Article
Infectious Diseases
Celia Llamazares, Natalia Sanz del Olmo, Juan Soliveri, F. Javier de la Mata, Jose Luis Copa-Patino, Sandra Garcia-Gallego
Summary: The study explores the impact of structural parameters on the antibacterial activity against Staphylococcus aureus biofilms by synthesizing and analyzing new generations of metal dendrimers. Results indicate that certain substituents can decrease the overall positive charge on the metal ion, reducing activity against planktonic bacteria. However, these substituents may contribute to increasing overall lipophilicity, which could be relevant for preventing biofilm formation.
Article
Polymer Science
Ekaterina M. Zubanova, Tatiana A. Ivanova, Evgenii A. Ksendzov, Sergei Kostjuk, Peter S. Timashev, Mikhail Ya Melnikov, Elena N. Golubeva
Summary: This study investigated the coil-to-globule transition and dynamics of inhomogeneities in aqueous solutions of graft copolymers with different contents of oligolactide groups using EPR spectroscopy. It was found that an increase in oligolactide content leads to the formation of looser globules, allowing for the exchange of probe molecules between the globules and the external solution.
Article
Chemistry, Multidisciplinary
Santina S. Cruz, Vadim Tanygin, Benjamin J. Lear
Summary: Using electron spin resonance spectroscopy, it has been demonstrated that morphological asymmetries in small spheroidal metallic nanoparticles significantly affect the electronic behavior of states near the metal's Fermi energy. The study found that morphological effects were more important than size distributions in explaining the asymmetry in electronic behavior, and this was consistent across various particles made from different metals. Additionally, the study also showed that morphological changes can tune the electronic properties of even small particles, as evidenced by the modeling used to explain asymmetries in both electron spin resonance spectra and plasmon spectra.
Article
Chemistry, Multidisciplinary
Sujit Das, Valentyn Laguta, Katherine Inzani, Weichuan Huang, Junjie Liu, Ruchira Chatterjee, Margaret R. McCarter, Sandhya Susarla, Arzhang Ardavan, Javier Junquera, Sinead M. Griffin, Ramamoorthy Ramesh
Summary: Solid-state materials are being explored as a platform for spin manipulation and quantum information science, and ferroelectric materials provide an alternative method to explore spin quantum phenomena. Experimental results using a model system demonstrate the intrinsic spin-polarization control of spins in complex ferroelectric vortex structures.
Article
Chemistry, Physical
Andrea Cantelli, Paola Franchi, Elisabetta Mezzina, Marco Lucarini
Summary: Electron paramagnetic resonance (EPR) and spin probe methodologies were used to study the complexation properties of cyclodextrins (CDs) and cucurbit[n]urils (CB[n]s) in the deep eutectic solvent (DES) choline chloride-urea. The results showed that similar affinity constants to those measured in water were obtained in DES.
Article
Chemistry, Multidisciplinary
Luana C. de Camargo, Matteo Briganti, Francielli S. Santana, Danilo Stinghen, Ronny R. Ribeiro, Giovana G. Nunes, Jaisa F. Soares, Enrico Salvadori, Mario Chiesa, Stefano Benci, Renato Torre, Lorenzo Sorace, Federico Totti, Roberta Sessoli
Summary: The study demonstrates that the 17-electron mixed sandwich complex has a remarkable coherence time at low temperatures, making it ideal for surface single-qubit addressing and quantum sensing applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Physics, Applied
Mark A. Hughes, Naitik A. Panjwani, Matias Urdampilleta, Kevin P. Homewood, Ben Murdin, J. David Carey
Summary: Erbium implanted silicon as a quantum technology platform is compatible with both telecommunications and integrated circuit processing, with silicon materials at specific concentrations exhibiting long spin-related times. The spin echo decay profile shows strong modulation, primarily due to the super-hyperfine interaction between Er3+ and Si-29 nuclei.
APPLIED PHYSICS LETTERS
(2021)
Article
Materials Science, Multidisciplinary
K. Sonowal, D. V. Boev, A. V. Kalameitsev, V. M. Kovalev, I. G. Savenko
Summary: The band structure of monolayer MoS2 consists of spin-split subbands due to the presence of broken inversion symmetry and strong spin-orbit coupling. Surface acoustic waves induce strain-induced effective magnetic fields, leading to spin-flip transitions and the emergence of spin-acoustic resonance and acoustoelectric current. External magnetic fields break valley degeneracy and result in valley-selective splitting of spin-acoustic resonances in both surface acoustic wave absorption and acoustoelectric current.
