Biomedical Applications of DNA‐Based Hydrogels

Biologically Inspired, Cell-Selective Release of Aptamer-Trapped Growth Factors by Traction Forces

(2019) Anna Stejskalová et al.   ADVANCED MATERIALS

Dynamically Programmed Switchable DNA Hydrogels Based on a DNA Circuit Mechanism

(2019) Motoi Oishi et al.   Small

Encoding Reversible Hierarchical Structures with Supramolecular Peptide–DNA Materials

(2019) Margaret L. Daly et al.   BIOCONJUGATE CHEMISTRY

Designable Immune Therapeutical Vaccine System Based on DNA Supramolecular Hydrogels

(2018) Yu Shao et al.   ACS Applied Materials & Interfaces

Logic Catalytic Interconversion of G-Molecular Hydrogel

(2018) Ruibo Zhong et al.   ACS Applied Materials & Interfaces

Aptamer-Patterned Hydrogel Films for Spatiotemporally Programmable Capture and Release of Multiple Proteins

(2018) Zheng Zhang et al.   ACS Applied Materials & Interfaces

Stimuli-Responsive Donor-Acceptor and DNA-Crosslinked Hydrogels: Application as Shape-Memory and Self-Healing Materials

(2018) Chen Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Self-Assembly of Enzyme-Like Nanofibrous G-Molecular Hydrogel for Printed Flexible Electrochemical Sensors

(2018) Ruibo Zhong et al.   ADVANCED MATERIALS

Target-responsive DNA hydrogel for non-enzymatic and visual detection of glucose

(2018) Yanli Ma et al.   ANALYST

Exploiting the conformational-selection mechanism to control the response kinetics of a “smart” DNA hydrogel

(2018) Anna J. Simon et al.   ANALYST

Fabrication of Defined Polydopamine Nanostructures by DNA Origami-Templated Polymerization

(2018) Yu Tokura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Smart DNA Hydrogel Integrated Nanochannels with High Ion Flux and Adjustable Selective Ionic Transport

(2018) Yafeng Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Manufacturing of an electrochemical biosensing platform based on hybrid DNA hydrogel: Taking lung cancer-specific miR-21 as an example

(2018) Shuopeng Liu et al.   BIOSENSORS & BIOELECTRONICS

Polymer tube nanoreactors via DNA-origami templated synthesis

(2018) Yu Tokura et al.   CHEMICAL COMMUNICATIONS

Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer

(2018) Hengyuan Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development of orally-deliverable DNA hydrogel by microemulsification and chitosan coating

(2018) Daiki Nomura et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Redox-triggered hydrogels revealing switchable stiffness properties and shape-memory functions

(2018) Michael Fadeev et al.   Polymer Chemistry

How to Construct DNA Hydrogels for Environmental Applications: Advanced Water Treatment and Environmental Analysis

(2018) Yingrong Wang et al.   Small

Surface-immobilized and self-shaped DNA hydrogels and their application in biosensing

(2018) Xiaoxia Mao et al.   Chemical Science

Photothermal fabrication of microscale patterned DNA hydrogels

(2018) Suguru Shimomura et al.   Royal Society Open Science

Combined encapsulation of a tumor antigen and immune cells using a self-assembling immunostimulatory DNA hydrogel to enhance antigen-specific tumor immunity

(2018) Yuka Umeki et al.   JOURNAL OF CONTROLLED RELEASE

Supramolecular Peptide/Polymer Hybrid Hydrogels for Biomedical Applications

(2018) Elham Radvar et al.   MACROMOLECULAR BIOSCIENCE

Floxuridine-containing nucleic acid nanogels for anticancer drug delivery

(2018) Yuan Ma et al.   Nanoscale

Autonomous Ultrafast Self-Healing Hydrogels by pH-Responsive Functional Nanofiber Gelators as Cell Matrices

(2018) Jasmina Gačanin et al.   ADVANCED MATERIALS

Reversible self-assembly of superstructured networks

(2018) Ronit Freeman et al.   SCIENCE

Aptamer Functionalized DNA Hydrogel for Wise-Stage Controlled Protein Release

(2018) Chen Liu et al.   Applied Sciences-Basel

Improved sustained release of antigen from immunostimulatory DNA hydrogel by electrostatic interaction with chitosan

(2017) Yumiko Ishii-Mizuno et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Supramolecular Protein Assemblies Based on DNA Templates

