Article
Pharmacology & Pharmacy
Arzu Ari, James B. Fink
Summary: This study compared drug delivery efficiency between jet and mesh nebulizers during various modes of ventilation in acutely ill children, finding that mesh nebulizers delivered a greater amount of drug during mechanical ventilation and had up to 3-fold higher delivery efficiency compared to jet nebulizers.
Article
Environmental Sciences
Simon D. Payne, Tyler J. Johnson, Jonathan P. R. Symonds
Summary: The Aerodynamic Aerosol Classifier (AAC) efficiently classifies particles with the desired aerodynamic diameter using concentric cylinders and a clean sheath flow. This study extends the characterization of the AAC up to 5 μm, showing high transmission efficiency and a narrow distribution as the aerodynamic diameter increases. The AAC demonstrates excellent performance for classifying particles up to 5 μm.
AEROSOL AND AIR QUALITY RESEARCH
(2023)
Article
Toxicology
Sripriya Nannu Shankar, Kiran Mital, Eric Le, Gregory S. Lewis, Arantzazu Eiguren-Fernandez, Tara Sabo-Attwood, Chang-Yu Wu
Summary: Real-time monitoring of dosimetry through the use of Scanning Mobility Particle Sizer (SMPS) was assessed in this study. CuO nanoparticles were aerosolized and diluted at different concentrations in ethanol using a nebulizer, and the resulting aerosol volume concentrations were measured by the SMPS. The calculated mass doses (DoseSMPS) and Cu concentrations (DoseICP) both increased exponentially over time. Regression analysis showed a strong correlation between DoseICP and DoseSMPS. This study demonstrates the potential of using SMPS for real-time monitoring and controlled delivery of mass doses.
TOXICOLOGY IN VITRO
(2023)
Article
Pharmacology & Pharmacy
Teerapol Srichana, Charisopon Chunhachaichana, Roongnapa Suedee, Somchai Sawatdee, Narumon Changsan
Summary: CBD formulated as an inhaler (CBD-MDI) showed significant anti-inflammatory effects against various stimuli, without triggering an immune response, and demonstrated comparable efficacy to budesonide. The study also found that CBD-MDI was more effective in treatment rather than prevention.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Chemical
Christie M. Sayes, Madhuri Singal
Summary: The study compared two different aerosol exposure apparatuses: a settling chamber and a gentle impactor. The gentle impactor showed higher deposition efficiency and shorter exposure duration, indicating greater potential as a high-throughput exposure tool.
JOURNAL OF AEROSOL SCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Weilin Jiang, Yuanyuan Zhu, Limin Zhang, Danny J. Edwards, Nicole R. Overman, Giridhar Nandipati, Wahyu Setyawan, Charles H. Henager, Richard J. Kurtz
Summary: This study investigated dose rate effects in self-ion irradiated mono-W and poly-W, revealing that the disordering rate in mono-W irradiated at 900 K is significantly influenced by dose rate. Voids were uniformly distributed in both mono-W and poly-W irradiated at 900 K, with a corrected diameter range of 1.5 to 3.4 nm.
JOURNAL OF NUCLEAR MATERIALS
(2021)
Article
Environmental Sciences
Anne Bannuscher, Otmar Schmid, Barbara Drasler, Alain Rohrbasser, Hedwig M. Braakhuis, Kirsty Meldrum, Edwin P. Zwart, Eric R. Gremmer, Barbara Birk, Manuel Rissel, Robert Landsiedel, Elisa Moschini, Stephen J. Evans, Pramod Kumar, Sezer Orak, Ali Doryab, Johanna Samulin Erdem, Tommaso Serchi, Rob J. Vandebriel, Flemming R. Cassee, Shareen H. Doak, Alke Petri-Fink, Shanbeh Zienolddiny, Martin J. D. Clift, Barbara Rothen-Rutishauser
Summary: The study conducted an inter-laboratory comparison of the VITROCELL (R) Cloud12 system, a commercially available device for aerosol-cell exposure. The results showed that the quartz crystal microbalance (QCM) integrated in the system accurately measured the dose of aerosolized materials delivered to the lung cell models. The study also demonstrated the dose-controlled aerosolization of material suspensions using the VITROCELL (R) Cloud12 system, which is an important step towards regulatory approved implementation of ALI lung cell cultures for in vitro hazard assessment.
