Article
Surgery
Timothy M. Ullmann, Heng Liang, Hector Mora, Jacques Greenberg, Katherine D. Gray, Jessica Limberg, Dessislava Stefanova, Xin Zhu, Brendan Finnerty, Toni Beninato, Rasa Zarnegar, Irene Min, Thomas J. Fahey
Summary: The study investigated the effects of polybrominated diphenyl ethers (PBDEs) and tris(2-chloroethyl) phosphate (TCEP) on thyrocytes. PBDEs demonstrated genotoxicity but not cytotoxicity in follicular thyrocytes in vitro. These findings suggest that PBDEs may have carcinogenic potential in human thyroid cells.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Environmental Sciences
Qian Zhang, Mingjun Hu, Huabing Wu, Qingshan Niu, Xuelei Lu, Jialiu He, Fen Huang
Summary: The study found that exposure to PBDEs, As, and Hg may be associated with the development of thyroid cancer, with high levels of exposure to As and Hg being linked to an increased risk of thyroid cancer. There is a positive interaction effect between some PBDE congeners and Hg, while a negative interaction effect was observed between BDE-209 and Pb. Further prospective research with large samples is needed to confirm these findings.
ENVIRONMENTAL POLLUTION
(2021)
Article
Food Science & Technology
Montse Marques, Marti Nadal, Jose L. Domingo
Summary: Polybrominated diphenyl ethers (PBDEs) are a type of brominated flame-retardants (BFRs) that are mainly introduced to the human body through dietary intake. This review discusses recent studies conducted from 2012 to 2022, which show a general trend of decreasing levels of PBDEs in food and consequently, a decrease in dietary intake. The lack of tolerable daily intakes of PBDEs remains a challenge for assessing the human health risks associated with these compounds.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Chemistry, Analytical
Marija Dvorscak, Karla Jagic, Lucija Besednik, Iva Simic, Darija Klincic
Summary: Microwave-assisted extraction (MAE) is an effective method for extracting organic pollutants from human milk samples. By optimizing extraction conditions such as solvent type and volume, extraction temperature, etc., high-quality extracts can be obtained.
MICROCHEMICAL JOURNAL
(2022)
Article
Environmental Sciences
Allison Kupsco, Andreas Sjodin, Whitney Cowell, Richard Jones, Sharon Oberfield, Shuang Wang, Lori A. Hoepner, Dympna Gallagher, Andrea A. Baccarelli, Jeff Goldsmith, Andrew G. Rundle, Julie B. Herbstman
Summary: Data collected from a birth cohort in New York City revealed that prenatal PBDE exposures were not associated with child growth trajectories in Dominican and African American children. The study found no significant impact of cord levels of individual PBDEs or total PBDE mixture on childhood BMIz. Adjusting for postnatal PBDE exposures did not alter the results.
ENVIRONMENTAL HEALTH
(2022)
Article
Environmental Sciences
Qiong Zhang, Jiajun Peng, Anyan Huang, Shukai Zheng, Xiaoling Shi, Boyu Li, Wenlong Huang, Wei Tan, Xin Wang, Kusheng Wu
Summary: Animal studies have shown that exposure to PBDEs can affect lipid balance, and this study investigated the relationship between PBDEs in adipose tissues and blood lipid metabolism in female patients undergoing plastic surgery. The results indicated that certain PBDE congeners were associated with dyslipidemia and blood pressure alteration, and a non-linear relationship was observed between PBDEs and blood lipid levels.
ENVIRONMENTAL RESEARCH
(2022)
Article
Engineering, Environmental
Yu Han, Jiali Cheng, Lei He, Minna Zhang, Shan Ren, Jiazheng Sun, Xiangyang Xing, Zhenwu Tang
Summary: The study conducted in Tianjin, China, revealed that PBDE concentrations in urban soils have decreased in recent years, primarily originating from local industrial production processes and consumer products. More research is needed to further investigate the changing trend of PBDE pollution and its potential impact on human health.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2021)
Article
Chemistry, Analytical
Rama Shanker Sahu, Yu-huei Peng, Chi-Fong Ko, Tzu-Ho Chou, Hepsiba Niruba Catherine, Chien-ying Yang, Chih-ping Tso, Yuh-fan Su, Yang-hsin Shih
Summary: Polybrominated diphenyl ethers (PBDEs), a class of brominated flame retardants, have attracted the attention of researchers due to their persistence in the environment and widespread use in consumer products. Described as endocrine-disrupting chemicals, PBDEs' full understanding regarding their environmental behavior and fate remains elusive.
