Review
Food Science & Technology
Pablo-Jesus Marin-Garcia, Nuria Planas, Lola Llobat
Summary: This article reviews the detection methods, prevalence, and control measures of Toxoplasma gondii in the food industry. T. gondii is a common parasite that causes infection through food contamination, but standardized detection methods are currently lacking in the industry. The main detection methods include bioassays, cell culture, molecular and microscopic techniques, and serological methods. Due to the high prevalence of T. gondii in many food products, standardized detection methods and control measures are necessary.
Article
Multidisciplinary Sciences
Iti Saraav, Luisa Cervantes-Barragan, Philipp Olias, Yong Fu, Qiuling Wang, Leran Wang, Yi Wang, Matthias Mack, Megan T. Baldridge, Thaddeus Stappenbeck, Marco Colonna, L. David Sibley
Summary: Oral infection with Toxoplasma gondii exacerbates damage to the colon caused by chemical irritant and impairs wound healing by suppressing stem cell regeneration. Enhanced tissue damage is due to inflammatory monocytes releasing inflammatory mediators.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, General & Internal
Agnieszka Pawelczyk, Malgorzata Bednarska, Kamila Caraballo Cortes, Marianna Glamkowska-Sady, Justyna Kowalska, Beata Uszynska-Kaluza, Marek Radkowski, Renata Welc-Faleciak
Summary: This study examined the detection of Toxoplasma gondii infection in asymptomatic HIV-infected individuals and found that T. gondii DNA could be detected in seronegative subjects. This suggests the need to supplement routine serologic testing with molecular methods to accurately monitor infection reactivation and introduce specific therapy in a timely manner. This is of high importance for ensuring the safety of blood donations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Mohammad Mahdi Jafari, Zahra Azimzadeh Tabrizi, Mohammad Saaid Dayer, Nazanin Atieh Kazemi-Sefat, Mahshid Mohtashamifard, Rahimeh Mohseni, Atefeh Bagheri, Saeed Bahadory, Amir Karimipour-Saryazdi, Fatemeh Ghaffarifar
Summary: Toxoplasma gondii infection is associated with immune response, which can be used as prognosis markers. Immunotherapy has become a new approach for toxoplasmosis treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Parasitology
Damien Dupont, Helene Fricker-Hidalgo, Marie-Pierre Brenier-Pinchart, Cecile Garnaud, Martine Wallon, Herve Pelloux
Summary: Serology is essential in the prevention and management of toxoplasmosis in immunocompromised patients, helping determine patients' immune status and diagnose complex cases of infection. New perspectives are available to further improve their yield and ease of use.
TRENDS IN PARASITOLOGY
(2021)
Article
Immunology
Ahmadreza Bazmjoo, Mohammad Aref Bagherzadeh, Rahim Raoofi, Ali Taghipour, Samaneh Mazaherifar, Hojatallah Sotoodeh, Zahra Ostadi, Enayat Shadmand, Mirza A. M. Jahromi, Amir Abdoli
Summary: This study investigated the serological and molecular status of T. gondii infection among HIV-infected individuals who had co-infection with HBV and HCV infections. The results showed that co-infections of T. gondii, HCV, and HBV were common among HIV-infected patients, and co-infections had a negative correlation with CD4 + cell counts of the patients.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Parasitology
Jiaofeng Huang, Jiaolong Zheng, Bang Liu, Lingling Lu, Haicong Wu, Su Lin, Dongliang Li
Summary: This study found that Toxoplasma gondii infection is associated with higher mortality in the general population, and this association is related to age and sex. This suggests that Toxoplasma gondii infection may be an important public health issue.
PARASITES & VECTORS
(2022)
Article
Multidisciplinary Sciences
Syrian G. Sanchez, Emilie Bassot, Aude Cerutti, Hoa Mai Nguyen, Amel Aida, Nicolas Blanchard, Sebastien Besteiro
Summary: Toxoplasma gondii is responsible for toxoplasmosis, a disease that can be serious when contracted during pregnancy, but can also be a threat for immunocompromised individuals. The study finds that targeting the apicoplast in bradyzoites, the latent form of the parasite, leads to a loss of long-term viability, suggesting the apicoplast as a potential therapeutic target.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Immunology
Xin-Yu Wei, Yang Gao, Chuang Lv, Wei Wang, Yu Chen, Quan Zhao, Qing-Long Gong, Xiao-Xuan Zhang
Summary: The global prevalence of Toxoplasma gondii in foxes is approximately 39.6%, with the highest prevalence in North America (51.2%) and the lowest in Asia (8.3%). The prevalence after 2006 is lower than before, and female foxes have a higher infection rate than males.