Article
Polymer Science
Ekaterina M. Zubanova, Sergei Kostjuk, Peter S. Timashev, Yury A. Rochev, Alexander Kokorin, Mikhail Ya Melnikov, Elena N. Golubeva
Summary: The coil to globule transition in poly(N-isopropylacrylamide) aqueous solutions was investigated using CW EPR spectroscopy with TEMPO radical as a guest molecule. By using Cu(II) ions as quencher, individual spectra of TEMPO radicals in polymer globule were obtained, showing inhomogeneities in solutions before globule collapsing. EPR spectra simulations confirmed the formation of molten globules initially, followed by further collapsing and densification of the globules as water molecules were released.
Article
Chemistry, Physical
Ellyessa Nascimento Borges, Lais Alonso, Murilo Barros Silveira, Rodolfo Bento Balbinot, Celso V. Nakamura, Andre Luis Batista da Rocha, Evilanna Lima Arruda, Gabriel Franco dos Santos, Boniek G. Vaz, Christian Dias Gomides, Luciano Morais Liao, Ricardo Menegatti, Antonio Alonso
Summary: In this study, novel chalcone-like compounds were synthesized and evaluated for their activity against Leishmania (L.) amazonensis. The compounds showed varying potency against the parasite, with compound 4 being the most effective. Electron paramagnetic resonance spectroscopy revealed that the compounds induced membrane rigidity in a concentration-dependent manner. The compounds also exhibited high affinity for the parasite membrane, similar to the antileishmanial drug miltefosine.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Analytical
Hideo Utsumi, Toshiki Masumizu, Ryoma Kobayashi, Tomoko Tahira, Fuminori Hyodo, Tatsuya Shimizu, Tatsuya Naganuma, Kazunori Anzai
Summary: Free radicals are key substances in organisms but can also cause oxidative diseases. Dynamic nuclear polarization- magnetic resonance imaging is a noninvasive imaging method that can be used for in vivo free radical imaging.
ANALYTICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Z. Wang, L. Balembois, M. Rancic, E. Billaud, M. Le Dantec, A. Ferrier, P. Goldner, S. Bertaina, T. Chaneliere, D. Esteve, D. Vion, P. Bertet, E. Flurin
Summary: Electron spin resonance spectroscopy is the preferred method for characterizing paramagnetic impurities, but it only provides ensemble-averaged quantities due to limited signal-to-noise ratio. To achieve single-electron spin sensitivity, we use spin fluorescence detection method and a microwave photon counter at millikelvin temperatures. By coupling individual paramagnetic erbium ions in a scheelite crystal to a high-quality-factor planar superconducting resonator to enhance their radiative decay rate, we obtain a fluorescence signal with a signal-to-noise ratio of 1.9 in one second integration time. This method has the potential for single-spin detection in a volume as large as the resonator magnetic mode volume, making it orders of magnitude larger than other single-spin detection techniques.
Article
Chemistry, Physical
Takashi Kobayashi, Joseph Salfi, Cassandra Chua, Joost van der Heijden, Matthew G. House, Dimitrie Culcer, Wayne D. Hutchison, Brett C. Johnson, Jeff C. McCallum, Helge Riemann, Nikolay Abrosimov, Peter Becker, Hans-Joachim Pohl, Michelle Y. Simmons, Sven Rogge
Summary: Strong spin-orbit coupling systems allow for electrically controlled spin qubits, with electron-spin qubits having long coherence times suitable for quantum technologies. Ultra-long coherence times of 10 ms have been demonstrated for strain-engineered hole states bound to boron acceptors in bulk silicon 28, promising to greatly improve spin qubit scalability and functionality. These results open up new possibilities for developing artificial quantum systems and enhancing the functionality and scalability of spin-based quantum technologies.
