Article
Clinical Neurology
Joyce R. Chong, Nicholas J. Ashton, Thomas K. Karikari, Tomotaka Tanaka, Francis N. Saridin, Anthonin Reilhac, Edward G. Robins, Ying-Hwey Nai, Henri Vrooman, Saima Hilal, Henrik Zetterberg, Kaj Blennow, Mitchell K. P. Lai, Christopher P. Chen
Summary: The P-tau181/A beta 42 ratio may be an effective means of identifying Alzheimer's disease in non-White patient cohorts and patients with concomitant cerebrovascular disease.
ALZHEIMERS & DEMENTIA
(2021)
Review
Biochemistry & Molecular Biology
Jonah Gordon, Gavin Lockard, Molly Monsour, Adam Alayli, Cesario Borlongan
Summary: This review examines the potential effects and challenges of combining stem cell therapy and Nrf2 targeting treatment in stroke patients, emphasizing the need for further research on upstream and downstream pathways in optimizing Nrf2 treatments.
Article
Clinical Neurology
Min Young Chun, Hyemin Jang, Soo-Jong Kim, Yu Hyun Park, Jihwan Yun, Samuel N. Lockhart, Michael Weiner, Charles De Carli, Seung Hwan Moon, Jae Yong Choi, Kyung Rok Nam, Byung-Hyun Byun, Sang-Moo Lim, Jun Pyo Kim, Yeong Sim Choe, Young Ju Kim, Duk L. Na, Hee Jin Kim, Sang Won Seo
Summary: Alzheimer's disease (AD) is characterized by amyloid-beta accumulation, tau aggregation, and neurodegeneration. Vascular burden has synergistic effects on cognitive decline with AD biomarkers. The distribution and longitudinal outcomes of AT(N) categories differ according to vascular burden, emphasizing the importance of incorporating a vascular biomarker into the AT(N) system.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neurosciences
Karin L. Meeker, Omar H. Butt, Brian A. Gordon, Anne M. Fagan, Suzanne E. Schindler, John C. Morris, Tammie L. S. Benzinger, Beau M. Ances
Summary: CSF NfL is a non-specific marker of aging and white matter integrity, and is more strongly associated with total white matter hyperintensity volume than with gray or white matter volume. Age and white matter hyperintensity volume are consistently more important predictors of CSF NfL than AD markers.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Neurosciences
Jovana Drljaca, Natasa Milosevic, Maja Milanovic, Ludovico Abenavoli, Natasa Milic
Summary: The gut microbiota-brain axis is a communication network between gut microflora and the central and autonomic nervous system. Alterations in gut microbiota have been targeted for therapy in neurodegenerative and psychiatric diseases. Psychobiotics, through interaction with commensal gut bacteria, have beneficial effects on brain function and mental health, although their mechanism of action is not fully understood. This review summarizes the potential therapeutic effects of psychobiotics alone or in combination with conventional medicine in neurodegenerative diseases such as Alzheimer's and Parkinson's, as well as in psychiatric disorders such as depression, schizophrenia, and bipolar disorder, providing evidence from preclinical and clinical trials.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Lukas Sveikata, Andreas Charidimou, Anand Viswanathan
Summary: This article reviews the implications of aducanumab amyloid-beta immunotherapy for treating Alzheimer's disease with comorbid cerebral amyloid angiopathy. It discusses the potential impact of cerebral amyloid angiopathy on the effectiveness of immunotherapy and proposes strategies to identify it in patients considered for this treatment.
Article
Clinical Neurology
Prashanthi Vemuri, Charles Decarli, Marco Duering
Summary: This focused review provides an update on current magnetic resonance imaging methods for measuring cerebrovascular disease lesions and early cerebrovascular disease-related brain injury. It discusses the clinical implications and relevance of these imaging markers for cognitive decline, incident dementia, and disease progression in Alzheimer's disease and related dementias. The review also presents the outlook and challenges in the field.
Article
Pharmacology & Pharmacy
Michelle Melgarejo da Rosa, Manoela de Aguiar Ferreira, Crysvane Araujo de Oliveira Lima, Anna Claudia Santos Mendonca, Yasmim Meneses Silva, Muhammad Sharjeel, Moacyr Jesus Barreto de Melo Rego, Michelly Cristiny Pereira, Maira Galdino da Rocha Pitta
Summary: Alzheimer's disease is the leading neurological disorder in the elderly, with protein molecules called galectins potentially playing a crucial role in brain immunosurveillance and neuroprotection. Understanding the interaction between galectins and AD may lead to improved diagnostic and therapeutic strategies for this debilitating condition.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Psychology, Applied
Nancy Yi-Feng Chen, J. Michael Crant, Nan Wang, Yu Kou, Yuhong Qin, Junhua Yu, Rongju Sun
Summary: The global COVID-19 pandemic has significantly impacted healthcare professionals, but a proactive personality can help them better cope with the crisis, improve job performance, and well-being.