MICROBIAL PATHOGENESIS
(2021)
Article
Geriatrics & Gerontology
Hira Mohyuddin, Blanca Laffon, Joao P. Teixeira, Solange Costa, Armanda Teixeira-Gomes, Eduardo Pasaro, Niel Constantine, Aline Dagdag, Heidi K. Ortmeyer, Boris Tizenberg, Liubov Afram, Poyu Yen, Christopher Marano, Christopher A. Lowry, Andrew J. Hoisington, Jill A. Rachbeisel, Vanessa Valdiglesias, Carlota Lema-Arranz, Natalia Fernandez-Bertolez, Ana Maseda, Jose C. Millan-Calenti, Elizabeth J. Kovacs, Johanna M. Gostner, Dietmar Fuchs, Lisa A. Brenner, Laura Lorenzo-Lopez, Teodor T. Postolache
Summary: This study revealed an association between Toxoplasma gondii and frailty, but further research is needed for validation. Certain biomarkers related to inflammaging were associated with both Toxoplasma gondii and frailty, but they did not fully mediate the association between the two.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Immunology
Amy C. Schumacher, Lina Elbadawi, Traci DeSalvo, Anne Straily, Daniel Ajzenberg, David Letzer, Ellen Moldenhauer, Tammy L. Handly, Dolores Hill, Marie-Laure Darde, Christelle Pomares, Karine Passebosc-Faure, Kristine Bisgard, Carlos A. Gomez, Cindy Press, Stephanie Smiley, Jose G. Montoya, James J. Kazmierczak
Summary: In 2017, an outbreak of toxoplasmosis was linked to undercooked venison served at a retreat in Wisconsin. Most of the attendees experienced illness, with laboratory results showing atypical features for toxoplasmosis. The strain of T. gondii found in the venison was a unique genotype, highlighting the potential risks of consuming undercooked game meat in North America.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Thais Cabral Monica, Fernanda Evers, Beatriz Souza Lima Nino, Fernanda Pinto-Ferreira, Jose Wander Bregano, Mariana Ragassi Urbano, Guita Rubinsky-Elefant, Roberta Lemos Freire, Italmar Teodorico Navarro, Regina Mitsuka-Bregano
Summary: The study examined the seroprevalence and risk factors of toxoplasmosis and toxocariasis in schoolchildren in Jataizinho, Parana, revealing associations with factors such as the mother's education level, age, presence of cats in the household, income, and presence of dogs. There was also an association between the two zoonoses, highlighting the importance of implementing control measures to reduce the incidence and risks of sequelae in children.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Ragab M. Fereig, Yoshifumi Nishikawa
Summary: In this study, the cyto-nuclear and mitochondrial localization of TgPrx1 and TgPrx3 proteins in Toxoplasma gondii were revealed. Knocking out TgPrx1 and TgPrx3 genes in T. gondii resulted in decreased survival rate in mice infected with TgPrx3KO strain compared to TgPrx1KO and control strains. Additionally, TgPrx1KO and TgPrx3KO induced high levels of interferon gamma (IFN-gamma) and increased IL-6 and IL-12p40 production in infected mice and murine macrophages. These findings suggest that TgPrx3 may be a potential sub-unit vaccine candidate for controlling toxoplasmosis in susceptible humans and animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Ragab M. Fereig, Hanan H. Abdelbaky, Amira M. Mazeed, El-Sayed El-Alfy, Somaya Saleh, Mosaab A. Omar, Abdullah F. Alsayeqh, Caroline F. Frey
Summary: The prevalence of antibodies to Neospora caninum and Toxoplasma gondii in raw milk samples from different ruminants and Egyptian governorates was estimated. The study found a seroprevalence of 15.4% for both N. caninum and T. gondii antibodies in bulk milk samples, and 25.7% and 14% for individual milk samples, respectively. The presence of DNA was also detected for both parasites. Pearson correlation analysis showed a strong correlation between bulk and individual samples for T. gondii and a moderately strong correlation for N. caninum.
