Review
Cell Biology
Roberta Romano, Anna Picca, Leonardo Henry Umberto Eusebi, Emanuele Marzetti, Riccardo Calvani, Loredana Moro, Cecilia Bucci, Flora Guerra
Summary: Pancreatic cancer is a devastating digestive tract cancer with difficult diagnosis and treatment. Researchers have been focusing on the role of extracellular vesicles, particularly exosomes, in the pathogenesis and progression of PC. Understanding the secretion and content analysis of extracellular vesicles may offer new diagnostic and prognostic tools for PC.
Article
Biochemistry & Molecular Biology
Han Du, Zixin Huang, Xin Zhou, Xielan Kuang, Chongde Long, Han Tang, Jingshu Zeng, Hao Huang, Huijun Liu, Binbin Zhu, Licheng Fu, Ke Hu, ShuiBin Lin, Hua Wang, Qingjiong Zhang, Jianhua Yan, Huangxuan Shen
Summary: This study identified a novel oxidative stress-related long noncoding RNA (lncRNA) named CYLD-AS1, which showed increased expression in retinal pigment epithelium (RPE) cells during oxidative stress. Depletion of CYLD-AS1 promoted cell proliferation and mitochondrial function and protected RPE cells against oxidative damage. CYLD-AS1 regulated the expression of NRF2 and NF-kappa B signaling pathway members, which are related to oxidative stress and inflammation. These effects were mediated by the interaction with miR-134-5p. Exosomes secreted by CYLD-AS1 knockdown RPE cells had a lower proinflammatory effect compared to control cells.
Article
Cell Biology
Mohammad Taheri, Arash Safarzadeh, Bashdar Mahmud Hussen, Soudeh Ghafouri-Fard, Aria Baniahmad
Summary: The construction of ceRNA network in prostate cancer and the identification of its importance in predicting patient survival were investigated in this study. The analysis of microarray data led to the identification of differentially expressed mRNAs, lncRNAs, and miRNAs. A ceRNA network consisting of miRNAs, lncRNAs, and mRNAs was constructed, and 10 hub genes were identified. The expression levels of these hub genes showed high diagnostic value. Overall, this study introduces novel diagnostic biomarkers for prostate cancer.
Review
Cell Biology
Hui Kong, Ming-Li Sun, Xin-An Zhang, Xue-Qiang Wang
Summary: By investigating the roles and interactions of miRNA, lncRNA, and circRNA in osteoarthritis, their significance in the prevention, diagnosis, and treatment of OA can be identified as potential future therapeutic targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Kai Su, Nannan Wang, Qianqian Shao, Hao Liu, Bao Zhao, Shiyin Ma
Summary: Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) play crucial roles in regulating gene expression and influencing cancer development. The regulatory network between them affects cell growth and development, disruption of which can lead to various diseases, especially cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Qi Lu, Li Wang, Yabiao Gao, Ping Zhu, Luying Li, Xue Wang, Youping Jin, Xiuling Zhi, Jerry Yu, Xin Li, Xingjun Qin, Ping Zhou
Summary: The study revealed that lncRNA APOC1P1-3 promotes breast cancer metastasis by regulating apoptosis and anoikis resistance-related protein expression. It acts as a sponge to block the inhibition of Bcl-2 by specifically binding to miRNA-188-3p.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Jingxing Liu, Shuyuan Xiao, Jing Chen
Summary: This study investigated the association between inflammation and breast cancer, and established an inflammation-related ceRNA network. It identified lncRNA LRRC75A-AS1 as a potential key player in modulating inflammation response during the initiation and progression of breast cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Food Science & Technology
Pan Chao, Feng Yongheng, Zhou Jin, Zhu Yu, Yang Shiyong, Yang Kunxing, Ma Yong
Summary: This study revealed that in gastric cancer development, HOTAIR expression increases while miRNA-206 expression decreases. Knockdown of HOTAIR suppresses cell viability, increases apoptosis, inhibits invasion and migration by regulating miRNA-206, and suppresses CCND1 and CCND2 expression. HOTAIR targeting miRNA-206 and miRNA-206 targeting CCND1 and CCND2 play crucial roles in the antitumor effects in gastric cancer.
