Review
Medicine, General & Internal
You Zheng, Kaifeng Huang, Xiaojing He, Tianwu Chen, Wei Jiang, Jun Zhou, Yangyang Liu, Dajing Guo
Summary: This meta-analysis demonstrates that MRE has good diagnostic accuracy for detecting GEV in patients with CLD.
Article
Acoustics
Renata Fofiu, Felix Bende, Alina Popescu, Roxana Sirli, Raluca Lupusoru, Ana-Maria Ghiuchici, Ioan Sporea
Summary: This study evaluated the utility of spleen and liver stiffness associated with spleen size as non-invasive markers for predicting high-risk varices in patients with compensated liver cirrhosis. The study found that the combination of factors performed better than each independent factor in predicting high-risk varices.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Tom Meyer, Heiko Tzschaetzsch, Brunhilde Wellge, Ingolf Sack, Thomas Kroencke, Alma Martl
Summary: This study investigated the effect of a standardized Valsalva maneuver on liver and spleen stiffness using time-harmonic elastography. The results showed that the Valsalva maneuver decreased the stiffness of both the liver and the spleen, and the decrease was more significant when the baseline stiffness was higher.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zih-En Jhang, Kuan-Lin Wu, Chia-Bang Chen, Yao-Li Chen, Ping-Yi Lin, Chen-Te Chou
Summary: Spleen stiffness (SS) via magnetic resonance elastography (MRE) demonstrates better diagnostic performance in predicting esophageal varices in cirrhotic patients compared to liver stiffness (LS), with a higher sensitivity and specificity.
ABDOMINAL RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Youwen Hu, Zhili Wen
Summary: Several non-invasive tests based on liver stiffness measurement have been developed to rule out varices needing treatment, and the VariScreen algorithm performed the best in patients with compensated advanced chronic liver disease.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Carolina Munoz-Codoceo, Maria Amo, Ana Martin, Cristina Martin-Arriscado Arroba, Lidia Cuevas del Campo, Maria Luisa Manzano, Raquel Munoz, Gregorio Castellano, Inmaculada Fernandez
Summary: The study aimed to investigate the accuracy of liver and spleen stiffness measurement for predicting gastroesophageal varices in cirrhotic patients with HCV treated with direct-acting antiviral agents. Results showed suboptimal diagnostic accuracy, with different non-invasive parameters not significantly improving the overall performance, suggesting that non-invasive methods cannot replace standard procedures for predicting gastroesophageal varices in this population.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2021)
Article
Gastroenterology & Hepatology
Maciej K. Janik, Beata Kruk, Benedykt Szczepankiewicz, Konrad Kostrzewa, Joanna Raszeja-Wyszomirska, Barbara Gornicka, Frank Lammert, Piotr Milkiewicz, Marcin Krawczyk
Summary: The study demonstrates that liver and spleen 2D-SWE are reliable complementary methods for diagnosing advanced fibrosis in patients with autoimmune hepatitis (AIH). Spleen 2D-SWE appears to be less influenced by inflammation and could aid in fibrosis assessment in therapy-naive patients or those with active hepatitis.
LIVER INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Long-Bao Yang, Xin Gao, Hong Li, Xin-Xing Tantai, Fen-Rong Chen, Lei Dong, Xu-Sheng Dang, Zhong-Cao Wei, Chen-Yu Liu, Yan Wang
Summary: A non-invasive prediction model for high bleeding risk esophageal varices (EVs) was developed based on spleen stiffness measurement (SSM) and liver stiffness measurement (LSM). The model was shown to be reliable in predicting EVs and can be used as an alternative to routine upper gastrointestinal endoscopy screening, assisting in clinical decision-making.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu Shi, Ya-fei Qi, Gong-yu Lan, Qijun Wu, Bing Ma, Xian-yi Zhang, Ruo-yun Ji, Yu-jia Ma, Yang Hong
Summary: The study evaluated the value of multiparametric three-dimensional MR elastography in chronic hepatitis B and C, showing its potential in detecting early necroinflammation, distinguishing necroinflammation from liver fibrosis, and correlating with hepatic venous pressure gradient.