Review
Infectious Diseases
Man-Yao Li, Xiao-Nan Gao, Jun-Yang Ma, Hany M. Elsheikha, Wei Cong
Summary: The global prevalence of T. gondii infection in wild marine mammals is estimated to be approximately 22.44%. The prevalence is higher in adult animals compared to younger age groups. North America has the highest prevalence among continents, and Spain has the highest prevalence among countries. Climatic variables, including a mean annual temperature >20 degrees C and an annual precipitation >800 mm, are associated with higher prevalence.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Review
Infectious Diseases
John Thornhill, Chloe Orkin, Muge Cevik
Summary: The COVID-19 pandemic has complex and varied effects on people with HIV (PWH), increasing the risk of severe illness and mortality. HIV does not appear to increase the risk of acquiring SARS-CoV-2, but once acquired, HIV worsens the outcomes of COVID-19. COVID-19 vaccines may be less effective in PWH, and disruptions to essential prevention and treatment services during the pandemic are negatively impacting progress in HIV control.
CURRENT OPINION IN INFECTIOUS DISEASES
(2023)
Review
Medicine, General & Internal
Sajad Khiali, Afra Rezagholizadeh, Hossein Behzad, Hossein Bannazadeh Baghi, Taher Entezari-Maleki
Summary: Currently, the global recovery from the COVID-19 pandemic is fragile despite the administration of COVID-19 vaccines recommended as the safest and most reliable tool for eliminating the disease. However, there have been reports of cardiovascular adverse events following widespread vaccination. This comprehensive review provides an update on the etiology, pathophysiology, clinical features, and management of these events, emphasizing the need for diagnostic scoring systems and further evaluation of vaccine safety.
POSTGRADUATE MEDICINE
(2023)
Review
Virology
Zahra Hamidi, Shaghaiegh Jabraeili-Siahroud, Yalda Taati-Alamdari, Parisa Shiri Aghbash, Ali Shamekh, Hossein Bannazadeh Baghi
Summary: Since the first reporting of the index case of SARS-CoV-2-associated disease in December 2019, the COVID-19 pandemic has become a global concern. People with autoimmune diseases are at higher risk due to compromised immune systems. However, the severity of COVID-19 complications varies among patients depending on their underlying autoimmune disease and treatment. This review discusses the impact of the pandemic on patients with autoimmune diseases and provides considerations for their healthcare during the COVID-19 outbreak.
Article
Medicine, General & Internal
Nicola Low, Laura H. Bachmann, Dimie Ogoina, Robert McDonald, Aziz Mert Ipekci, Laura A. S. Quilter, Muge Cevik
Summary: In a Policy Forum piece, Dr. Nicola Low and colleagues outline the research agenda for studying Mpox virus and its transmission through sexual contact.
Review
Medicine, Research & Experimental
Seyed Mohammad Reza Hashemian, Amirhossein Sheida, Mohammad Taghizadieh, Mohammad Yousef Memar, Michael R. Hamblin, Hossein Bannazadeh Baghi, Javid Sadri Nahand, Zatollah Asemi, Hamed Mirzaei
Summary: Due to the lack of effective therapies for COVID-19, patients have to rely on supportive and nonspecific treatments. Certain proteins of SARS-CoV-2, such as 3 C-like protease (3CLpro) and major protease (Mpro), have been identified as potential targets for antiviral drugs. Nirmatrelvir, combined with ritonavir, has shown potent antiviral activity against SARS-CoV-2 variants, but there are still uncertainties regarding their efficacy, safety, and side effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, General & Internal
Reyhaneh Rasizadeh, Ali Shamekh, Parisa Shiri Aghbash, Hossein Bannazadeh Baghi
Summary: Variola virus, the cause of smallpox, was eliminated in the 1980s with no new cases reported. Monkeypox, a zoonotic disease similar to smallpox, has become a major health concern worldwide. Varicella zoster virus (VZV) is a neurotropic virus causing chickenpox and shingles, both highly infectious diseases. Monkeypox, smallpox, and chickenpox share similar symptoms such as fever and rash, but can be distinguished by their distinct characteristics.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Article
Microbiology
Ammar Khalo Abass Kasho, Javid Sadri Nahand, Arash Salmaninejad, Hamed Mirzaei, Mohsen Moghoofei, Ahad Bazmani, Parisa Shiri Aghbash, Reyhaneh Rasizadeh, Nader Farsad-Akhtar, Hossein Bannazadeh Baghi
Summary: This study found that the expression profiles of peripheral blood mononuclear cell miRNAs in COVID-19 patients differed based on normal and abnormal coagulation indices. miR-223-3p and miR-494-3p may serve as promising biomarkers for diagnosing coagulation abnormalities in COVID-19 patients.