TRENDS IN ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2021)
Article
Environmental Sciences
Bingmeng Xie, Xueqiong Lin, Kusheng Wu, Jiongyu Chen, Shuyi Qiu, Jianan Luo, Yiteng Huang, Lin Peng
Summary: This study found that certain polybrominated diphenyl ethers (PBDEs) in breast adipose tissues are associated with prognostic biomarkers and progression-free survival of breast cancer patients. Further research is needed for confirmation.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Luze Yang, Peixuan Sun, Wenjin Zhao, Miao Liu
Summary: In this study, the developmental toxicity characteristics of pollutants, such as PBBs, were investigated using various methods. Key structural parameters affecting human development were identified, and supplementary food factors that can alleviate developmental toxicity were screened. The results provide important theoretical support for the regulation strategy of developmental toxicity caused by pollutants.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Xinran Guo, Shaohong Peng, Liwang Jiang, Xiaoning Mo, Yunhong Zhu, Yang Liu, Kaihan Cai, Qingbin Song
Summary: Improper disposal of e-waste can lead to environmental pollution and human health risks due to the release of high concentrations of PBDEs. However, recycling waste electronic plastics using solvent processes can help reduce these risks. This study focused on the recycling of HIPS from waste TV sets using d-limonene and n-propanol as solvent and precipitant, respectively. The research investigated the relationship between precipitation conditions and the size of precipitate particles, as well as the effect of these conditions on the removal percentage of PBDEs. The results showed that specific conditions, such as lower HIPS concentration, lower precipitation temperature, higher mass ratio of n-propanol to HIPS solution, and greater stirring speed, can promote the formation of smaller and more uniform precipitate particles, thereby improving the removal percentage of PBDEs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Engineering, Environmental
Mantong Jin, Ziyu Xu, Shunfei Zhang, Liwei Sun, Jiangfan Wu
Summary: Polybrominated diphenyl ethers (PBDEs) are commonly found in the environment due to the use of brominated flame retardants. This study detected PBDEs in air, dust, and particulate matter samples from bedrooms in Hangzhou, indicating wide occurrence of PBDE pollution in bedrooms. The concentration of PBDEs was highest in dust, followed by air and particulate matter. The main source of PBDEs in residential environments was identified as mattresses, curtains, and mattresses combined with curtains. The study also found that infants had the highest daily exposure dose of PBDEs in the air and particulate matter phases.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Environmental Sciences
Qi Xu, Jian Li, Shang Cao, Guangcai Ma, Xianglong Zhao, Qiuyi Wang, Xiaoxuan Wei, Haiying Yu, Zhiguo Wang
Summary: In this study, 18 OH-PBDEs with neutral and anionic forms were selected to estimate their binding interactions with the ligand binding domain (LBD) of thyroid hormone receptor O (TRO) through molecular dynamics simulations. The results indicate that most OH-PBDEs have stronger binding affinities to TRO-LBD compared to their anionic counterparts, and the hydroxyl dissociation of ligands plays a major role in their binding. Additionally, 5 hydrophobic residues (Met313, Leu330, Ile276, Leu346, and Phe272) are identified to have important contributions to binding OH-PBDEs. These findings provide a solid theoretical basis for accurately assessing the thyroid hormone disrupting effects of these chemicals.
Article
Public, Environmental & Occupational Health
Ming-Jun Hu, Jin-Liang Zhu, Qian Zhang, Jia-Liu He, Wan-Jun Yang, Zhen-Yu Zhu, Jia-Hu Hao, Fen Huang
Summary: Exposure to PBDEs and metals among rural adult residents along the Yangtze River in China may influence thyroid function, with some PBDE congeners and metals showing associations with thyroid hormones. However, there was no statistically significant association observed between PBDEs, metals, and thyroid-stimulating hormone. Bayesian Kernel Machine Regression analysis suggested similar trends in the relationship between PBDEs, metals mixtures, and thyroid hormones. Additional studies are needed to confirm these findings and identify potential mechanisms.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Environmental Sciences
Cornelius Rimayi, Lawrence M. Madikizela
Summary: This study evaluates an alternative analytical method for the analysis of persistent organic pollutants in soil near industrial areas in Durban, South Africa. The study found that the pollution levels in Durban are relatively low compared to other regions around the world. The developed analytical methods provide a starting point for the assessment and management of soil contamination.
INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT
(2023)
Article
Environmental Sciences
Nicole C. Deziel, Joshua L. Warren, Huang Huang, Haoran Zhou, Andreas Sjodin, Yawei Zhang
Summary: The study did not find a clear association between PCB or OCP exposure and PTC using single and multi-pollutant modeling. However, some associations were found in individuals born during peak production, suggesting further investigation into early-life exposures and subsequent thyroid cancer risk may be warranted.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Jennifer A. Rusiecki, Hristina Denic-Roberts, Dana L. Thomas, Jacob Collen, John Barrett, Kate Christenbury, Lawrence S. Engel
Summary: The study found that participation in oil spill clean-up actions was associated with moderately increased risk for longer term respiratory conditions among active duty Coast Guard personnel.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Hristina Denic-Roberts, Nicole Rowley, Mark C. Haigney, Kate Christenbury, John Barrett, Dana L. Thomas, Lawrence S. Engel, Jennifer A. Rusiecki
Summary: The study found that USCG responders involved in oil spill clean-up were at higher risk for acute and longer-term cardiovascular symptoms/conditions, with greater risks associated with exposure to crude oil and oil dispersants.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Xinyi Shen, Yuping Cai, Lingeng Lu, Huang Huang, Hong Yan, Philip B. Paty, Engjel Muca, Nita Ahuja, Yawei Zhang, Caroline H. Johnson, Sajid A. Khan
Summary: This study explores the impact of tumor metabolome and sex on the prognosis of colorectal cancer patients. It reveals that the metabolites asparagine and serine have interactions with sex and are associated with poor survival rates and increased risk of recurrence in female patients. Additionally, lysophospholipid and polyamine synthesis also have negative prognostic effects on females. These findings provide insights for precision medicine in colorectal cancer treatment stratified by sex.
Article
Immunology
Nusrat J. Epsi, Stephanie A. Richard, David A. Lindholm, Katrin Mende, Anuradha Ganesan, Nikhil Huprikar, Tahaniyat Lalani, Anthony C. Fries, Ryan C. Maves, Rhonda E. Colombo, Derek T. Larson, Alfred Smith, Sharon W. Chi, Carlos J. Maldonado, Evan C. Ewers, Milissa U. Jones, Catherine M. Berjohn, Daniel H. Libraty, Margaret Sanchez Edwards, Caroline English, Julia S. Rozman, Rupal M. Mody, Christopher J. Colombo, Emily C. Samuels, Princess Nwachukwu, Marana S. Tso, Ann Scher, Celia Byrne, Jennifer Rusiecki, Mark P. Simons, David Tribble, Christopher C. Broder, Brian K. Agan, Timothy H. Burgess, Eric D. Laing, Simon D. Pollett
Summary: Prior SARS-CoV-2 infection followed by vaccination, or vice versa, leads to a stronger and more enduring IgG response compared to infection or vaccination alone. The timing between infection and vaccination affects the magnitude of post-vaccine immune response.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Oncology
Penghui Niu, Huang Huang, Lulu Zhao, Tongbo Wang, Xiaojie Zhang, Wanqing Wang, Yawei Zhang, Chunguang Guo, Dongbing Zhao, Yingtai Chen
Summary: This study explores the clinicopathological characteristics, survival outcomes, and genetic alterations of younger and older patients with gastric cancer (GC). Younger GC patients had more poorly differentiated lesions and lower survival rates in stage III compared to older patients. Distinct molecular characteristics were identified in younger GC patients, which may explain the histopathology and prognosis specific to this subpopulation.
Article
Psychology, Clinical
Jeanny H. Wang, Hristina Denic-Roberts, Jeffrey L. Goodie, Dana L. Thomas, Lawrence S. Engel, Jennifer A. Rusiecki
Summary: This study investigated the acute mental health symptoms and tobacco initiation among nonlocal responders involved in the Deepwater Horizon oil spill response. The results showed that female responders were more likely to experience concurrent depression and anxiety symptoms, while tobacco initiation was negatively associated with age and officer rank. These findings suggest that the oil spill response work has an impact on the mental health and behavior of responders, highlighting the importance of addressing the mental health needs of nonlocal responders and implementing appropriate interventions.
