Article
Otorhinolaryngology
Anna Oleszkiewicz, Laura Bottesi, Michal Pieniak, Shuji Fujita, Nadejda Krasteva, Gabriele Nelles, Thomas Hummel
Summary: This study found that performing OT twice a day was more effective in supporting olfactory rehabilitation and interventions targeted to verbal semantic fluency, especially in subjects with lower baseline scores.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Review
Behavioral Sciences
Michal Pieniak, Anna Oleszkiewicz, Vittoria Avaro, Federico Calegari, Thomas Hummel
Summary: Olfactory training (OT) has been shown to benefit olfactory recovery and is debated for its potential to improve psychological functioning. Research focuses on its utility in clinical practice and the accompanying changes in olfactory loss patients and animal models. Challenges lie in methodological issues in OT research and areas requiring further scientific attention.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Biology
Maria A. Callejon-Leblic, Daniel Martin-Jimenez, Ramon Moreno-Luna, Jose M. Palacios-Garcia, Marta Alvarez-Cendrero, Julissa A. Vizcarra-Melgar, Carlos Fernandez-Velez, Isabel M. Reyes-Tejero, Juan Maza-Solano, Jaime Gonzalez-Garcia, Beatriz Tena-Garcia, Maria E. Acosta-Mosquera, Alfonso Del Cuvillo, Serafin Sanchez-Gomez
Summary: Persistent chemosensory dysfunction and parosmia can occur one year after COVID-19 infection, with age and duration of loss of smell as predictive factors. Olfactory dysfunction is moderately correlated with self-reported symptoms.
Article
Medicine, Research & Experimental
Ayaho Yoshino, Goekhan Goektas, Mehmet K. Mahmut, Yunmeng Zhu, Oender Goektas, Taro Komachi, Kimihiro Okubo, Thomas Hummel
Summary: The study developed a test for assessing retronasal olfaction in healthy individuals and patients with olfactory disorders using tasteless powders. Results showed high correlation between retronasal and orthonasal olfaction, with 16 stimuli effectively differentiating patients from controls.
Article
Medicine, Research & Experimental
David T. Liu, Maha Sabha, Michael Damm, Carl Philpott, Anna Oleszkiewicz, Antje Haehner, Thomas Hummel
Summary: The study found that the presence of parosmia is associated with clinically relevant recovery in olfactory discrimination and identification function in patients with PIOD receiving olfactory training, with patients who have lower baseline olfactory function being more likely to show significant improvements.
Article
Otorhinolaryngology
Marcello Bailarini Aniteli, Fernando Augusto Lima Marson, Fernanda Rodrigues Cunha, Eulalia Sakano
Summary: This study evaluated the correlation and agreement between the Chemosensory Clinical Research Center olfactory test and the Brief-Smell Identification Test - University of Pennsylvania Smell Identification Test in both healthy participants and participants with olfactory disorders. The results showed that both tests were effective in distinguishing groups, and there was a strong correlation and agreement between the tests.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)
Article
Medicine, General & Internal
Alna Carolina Mendes Paranhos, Apio Ricardo Nazareth Dias, Livia Caroline Machado da Silva, Gisele Vieira Hennemann Koury, Emanuel de Jesus Sousa, Antonio Jose Cerasi Jr, Givago Silva Souza, Juarez Antonio Simoes Quaresma, Luiz Fabio Magno Falcao
Summary: Determining the characteristics, type, and severity of olfactory dysfunction in patients with long COVID is crucial. This study aimed to describe the socio-demographic and clinical features of patients with persistent olfactory dysfunction. The results showed that olfactory dysfunction is one of the most common long-term neurological symptoms of COVID-19, and patients with this condition may experience severe hyposmia or anosmia for more than 1 year from the onset of symptoms.