(2017) Chunxi Hou et al.   Journal of Physical Chemistry Letters

Self-Healing, Self-Assembled β-Sheet Peptide–Poly(γ-glutamic acid) Hybrid Hydrogels

(2017) David E. Clarke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA Hydrogel with Aptamer-Toehold-Based Recognition, Cloaking, and Decloaking of Circulating Tumor Cells for Live Cell Analysis

(2017) Ping Song et al.   NANO LETTERS

Biotechnological mass production of DNA origami

(2017) Florian Praetorius et al.   NATURE

Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components

(2017) Luvena L. Ong et al.   NATURE

Gigadalton-scale shape-programmable DNA assemblies

(2017) Klaus F. Wagenbauer et al.   NATURE

DNA sequence–directed shape change of photopatterned hydrogels via high-degree swelling

(2017) Angelo Cangialosi et al.   SCIENCE

Displacement and hybridization reactions in aptamer-functionalized hydrogels for biomimetic protein release and signal transduction

(2017) Jinping Lai et al.   Chemical Science

Stimuli-responsive nucleic acid-functionalized metal–organic framework nanoparticles using pH- and metal-ion-dependent DNAzymes as locks

(2017) Wei-Hai Chen et al.   Chemical Science

pH- and ligand-induced release of loads from DNA–acrylamide hydrogel microcapsules

(2017) Wei-Ching Liao et al.   Chemical Science

Instructing cells with programmable peptide DNA hybrids

(2017) Ronit Freeman et al.   Nature Communications

Retardation of Antigen Release from DNA Hydrogel Using Cholesterol-Modified DNA for Increased Antigen-Specific Immune Response

(2017) Yuka Umeki et al.   Advanced Healthcare Materials

Spatiotemporally Controlled Release of Rho-Inhibiting C3 Toxin from a Protein-DNA Hybrid Hydrogel for Targeted Inhibition of Osteoclast Formation and Activity

(2017) Jasmina Gačanin et al.   Advanced Healthcare Materials

An aptamer-patterned hydrogel for the controlled capture and release of proteins via biorthogonal click chemistry and DNA hybridization

(2017) Zheng Zhang et al.   Journal of Materials Chemistry B

DNA nanotechnology

(2017) Nadrian C. Seeman et al.   Nature Reviews Materials

Microfluidic Distance Readout Sweet Hydrogel Integrated Paper-Based Analytical Device (μDiSH-PAD) for Visual Quantitative Point-of-Care Testing

(2016) Xiaofeng Wei et al.   ANALYTICAL CHEMISTRY

Designer Extracellular Matrix Based on DNA-Peptide Networks Generated by Polymerase Chain Reaction

(2016) Alexander Finke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bottom-Up Fabrication of Nanopatterned Polymers on DNA Origami by In Situ Atom-Transfer Radical Polymerization

(2016) Yu Tokura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy

(2016) Hong-Min Meng et al.   CHEMICAL SOCIETY REVIEWS

Orthogonal Dual-Triggered Shape-Memory DNA-Based Hydrogels

(2016) Xu Yu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Bioresponsive DNA-co-polymer hydrogels for fabrication of sensors

(2016) Eleonóra Parelius Jonášová et al.   CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

Portable visual quantitative detection of aflatoxin B1 using a target-responsive hydrogel and a distance-readout microfluidic chip

(2016) Yanli Ma et al.   LAB ON A CHIP

Generation of Large-Scale DNA Hydrogels with Excellent Blood and Cell Compatibility

(2016) Heidi Stoll et al.   MACROMOLECULAR BIOSCIENCE

Self-assembling DNA hydrogel-based delivery of immunoinhibitory nucleic acids to immune cells

(2016) Yu Nishida et al.   Nanomedicine-Nanotechnology Biology and Medicine

Programmable DNA scaffolds for spatially-ordered protein assembly

(2016) Arun Richard Chandrasekaran   Nanoscale

Designer nanoscale DNA assemblies programmed from the top down

(2016) R. Veneziano et al.   SCIENCE

Bioresponsive materials

(2016) Yue Lu et al.   Nature Reviews Materials

Design and Synthesis of Target-Responsive Aptamer-Cross-linked Hydrogel for Visual Quantitative Detection of Ochratoxin A