JOURNAL OF APPLIED PSYCHOLOGY
(2021)
Review
Geriatrics & Gerontology
Sarah Gregory, Hannah Pullen, Craig W. Ritchie, Oliver M. Shannon, Emma J. Stevenson, Graciela Muniz-Terrera
Summary: This systematic review evaluated the association between adherence to the Mediterranean diet (MedDiet) and hippocampal volume and white matter hyperintensity volume (WMHV). The results showed a link between the MedDiet and better cognitive performance, lower incidence of dementia, and lower Alzheimer's disease biomarker burden. However, the evidence on the association between the MedDiet and hippocampal volume or WMHV is still inconclusive.
EXPERIMENTAL GERONTOLOGY
(2023)
Review
Nutrition & Dietetics
Lorenzo Bertani, Davide Giuseppe Ribaldone, Massimo Bellini, Maria Gloria Mumolo, Francesco Costa
Summary: Nutrition plays a crucial role in the pathogenesis and treatment of inflammatory bowel diseases (IBD). Nutritional suggestions are important in correcting deficiencies in micro- and macro-nutrients, especially in severe cases of IBD.
Review
Medicine, General & Internal
Nicholas Aderinto, Deji Olatunji, Muili Abdulbasit, Mariam Edun
Summary: This review examines the role and effectiveness of neuroimaging techniques in diagnosing and managing cerebrovascular disease in Africa. CT, MRI, and Skull x-ray are the most commonly used neuroimaging techniques, playing a crucial role in diagnosing and managing cerebrovascular disease in Africa. However, challenges such as high cost, lack of trained personnel, and inadequate infrastructure limit the widespread use of neuroimaging in Africa.
ANNALS OF MEDICINE
(2023)
Article
Clinical Neurology
Dorothee Schoemaker, Andreas Charidimou, Maria Clara Zanon Zotin, Nicolas Raposo, Keith A. Johnson, Justin S. Sanchez, Steven M. Greenberg, Anand Viswanathan
Summary: This study found that memory impairment in patients with probable CAA may be associated with tau pathology, as indicated by cognitive dysfunction, reduced hippocampal volume, and increased tau-PET binding. Tau-PET retention and hippocampal volume were significant predictors of memory performance.
Article
Evolutionary Biology
Xiyun Jiao, Ziheng Yang
Summary: This study demonstrates that in the presence of cross-species gene flow, individuals of the same species may not necessarily be more genetically similar to each other than to individuals of another species. The research highlights the significant impact that gene flow can have on genetic history and suggests a novel approach for detecting reproductive barriers and defining species boundaries.
SYSTEMATIC BIOLOGY
(2021)
Editorial Material
Clinical Neurology
Jonathan K. Kleen, Kathryn A. Davis
Summary: Do transient bursts of interictal epileptiform activity have a clinically relevant effect on cognition? This study examines the impact of such bursts on cognitive impairment and reaction times. Scalp EEG has demonstrated focal effects of discharges within a particular hemisphere or lobe, while recent intracranial work has provided more functional-anatomic detail and mechanistic studies. However, most clinicians still hesitate to treat the interictal EEG without clear quantitative guidance.
Review
Biochemistry & Molecular Biology
M. T. Ciubuc-Batcu, N. J. C. Stapelberg, J. P. Headrick, G. M. C. Renshaw
Summary: The nervous system relies on mitochondria, and impaired mitochondrial function is associated with major depressive disorder. Modulating mitochondrial function may be a therapeutic target for treating MDD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Correction
Biochemistry & Molecular Biology
Saowaluk Saisomboon, Ryusho Kariya, Piyanard Boonnate, Kanlayanee Sawanyawisuth, Ubon Cha'on, Vor Luvira, Yaovalux Chamgramol, Chawalit Pairojkul, Wunchana Seubwai, Atit Silsirivanit, Sopit Wongkham, Seiji Okada, Sarawut Jitrapakdee, Kulthida Vaeteewoottacharn
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Pavan Thapak, Zhe Ying, Victoria Palafox-Sanchez, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla
Summary: Traumatic brain injury (TBI) impairs cellular energy demand, compromising neuronal function and plasticity. This study demonstrates that the mitochondrial activator humanin (HN) can counteract the reduction in mitochondrial bioenergetics caused by TBI, restore memory function and synaptic protein levels, and suppress inflammation and astrocyte proliferation. HN plays an integral role in normalizing fundamental aspects of TBI pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Paul Murphy, Valeria A. Buzinova, Carrie E. Johnson
Summary: Progress has been made in the treatment of Alzheimer's disease through the development of anti-A beta therapeutics, which have shown modest efficacy in slowing the progression of the disease. However, the puzzling issue remains as to why completely removing A beta does not fully stop the disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Mengxin Li, Xuanzhong Wang, Xuyang Chen, Jinghui Hong, Ye Du, Dong Song