Article
Environmental Sciences
Kotaro Takamure, Yasumasa Iwatani, Hiroshi Amano, Tetsuya Yagi, Tomomi Uchiyama
Summary: A non-filter virus inactivation unit was developed to control the irradiation dose of aerosolized viruses. The study evaluated the inactivation properties of aerosolized SARS-CoV-2 by controlling the irradiation dose. When the total irradiation dose exceeded 16.5 mJ/cm2, the RNA concentration remained constant, but decreased with decreasing LED irradiation dose below 16.5 mJ/cm2. The plaque assay showed that 99.16% of the virus was inactivated at 8.1 mJ/cm2 of irradiation and no virus was detected at 12.2 mJ/cm2, resulting in a 99.89% virus inactivation rate.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Basma M. E. Mohamed, Randa Salah Eldin, Abeer Salah Eldin, Mohamed E. A. Abdelrahim, Raghda R. S. Hussein
Summary: This study aimed to assess the influence of smoking on the lung deposition of aerosol delivered to exacerbated COPD subjects. The results showed that smoking reduced the lung deposition of inhaled salbutamol but increased systemic absorption. Further studies are needed to consider these effects when prescribing inhaled medication to COPD smokers, especially exacerbated patients.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Environmental Sciences
Wen Ji, Michel Boufadel, Lin Zhao, Brian Robinson, Thomas King, Chunjiang An, Baiyu (Helen) Zhang, Kenneth Lee
Summary: The study found that under different mixing energy conditions, the impact of kaolinite on oil droplets varies. At low mixing energy, original kaolinite reaggregated after 24 hours, while modified kaolinite continued to form OPAs throughout 24 hours. At high mixing energy, d50 of both kaolinites significantly decreased within 24 hours, and the oil trapped in negatively buoyant OPAs increased significantly.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Agricultural Engineering
Fabio H. R. Baio, Alex R. A. Zanin, Larissa P. R. Teodoro, Joao V. P. F. Fontoura, Paulo E. Teodoro
Summary: This study investigated the influence of spray nozzle wear rate on droplet characteristics. The results showed that an increase in wear rate led to an increase in flow rate and droplet size, while the droplet size homogeneity also significantly increased.
ENGENHARIA AGRICOLA
(2022)
Article
Chemistry, Multidisciplinary
Byungdu Jo, Kyeongyun Park, Dongho Shin, Young Kyung Lim, Jong Hwi Jeong, Se Byeong Lee, Hee-Joung Kim, Haksoo Kim
Summary: The study developed a robust optimization algorithm to minimize dose delivery uncertainties caused by potential applicator-positional errors in Cervix Brachytherapy, aiming to improve clinical outcomes. The robust optimization method utilized a genetic algorithm combined with a median absolute deviation as a robustness evaluation function, which may be worth considering according to the GEC-ESTRO guidelines.
APPLIED SCIENCES-BASEL
(2021)
Article
Toxicology
Jeremy A. Boydston, John J. Yeager, Jill R. Taylor, Paul A. Dabisch
Summary: The study compared the potency of BoNT in aerosols with different aerodynamic particle sizes and found that the particle size significantly affected BoNT inhalational toxicity in mice.
INHALATION TOXICOLOGY
(2021)
Article
Pediatrics
Ozge Surmeli Onay, Damla Gunes, Ozge Aydemir, Neslihan Tekin
Summary: The study showed that aminophylline can increase urine output in infants undergoing therapeutic hypothermia, but does not significantly increase eGFR. Understanding the pharmacokinetics of therapeutic hypothermia may impact future studies.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Sport Sciences
Nasreen Khan, Saurabh Sharma, Indu Dahiya, Junaid Khan, Shalini Sharma, Raj Kumar Sharma
Summary: This review examined the dose-response and temporal effects of ginseng on physical performance and physiological measures in athletes and active participants. It found that high dosage ginseng supplementation had a significant short-term effect on vertical jump improvement, but had no effect on other measures such as visual analogue scale, rating of perceived exertion, peak power output, heart rate, creatine kinase, and VO2 max.
