for risk stratification in treatment decisions.
Article
Oncology
C. Moreau-Bachelard, L. Campion, M. Toulmonde, A. Le Cesne, M. Brahmi, A. Italiano, O. Mir, S. Piperno-Neumann, V Laurence, N. Firmin, N. Penel, F. Duffaud, C. Chevreau, F. Bertucci, B. Narciso, P. Dubray-Longeras, C. Delcambre, E. Saada-Bouzid, P. Boudou-Rouquette, P. Soulie, C. Perrin, J. Y. Blay, E. Bompas
Summary: This study describes the outcomes, prognostic factors, and treatment of patients with metastatic synovial sarcoma (SS) in a nationwide cohort in France. The results showed that local treatment, management in reference centers, and cytotoxic treatments given in the perioperative and metastatic setting influenced the outcome of patients.
Article
Oncology
Joshua J. J. Thompson, Rachel A. A. Koch, Vicki L. L. Keedy, Deepa R. R. Magge
Summary: Synovial sarcoma is a rare soft tissue sarcoma that often affects the upper or lower extremities. It has a tendency to metastasize to the lungs, but metastatic lesions in other locations are rare. We report a case of a 49-year-old patient who underwent neoadjuvant chemoradiation for an upper extremity synovial sarcoma, and later presented with abdominal pain and hemoperitoneum. It was found that the synovial sarcoma had metastasized to the stomach and surrounding soft tissue. We discuss the multidisciplinary management of this complex case and suggest the importance of expanded surveillance imaging for high-risk tumors.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Cecilia Tetta, Grazia Montrone, Alessandra Longhi, Michele Rocca, Francesco Londero, Gianmarco Parise, Orlando Parise, Jos G. Maessen, Marco Miceli, Sandro Gelsomino
Summary: For patients with HGSS, adjuvant chemotherapy did not show any advantage in terms of freedom from SS-specific mortality, and was associated with a higher risk of SS-specific mortality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Alberto Righi, Marco Gambarotti, Stefania Benini, Dino Gibertoni, Sofia Asioli, Giovanna Magagnoli, Gabriella Gamberi, Marta Sbaraglia, Stefania Cocchi, Eric Staals, Emanuela Palmerini, Angelo Paolo Dei Tos
Summary: This study evaluated the diagnostic accuracy of SSX and SSX::SS18 antibodies in decalcified surgical specimens and the outcome of synovial sarcomas (SS) of bone. The results showed that SS18::SSX fusion-specific and SSX C-terminus antibodies were useful in supporting the diagnosis of SS. The study also found that adjustment chemotherapy was associated with improved prognosis.
Article
Medicine, General & Internal
Kazuhiko Hashimoto, Shunji Nishimura, Yu Shinyashiki, Tomohiko Ito, Ryosuke Kakinoki, Masao Akagi
Summary: This study aimed to determine the involvement of NY-ESO-1 and MAGE-A4 in desmoid tumors (DTs) and found that both might be involved in the DT microenvironment, suggesting that they may serve as diagnostic markers for DTs.