Article
Gastroenterology & Hepatology
Elton Dajti, Federico Ravaioli, Giovanni Marasco, Luigina Vanessa Alemanni, Luigi Colecchia, Alberto Ferrarese, Caterina Cusumano, Stefano Gemini, Amanda Vestito, Matteo Renzulli, Rita Golfieri, Davide Festi, Antonio Colecchia
Summary: The addition of spleen stiffness measurement (SSM) improves the diagnostic algorithm for clinically significant portal hypertension (CSPH) in patients with compensated advanced chronic liver disease.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Joel Ferreira-Silva, Rui Gaspar, Rodrigo Liberal, Helder Cardoso, Guilherme Macedo
Summary: In patients with NCPH, TSE is useful in predicting high-risk varices, while TLE, spleen size, and platelet count are not related to high-risk varices.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Renata Fofiu, Felix Bende, Raluca Lupusoru, Roxana Sirli, Alina Popescu, Ioan Sporea
Summary: The study found that using two elastography techniques to measure spleen stiffness values can serve as reliable markers for predicting varices needing treatment, with no significant difference in performance between the two techniques.
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Sona Frankova, Mariia Lunova, Halima Gottfriedova, Renata Senkerikova, Magdalena Neroldova, Jozef Kovac, Eva Kieslichova, Vera Lanska, Petr Urbanek, Julius Spicak, Milan Jirsa, Jan Sperl
Summary: Liver stiffness is a reliable predictor of HVPG above 10 mm Hg, especially effective when HVPG is below 30 mm Hg. However, it is not accurate in predicting higher HVPG thresholds. In liver transplant candidates, liver stiffness performs better than blood biomarkers in predicting HVPG, but a superior composite predictor could not be established.
Article
Gastroenterology & Hepatology
Monica Pons, Salvador Augustin, Bernhard Scheiner, Maeva Guillaume, Matteo Rosselli, Susana G. Rodrigues, Horia Stefanescu, Mang M. Ma, Mattias Mandorfer, Mayka Mergeay-Fabre, Bogdan Procopet, Philipp Schwabl, Arnulf Ferlitsch, Georg Semmler, Annalisa Berzigotti, Emmanuel Tsochatzis, Christophe Bureau, Thomas Reiberger, Jaime Bosch, Juan G. Abraldes, Joan Genesca
Summary: This study aimed to explore the prevalence of portal hypertension in different etiologies of patients with cACLD and develop classification rules based on LSM. The prevalence of portal hypertension was high in most etiologies except for NASH patients, especially obese ones. LSM >= 25 kPa was sufficient to diagnose CSPH in most etiologies, except for obese NASH patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Xing Hu, Xiaojie Huang, Jianhua Hou, Lei Ding, Chunling Su, Fankun Meng
Summary: Based on a meta-analysis of 32 studies, spleen stiffness measurement shows high sensitivity and specificity in diagnosing portal hypertension and esophageal varices in patients with chronic liver diseases, making it a useful tool for ruling out high-risk esophageal varices.
EUROPEAN RADIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Giacomo Zaccherini, Maurizio Baldassarre, Manuel Tufoni, Silvia Nardelli, Salvatore Piano, Carlo Alessandria, Sergio Neri, Francesco Giuseppe Foschi, Fabio Levantesi, Giorgio Bedogni, Marco Domenicali, Mauro Bernardi, Paolo Caraceni
Summary: This study assessed the impact of long-term albumin administration on hyponatremic patients with ascites enrolled in the ANSWER trial. The normalization rate of baseline hyponatremia and the 18-month incidence rate of at least moderate hyponatremia were evaluated. The results showed that albumin treatment had a higher hyponatremia normalization rate compared to standard medical treatment (45% vs 28%, P = 0.042 at 1 month). Long-term albumin administration ensured a lower incidence of at least moderate hyponatremia than standard medical treatment (incidence rate ratio: 0.245 [CI 0.167-0.359], P < 0.001).
