Journal
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
Volume 12, Issue -, Pages 1543-1553Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/DMSO.S219013
Keywords
cholesterol homeostasis; CVD; HMGCR; LDLR
Categories
Funding
- Shandong Provincial Natural Science Foundation [ZR2019BH023]
- [81900716]
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Cholesterol homeostasis is critical and necessary for the body's functions. Hypercholesterolemia can lead to significant clinical problems, such as cardiovascular disease (CVD). 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and low-density lipoprotein cholesterol receptor (LDLR) are major points of control in cholesterol homeostasis. We summarize the regulatory mechanisms of HMGCR and LDLR, which may provide insight for new drug design and development.
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