JOURNAL OF SPORTS SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Gustavo Vaz, Adryana Clementino, Evgenia Mitsou, Elena Ferrari, Francesca Buttini, Cristina Sissa, Aristotelis Xenakis, Fabio Sonvico, Cristiana Lima Dora
Summary: The nose-to-brain delivery of neuroprotective natural compounds is a promising approach for the treatment of neurodegenerative diseases. Nanoemulsions containing curcumin and quercetin were found to effectively protect and deliver these compounds, showing potential as an anti-inflammatory treatment.
Article
Chemistry, Multidisciplinary
Gustavo Richter Vaz, Mariana Correa Falkembach Carrasco, Matheus Monteiro Batista, Paula Alice Bezerra Barros, Meliza da Conceicao Oliveira, Ana Luiza Muccillo-Baisch, Virginia Campello Yurgel, Francesca Buttini, Felix Alexandre Antunes Soares, Larissa Marafiga Cordeiro, Flavia Fachel, Helder Ferreira Teixeira, Juliana Bidone, Patricia Diaz de Oliveira, Fabio Sonvico, Cristiana Lima Dora
Summary: This study developed omega-3 fatty acid nanoemulsions loaded with CUR and QU for the treatment of brain diseases. The formulations prepared by two different methods exhibited good stability and similar incorporation of CUR and QU. High-pressure homogenization (HPH) was found to be advantageous, and the obtained CQ NE showed potential for sustained release. Toxicity studies showed that the formulations were not toxic for Caenorhabditis elegans. The developed omega-3 fatty acid nanoemulsions have the potential to enhance the nose-to-brain permeation of CUR and QU for improved treatment efficacy.
Article
Pharmacology & Pharmacy
Eride Quarta, Lorenzo Degli Esposti, Ruggero Bettini, Fabio Sonvico, Daniele Catalucci, Michele Iafisco, Claudio De Luca, Giovanna Trevisi, Paolo Colombo, Alessandra Rossi, Francesca Buttini, Gaia Colombo
Summary: This study developed a dry powder for inhalation, which carries calcium phosphate nanoparticles in mannitol microparticles for direct delivery of loaded bioactive peptide to the heart. By discussing the quality attributes of inhalable microparticles embedding nanoparticles and studying the release of peptide drug from microparticles, the dissolution of microparticles and degradation of nanoparticles were correlated.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Paraskevi Papakyriakopoulou, Dimitrios M. Rekkas, Gaia Colombo, Georgia Valsami
Summary: The objective of this study is to develop and optimize a novel nasal film of Donepezil hydrochloride (DH) for the treatment of Alzheimer's disease. Factors affecting DH permeation and film flexibility were determined through experimental design, and the optimal combination was identified. The prepared nasal films exhibited good quality and stability.
Article
Pharmacology & Pharmacy
Davide 'Angelo, Veronica Chierici, Eride Quarta, Giada Varacca, Luca Cavalieri, Alessio Piraino, Andrea S. Melani, Fabio Sonvico, Francesca Buttini
Summary: This study investigates the effects of unshaken, shaken, and delayed use of suspension pressurized metered-dose inhalers (pMDIs) on Fine Particle Mass (<5 μm), Extra Fine Particle Mass (<2 μm), and MMAD. Most suspension pMDIs produce variable amounts of respirable size drug when subjected to shake-fire delays, with FPM ranging from -82% for Symbicort to 363% for Ventolin compared to the control values if not shaken. In terms of MMAD measurements, Seretide and Serzyl inhalers experience an increase from around 3 μm to 4.2-5.1 μm when not shaken. On the other hand, FPM and MMAD for solution aerosols remain unchanged regardless of being shaken or the delay in actuation after shaking.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Giada Varacca, Davide D'Angelo, Stefania Glieca, Luca Cavalieri, Alessio Piraino, Eride Quarta, Fabio Sonvico, Francesca Buttini
Summary: The correct use of dry powder inhalers is crucial for effective treatment and management of the disease. This study evaluated the impact of inhaler misuse on dose delivery and aerodynamic parameters. Two different inhaler devices, NEXThaler and Ellipta, were investigated. NEXThaler consistently delivered the correct dose, while Ellipta had reduced dose delivery when operated facing downward. NEXThaler's dose protector prevented powder loss during incorrect manipulations. Both devices proved reliable during double activation. Exhalation conditions had a slight effect on the aerodynamic profile of the inhalers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Instruments & Instrumentation