Article
Multidisciplinary Sciences
Patryk Kuleta, Jonathan Lasham, Marcin Sarewicz, Iwona Ekiert, Vivek Sharma, Robert Ekiert, Artur Osyczka
Summary: This study identifies a dual role of hydrogen bonding in regulating the redox potential of heme in cytochrome bc1, which is essential for maintaining proper function of energy-conserving systems. By stabilizing this hydrogen bond, both the redox potential of the heme and its spin state can be influenced, potentially leading to changes in electron transfer rates and interactions with redox partners. These findings suggest a delicate balance between H-bond stability and heme-protein interactions in fine-tuning the redox properties of heme proteins.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Physical
Wern Ng, Shuyao Zhang, Hao Wu, Irena Nevjestic, Andrew J. P. White, Mark Oxborrow
Summary: This study focuses on the triplet spin dynamics of the charge-transfer co-crystal PNZ/TCNB, revealing decay times in the sub-microsecond regime. Additionally, with the assistance of a dielectric cavity, PNZ/TCNB can output a laser burst at room temperature and zero field, showing potential for maser applications in other charge-transfer co-crystals with similar triplet spin dynamics.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Biochemistry & Molecular Biology
Sara Quintana-Sanchez, Natalia Gomez-Casanova, Javier Sanchez-Nieves, Rafael Gomez, Jaroslaw Rachuna, Slawomir Wasik, Jacek Semaniak, Barbara Maciejewska, Zuzanna Drulis-Kawa, Karol Ciepluch, F. Javier de la Mata, Michal Arabski
Summary: The search for new microbicides against biofilm-forming bacteria is urgent. Cationic multivalent dendrimers have potential as antibacterials and carriers of active molecules. This study evaluated the antimicrobial activity of cationic carbosilane (CBS) dendrimers, with and without modification with polyethylene glycol (PEG), against planktonic and biofilm-forming P. aeruginosa culture. The presence of PEG reduced antibacterial activity, but combining the CBS dendrimers with endolysin improved the antimicrobial effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Sarah Tassinari, Silvia Moreno, Hartmut Komber, Riccardo Carloni, Michela Cangiotti, Maria Francesca Ottaviani, Dietmar Appelhans
Summary: This study demonstrates the potential of glycodendrimers and oligopeptides in inhibiting the formation of immunocomplexes and breaking down preformed immunocomplexes in Systemic Lupus Erythematosus (SLE). The 3(rd) generation poly(propyleneimine) (PPI) dendrimer exhibits the most promising anti-SLE activity.
Article
Chemistry, Physical
Sergio E. Dominguez, Antti Vuolle, Alberto Fattori, Timo Aaritalo, Michela Cangiotti, Pia Damlin, M. Francesca Ottaviani, Carita Kvarnstrom
Summary: This study investigates the effect of O-alkylation proximity on the hydrogen bonding capabilities of alkoxy-CPTs. The results show that a closer proximity of O-alkylation strengthens the hydrogen bonding capabilities of the CPTs. The study also highlights the influence of solvent conditions and side chain lengths on the morphology and surface free energy of the CPTs.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Pharmacology & Pharmacy
Francisco Javier de la Mata, Paula Ortega, Sandra Garcia-Gallego
Article
Geochemistry & Geophysics
Michele Mattioli, Paolo Ballirano, Alessandro Pacella, Michela Cangiotti, Fulvio Di Lorenzo, Laura Valentini, Maria Assunta Meli, Carla Roselli, Ivan Fagiolino, Matteo Giordani
Summary: This study investigates the morphology, crystal structure, chemistry, and surface activity of fibrous ferrierite found in northern Italy using various analytical techniques. The results show that these fibers are breathable, able to reach the alveolar space, and have a high ability to adsorb and interact with chemicals. Fibrous ferrierite can be considered a potential health hazard, requiring precautionary measures.
Article
Chemistry, Multidisciplinary
Christopher M. Brown, David J. Lundberg, Jessica R. Lamb, Ilia Kevlishvili, Denise Kleinschmidt, Yasmeen S. Alfaraj, Heather J. Kulik, Maria Francesca Ottaviani, Nathan J. Oldenhuis, Jeremiah A. Johnson
Summary: This study introduces a modular heterogeneous catalysis platform that immobilizes catalysts onto supports to improve recyclability and efficiency. The approach utilizes self-assembled metal-organic cages/polyhedra to create well-defined catalyst-functionalized junctions, resulting in nanoconfined catalyst domains.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Physical
Riccardo Carloni, Maria Francesca Ottaviani, Mario Ficker, Jorn B. Christensen
Summary: The study analyzed the interactions between differently functionalized PAMAM dendrimers and model membranes. The results showed that acetamide- and pyrrolidone-dendrimers can be used as good alternatives to amino-dendrimers for drug delivery.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Pharmacology & Pharmacy
Philipp F. Popp, Tania Lozano-Cruz, Franziska Duerr, Addis Londaitsbehere, Johanna Hartig, Francisco Javier de la Mata, Rafael Gomez, Thorsten Mascher, Ainhoa Revilla-Guarinos
Summary: The threat of antimicrobial-resistant bacteria is increasing, but the development of new therapeutic countermeasures has stopped. Carbosilane dendritic systems with antimicrobial properties can be used as synthetic molecules for therapeutics. The bow-tie topology of BDTL049 has strong bactericidal properties against Bacillus subtilis. In this study, a fluorescent-labeled version of BDTL049 was synthesized to study its interaction with bacterial membrane, and a mutational study of known resistance determinants was conducted. The compound also showed high cytotoxicity in human cells. These insights highlight the potential and challenges of BDTL049 as an antimicrobial agent.