(2015) Rudi Liu et al.   ACS Applied Materials & Interfaces

Target-Responsive DNA Hydrogel Mediated “Stop-Flow” Microfluidic Paper-Based Analytic Device for Rapid, Portable and Visual Detection of Multiple Targets

(2015) Xiaofeng Wei et al.   ANALYTICAL CHEMISTRY

Molecular Encryption and Reconfiguration for Remodeling of Dynamic Hydrogels

(2015) Shihui Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid Formation of a Supramolecular Polypeptide-DNA Hydrogel for In Situ Three-Dimensional Multilayer Bioprinting

(2015) Chuang Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aptamer-Based Polyvalent Ligands for Regulated Cell Attachment on the Hydrogel Surface

(2015) Erin R. Gaddes et al.   BIOMACROMOLECULES

Aptamers as a replacement for antibodies in enzyme-linked immunosorbent assay

(2015) Saw Yi Toh et al.   BIOSENSORS & BIOELECTRONICS

Replacing antibodies with aptamers in lateral flow immunoassay

(2015) Ailiang Chen et al.   BIOSENSORS & BIOELECTRONICS

The Pathophysiology and Treatment of Osteoporosis

(2015) Matthew T. Drake et al.   CLINICAL THERAPEUTICS

Aptamer-functionalized hydrogel as effective anti-cancer drugs delivery agents

(2015) Zonghua Wang et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Nasal delivery of Japanese cedar pollen Cryj1 by using self-gelling immunostimulatory DNA for effective induction of immune responses in mice

(2015) Yumiko Ishii-Mizuno et al.   JOURNAL OF CONTROLLED RELEASE

Multitriggered Shape-Memory Acrylamide–DNA Hydrogels

(2015) Chun-Hua Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA hydrogel delivery vehicle for light-triggered and synergistic cancer therapy

(2015) Jaejung Song et al.   Nanoscale

A Drosera-bioinspired hydrogel for catching and killing cancer cells

(2015) Shihui Li et al.   Scientific Reports

Light-responsible DNA hydrogel–gold nanoparticle assembly for synergistic cancer therapy

(2015) Jaejung Song et al.   Journal of Materials Chemistry B

Aptamer Selection Technology and Recent Advances

(2015) Michael Blind et al.   Molecular Therapy-Nucleic Acids

pH-Stimulated DNA Hydrogels Exhibiting Shape-Memory Properties

(2014) Weiwei Guo et al.   ADVANCED MATERIALS

Hydrogels and Scaffolds for Immunomodulation

(2014) Ankur Singh et al.   ADVANCED MATERIALS

Target-Responsive DNAzyme Cross-Linked Hydrogel for Visual Quantitative Detection of Lead

(2014) Yishun Huang et al.   ANALYTICAL CHEMISTRY

Au@Pt Nanoparticle Encapsulated Target-Responsive Hydrogel with Volumetric Bar-Chart Chip Readout for Quantitative Point-of-Care Testing

(2014) Zhi Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Double-Imprinted Diffraction-Grating Sensor Based on a Virus-Responsive Super-Aptamer Hydrogel Derived from an Impure Extract

(2014) Wei Bai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Switchable Bifunctional Stimuli-Triggered Poly-N-Isopropylacrylamide/DNA Hydrogels

(2014) Weiwei Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polymerization of Affinity Ligands on a Surface for Enhanced Ligand Display and Cell Binding

(2014) Erin Richards et al.   BIOMACROMOLECULES

Programmable protein–DNA hybrid hydrogels for the immobilization and release of functional proteins

(2014) Yuzhou Wu et al.   CHEMICAL COMMUNICATIONS

Reversible Ag+-crosslinked DNA hydrogels

(2014) Weiwei Guo et al.   CHEMICAL COMMUNICATIONS

Tuning the thermosensitive properties of hybrid collagen peptide–polymer hydrogels

(2014) Charles M. Rubert Pérez et al.   CHEMICAL COMMUNICATIONS

Stability of DNA Origami Nanostructure under Diverse Chemical Environments

(2014) Hyojeong Kim et al.   CHEMISTRY OF MATERIALS

Injectable, self-gelling, biodegradable, and immunomodulatory DNA hydrogel for antigen delivery

(2014) Makiya Nishikawa et al.   JOURNAL OF CONTROLLED RELEASE

Large-scale de novo DNA synthesis: technologies and applications

(2014) Sriram Kosuri et al.   NATURE METHODS

A Writable Polypeptide-DNA Hydrogel with Rationally Designed Multi-modification Sites

