Single Domain Antibody-Mediated Blockade of Programmed Death-Ligand 1 on Dendritic Cells Enhances CD8 T-cell Activation and Cytokine Production

Broadening the Message: A Nanovaccine Co-loaded with Messenger RNA and α-GalCer Induces Antitumor Immunity through Conventional and Natural Killer T Cells

(2019) Rein Verbeke et al.   ACS Nano

Evaluating a Single Domain Antibody Targeting Human PD-L1 as a Nuclear Imaging and Therapeutic Agent

(2019) Broos et al.   Cancers

Optimal Evaluation of Programmed Death Ligand-1 on Tumor Cells Versus Immune Cells Requires Different Detection Methods

(2018) Kelly A. Schats et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Dendritic Cell–Based Cancer Vaccines

(2018) Patricia M. Santos et al.   JOURNAL OF IMMUNOLOGY

A versatile T cell-based assay to assess therapeutic antigen-specific PD-1-targeted approaches

(2018) Maarten Versteven et al.   Oncotarget

Dendritic Cells and Programmed Death-1 Blockade: A Joint Venture to Combat Cancer

(2018) Maarten Versteven et al.   Frontiers in Immunology

Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety

(2018) Kevin Van der Jeught et al.   ACS Nano

Non-invasive assessment of murine PD-L1 levels in syngeneic tumor models by nuclear imaging with nanobody tracers

(2017) Katrijn Broos et al.   Oncotarget

Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab

(2017) Shuguang Tan et al.   Protein & Cell

PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome

(2017) Hashem O. Alsaab et al.   Frontiers in Pharmacology

Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade

(2017) Fei Zhang et al.   Cell Discovery

Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy

(2016) Kefang Liu et al.   CELL RESEARCH

PD-1 Blockade Expands Intratumoral Memory T Cells

(2016) A. Ribas et al.   Cancer Immunology Research

Intratumoral Delivery of TriMix mRNA Results in T-cell Activation by Cross-Presenting Dendritic Cells

(2015) S. Van Lint et al.   Cancer Immunology Research

Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells

(2015) B. Boyerinas et al.   Cancer Immunology Research

NK cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy

(2015) Wei Wang   Frontiers in Immunology

mRNA-based dendritic cell vaccines

(2014) Daphné Benteyn et al.   Expert Review of Vaccines

Interference with PD-L1/PD-1 co-stimulation during antigen presentation enhances the multifunctionality of antigen-specific T cells

(2014) J J Pen et al.   GENE THERAPY

The immune synapse clears and excludes molecules above a size threshold

(2014) Adam N. R. Cartwright et al.   Nature Communications

Targeting of Human Antigen-Presenting Cell Subsets

(2013) C. Goyvaerts et al.   JOURNAL OF VIROLOGY

Imaging and radioimmunotherapy of multiple myeloma with anti-idiotypic Nanobodies

(2013) M Lemaire et al.   LEUKEMIA

Preclinical Evaluation of TriMix and Antigen mRNA-Based Antitumor Therapy

(2012) S. Van Lint et al.   CANCER RESEARCH

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

(2012) Tadashi Yokosuka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+T cells

(2011) Katarzyna Karwacz et al.   EMBO Molecular Medicine

siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen-specific CD8+ T cells

(2010) W. Hobo et al.   BLOOD

Blockade of Programmed Death Ligand 1 Enhances the Therapeutic Efficacy of Combination Immunotherapy against Melanoma

(2010) S. Pilon-Thomas et al.   JOURNAL OF IMMUNOLOGY

Single-Step Antigen Loading and Activation of Dendritic Cells by mRNA Electroporation for the Purpose of Therapeutic Vaccination in Melanoma Patients

(2009) A. Bonehill et al.   CLINICAL CANCER RESEARCH

PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+CD25Hi regulatory T cells

(2009) Wenshi Wang et al.   INTERNATIONAL IMMUNOLOGY

TCR Down-Regulation Controls T Cell Homeostasis

(2009) L. Boding et al.   JOURNAL OF IMMUNOLOGY

Enhancing the T-cell Stimulatory Capacity of Human Dendritic Cells by Co-electroporation With CD40L, CD70 and Constitutively Active TLR4 Encoding mRNA

(2008) Aude Bonehill et al.   MOLECULAR THERAPY