Summary: Pancreatic adenocarcinoma (PAAD) is a common digestive malignant tumor with limited treatment options. This study demonstrates that TGM2 may serve as a marker for treatment and prognosis in pancreatic cancer patients. Co-treatment of low dose cisplatin (DDP) and the TGM2 inhibitor GK921 effectively inhibits PAAD cell viability and proliferation in vitro and in vivo, by inhibiting epithelial-to-mesenchymal transition (EMT) induced by TGM2 and enhancing cell cycle arrest and apoptosis caused by DDP. These findings suggest that the combination of GK921 and DDP holds promise as a treatment for PAAD patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Liaoran Niu, Qi Wang, Fan Feng, Wanli Yang, Zhenyu Xie, Gaozan Zheng, Wei Zhou, Lili Duan, Kunli Du, Yiding Li, Ye Tian, Junfeng Chen, Qibin Xie, Aqiang Fan, Hanjun Dan, Jinqiang Liu, Daiming Fan, Liu Hong, Jian Zhang, Jianyong Zheng
Summary: This review provides a comprehensive summary of the interaction between cancer cells and macrophages in the tumor microenvironment, and discusses the role of small extracellular vesicles (sEVs) in this process. It also explores the various effects of macrophage-secreted sEVs on tumor malignant transformation, and addresses the therapeutic advancements and challenges associated with these vesicles.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Neha Sawant, Sudhir Kshirsagar, P. Hemachandra Reddy, Arubala P. Reddy
Summary: Depression is a common neuropsychiatric comorbidity in Alzheimer's disease (AD) and other Tauopathies. Selective serotonin reuptake inhibitor (SSRI) treatment, such as Citalopram, not only has anti-depressive and anxiolytic effects, but also helps improve neurogenesis, reduce amyloid burden & Tau pathologies, and neuroinflammation in AD. In this study, Citalopram was found to reduce pathologically pTau level, increase synaptic gene expression and cytoskeletal structure, as well as improve cell survival, mitochondrial respiration, and mitochondrial morphology in cells expressing mutant APP and Tau. These findings suggest that Citalopram could be a promising therapeutic drug for treating depression and AD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Chen, Jiulin Tan, Chuan Yang, Zhiguo Ling, Jianzhong Xu, Dong Sun, Fei Luo
Summary: Bone is a self-healing organ that undergoes continuous regeneration through the cooperation of osteoclasts and osteoblasts. This study used ATAC-seq and RNA-Seq techniques to investigate the chromatin accessibility and transcriptomic landscape of osteoblast differentiation and mineralization. The results showed that global chromatin accessibility was extensively improved during osteoblastogenesis. Additionally, several transcription factors including MEF2A, PRRX1, Shox2, and HOXB13 were found to modulate the promoter accessibility of target genes during osteoblast differentiation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang
Summary: The study demonstrates that BCAA metabolism is involved in the development of colorectal cancer (CRC). BCAT2 deficiency promotes CRC progression by inhibiting BCAA metabolism and chronically activating the mTORC1 pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Chao Zheng, Lingling Liu, Caiyun Liu, Fengna Chu, Yue Lang, Shan Liu, Yan Mi, Jie Zhu, Tao Jin
Summary: Inducing tolerogenic dendritic cells (tDCs) with low RelB expression could effectively alleviate symptoms and reduce immune cell infiltration and demyelination in experimental autoimmune encephalomyelitis (EAE) mouse model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Hang Lam Li, Simei Go, Jung-Chin Chang, Arthur Verhoeven, Ronald Oude Elferink
Summary: This review highlights the distinct characteristics and crucial role of soluble adenylyl cyclase (sAC) in cellular processes, as well as recent significant advancements in the field of sAC research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Seco-Cervera, D. Ortiz-Masia, D. C. Macias-Ceja, S. Coll, L. Gisbert-Ferrandiz, J. Cosin-Roger, C. Bauset, M. Ortega, B. Heras-Moran, F. Navarro-Vicente, M. Millan, J. V. Esplugues, S. Calatayud, M. D. Barrachina
Summary: The study revealed the presence of resistance to apoptosis in complicated ileal Crohn's disease, with PDGFB inducing an ETS1-mediated resistance to apoptosis associated with an inflammatory and fibrogenic pattern of expression in intestinal fibroblasts. Potential targets against ileal fibrosis include PDGFRB, IL1R1, or MCL1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yunmeng Wang, Ping Cheng
Summary: Oncolytic viruses (OVs) are emerging as therapeutically relevant anticancer agents, especially when combined with genetically modified bispecific T cell engagers (BiTEs). This combination strategy can overcome the limitations of BiTEs alone and provide targeted cytotoxicity to solid tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Stephanie Tannous, Hassan Y. Naim
Summary: Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder caused by variants in the SI gene. A frameshift mutation called c.273_274delAG (p.Gly92Leufs*8) has been identified in CSID patients in Greenlandic population, which leads to loss of digestive function of SI. Surprisingly, the truncated mutant can still be located on the cell surface and interacts with wild type SI, negatively affecting its enzymatic function. Furthermore, heterozygote carriers of this mutation may also exhibit CSID symptoms.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)