FOOD SCIENCE & NUTRITION
(2021)
Review
Microbiology
Tian Gan, Jianwei Yu, Jun He
Summary: Mycoplasma pneumoniae (MP) is a respiratory pathogen causing community-acquired pneumonia, especially in infants and the elderly. Non-coding RNAs (miRNAs, lncRNAs, and circRNAs) play a critical role in MP infection by regulating inflammatory responses, apoptosis, and pulmonary fibrosis. Understanding the association of these RNAs with MP infection can provide insights for early diagnosis and therapeutic strategies.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Immunology
Junsong Zhu, Shaoheng Tu, Qunwei Qu
Summary: The dysregulation of BZRAP1-AS1 in rheumatoid arthritis affects cell proliferation, inflammation levels, and cell apoptosis.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Review
Medicine, Research & Experimental
Benchi Ma, Shihao Wang, Wenzheng Wu, Pufan Shan, Yufan Chen, Jiaqi Meng, Liping Xing, Jingyi Yun, Longhui Hao, Xiaoyu Wang, Shuyan Li, Yinghui Guo
Summary: In recent years, significant progress has been made in bioinformatics with the discovery of functional non-coding RNAs (ncRNAs). These ncRNAs play a crucial role in regulating intracellular gene expression, assisting in diagnosis, guiding drug use, and determining prognosis in various diseases. MicroRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) are the three major types of ncRNAs that interact with each other. Studies have shown that lncRNAs and circRNAs can sponge miRNAs, influencing normal physiological processes and regulating mRNA expression, and ultimately affecting cellular physiology. This paper provides a summary of the mechanisms and research progress of these three ncRNAs and their potential implications in disease diagnosis, treatment, and drug development.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemical Research Methods
Lei Tian, Shu-Lin Wang
Summary: The study developed a new method (MSDNMDL) that combines miRNA-disease-lncRNA and miRNA-target networks to explore miRNA sponge networks of breast cancer more effectively.
CURRENT BIOINFORMATICS
(2021)
Article
Engineering, Biomedical
Ruonan Zhang, Ting Pan, Yu Xiang, Mingming Zhang, Han Xie, Zimao Liang, Bi Chen, Cong Xu, Jing Wang, Xingxing Huang, Qianru Zhu, Ziming Zhao, Quan Gao, Chengyong Wen, Wencheng Liu, Weirui Ma, Jiao Feng, Xueni Sun, Ting Duan, Elaine Lai-Han Leung, Tian Xie, Qibiao Wu, Xinbing Sui
Summary: Curcumenol has been found to induce cell death and inhibit cell proliferation in lung cancer cells. The study also reveals that the long non-coding RNA H19 (lncRNA H19) is downregulated in lung cancer cells treated with curcumenol, and its decreased expression enhances curcumenol-induced ferroptotic cell death through the miR-19b-3p/FTH1 axis.
BIOACTIVE MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Mehrdad Hashemi, Marzieh Sadat Moosavi, Hedyeh Maghareh Abed, Maryam Dehghani, Masoumeh Aalipour, Elaheh Ali Heydari, Mitra Behroozaghdam, Maliheh Entezari, Shokooh Salimimoghadam, Emine Selda Gunduz, Afshin Taheriazam, Sepideh Mirzaei, Saeed Samarghandian
Summary: Initiation and development of cancer depend on multiple factors including gene mutations and epigenetic changes. LncRNA H19, a non-coding RNA molecule, is found to be abnormally expressed in various cancers and contributes to tumor growth, metastasis and drug resistance. It has the potential to serve as a biomarker for poor prognosis and therapy response.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemical Research Methods
Long Yang, Li-Ping Li, Hai-Cheng Yi
Summary: In this study, a method called DWLMI is proposed to infer potential associations between lncRNAs and miRNAs by representing them as vectors and combining multiple information for prediction. Experimental results show that this method can effectively predict potential lncRNA-miRNA associations.
BMC BIOINFORMATICS
(2022)
Article
Pathology
Yumei Pu, Liang Ding, Yujia Wang, Yuxin Wang, Sheng Chen, Xiaofeng Huang, Zhifeng He, Yanhong Ni, Qingang Hu
Summary: This study aimed to assess the depth of invasion and worst pattern of invasion in early-stage oral squamous cell carcinoma, and found that the biopsy pattern of invasion could predict the worst pattern of invasion and depth of invasion preoperatively.
Article
Oncology
Dongya Zhang, Yuxian Song, Dan Li, Xinghan Liu, Yuchen Pan, Liang Ding, Guoping Shi, Yong Wang, Yanhong Ni, Yayi Hou
Summary: CAF are abundant stromal cells in tumors and have a pro-tumoral effect, while the upregulation of lncRNA LOC100506114 significantly influences the functional transformation of normal fibroblasts and CAF by enhancing the expression of fibroblast activation protein alpha and alpha-smooth muscle actin. By positively correlating with GDF10 expression, LOC100506114 plays a critical role in the interaction between stromal fibroblasts and tumor cells in oral squamous cell carcinoma.
MOLECULAR ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuqin Jin, Jialing Li, Liang Ding, Qing Zhao, Yuxian Song, Guifeng Li, Jun Ji, Yanhong Ni, Qingang Hu
Summary: The study demonstrated that madecassic acid has antioxidant and protective effects by reducing intracellular ROS production to maintain cellular stability.