Article
Otorhinolaryngology
Mustafa Caner Kesimli, Deniz Kaya, Levent Aydemir, Haci Omer Durmaz
Summary: The study demonstrated the effectiveness of using sinus rinse kits to spray odor particles for olfactory rehabilitation in patients with total laryngectomy. The results showed significant improvement in olfactory function after 6 months of rehabilitation.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Medicine, General & Internal
Jeong-Whun Kim, Hyo Sang Kim, Minju Kim, Su Hwan Kim, Sung-Woo Cho, Jin Youp Kim
Summary: The study developed and validated a reliable olfactory function questionnaire for assessing olfactory loss in COVID-19 patients. The questionnaire showed significant correlations with conventional olfactory function tests and demonstrated high predictive power in discriminating different levels of olfactory dysfunction. This questionnaire could serve as an alternative tool for olfactory function testing in cases where traditional psychophysical tests are challenging to perform.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Behavioral Sciences
Raul Alfaro, Jessica G. Nicanor-Carreon, Tasha Doty, Heather Lugar, Tamara Hershey, Marta Yanina Pepino
Summary: Wolfram syndrome is associated with impairment in smell identification and taste function, but odor-induced taste enhancement is preserved in the presence of reduced olfactory intensity.
Article
Clinical Neurology
Aliyah Glover, Lakshmi Pillai, Rohit Dhall, Tuhin Firmani
Summary: Olfactory dysfunction in Parkinson's disease can be detected before motor symptoms, and a specific pattern of odorant identification on the UPSIT may discriminate between patients with and without freezing of gait. Freezers showed more severe hyposmia and had significantly worse identification of nine odors compared to non-freezers. A 3-odorant score can effectively categorize freezers and non-freezers with similar sensitivity and specificity to short odorant Parkinson's disease identification batteries.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Clair Vandersteen, Magali Payne, Louise-Emilie Dumas, Elisa Cancian, Alexandra Plonka, Gregoire D'Andrea, David Chirio, Elisa Demonchy, Karine Risso, Florence Askenazy-Gittard, Charles Savoldelli, Nicolas Guevara, Philippe Robert, Laurent Castillo, Valeria Manera, Auriane Gros
Summary: This study evaluated the efficacy of olfactory training (OT) on persistent post-viral olfactory disorders (PPVOD) after COVID-19 infection. The results showed that OT led to improvements in olfactory function and quality of life in patients with PPVOD. However, further research is needed to confirm the role of OT and explore new therapeutic strategies for the central aspects of PPVOD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Otorhinolaryngology
Tae-Seong Eo, Ho Young Lee, Hyung-Ju Cho, Joo-Heon Yoon, Min-Seok Rha, Chang-Hoon Kim
Summary: This study investigated the clinical characteristics and associated factors of parosmia and phantosmia in patients with subjective smell disturbance. The results showed that younger age and female sex were related to both parosmia and phantosmia. Patients with COVID-19 had younger ages and higher TDI scores. Patients with parosmia or phantosmia had higher TDI scores and experienced more disruption in daily life. Younger age and higher TDI score were identified as independent factors associated with both parosmia and phantosmia.
Article
Clinical Neurology
Natallia Kharytaniuk, E. A. Lim, E. Chan, M. Pavlou, D. J. Werring, D. E. Bamiou
Summary: This study found a high prevalence of olfactory dysfunction in iSS, and the severity of which correlated with hearing loss. Olfaction appears to be a core feature of the iSS clinical syndrome that should be assessed routinely.
JOURNAL OF NEUROLOGY
(2022)
Article
Otorhinolaryngology
Simon Berube, Claudia Demers, Nicholas Bussiere, Frank Cloutier, Valerie Pek, Angela Chen, Josiane Bolduc-Begin, Johannes Frasnelli
Summary: Olfactory training (OT) shows subjective improvement in post-COVID-19 olfactory dysfunction, but no significant effect on objective olfactory function. OT also reduces the frequency of parosmia.
