Article
Chemistry, Analytical
Xiao Hu, Zijuan Hai, Chengfan Wu, Wenjun Zhan, Gaolin Liang
Summary: In this study, a Golgi-targeting and dual-color Turn-On probe Q-RVRR-DCM was developed for accurate detection of cancer-related enzyme activity. The probe exhibited high spatial precision and dual fluorescence color activation upon furin cleavage, with superior colocalization with a Golgi tracker. This furin probe has the potential to be applied in early cancer diagnosis due to its excellent properties.
ANALYTICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Fenglin Li, Yi Lai, Jiayi Ye, Madiha Saeed, Yijing Dang, Zhifeng Zou, Fangmin Chen, Wen Zhang, Zhiai Xu
Summary: The study presents a dual-targeting nanotheranostic for precise photo-immunotherapy of glioblastoma (GBM). The nanotheranostic can deliver drugs to the tumor site and induce a photothermal effect, enhancing the therapeutic effect.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Multidisciplinary
Faustine d'Orchymont, Jason P. Holland
Summary: We synthesized and characterized bimodal mechanically interlocked rotaxane-based imaging agents using the cucurbit[6]uril CB[6]-mediated alkyne-azide 'click' reaction. Two synthetic routes involving four- or six-component reactions were developed to access asymmetric rotaxanes. A peptide-based rotaxane targeted toward the clinical prostate cancer biomarker, prostate-specific membrane antigen (PSMA), was synthesized with Ga-68-radiometal ion complex for positron emission tomography and fluorescein as an optically active imaging agent. The results showed the feasibility of using an asymmetric rotaxane platform to produce dual-modality imaging agents specifically targeting prostate cancer cells.
COMMUNICATIONS CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Shuping Xu, Ying Liu, Zhou Wang, Aolin He, Guofan Jin
Summary: In this study, fluorescence probes with anti-tumor activity were developed by introducing pyrimidine groups with high anti-tumor activity into the parent nucleus of BODIPY. These probes exhibited strong fluorescence and photosensitivity, and showed high biocompatibility and photostability for localizing to cancer cells. In vivo imaging in mice confirmed the specific localization and real-time visualization of tumor cells, while in vitro cytotoxicity experiments and molecular docking simulations supported the potential of these probes as anticancer agents.
FRONTIERS IN CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Rajakar Selvam, Ashish Gandhi, Shih-Che Hung, Artashes V. Karmenyan, Elena Perevedentseva, Wang-Chi Yeh, Sheng-Yun Wu, Hsin-Hou Chang, Chia-Liang Cheng
Summary: The study utilized magnetic nanodiamond particles as an efficient drug delivery vehicle, conjugated with human serum albumin to improve dispersion in biological medium and facilitate controlled release of drugs. Results showed that when loaded with clinical drug, the particles exhibited significantly improved effectiveness against cancer cells when exposed to a magnetic field.
DIAMOND AND RELATED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Thinzar M. Lwin, Michael A. Turner, Hiroto Nishino, Siamak Amirfakhri, Sophie Hernot, Robert M. Hoffman, Michael Bouvet
Summary: Tumor-specific targeting can be enhanced with fluorescent nanobodies, allowing for rapid localization and labeling of pancreatic cancer tumors. The fluorescence signal is durable, and both targeting and imaging can be performed on the same day as surgery.
Article
Nanoscience & Nanotechnology
Bong Han Lee, Roberto Gonzalez-Rodriguez, Alina Valimukhametova, Olga Zub, Veronica Lyle, Olivia Fannon, Jingbiao Cui, Anton V. Naumov
Summary: In this study, highly biocompatible aluminum-doped graphene quantum dots (Al-GQDs) were developed as potential adjuvant delivery vehicles with dual-mode fluorescence and ultrasound imaging capabilities. The Al-GQDs showed promising results in terms of cell viability and pH-dependent fluorescence response. The multifunctional adjuvant-inspired system has the potential to advance vaccine research and development.
ACS APPLIED NANO MATERIALS
(2023)
Article
Optics
Dan Yao, Peter W. R. Connolly, Arran J. Sykes, Yash D. Shah, Claudio Accarino, James Grant, David R. S. Cumming, Gerald S. Buller, Stephen Mclaughlin, Yoann Altmann
Summary: This paper presents an experimental demonstration of a Bayesian image reconstruction approach for rapid single-photon color imaging of moving objects. The authors address the challenges of efficient spectral separation and high-speed image reconstruction in low-photon flux environments using hardware and computational solutions.