(2014) Chuang Li et al.   Small

Quick-Response Magnetic Nanospheres for Rapid, Efficient Capture and Sensitive Detection of Circulating Tumor Cells

(2013) Cong-Ying Wen et al.   ACS Nano

Thermostable Branched DNA Nanostructures as Modular Primers for Polymerase Chain Reaction

(2013) Mark R. Hartman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An ultra-sensitive colorimetric detection of tetracyclines using the shortest aptamer with highly enhanced affinity

(2013) Young Seop Kwon et al.   CHEMICAL COMMUNICATIONS

c(RGDfK) decorated micellar drug delivery system for intravesical instilled chemotherapy of superficial bladder cancer

(2013) Danhua Zhou et al.   JOURNAL OF CONTROLLED RELEASE

Macromolecular Amplification of Binding Response in Superaptamer Hydrogels

(2013) Wei Bai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Target-Responsive “Sweet” Hydrogel with Glucometer Readout for Portable and Quantitative Detection of Non-Glucose Targets

(2013) Ling Yan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Responsive DNA-Based Hydrogels and Their Applications

(2013) Xiangling Xiong et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Switchable Catalytic Acrylamide Hydrogels Cross-Linked by Hemin/G-Quadruplexes

(2013) Chun-Hua Lu et al.   NANO LETTERS

Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets

(2013) Hyeun Joong Yoon et al.   Nature Nanotechnology

Advances in targeting cell surface signalling molecules for immune modulation

(2013) Sheng Yao et al.   NATURE REVIEWS DRUG DISCOVERY

C3 Rho-Inhibitor for Targeted Pharmacological Manipulation of Osteoclast-Like Cells

(2013) Andrea Tautzenberger et al.   PLoS One

Inertial Focusing for Tumor Antigen-Dependent and -Independent Sorting of Rare Circulating Tumor Cells

(2013) E. Ozkumur et al.   Science Translational Medicine

Aptamer-Functionalized Hydrogel Microparticles for Fast Visual Detection of Mercury(II) and Adenosine

(2012) Youssef Helwa et al.   ACS Applied Materials & Interfaces

Complex heterogeneous tissue constructs containing multiple cell types prepared by inkjet printing technology

(2012) Tao Xu et al.   BIOMATERIALS

Endonuclease-responsive aptamer-functionalized hydrogel coating for sequential catch and release of cancer cells

(2012) Shihui Li et al.   BIOMATERIALS

AS1411 aptamer tagged PLGA-lecithin-PEG nanoparticles for tumor cell targeting and drug delivery

(2012) Athulya Aravind et al.   BIOTECHNOLOGY AND BIOENGINEERING

Macroscopic Volume Change of Dynamic Hydrogels Induced by Reversible DNA Hybridization

(2012) Lu Peng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Programmable Hydrogels for Controlled Cell Catch and Release Using Hybridized Aptamers and Complementary Sequences

(2012) Zhaoyang Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Programmable Release of Multiple Protein Drugs from Aptamer-Functionalized Hydrogels via Nucleic Acid Hybridization

(2012) Mark R. Battig et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A mechanical metamaterial made from a DNA hydrogel

(2012) Jong Bum Lee et al.   Nature Nanotechnology

Bioinspired multivalent DNA network for capture and release of cells

(2012) W. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Splenocyte Apoptosis and Autophagy Is Mediated by Interferon Regulatory Factor 1 During Murine Endotoxemia

(2012) Lemeng Zhang et al.   SHOCK

High-Density, Multiplexed Patterning of Cells at Single-Cell Resolution for Tissue Engineering and Other Applications

(2011) Udi Vermesh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Affinity hydrogels for controlled protein release using nucleic acid aptamers and complementary oligonucleotides

(2011) Boonchoy Soontornworajit et al.   BIOMATERIALS

DNAzyme crosslinked hydrogel: a new platform for visual detection of metal ions

(2011) Haoxue Lin et al.   CHEMICAL COMMUNICATIONS

Colorimetric logic gates based on aptamer-crosslinked hydrogels

(2011) Bin-Cheng Yin et al.   CHEMICAL COMMUNICATIONS

Engineering DNA-based functional materials

(2011) Young Hoon Roh et al.   CHEMICAL SOCIETY REVIEWS

Improving the Stability of Aptamers by Chemical Modification

(2011) R. E. Wang et al.   CURRENT MEDICINAL CHEMISTRY

Design properties of hydrogel tissue-engineering scaffolds

(2011) Junmin Zhu et al.   Expert Review of Medical Devices

DNA-Mediated Assembly of Cytochrome P450 BM3 Subdomains

(2011) Michael Erkelenz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photo-Cross-Linking-Assisted Thermal Stability of DNA Origami Structures and Its Application for Higher-Temperature Self-Assembly

