Journal
BIOCONJUGATE CHEMISTRY
Volume 28, Issue 2, Pages 362-370Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.6b00522
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Funding
- POCTEP (Operational Program for Cross-border Cooperation Spain-Portugal) through InveNNta project
- ERDF (European Regional Development Fund)
- P.O Norte CCDR-N/ON.2 program
- Instituto de Salud Carlos III [PI13/00292, PI14/01879]
- Spanish Research Network on Cerebrovascular Diseases RETICS-INVICTUS [RD12/0014]
- Xunta de Galicia (Conselleria Educacion) [GRC2014/027]
- European Union program ERDF
- Promoting Active Ageing: Functional Nanostructures For Alzheimer's Disease At Ultra-Early Stages within the EU Horizon 2020 Program [PANA_686009]
- Marie Curie COFUND Program (NanoTRAINfor-Growth)
- Miguel Servet Program of Instituto de Salud Carlos III [CP12/03121, CP14/00154]
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Superparamagnetic iron oxide nanoparticles (SPIO-PAA), ultrasmall iron oxide nanoparticles (USPIO-PAA), and glucosamine-modified iron oxide nanoparticles (USPIO-PAA-GIcN) were studied as mesenchymal stem cell (MSCs) labels for cell tracking applications by magnetic resonance imaging (MRI). Pronounced differences were found in the labeling performance of the three samples in terms of cellular dose and labeling efficiency. In combination with polylysine, SPIO-PAA showed nonhomogeneous cell internalization, while for USPIO-PAA no uptake was found. On the contrary, USPIO-PAA-GIcN featured high cellular uptake and biocompatibility, and sensitive detection in both in vitro and in vivo experiments was found by MRI, showing that glucosamine functionalization can be an efficient strategy to increase cell uptake of ultrasmall iron oxide nanoparticles by MSCs.
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