Article
Environmental Sciences
John D. Hansen, Keith A. Loftin, Zachary Laughrey, Ondrej Adamovsky
Summary: Various stressors can have profound impacts on immunity to pathogens, with little research into the effects of cyanobacterial toxins on disease resistance in mammals. Recent studies suggest that freshwater cyanotoxins may alter disease susceptibility parameters for fish, wildlife, and human health through interaction with specific components of innate immunity. However, the results of this study indicate that the tested toxins did not directly interact with key pathogen recognition receptors for innate immunity in humans.
Article
Veterinary Sciences
Kai Ning Ma, Yao Zhang, Zhao Yu Zhang, Bo Ning Wang, Yan Yan Song, Lu Lu Han, Xin Zhuo Zhang, Shao Rong Long, Jing Cui, Zhong Quan Wang
Summary: This study demonstrates that Tsgal protein binds to TLR-4 and activates an inflammatory pathway, mediating the invasion of T. spiralis larvae in the gut. These findings suggest that Tsgal could be a potential molecular target for a vaccine against the enteral invasive stage of T. spiralis.
VETERINARY RESEARCH
(2023)
Review
Cell Biology
Valerie Lannoy, Anthony Cote-Biron, Claude Asselin, Nathalie Rivard
Summary: Phosphatases are important regulators of TLRs signaling and may represent novel therapeutic targets to control pathogenic TLRs signaling.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Endocrinology & Metabolism
Zixi Chen, Jinpeng Li, Wenjuan Xu, Xiaomei Wu, Fenfen Xiang, Xiaoxiao Li, Mengzhe Zhang, Jin Zheng, Xiangdong Kang, Rong Wu
Summary: The study found that TLR4 expression on CD14+ maternal blood monocytes was significantly higher in the third trimester compared to the first and second trimesters. Maternal serum concentrations of TLR4 and cytokines were significantly higher in the term labor group compared to the term non-labor group.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiaodi Zhang, Zhengfang Sun, Ying Zhang, Liuzhu Pan, Wei Jiang, Hui Dong, Zhengxin Jin, Jianning Kang, Ronghan Liu, Bin Ning
Summary: This study demonstrates that Periplocin can reduce inflammation and attenuate bone resorption in osteoporosis by inhibiting MAPK and NF-kappa B signaling pathways. It also exerts anti-inflammatory and anti-osteoclastic effects by binding to LRP4. These findings provide new possibilities for the treatment of osteoporosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Ophthalmology
Chun-Chieh Lai, Sung-Huei Tseng, Sheng-Min Hsu, Yin-Ting Huang, Chi-Chang Shieh
Summary: The study demonstrated that UVB exposure may lead to pterygium formation through the expression of TLR3 and activation of NF-kappa B.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Veterinary Sciences
Yang Chen, Zebu Song, Hao Chang, Yanchen Guo, Zhi Wei, Yankuo Sun, Lang Gong, Zezhong Zheng, Guihong Zhang
Summary: African swine fever (ASF) caused by ASF virus (ASFV) infection poses a significant threat to the pork industry, and there is an urgent need to develop strategies to prevent its spread. In this study, a natural flavonoid, dihydromyricetin (DHM), was identified as the compound with the strongest anti-ASFV activity. DHM not only inhibited ASFV replication but also showed broad-spectrum antiviral effects against other viruses. The mechanism of action of DHM involved inhibiting inflammatory mediators and reactive oxygen species accumulation, ultimately suppressing pyroptosis. Targeting the TLR4 signaling pathway was found to be effective in inhibiting ASFV replication.
VETERINARY RESEARCH
(2023)
Article
Environmental Sciences
Wisurumuni Arachchilage Hasitha Maduranga Karunarathne, Ilandarage Menu Neelaka Molagoda, Yung Hyun Choi, Sang Rul Park, Seungheon Lee, Gi-Young Kim
Summary: Low concentrations of BPA induce inflammation by activating the NF-kappa B signaling pathway and increasing the release of proinflammatory mediators. Molecular modeling suggests that BPA binds to the TLR4/MD2 complex to initiate downstream molecules and elicit an immune response.