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Francesco Palmese, Maria Elena Bonavita, Enrico Pompili, Maria Teresa Migliano, Nicola Reggidori, Cecilia Di Stefano, Marta Grieco, Stefano Colazzo, Manuel Tufoni, Maurizio Baldassarre, Paolo Caraceni, Francesco Giuseppe Foschi, Fabrizio Giostra, Gabriele Farina, Rossella Del Toro, Giorgio Bedogni, Marco Domenicali
Summary: This study assessed long-term mortality and its association with chronic alcohol-related diseases in patients with acute alcoholic intoxication. The results showed that patients with alcohol use disorder, substance use disorder, and liver cirrhosis had higher death rates compared to the general population, indicating a clear excess of mortality.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Allergy
Rita Nocerino, Serena Coppola, Laura Carucci, Anna Fiorenza de Giovanni di Santa Severina, Franca Oglio, Roberta de Michele, Ilaria di Sessa, Antonio Masino, Giorgio Bedogni, Roberto Berni Canani
Summary: This study investigated the tolerability and immune tolerance acquisition rate in infants with cow's milk allergy (CMA) who were treated with amino acid-based formula (AAF) and then switched to EHCF + LGG, a formula containing the probiotic Lacticaseibacillus rhamnosus GG. The results showed that after 12 months of treatment, the immune tolerance acquisition rate to cow milk proteins was higher in the EHCF + LGG group compared to the AAF group.
Review
Biochemistry & Molecular Biology
Giorgio Bedogni, Francesco Palmese, Francesco Giuseppe Foschi
Summary: The article discusses two controversial issues in fatty liver research: the proposal to replace nonalcoholic fatty liver disease (NAFLD) with metabolically associated fatty liver disease (MAFLD), and the suggestion to extend noninvasive testing for liver fibrosis from secondary care to primary care.
CURRENT OPINION IN LIPIDOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mauro Giuffre, Rita Moretti, Claudio Tiribelli
Summary: The human gut microbiome is important for human health and is the subject of increasing research. Omics-based methods, such as metagenomics and metabolomics, are commonly used for studying the gut microbiome due to their ability to provide high-throughput and high-resolution data. However, there are challenges in using machine learning-based approaches to analyze the relationship between microbiota and disease, such as small sample sizes and inconsistent experimental protocols. Efforts are being made to address these challenges, including the construction of data repositories and improved data transparency guidelines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Nutrition & Dietetics
Alessandro Leone, Simona Bertoli, Giorgio Bedogni, Laila Vignati, Marta Pellizzari, Alberto Battezzati
Article
Medicine, General & Internal
Rossella Del Toro, Francesco Palmese, Francesco Feletti, Gianluca Zani, Maria Teresa Minguzzi, Ernesto Maddaloni, Nicola Napoli, Giorgio Bedogni, Marco Domenicali
Summary: Little is known about the changes in organs and tissues that may make elder patients more vulnerable to acute stressors such as SARS-CoV-2 infection. In this study of elderly patients with SARS-CoV-2 infection, the association between vascular calcifications, bone density, muscle density, and the odds of dying was evaluated. Age was found to be the strongest predictor of body composition and death, overshadowing the relationships between these factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Andrea Foppiani, Fabiana Ciciriello, Arianna Bisogno, Silvia Bricchi, Carla Colombo, Federico Alghisi, Vincenzina Lucidi, Maria Ausilia Catena, Mariacristina Lucanto, Andrea Mari, Giorgio Bedogni, Alberto Battezzati
Summary: This study aimed to describe the distribution and provide reference quartiles of OGTT-related variables in the Italian cystic fibrosis population. The results showed the deterioration of glucose tolerance and insulin secretion with age according to sex and pancreatic insufficiency, highlighting a deviation from linearity for patients 35 years of age.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biology
John Paul Llido, Emanuela Fioriti, Devis Pascut, Mauro Giuffre, Cristina Bottin, Fabrizio Zanconati, Claudio Tiribelli, Silvia Gazzin
Summary: Severe neonatal hyperbilirubinemia can lead to brain damage and cause motor, cognitive, and auditory abnormalities. Bilirubin has been found to control the genetic development of the cerebellum, which is susceptible to bilirubin-induced damage. This study expands the research on the impact of bilirubin on postnatal brain development in regions that correlate with human symptoms. The findings show temporary alterations in gene expression in areas related to memory, learning, cognition, and auditory functions, but permanent changes in areas controlling movements, which coincide with clinical descriptions of bilirubin-induced neurotoxicity.
Article
Gastroenterology & Hepatology
Enrico Pompili, Maurizio Baldassarre, Giacomo Zaccherini, Manuel Tufoni, Giulia Iannone, Dario Pratelli, Francesco Palmese, Luca Vizioli, Chiara Faggiano, Giorgio Bedogni, Marco Domenicali, Paolo Caraceni
Summary: This study aimed to characterize unscheduled readmissions and identify predictors of 30-day readmission in patients with decompensated cirrhosis. The results showed that early liver-related readmission was associated with higher 1-year mortality, and the model for end-stage liver disease-sodium score and low hemoglobin level at discharge were identified as independent risk factors for early readmissions.