Article
Chemistry, Physical
Judith Recio-Ruiz, Riccardo Carloni, Srivathsan Ranganathan, Laura Munoz-Moreno, Maria Jose Carmena, Maria Francesca Ottaviani, Francisco Javier de la Mata, Sandra Garcia-Gallego
Summary: Carbosilane dendrimers are used for the first time to generate functional hydrogels with amphiphilic properties for biomedical applications. The controlled synthesis and lipophilicity of these dendrimers enable precise control of the network and compatibility with poorly soluble drugs. The study demonstrates the impact of the carbosilane dendritic nanodomains on drug encapsulation and release, and shows the effectiveness of curcumin-loaded hydrogels against advanced prostate cancer cells. The dendritic hydrogels also achieve controlled release of ibuprofen through fluoride-promoted esterification.
CHEMISTRY OF MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Marcin Holota, Sylwia Michlewska, Sandra Garcia-Gallego, Natalia Sanz del Olmo, Paula Ortega, Maria Bryszewska, Francisco Javier de la Mata, Maksim Ionov
Summary: Copper carbosilane metallodendrimers were conjugated with conventional anticancer drugs and showed enhanced effectiveness against cancer cells. The combination therapy significantly decreased cancer cell viability and induced apoptosis and necrosis. The presence of copper ions in the dendrimer structures enhanced the anticancer properties of the whole nanosystem.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Elzbieta Okla, Piotr Bialecki, Marta Kedzierska, Elzbieta Pedziwiatr-Werbicka, Katarzyna Milowska, Samuel Takvor, Rafael Gomez, Francisco Javier de la Mata, Maria Bryszewska, Maksim Ionov
Summary: Drug delivery systems such as dendrimers, liposomes, polymers or gold/silver nanoparticles could advance modern medicine by overcoming biological barriers. This study evaluated the biophysical properties and biological safety of pegylated gold nanoparticles complexed with therapeutic siRNA against APOE4. The results showed that the complexes were stable and non-toxic to healthy cells, suggesting their potential use in delivering nucleic acids and treating neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Faridah Namata, Natalia Sanz del Olmo, Lars Wagberg, Michael Malkoch
Summary: This study aimed to fabricate electrostatically cross-linked hybrid hydrogels by combining structurally perfect cationic polyester dendrimers with anionic cellulose nanofibrils. The self-assembly process resulted in well-organized and self-supporting hydrogels with high water content and storage modulus similar to skin tissue. The antibacterial activity and cytotoxicity of the hydrogels were evaluated, and one hydrogel showed promising antibacterial activity without toxicity.
CHEMISTRY OF MATERIALS
(2023)
Review
Engineering, Biomedical
Almudena Naharros-Molinero, Maria angela Caballo-Gonzalez, F. Javier de la Mata, Sandra Garcia-Gallego
Summary: This article provides an overview of the important factors related to the manufacturing and stability of soft gelatin capsules, as well as the use of mechanical and thermal techniques in characterizing and evaluating their properties.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Natalia Sanz del Olmo, Juan Carlos Garcia, Rafael Gomez, F. Javier de la Mata, Paula Ortega
Summary: Reactive oxygen species (ROS) play a critical role in human pathophysiological processes, and redox-active groups such as polyphenols are involved in maintaining intracellular redox homeostasis. In this study, a new family of first-generation carbosilane dendrons functionalised with polyphenols at the focal point and dimethylammonium groups at the periphery was successfully synthesized using two strategies. Their antioxidant activity was evaluated using spectrophotometric methods, and a correlation between the number of hydroxyl groups and antioxidant activity was established.