ENVIRONMENTAL POLLUTION
(2021)
Article
Medicine, Research & Experimental
Kaveri M. Adki, Yogesh A. Kulkarni
Summary: The study demonstrated that Paeonol can effectively lower blood glucose levels in diabetic rats and alleviate mechanical and thermal hypersensitivity caused by neuropathy. Additionally, Paeonol also improved nerve conduction velocity, reduced oxidative stress, and prevented neuronal damage in the sciatic nerve.
Article
Pharmacology & Pharmacy
Yingying Chen, Dongyue Li, Liying Sun, Kai Qi, Lijun Shi
Summary: This study aimed to evaluate the effect and mechanism of toll-like receptor 4 (TLR4) inhibitor TLR4-IN-C34 on gut microbiota in mice with ulcerative colitis (UC). The results showed that TLR4-IN-C34 partially improved dysbiosis of intestinal flora, inflammatory infiltration, oxidative stress, and intestinal barrier function in UC mice.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Dahu Qi, Hui Liu, Xuying Sun, Danni Luo, Meipeng Zhu, Tenghui Tao, Chenghao Gao, Chuankun Zhou, Wei Zhou, Jun Xiao
Summary: Pristimerin exerts potential therapeutic effects on osteoporosis by inhibiting NF-kappa B and MAPK signaling pathways, reducing ROS production, activating Nrf2/HO-1 signaling pathway, and affecting osteoclast differentiation and function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Guobin Qi, Zengxin Jiang, Wei Lu, Defang Li, Weibing Chen, Xiuying Yang, Lei Ding, Hengfeng Yuan
Summary: Berbamine, a natural product from Berberis amurensis Rupr, was found to have a protective effect against osteoporosis by inhibiting osteoclastogenesis and bone resorption without affecting osteogenesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yushun Cui, Hongwei Gao, Shan Han, Renyikun Yuan, Jia He, Youqiong Zhuo, Yu-Lin Feng, Meiwen Tang, Jianfang Feng, Shilin Yang
Summary: This study found that oleuropein significantly reduces the expression of inflammatory mediators and inhibits key proteins in inflammatory pathways. It plays an important role in binding to TLR4, inhibiting TLR4 dimerization, and suppressing the binding of TLR4 to MyD88. Oleuropein has a notable therapeutic effect on LPS-induced acute kidney injury in vivo, reducing serum creatinine and blood urea nitrogen levels, as well as proinflammatory cytokines.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wei Liu, Hao Zhang, Yun-yi Hou, Rui-yi Hu, Jun-jie Zhang, Xuan Chen, Shuang Wang, Jun-nan Hu, Zi Wang, Wei Li
Summary: This study evaluates the protective effects of arginyl-fructosyl-glucose (AFG), a major Maillard reaction product of red ginseng, against cisplatin-induced intestinal toxicity. The results showed that AFG can alleviate cisplatin-induced gastrointestinal damage and inhibit cell apoptosis by regulating the Wnt/beta-catenin signaling pathway.
Article
Biochemistry & Molecular Biology
Donghui Bai, Tianxiao Sun, Fang Lu, Yancheng Shen, Yan Zhang, Bo Zhang, Guangli Yu, Haihua Li, Jiejie Hao
Summary: The study showed that Eupatilin can attenuate the inflammatory response in OVA-induced asthma by regulating NF-kappa B, MAPK, and Nrf2 signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Abril Alondra Barrientos-Bonilla, Paola Belem Pensado-Guevara, Abraham Puga-Olguin, Rasajna Nadella, Aurora del Carmen Sanchez-Garcia, Laura Mireya Zavala-Flores, Arnulfo Villanueva-Olivo, Iliana Tamara Cibrian-Llanderal, Maria de Jesus Rovirosa-Hernandez, Daniel Hernandez-Baltazar
Summary: This study evaluated the impact of BrdU on liver function and found that multiple injections of BrdU did not induce hepatocellular damage.
Article
Cell Biology
Pan Zhang, Qun Feng, Wenxiao Chen, Xizhuang Bai
Summary: It was found that catalpol antagonizes LPS-mediated inflammation and suppressive osteoblast differentiation by inhibiting inflammation and promoting osteoblast differentiation. This finding contributes to a better understanding of the pathogenesis of osteoporosis.