Article
Chemistry, Multidisciplinary
Sai S. Sunku, Dorri Halbertal, Rebecca Engelke, Hyobin Yoo, Nathan R. Finney, Nicola Curreli, Guangxin Ni, Cheng Tan, Alexander S. McLeod, Chiu Fan Bowen Lo, Cory R. Dean, James C. Hone, Philip Kim, D. N. Basov
Summary: Graphene-based heterostructures present a variety of phenomena tunable by electrostatic local gates. While monolayer graphene exhibits tunable surface plasmon polaritons, bilayer graphene may display unique plasmonic effects such as plasmon amplification and domain wall plasmons. These effects are highly sensitive to displacement fields and have potential applications in nano-optics.
Article
Cardiac & Cardiovascular Systems
Qimin Wu, Wei Pan, Guifu Wu, Fensheng Wu, Yousheng Guo, Xinxia Zhang
Summary: This study aimed to design a CD40-targeted MRI/optical multimodal molecular imaging probe and explore its ability to detect and target vulnerable atherosclerotic plaques. The results showed that CD40-Cy5.5-SPIONs had the ability to bind specifically to macrophages and smooth muscle cells. Fluorescence imaging results demonstrated a stronger fluorescence signal in the atherosclerotic group injected with CD40-Cy5.5-SPIONs compared to the control group and the group injected with non-specific BSA-Cy5.5-SPIONs. T2-weighted imaging showed a significant T2 contrast enhancement effect in the carotid arteries of atherosclerotic mice injected with CD40-Cy5.5-SPIONs.
Article
Engineering, Electrical & Electronic
Qiang Li, Xianming Liu, Junjun Jiang, Cheng Guo, Xiangyang Ji, Xiaolin Wu
Summary: This paper introduces a novel technique of deep autofocusing for whole slide imaging (WSI) in digital pathology. The deep autofocusing network (DAFNet) works with only two images taken at different focal distances, reducing the cost and time compared to traditional methods that require capturing a stack of images with varying focal distances for each tile of the target image. The experimental results demonstrate the refocusing capability of the DAFNet method.
IEEE TRANSACTIONS ON COMPUTATIONAL IMAGING
(2021)
Article
Oncology
Xianyu Chen, Yongsheng Tang, Donghao Wu, Ruixi Li, Zhiqun Lin, Xuhui Zhou, Hezhen Wang, Hang Zhai, Junming Xu, Xianjie Shi, Guangquan Zhang
Summary: This study highlights the potential of integrating FOXM1 expression and radiomics in understanding the complexity of hepatocellular carcinoma (HCC). The researchers found that overexpression of FOXM1 is a determinant of poor prognosis in HCC and has an impact on immune cell infiltration. They developed a radiomics score to predict FOXM1 expression non-invasively and create a nomogram for predicting survival probabilities. Further research is needed to validate these findings and explore their clinical implications in HCC management.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Physical
Ruixiang Wu, Xiaoshuai Wang, Jingjing Luo, Xin Liu, Bin Li, Shengzhi Wang, Liu-Yong Cheng, Xiangyang Miao
Summary: The combination of doped quantum dots and graphene oxide results in QD-GO composites with enhanced light absorption properties, improving the energy transfer efficiency between QDs and GO. Moreover, increasing the concentration and reduction degree of GO can enhance the electron population of defect states of QDs.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Biochemistry & Molecular Biology
Shan-Shan Wang, Shao-Ying Du, Xu He, Yu-Ming Qi, Xiao-Li Li, Rui-Xue Rong, Zhi-Ran Cao, Ke-Rang Wang
Summary: This study designed and synthesized a series of modified naphthalimide derivatives, and found that different modifications had varying effects on cytotoxicity. The nucleus-targeting effects were shown to have a significant impact on cytotoxicity, DNA binding interactions, and cell cycle progression.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Analytical
Jing Wang, Ruiyuan Zhang, Xiaoting Ji, Peipei Wang, Caifeng Ding
Summary: A dual-selective recognition and multi-enhanced SERS-fluorescence detection platform was designed for circulating tumor cells (CTCs), utilizing aptamers and anti-EpCAM for improved selectivity; the released CTCs were detected using SERS and fluorescence with good linear relationships.
ANALYTICA CHIMICA ACTA
(2021)