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY
(2023)
Article
Otorhinolaryngology
Ellen Cristine Duarte Garcia, Lucas de Almeida Luz, Lucas Kanieski Anzolin, Jose Lucas Barbosa da Silva, Richard L. Doty, Fabio de Rezende Pinna, Richard Louis Voegels, Marco Aurelio Fornazieri
Summary: This study aimed to determine the safety and efficacy of harvesting olfactory epithelium cells, nerve bundles, and olfactory epithelium proper for morphological analysis from the superior nasal septum. The technique depicted for olfactory epithelium biopsy is highly effective in obtaining neuronal olfactory tissue, but it has moderate efficacy in achieving samples useful for morphological analysis. Olfactory sensitivity remained intact.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Thiago Carvalho, Daniel Calduro Salgado, Olavo de Godoy Mion, Joao Ferreira de Mello Junior, Richard Louis Voegels
Summary: The study analyzed the effects of intranasal BTX-A injection for controlling symptoms of idiopathic rhinitis. Results showed significant improvement in sneezing/itching and nasal obstruction symptoms in the group receiving the injection, with acoustic rhinometry confirming the improvement in nasal obstruction. No major adverse effects were reported during the study.
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Marco A. Fornazieri, Lucas K. Ebara, Rafael Goulart de Araujo, Joao Vitor Fernandes Lima, Felipe B. Favareto, Fabio R. Pinna, Richard L. Voegels, Richard L. Doty
Summary: This study validated the Pediatric Smell Wheel (PSW) for evaluating olfactory function in Brazilian children, and established normative data for Brazilian children. The PSW test clearly differentiated the olfactory function of healthy children and children with adenoid hypertrophy, and showed the restoration of function after adenoidectomy.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Rogerio Pezato, Camila Dassi, Aldo Cassol Stamm, Richard Louis Voegels
Summary: The study introduced a new nasopharyngeal flap for reconstruction of middle and lower clival resection, demonstrating its capability to provide coverage for the lower and middle portions of the clivus. The new nasopharyngeal flap, called the upper-tongue flap, is considered a suitable alternative for cases where other reconstructive methods may not provide enough mucosal coverage.
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Marco Cesar J. Santos, Henrique F. Pauna, Kazuko U. Graziano, Richard L. Voegels
Summary: This study aimed to demonstrate the efficacy of 70% ethanol disinfection on rigid endoscopes to reduce microbial growth in microbiological cultures. The results showed a significant difference in the presence of certain microorganisms between the control and experimental groups, with no microorganisms recovered from the samples of the experimental group, indicating the germicidal action of 70% ethanol for intermediate-level disinfection.
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Eduardo Macoto Kosugi, Jonatas Figueiredo Villa, Henrique Faria Ramos, Gabriela Ricci Luz-Matsumoto, Thiago Luis Infanger Serrano, Carlos Augusto Correia de Campos, Carolina Cincura Barreto, Clara Monica Lima, Marco Aurelio Fornazieri, Otavio Piltcher, Marcus Miranda Lessa, Fabrizio Ricci Romano
Summary: This study evaluates the current evidence regarding three safety-related topics in the context of COVID-19: mask and respirator use, performance of nasal endoscopic procedures, and use of topical nasal and intranasal medications. The findings suggest that N95 respirators are essential for protecting otolaryngologists, nasal corticosteroids can be used without contraindications, and nasal irrigation with saline solution does not appear to increase the risk of COVID-19.
