Review
Chemistry, Multidisciplinary
Pingping Liang, Byron Ballou, Xinyi Lv, Weili Si, Marcel P. Bruchez, Wei Huang, Xiaochen Dong
Summary: Anti-angiogenic therapy targeting vascular endothelial cells to prevent tumor growth has shown modest clinical efficiency in solid tumors. Combining advanced drug delivery techniques or other therapeutic strategies with anti-angiogenic therapy can result in significantly synergistic effects in fighting cancer. Clinical difficulties of traditional anti-angiogenic therapy are discussed, while promising applications of anti-angiogenic nanoagents in monotherapies and combination therapies are highlighted.
ADVANCED MATERIALS
(2021)
Review
Nanoscience & Nanotechnology
Yingli Wu, Yu Yang, Xiaolin Lv, Menghan Gao, Xujin Gong, Qingqiang Yao, Yanna Liu
Summary: Ovarian cancer is commonly treated with combination therapy, such as paclitaxel and platinum anticancer drug. Nanoparticles provide opportunities to overcome the limitations of combination therapy by improving drug properties and increasing drug accumulation in targeted tissues. This review summarizes nanoparticle-based combination therapies for ovarian cancer, highlighting the advantages of nanocarriers in combination treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Engineering, Biomedical
Linzhuo Huang, Rui Xu, Weirong Li, Li Lv, Chunhao Lin, Xianzhu Yang, Yandan Yao, Phei Er Saw, Xiaoding Xu
Summary: Sorafenib is the first line drug for hepatocellular carcinoma therapy, but patients often develop resistance within 6 months. Anticancer drugs with antiangiogenesis effect like sorafenib can worsen hypoxia and promote infiltration of tumor-associated macrophages (TAMs). This study developed a pH-responsive nanoplatform for co-delivery of sorafenib and modified resiquimod (R848), which could inhibit tumor growth by simultaneously targeting HCC cells and repolarizing TAMs.
ACTA BIOMATERIALIA
(2023)
Review
Nanoscience & Nanotechnology
Zhenni Lu, Dongya Liu, Peng Wei, Tao Yi
Summary: The development of novel therapeutic strategies and modalities for tumors is still an important area of research. Low permeability and short residence time of drugs in solid tumor areas hinder the effectiveness of current therapeutic strategies. This review focuses on activatable aggregation systems that can be activated by cancer-related substances for cancer therapy. By summarizing and classifying these systems, potential challenges are also identified. A potential solution to enhance drug delivery to solid tumors is the use of larger nanoparticles or increasing the size of small nanoparticles in tumor areas.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yanxin Xiang, Huanv Mao, Si-cheng Tong, Can Liu, Rui Yan, Li Zhao, Linyong Zhu, Chunyan Bao
Summary: Short peptides that respond to external stimuli have been utilized to construct hydrogels for biomedical applications. In this study, a photoactivated peptide hydrogel was developed using a photo-chemical reaction and a positively charged dipeptide. Light irradiation triggered the self-assembly of peptides and the formation of hydrogel, allowing precise control over its structure and mechanical properties. The optimized photoactivated hydrogel was suitable for cell culture and showed photocontrollable mechanical strength that regulated stem cell spreading. This strategy provides an alternative method for constructing photoactivated peptide hydrogels with broad applications in biomedicine.