Annalisa Bianchera, Viviana Vilardo, Roberta Giaccari, Annalisa Michielon, Gianluca Bazzoli, Francesca Buttini, Marina Aiello, Alfredo Chetta, Stefano Bruno, Ruggero Bettini
Summary: Two nebulizers, a jet and a mesh vibrating system, were compared in terms of performance and effectiveness for delivering alpha-1 antitrypsin (AAT) to the lungs. The mesh nebulizer demonstrated higher efficiency in drug delivery, with preserved protein activity and conformation. Nebulization of AAT is a suitable administration strategy for AATD patients, either as a support therapy or for preventive purposes.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Davide D'Angelo, Eride Quarta, Stefania Glieca, Giada Varacca, Lisa Flammini, Simona Bertoni, Martina Brandolini, Vittorio Sambri, Laura Grumiro, Giulia Gatti, Giorgio Dirani, Francesca Taddei, Annalisa Bianchera, Fabio Sonvico, Ruggero Bettini, Francesca Buttini
Summary: This study developed a dry inhalation powder of cyclosporine-A for lung transplantation rejection prevention and COVID-19 treatment. The impact of excipients on the powder's critical quality attributes was investigated. The optimized powder exhibited faster dissolution, better respirability, and showed efficacy in reducing IL-6 and inhibiting SARS-CoV-2 replication, suggesting its potential as a therapeutic strategy for lung rejection prevention and COVID-19 treatment.
Article
Veterinary Sciences
Elena Canelli, Luca Ferrari, Paolo Borghetti, Francesco Candela, Nkemjika Sopuru Abiakam, Annalisa Bianchera, Francesca Buttini, Gian Enrico Magi, Fabio Sonvico, Paolo Martelli, Ruggero Bettini
Summary: Nasal vaccination provides optimal protection against respiratory pathogens, and nanotechnology can enhance the effectiveness of mucosal vaccines. This study developed an innovative dry powder nasal vaccine using a solid carrier and a chitosan-coated nanoemulsion as an adjuvant.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Engineering, Biomedical
Eride Quarta, Michele Chiappi, Alessio Adamiano, Anna Tampieri, Weijie Wang, Teresa D. Tetley, Francesca Buttini, Fabio Sonvico, Daniele Catalucci, Paolo Colombo, Michele Iafisco, Lorenzo Degli Esposti
Summary: There has been a growing interest in developing biocompatible inhalable nanoparticle formulations for treating and diagnosing lung disease. In this study, superparamagnetic iron-doped calcium phosphate nanoparticles (FeCaP NPs) were found to be safe for inhalation administration to human lung cells. D-mannitol spray-dried microparticles embedding FeCaP NPs were formulated to achieve optimal particle size distribution for successful inhalation and deposition. This work demonstrates a spray drying method to provide a dry powder platform for the lung delivery of safe FeCaP NPs for magnetically driven applications.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Pharmacology & Pharmacy
Fabio Sonvico, Gaia Colombo, Eride Quarta, Fabiola Guareschi, Sabrina Banella, Francesca Buttini, Regina Scherliess
EXPERT OPINION ON DRUG DELIVERY
(2023)
Review
Pharmacology & Pharmacy
Francesca Buttini, Stefania Glieca, Fabio Sonvico, David A. Lewis
Summary: The urgency to replace propellants with sustainable alternatives has led to the need for investigation and reformulation of pMDIs.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Biochemistry & Molecular Biology
Sabrina Banella, Aishwarya Saraswat, Akanksha Patel, Abu T. M. Serajuddin, Paolo Colombo, Ketan Patel, Gaia Colombo
Summary: Loco-regional chemotherapy is an effective strategy to deliver anticancer drugs directly to tumor tissues, reducing systemic side effects. The complex of cisplatin and hyaluronan has shown improved efficacy and safety in pleural mesothelioma. The complex targets cancer cells locally and has the potential to prevent metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Respiratory System
Davide D'Angelo, Eride Quarta, Stefania Glieca, Veronica Chierici, Giada Varacca, Fabio Sonvico, Francesca Buttini
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY
(2022)