(2011) Arivazhagan Rajendran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Multi-hierarchical self-assembly of a collagen mimetic peptide from triple helix to nanofibre and hydrogel

(2011) Lesley E. R. O'Leary et al.   Nature Chemistry

Stabilization of DNA nanostructures by photo-cross-linking

(2011) Miho Tagawa et al.   Soft Matter

Self-Assembled DNA Hydrogels with Designable Thermal and Enzymatic Responsiveness

(2010) Yongzheng Xing et al.   ADVANCED MATERIALS

Semisynthetic DNA-Protein Conjugates for Biosensing and Nanofabrication

(2010) Christof M. Niemeyer   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Aptamer Cross-Linked Hydrogel as a Colorimetric Platform for Visual Detection

(2010) Zhi Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aptamer-Functionalized In Situ Injectable Hydrogel for Controlled Protein Release

(2010) Boonchoy Soontornworajit et al.   BIOMACROMOLECULES

PEG-Based Hydrogels with Collagen Mimetic Peptide-Mediated and Tunable Physical Cross-Links

(2010) Patrick J. Stahl et al.   BIOMACROMOLECULES

Biodegradable CpG DNA hydrogels for sustained delivery of doxorubicin and immunostimulatory signals in tumor-bearing mice

(2010) Makiya Nishikawa et al.   BIOMATERIALS

Hydrogel functionalization with DNA aptamers for sustained PDGF-BB release

(2010) Boonchoy Soontornworajit et al.   CHEMICAL COMMUNICATIONS

Regenerable DNA-Functionalized Hydrogels for Ultrasensitive, Instrument-Free Mercury(II) Detection and Removal in Water

(2010) Neeshma Dave et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A hybrid particle–hydrogel composite for oligonucleotide-mediated pulsatile protein release

(2010) Boonchoy Soontornworajit et al.   Soft Matter

Effect of Dynamic Stiffness of the Substrates on Neurite Outgrowth by Using a DNA-Crosslinked Hydrogel

(2010) Frank Xue Jiang et al.   TISSUE ENGINEERING PART A

Ligands for Mapping αvβ3-Integrin Expression in Vivo

(2009) Margret Schottelius et al.   ACCOUNTS OF CHEMICAL RESEARCH

Hydrogels in Regenerative Medicine

(2009) Brandon V. Slaughter et al.   ADVANCED MATERIALS

A pH-Triggered, Fast-Responding DNA Hydrogel

(2009) Enjun Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Self-Assembled Hydrogels from Poly[N-(2-hydroxypropyl)methacrylamide] Grafted with β-Sheet Peptides

(2009) Larisa C. Radu-Wu et al.   BIOMACROMOLECULES

The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells

(2009) Akhilesh Banerjee et al.   BIOMATERIALS

Rational design and application of responsive α-helical peptide hydrogels

(2009) Eleanor F. Banwell et al.   NATURE MATERIALS

Complexity in biomaterials for tissue engineering

(2009) Elsie S. Place et al.   NATURE MATERIALS

Peptide-directed self-assembly of hydrogels

(2008) Jindřich Kopeček et al.   Acta Biomaterialia

TLR9 as a key receptor for the recognition of DNA☆

(2008) Y KUMAGAI et al.   ADVANCED DRUG DELIVERY REVIEWS

Neurite Outgrowth on a DNA Crosslinked Hydrogel with Tunable Stiffnesses

(2008) Frank Xue Jiang et al.   ANNALS OF BIOMEDICAL ENGINEERING

Accessing the therapeutic potential of immunostimulatory nucleic acids

(2008) Winfried Barchet et al.   CURRENT OPINION IN IMMUNOLOGY

Engineering Target-Responsive Hydrogels Based on Aptamer−Target Interactions

(2008) Huanghao Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biomimetic materials for tissue engineering

(2007) Peter X. Ma   ADVANCED DRUG DELIVERY REVIEWS

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY