Article
Biochemistry & Molecular Biology
Xiao Lu, Alice Prodger, Jingwei Sim, Colin E. Evans
Summary: Cancer patients have a higher risk of thrombosis compared to individuals without cancer. Thrombosis can also be a diagnostic predictor of cancer, but the mechanisms by which thrombosis promotes tumor propagation are not fully understood. This study investigates the role of hypoxia-inducible factors (HIF) in myeloid cells in thrombosis-induced tumorigenesis. The results show that HIF1-alpha and HIF2-alpha levels are increased in myeloid cells of murine thrombi. Additionally, thrombosis increases HIF1-alpha and HIF2-alpha levels in murine lungs, promoting tumor development. In vitro studies also demonstrate that hypoxia upregulates tumorigenic factors in the secretome of neutrophils and macrophages, leading to lung cancer cell proliferation and migration in a myeloid-HIF-dependent manner. These findings highlight the importance of thrombotic insult and myeloid HIFs in mediating tumorigenic success.
Article
Multidisciplinary Sciences
Liuhua Zhou, Tianli Yang, Feng Zhao, Kaiwei Song, Luwei Xu, Zhongle Xu, Changcheng Zhou, Zhiqiang Qin, Zheng Xu, Ran Wu, Hua Xu, Ruipeng Jia
Summary: This study evaluated the preventive effect of uncultured adipose derived stromal vascular fraction (SVF) on urethral fibrosis in a rat model of urethral stricture (US). The results demonstrated that SVF administration reduced the extent of urethral changes and fibrosis, as well as decreased the expression of collagen and TGF beta 1R, while increasing vascularization and the expression of VEGF and bFGF. Additionally, SVF exerted anti-inflammatory effects and modulated macrophage phenotype. These findings suggest that uncultured SVF has an inhibitory effect on stricture formation in the early stage of urethral fibrosis.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Ana Karen Torres-Soria, Yair Romero, Yalbi Balderas-Martinez, Rafael Velazquez-Cruz, Luz Maria Torres-Espindola, Angel Camarena, Edgar Flores-Soto, Hector Solis-Chagoyan, Victor Ruiz, Angeles Carlos-Reyes, Citlaltepetl Salinas-Lara, Erika Rubi Luis-Garcia, Jaime Chavez, Manuel Castillejos-Lopez, Arnoldo Aquino-Galvez
Summary: This review focuses on the impact of hypoxia on the pathophysiology of idiopathic pulmonary fibrosis (IPF), particularly in lung development, regeneration, and repair. The study finds that HIF-1α and HIF-2α have different roles in the acute and chronic phases of hypoxia response, with HIF-2α being involved in persistent aberrant regeneration associated with IPF development.
Article
Pharmacology & Pharmacy
Lina Wang, Xiaoyu Zhang, Yapeng Cao, Qian Ma, Xiaoxiao Mao, Jiean Xu, Qiuhua Yang, Yaqi Zhou, Rudolf Lucas, David J. Fulton, Yunchao Su, Scott A. Barman, Mei Hong, Zhiping Liu, Yuqing Huo
Summary: The study demonstrates that the reduced expression of glycolytic molecules in lung macrophages due to Pfkfb3 deficiency or inhibition can effectively alleviate the development of pulmonary hypertension, with lower levels of growth factors and pro-inflammatory cytokines produced by alveolar macrophages.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Urology & Nephrology
Anne M. Huesing, Vera C. Wulfmeyer, Svenja Gaedcke, Susanne V. Fleig, Song Rong, David DeLuca, Hermann Haller, Roland Schmitt, Sibylle von Vietinghoff
Summary: The risk of cardiovascular events increases after renal ischemia-reperfusion (IR) injury. Leukocytes play a crucial role in the growth and instability of atherosclerotic plaques. This study established a model of enhanced remote atherosclerosis after renal IR injury and investigated the underlying inflammatory mechanisms.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Hematology
Kathryn N. Phoenix, Zhichao Yue, Lixia Yue, Chunxia G. Cronin, Bruce T. Liang, Luke H. Hoeppner, Kevin P. Claffey
Summary: This study identifies PLC beta 2 as a key regulator of vascular permeability induced by VEGF, functioning through regulation of calcium flux and phosphatidylinositol 4,5-bisphosphate levels. Targeting PLC beta 2 could provide a novel approach to regulate vascular permeability in patients.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dongjoon Kim, Marcela Votruba, Sayon Roy
Summary: Reduced level of Opa1 promotes apoptosis and retinal vascular lesions associated with diabetic retinopathy. Downregulation of Opa1 expression contributes to the development of retinal cell death and capillary damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Biomaterials
Tao Yang, Guangxu Li, Xifeng Li, Boyang Wei, Hengxian Su, Wenchao Liu, Shenquan Guo, Nan Yang, Tao Xu, Chuanzhi Duan
Summary: Previous research on tissue-engineered blood vessels mainly focused on one layer, neglecting the equal importance of both the intima and adventitia. This study developed a small-diameter graft that can gradually release growth factors and inhibitors to enhance tissue regeneration and remodeling in both layers.
REGENERATIVE BIOMATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Panagiotis Chronopoulos, Caroline Manicam, Jenia Kouchek Zadeh, Panagiotis Laspas, Johanna Charlotte Unkrig, Marie Luise Goebel, Aytan Musayeva, Norbert Pfeiffer, Matthias Oelze, Andreas Daiber, Huige Li, Ning Xia, Adrian Gericke
Summary: This study demonstrates that resveratrol has a protective effect against ischemia-reperfusion injury in the murine retina, reducing the loss of retinal ganglion cells and endothelial dysfunction of retinal blood vessels. This protective effect may be achieved by suppressing upregulation of nitric oxide synthase 2 and alleviating nitro-oxidative stress.
Article
Cell Biology
Jinghui Lei, Xiaoyu Jiang, Daoyuan Huang, Ying Jing, Shanshan Yang, Lingling Geng, Yupeng Yan, Fangshuo Zheng, Fang Cheng, Weiqi Zhang, Juan Carlos Izpisua Belmonte, Guang-Hui Liu, Si Wang, Jing Qu
Summary: Using CRISPR/Cas9 gene editing, researchers investigated the response mechanism of human vascular cells to HIF-1α under hypoxic conditions. They found that HIF-1α plays an important role in promoting ischemic vascular regeneration and that MSCs are particularly susceptible to HIF-1α deficiency. Transcriptional inactivation of ANKZF1, an effector of HIF-1α, was found to impair pro-angiogenic processes.
Review
Cell Biology
Lay Khoon Too, Matthew P. Simunovic
Summary: Over the past two decades, significant progress has been made in understanding the functions of glial cells, particularly Muller glia (MG), in retinal homeostasis and regeneration. While MG show regenerative capacity varying across species, their in vivo regenerative potential in mammals, including humans, is limited. Advances in stem cell therapy have shed light on critical mechanisms underlying MG reprogramming in fish, showing promising results when applied to rodents.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Xiaomei Zhang, Lijia Hou, Fengjie Li, Weiwei Zhang, Chun Wu, Lixin Xiang, Jiuxuan Li, Luping Zhou, Xiaojie Wang, Yang Xiang, Yanni Xiao, Shengwen Calvin Li, Li Chen, Qian Ran, Zhongjun Li
Summary: This study reveals the critical role of BM-Mfs in sensing and responding to structural changes after irradiation injury, promoting vascular niche regeneration and enhancing hematopoietic reconstruction.
Article
Pharmacology & Pharmacy
Mingjin Wang, Weida Wang, Shen You, Zhenyan Hou, Ming Ji, Nina Xue, Tingting Du, Xiaoguang Chen, Jing Jin
Summary: Glioblastoma (GBM) is a highly aggressive and lethal brain tumor with an immunosuppressive tumor microenvironment (TME). Myeloid-derived suppressor cells (MDSCs) play a crucial role in suppressing antitumor immunity in this environment. Lipometabolism is closely related to the function of myeloid cells. The study shows that acetyl-CoA acetyltransferase 1 (ACAT1), a key enzyme of fatty acid oxidation (FAO) and ketogenesis, is significantly downregulated in the infiltrated MDSCs in GBM patients. Depletion of ACAT1 in mice resulted in the accumulation of MDSCs and increased tumor progression, likely due to elevated secretion of C-X-C motif ligand 1 (CXCL1) by macrophages (M4). These findings suggest that ACAT1 could be a promising drug target for GBM by regulating the function of MDSCs in the TME.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Hematology
Yung-Chun Wang, Dunpeng Cai, Xiao-Bing Cui, Ya-Hui Chuang, William P. Fay, Shi-You Chen
Summary: JAK3 plays a crucial role in reendothelialization after vascular injury, with JAK3 deficiency attenuating intimal hyperplasia and enhancing the rate of reendothelialization. Knockdown of JAK3 restores smooth muscle cell expression and promotes endothelial cell proliferation in the injured area.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
C. Park, M. Song, S. Y. Kim, B. M. Min
Summary: This study demonstrates that VnP-16 promotes odontoblast differentiation, mineralization, and reparative dentin formation in a pulp exposure model. VnP-16 showed comparable effects to vitronectin in promoting cellular behavior in human dental pulp cells. It also induced reparative dentin formation similar to MTA and rhBMP-2 without causing inflammation.
JOURNAL OF DENTAL RESEARCH
(2022)