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Marcio Nakanishi, Marco Aurelio Fornazieri, Pedro Lanca Gomes, Luis Augusto de Miranda Dias, Gustavo Subtil Magalhaes Freire, Luis Gustavo do Amaral Vinha, Leonardo Conrado Barbosa de Sa, Richard Louis Voegels, Claudia Galvao Eng, Wilma Terezinha Anselmo Lima
Summary: The study aimed to determine the feasibility of a new handheld digital scent device (DSD) as an olfactory assessment test. The research found that the DSD test scores were higher than the 40-item Smell Identification Test (SIT-40), with strong correlation and high agreement between the two tests. Therefore, the DSD has the potential to be an effective tool for olfactory assessment testing.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2022)
Article
Otorhinolaryngology
Diogo Barreto Plantier, Renata R. M. Pilan, Rodrigo Athanazio, Mary Anne K. Olm, Eloisa M. S. Gebrim, Richard Louis Voegels
Summary: This study provides a detailed description of CT findings in patients with primary ciliary dyskinesia. We also describe abnormalities that must be identified for safer surgical planning and that suggest a diagnosis of primary ciliary dyskinesia if found in patients with a consistent clinical picture.
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Marco Aurelio Fornazieri, Jose Lucas Barbosa da Silva, Juliana Gutschow Gameiro, Henrique Ochoa Scussiato, Rafael Antonio Matias Ribeiro Ramos, Bruno Machado Cunha, Alan Felipe Figueiredo, Eduardo Hideki Takahashi, Gabrielli Algazal Marin, Igor Ruan de Araujo Caetano, Tainara Kawane Meli, Diego Issamu Higuchi, Rafael Rodrigues Pinheiro dos Santos, Ana Carla Mondek Rampazzo, Fabio de Rezende Pinna, Richard Louis Voegels, Richard L. Doty
Summary: The objective of this study was to examine the prevalence and recovery of olfactory, gustatory, and oral chemesthetic deficits in COVID-19 infected individuals using quantitative testing. The results showed that nearly all patients had olfactory disturbances during the acute infection phase, while taste and chemesthetic deficits were less common. By the 3-month follow-up evaluation, taste and chemesthetic function had largely recovered, but over half of the patients still had some degree of olfactory dysfunction. Additionally, it was found that olfactory impairment was more common in women and patients who had been treated earlier with anticoagulants showed greater improvement.
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Jose Lucas Barbosa da Silva, Lucas Kanieski Anzolin, Samuel Pissinati Nicacio, Richard L. L. Doty, Fabio de Rezende Pinna, Richard Louis Voegels, Marco Aurelio Fornazieri
Summary: This study quantitatively tested the olfactory function of patients with head and neck cancer and compared it to that of healthy controls. The results showed that the olfactory function of patients with HNC was significantly worse, and most of them had olfactory disorders. Therefore, smell disorders may serve as a potential marker for early diagnosis of head and neck cancer.
ACTA OTO-LARYNGOLOGICA
(2023)
Article
Otorhinolaryngology
Andressa Pelaquim, Milaine Dominici Sanfins, Marco Aurelio Fornazieri
Summary: This study aimed to standardize latency and amplitude values for short-, middle-, and long-latency auditory evoked potentials in adults with normal hearing thresholds. The results showed that the absolute latency and interpeak values for middle- and long-latency auditory evoked potentials were lower than internationally suggested. However, the means for brainstem auditory evoked potential were within the range considered as normal. This study provided measurements of normal latencies and amplitudes for short-, middle-, and long-latency auditory evoked potentials in adults.
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Alexandre Wady Debes Felippu, Thiago Picolli Morsch, Andre Wady Debes Felippu, Filippo Cascio, Claudia Regina Gomes Cardim Mendes de Oliveira, Alexandre Felippu, Richard Louis Voegels
Summary: This study investigated the structure, presence of vessels and nerves, and location of the ethmoidal canals through endoscopic dissection of the anterior base of the skull. Histological analysis of the canal contents was also performed. The results showed variations in the presence of vessels in different ethmoidal canals. This study contributes to a better understanding of the structure and function of the ethmoidal canals.
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Andressa Pelaquim, Milaine Dominici Sanfins, Marco Aurelio Fornazieri
Summary: The study aimed to measure the accuracy of middle and long latency auditory evoked potentials in the diagnosis of auditory processing disorder in adults. The results showed that the long-latency potentials had significant results in the diagnosis, and can be used as a complementary tool to confirm the diagnosis.
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2023)