CURRENT MICROBIOLOGY
(2023)
Correction
Immunology
Maryam Fatemipour, Javid Sadri Nahand, Maryam Ebadi Fard Azar, Hossein Bannazadeh Baghi, Mohammad Taghizadieh, Saba Sorayyayi, Bashdar Mahmud Hussen, Hamed Mirzaei, Mohsen Moghoofei, Farah Bokharaei-Salim
MICROBIAL PATHOGENESIS
(2023)
Article
Medicine, General & Internal
Parisa Shiri Aghbash, Reyhaneh Rasizadeh, Milad Shirvaliloo, Javid Sadri Nahand, Hossein Bannazadeh Baghi
Summary: This study investigated the correlation between viral shedding in saliva and white blood cell count in COVID-19 patients. The results showed a significant increase in white blood cells, lymphocytes, and neutrophils on the 5th day in patients with sputum. The study proves that blood lymphocytes, as well as CRP, LDH, and ESR, can accurately indicate the amount of viral shedding in people with or without sputum.
FRONTIERS IN MEDICINE
(2023)
Article
Veterinary Sciences
Kareem Hatam-Nahavandi, David Carmena, Mostafa Rezaeian, Hamed Mirjalali, Hanieh Mohammad Rahimi, Milad Badri, Aida Vafae Eslahi, Farzaneh Faraji Shahrivar, Sonia Rodrigues M. Oliveira, Maria de Lourdes Pereira, Ehsan Ahmadpour
Summary: This study investigated the prevalence of intestinal parasites in livestock in Iranshahr County, Southeastern Iran. Most animals studied were infected with at least one species of intestinal parasite. It is important to conduct parasitological monitoring in livestock and take preventive measures to prevent the spread of parasites to humans.
VETERINARY SCIENCES
(2023)
Article
Medicine, General & Internal
Alasdair Munro, Danilo Buonsenso, Sebastian Gonzalez-Dambrauskas, Robert C. Hughes, Sunil S. Bhopal, Pablo Vasquez-Hoyos, Muge Cevik, Maria Lucia Mesa Rubio, Damian Roland
BMJ EVIDENCE-BASED MEDICINE
(2023)
Review
Microbiology
Parisa Shiri Aghbash, Reyhaneh Rasizadeh, Vahid Arefi, Javid Sadri Nahand, Hossein Bannazadeh Baghi
Summary: Cytomegalovirus (CMV) mostly causes mild symptoms or can be asymptomatic in immunocompetent individuals, but is a significant cause of morbidity in immunocompromised patients, such as transplant recipients. Therefore, the diagnosis of CMV infection after transplantation is crucial. New diagnostic methods have been developed for the quick detection of CMV.
ARCHIVES OF MICROBIOLOGY
(2023)
Review
Infectious Diseases
Christophe Van Dijck, Nicole A. Hoff, Placide Mbala-Kingebeni, Nicola Low, Muge Cevik, Anne W. Rimoin, Jason Kindrachuk, Laurens Liesenborghs
Summary: This article provides an overview of mpox epidemiology from its discovery to the global outbreak in 2022. The virus initially emerged as a zoonosis in Central and West Africa in the 1970s and gradually shifted to human-to-human transmission, including sexual contact. By 2022, mpox caused a large-scale outbreak with over 86,000 cases in 110 countries. While the global epidemic has waned in most countries by February 2023, endemic regions continue to be affected. Further research on mpox pathophysiology and transmission dynamics is needed, and preventive and therapeutic interventions should be evaluated. Strengthening outbreak response systems in endemic regions is crucial to reduce the global threat of mpox.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Medicine, Research & Experimental
Bronner P. Goncalves, Waasila Jassat, Joaquin Baruch, Madiha Hashmi, Amanda Rojek, Abhishek Dasgupta, Ignacio Martin-Loeches, Luis Felipe Reyes, Chiara Piubelli, Barbara Wanjiru Citarella, Christiana Kartsonaki, Benjamin Lefevre, Jose W. Lopez Revilla, Miles Lunn, Ewen M. Harrison, Moritz U. G. Kraemer, Sally Shrapnel, Peter Horby, Zeno Bisoffi, Piero L. Olliaro, Laura Merson
Summary: Vaccinated and unvaccinated COVID-19 patients may differ in clinical presentation and comorbidities, with significant between-country variation.
Article
Medicine, Research & Experimental
Parisa Shiri Aghbash, Nima Hemmat, Behzad Baradaran, Hossein Bannazadeh Baghi
Summary: The combination therapy of E6-siRNA and Oxaliplatin increased sensitivity of cervical cancer cells to Oxaliplatin, reducing cell survival, proliferation, and metastasis, and enhancing apoptosis rate and cell cycle arrest at the sub-G1 stage, thus allowing for reduced chemotherapy drug dosage.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)