Editorial Material
Biochemistry & Molecular Biology
Mauro Giuffre, Rita Moretti
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Fabrizia Carli, Silvia Sabatini, Melania Gaggini, Anna Maria Sironi, Giorgio Bedogni, Amalia Gastaldelli
Summary: This study found that a fatty liver index (FLI) greater than 60 is associated with a high risk of metabolic dysfunction-associated steatotic liver disease (MASLD), diabetes, and cardiovascular disease. FLI was also positively associated with cardiac fat, visceral fat, and components of metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Enrico Pompili, Maurizio Baldassarre, Giorgio Bedogni, Giacomo Zaccherini, Giulia Iannone, Clara De Venuto, Dario Pratelli, Francesco Palmese, Marco Domenicali, Paolo Caraceni
Summary: The PREDICT study found that acutely decompensated patients with cirrhosis can have three different clinical trajectories: pre-ACLF, unstable decompensated cirrhosis (UDC), and stable decompensated cirrhosis (SDC). This study aimed to validate these trajectories and identify predictors for each trajectory.
LIVER INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Francesco Palmese, Maria Elena Bonavita, Enrico Pompili, Nicola Reggidori, Maria Teresa Migliano, Cecilia Di Stefano, Marta Grieco, Stefano Colazzo, Maurizio Baldassarre, Paolo Caraceni, Francesco Giuseppe Foschi, Fabrizio Giostra, Gabriele Farina, Rossella Del Toro, Giorgio Bedogni, Marco Domenicali
Summary: A logistic regression model was developed and internally validated to predict the probability of 1-year readmission to the emergency department in patients with acute alcohol intoxication. The simplified model based on sex, age, previous admissions for trauma or mental/behavioral disease, and homelessness performed as well as the benchmark model. Further external validation is needed to assess the clinical utility of this model.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Mauro Giuffre, Alessia Visintin, Cristiana Abazia, Flora Masutti, Saveria Lory Croce
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Fakhar Ali Qazi Arisar, Rhea Varghese, Shiyi Chen, Wei Xu, Markus Selzner, Ian Mcgilvray, Blayne Sayed, Trevor Reichman, Chaya Shwaartz, Mark Cattral, Anand Ghanekar, Gonzalo Sapisochin, Elmar Jaeckel, Cynthia Tsien, Nazia Selzner, Leslie Lilly, Mamatha Bhat
Summary: Recurrent cirrhosis complicates a significant percentage of liver transplants and may require re-transplantation. This study examined the trajectories of relisted versus primary listed patients on the waitlist and assessed their overall survival and cumulative incidence of transplant.
ANNALS OF HEPATOLOGY
(2024)
Article
Gastroenterology & Hepatology
Helena Hernandez-Evole, Natalia Jimenez-Esquivel, Elisa Pose, Ram on Bataller
Summary: Alcohol is the leading cause of preventable morbidity and mortality worldwide, and the most frequent cause of liver disease. Alcohol-associated liver disease has a complex pathogenesis, with unknown precise mechanisms. Currently, there are no targeted therapies to interfere with the disease's progression, making alcohol abstinence the most effective measure to improve prognosis in patients with this disease.
ANNALS OF HEPATOLOGY
(2024)
Letter
Gastroenterology & Hepatology
Alexander M. Sy
ANNALS OF HEPATOLOGY
(2024)
Letter
Gastroenterology & Hepatology
Eric David Ornos, Janus P. Ong
ANNALS OF HEPATOLOGY
(2024)
Review
Gastroenterology & Hepatology
Lauren Loeb, Jason Lewis, Zhongwei Peng, Michael G. Heckman, Raouf Nakhleh, Andrew P. Keaveny
Summary: Congenital hepatic fibrosis (CHF) is a rare condition characterized by biliary tract changes and liver fibrosis. This study reviewed the medical records of 24 adult patients with CHF and found that renal cysts, splenomegaly, and a cirrhotic-appearing liver were the most common imaging findings. The most common liver-related complications were cholangitis, varices, and hepatic encephalopathy. Liver transplantation may be required for patients with decompensated disease.
ANNALS OF HEPATOLOGY
(2024)