Article
Chemistry, Multidisciplinary
Mengke Xu, Jie Yu, Chi Zhang, Cheng Xu, Xin Wei, Kanyi Pu
Summary: Cytokine therapy is a promising approach in cancer therapy, but it has limitations due to dose-dependent adverse effects and non-selective stimulation. In this study, a sonodynamic cytokine nano-immunocomplex (SPNAI) was developed to specifically activate Teffs for antitumor immunotherapy. SPNAI not only blocks the interaction between IL-2 and Tregs, but also triggers immunogenic cell death of cancer cells, leading to inhibition of tumor growth and prevention of relapse.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Mengke Xu, Jie Yu, Chi Zhang, Cheng Xu, Xin Wei, Kanyi Pu
Summary: In this study, a sonodynamic cytokine nano-immunocomplex (SPNAI) was developed, which specifically activates T cells for antitumor immunotherapy. By blocking the interaction between regulatory T cells and cytokines, the SPNAI selectively activates effector T cells in the tumor microenvironment. Additionally, the SPNAI induces immunogenic cell death of cancer cells and promotes the maturation and proliferation of immune cells. This immunotherapy approach inhibits tumor growth, suppresses lung metastasis and prevents tumor relapse.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yin Zhao, Bo Yuan, Lang Yan, Zhiwei Wang, Zheng Xu, Bijiang Geng, Xiang Guo, Xiongsheng Chen
Summary: In this study, a one-step in situ synthesis strategy was reported to construct Ru/TiO2-x@TiCN heterojunctions, which improved the catalytic activity of nanozymes and ultrasound-activated ROS generation. The enhanced ROS production was achieved through triple enzyme-like activities, and the complete elimination of tumors was achieved through synergetic sonodynamic therapy and NCT.
Article
Chemistry, Multidisciplinary
Xuan He, Fangman Chen, Zhimin Chang, Kasim Waqar, Hanze Hu, Xiao Zheng, Yingshuai Wang, Wen-fei Dong, Chao Yang
Summary: This review comprehensively discusses the recent progress in the fabrication and application of silver mesoporous silica nanoparticles (Ag-MSNs) for combination therapies for cancer and infection. Different structures of Ag-MSNs are elaborated, and their applications in imaging, therapy, and antibacterial treatment are highlighted. The challenges and future directions are also summarized.
Article
Chemistry, Multidisciplinary
Lei Zhou, Chang Du, Rong Zhang, Changming Dong
Summary: The study developed a novel multifunctional nanocarrier PDOXCBs for combined photothermal-chemotherapy treatment, demonstrating a significant synergistic effect in vitro.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Tong Yu, Chenpu Wu, Zhongyan Chen, Mingen Zhang, Zhuan Hong, Honghui Guo, Wenyao Shao, Quanling Xie
Summary: In this study, a novel self-cleaning nanofiltration (NF) membrane was fabricated by introducing AGQDs into the PDA/PEI selective layer, and its structure and separation performance were investigated. The results showed that the incorporation of AGQDs improved the membrane flux and rejection, and exhibited better photocatalytic self-cleaning performance.
Review
Pharmacology & Pharmacy
Mengru Yang, Ying Zhang, Zheming Hu, Haonan Xie, Wenli Tian, Zhidong Liu
Summary: This article summarizes the application of hyaluronic acid-based nanoparticles in combination therapy for cancer treatment. These nanoparticles have exceptional biocompatibility and targeting capabilities, offering a new approach for precise drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Qifang Chen, Xianbin Ma, Li Xie, Wenjie Chen, Zhigang Xu, Erqun Song, Xiaokang Zhu, Yang Song
Summary: The nanosystem designed in this study, coated with FDA approved PLGA, Fe3O4, and Ce6, is capable of synergistic ferroptosis-photodynamic anticancer therapy by releasing ferrous/ferric ions and Ce6 in the acidic TME for Fenton reaction and ROS generation under laser irradiation. The nanosystem also possesses excellent MRI properties and highly efficient tumor suppression in vivo due to the synergism of photodynamic and ferroptosis antitumor therapies.
Article
Engineering, Biomedical
Zachary R. Stephen, Miqin Zhang
Summary: Immunotherapy has shown success in certain cancers, and combinational approaches with hyperthermia therapy are being explored to enhance its effectiveness. Nanoparticle-based hyperthermia increases tumor immunogenicity and permeability, particularly effective in solid tumors.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Irum Shaheen, Khuram Shahzad Ahmad, Camila Zequine, Ram K. Gupta, Andrew G. Thomas, Anjum Qureshi, Mohammad Azad Malik, Javed H. Niazi
Summary: A facile nanocomposite of Pd/NiOPdO was synthesized using foliar phyto eco-friendly agents and showed enhanced electrochemical properties for supercapacitor application, with a specific capacitance of 88 F g(-1) and low internal resistance of 0.8 omega. The nanocomposite exhibited a mixed phase of rhombohedral NiO and tetragonal PdO.