JOURNAL OF TRAUMATIC STRESS
(2022)
Article
Medicine, General & Internal
Sameh Yousef, Andrea Amabile, Chirag Ram, Huang Huang, Varun Korutla, Saket Singh, Ritu Agarwal, Roland Assi, Rita K. Milewski, Yawei Zhang, Prakash A. Patel, Markus Krane, Arnar Geirsson, Prashanth Vallabhajosyula
Summary: A risk prediction model was developed to predict the risk of having >= moderate AS in patients based on demographic and clinical variables from a large population cohort. This tool can guide targeted screening for patients with advanced AS in the general population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Stephanie A. Richard, Nusrat J. Epsi, David A. Lindholm, Allison M. W. Malloy, Ryan C. Maves, Catherine M. Berjohn, Tahaniyat Lalani, Alfred G. Smith, Rupal M. Mody, Anuradha Ganesan, Nikhil Huprikar, Rhonda E. Colombo, Christopher J. Colombo, Cristian Madar, Milissa U. Jones, Derek T. Larson, Evan C. Ewers, Samantha Bazan, Anthony C. Fries, Carlos J. Maldonado, Mark P. Simons, Julia S. Rozman, Liana Andronescu, Katrin Mende, David R. Tribble, Brian K. Agan, Timothy H. Burgess, Simon D. Pollett, John H. Powers
Summary: This study found that being fully vaccinated against SARS-CoV-2 is associated with a lower severity of patient-reported symptoms, leading to an earlier return to usual activities. Infection with the Delta variant is associated with higher FLU-PRO Plus scores, even after controlling for vaccination status.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Environmental Sciences
Haoran Zhuo, Huang Huang, Andreas Sjodin, Lan Jin, Shuangge Ma, Hristina Denic-Roberts, Joshua L. Warren, Richard Jones, Mark Davis, Peiyuan Sun, Herbert Yu, Mary H. Ward, Robert Udelsman, Yawei Zhang, Jennifer A. Rusiecki
Summary: Exposure to certain PCBs and PCB mixtures was associated with an increased risk of papillary thyroid cancer. The main driver of the observed association was PCB-118, with lesser effects from PCB-74 and PCB-99.
ENVIRONMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Yuping Cai, Xinyi Shen, Lingeng Lu, Hong Yan, Huang Huang, Patricia Gaule, Engjel Muca, Casey M. Theriot, Zahra Rattray, Nicholas J. W. Rattray, Jun Lu, Nita Ahuja, Yawei Zhang, Philip B. Paty, Sajid A. Khan, Caroline H. Johnson
Summary: The study revealed that the distribution of bile acid abundances in colon cancer patients is tumor location-, age- and sex-specific, and are linked to patient prognosis. The results provide new implications for targeting bile acid metabolism, microbiome, and immune responses for colon cancer patients by taking into account primary tumor location and sex.
BIOLOGY OF SEX DIFFERENCES
(2022)
Article
Public, Environmental & Occupational Health
Clinton Hall, Ava Marie S. Conlin, Monica Burrell, Celeste J. Romano, Anna T. Bukowinski, Gia R. Gumbs, Emily W. Harville, Dana L. Thomas, Hristina Denic-Roberts, Jennifer A. Rusiecki
Summary: This study evaluated the potential adverse health outcomes among infants born to US Coast Guard responders to the Deepwater Horizon oil spill disaster. The health outcomes of infants born to male responders were similar to non-responders, while infants born to female responders had a higher frequency of poor live birth outcomes. However, the findings should be interpreted with caution due to the small sample size.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Clinical Neurology
Ranran Qie, Huang Huang, Peiyuan Sun, Jianjun Wu, Yue Ba, Guoyu Zhou, Fangfang Yu, Daming Zhang, Yaqun Zhang, Yuting Xie, Zhuolun Hu, Kaiyong Zou, Yawei Zhang
Summary: This study aimed to investigate the associations between different types of physical activity and depressive symptoms. The results showed that leisure-time physical activity and transport physical activity were negatively associated with depressive symptoms, while occupational physical activity was positively associated. Household physical activity had a negative trend for men but had no effect on women. Four physical activity patterns were identified, and a lower risk of depressive symptoms was associated with the low occupational physical activity pattern.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Environmental Sciences
Matthew O. Gribble, Taj Keshav, Hristina Denic-Roberts, Lawrence S. Engel, Jennifer A. Rusiecki
Summary: By analyzing the experiences of USCG oil spill responders, we identified four main exposure patterns that can guide future studies on the health impacts of exposure mixtures among these responders.
ENVIRONMENTAL EPIDEMIOLOGY
(2022)