MOLECULAR & CELLULAR TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Ting Liu, Aerdake Aman, Muniremu Ainiwaer, Liang Ding, Fei Zhang, Qingang Hu, Yuxian Song, Yanhong Ni, Xuna Tang
Summary: The study aimed to design AgNPs-PL gel with sustained antibacterial activity against E. faecalis in the root canal. The gel was non-toxic to HPDLFs and more effective in removing E. faecalis biofilm compared to other materials. AgNPs-PL exhibited strong antibacterial activity and may be a candidate for new root canal disinfection.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Meng Ding, Yuxian Song, Junyan Jing, Mei Tian, Liang Ding, Qiang Li, Chongchong Zhou, Heng Dong, Yanhong Ni, Yongbin Mou
Summary: Dynamic changes in immune-inflammatory cell ratios are important prognostic factors for oral squamous cell carcinoma (OSCC), with high LMR and low NWR associated with better survival outcomes, and high NLR and low LWR associated with poorer outcomes. LMR is an independent prognostic factor for OS and DFS, while LWR is an independent prognostic factor for MFS in OSCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xinwen Zhang, Yong Fu, Zhuang Ding, Nisha Zhu, Mengxiang Zhao, Yuxian Song, Xiaofeng Huang, Sheng Chen, Yan Yang, Caihong Zhang, Qingang Hu, Yanhong Ni, Liang Ding
Summary: Reelin plays a versatile role in OSCC by influencing tumor cell and stroma microenvironment, with its high expression associated with the malignancy and survival rate.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zhuang Ding, Yijia He, Yong Fu, Nisha Zhu, Mengxiang Zhao, Yuxian Song, Xiaofeng Huang, Sheng Chen, Yan Yang, Caihong Zhang, Qingang Hu, Yanhong Ni, Liang Ding
Summary: CD38 is a poor prognostic biomarker for OSCC patients, governing immune microenvironment and circulating lymphocyte homeostasis. Co-expression with immune checkpoint molecules sheds new light on immune checkpoint therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Engineering, Biomedical
Di Cui, Na Kong, Liang Ding, Yachong Guo, Wenrong Yang, Fuhua Yan
Summary: Ti3C2Tx has shown satisfactory biocompatibility and induced osteogenic differentiation of human PDLCs, promoting periodontal defect repair. By activating the Wnt/beta-catenin signaling pathway, Ti3C2Tx enhances periodontal regeneration.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Oncology
Yong Fu, Xinwen Zhang, Zhuang Ding, Nisha Zhu, Yuxian Song, Xiaoxin Zhang, Yue Jing, Yijun Yu, Xiaofeng Huang, Lei Zhang, Qingang Hu, Yanhong Ni, Liang Ding
Summary: The study subclassified traditional PNI into four types in patients with oral squamous cell carcinoma, and proposed a new variable of WPNI that correlated with patient prognosis. High score of PNI types within one tumor tended to have worse prognosis, and WPNI 3 independently predicted patients' prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yawei Sun, Shuai Wang, Xingwei Zhang, Zhuhao Wu, Zihui Li, Zhuang Ding, Xiaofeng Huang, Sheng Chen, Yue Jing, Xiaoxin Zhang, Liang Ding, Yuxian Song, Guowen Sun, Yanhong Ni
Summary: The study revealed the significant role of PLOD2 in oral squamous cell carcinoma, with high expression of PLOD2 associated with poor prognosis in patients, potentially affecting metastasis through the epithelial-mesenchymal transition pathway.
Article
Oncology
Yijia He, Yuexin Dong, Xinwen Zhang, Zhuang Ding, Yuxian Song, Xiaofeng Huang, Sheng Chen, Zhiyong Wang, Yanhong Ni, Liang Ding
Summary: PLIN2, mainly expressed in tumor-infiltrating immunocytes of oral squamous cell carcinoma, plays a role in regulating the immune balance and has implications in tumor progression and metastasis. High expression of PLIN2 is associated with advanced stage, increased postoperative metastasis risk, and immune suppression in the tumor microenvironment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Liang Ding, Yong Fu, Nisha Zhu, Mengxiang Zhao, Zhuang Ding, Xiaoxin Zhang, Yuxian Song, Yue Jing, Qian Zhang, Sheng Chen, Xiaofeng Huang, Lorraine A. O'Reilly, John Silke, Qingang Hu, Yanhong Ni
Summary: The authors identified a subset of fibroblasts expressing oxytocin receptor enriched in highly invasive WPOI 4-5 OSCC tumors, which can be targeted to reduce desmoplastic stroma and tumor metastasis. Targeting ERK5 signaling in OXTRHigh CAFs is suggested as a potential therapeutic strategy for OSCC patients with WPOI 4-5, as these fibroblasts contribute to local-regional metastasis.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Mengxiang Zhao, Yijia He, Nisha Zhu, Yuxian Song, Qingang Hu, Zhiyong Wang, Yanhong Ni, Liang Ding
Summary: This study found that IL-33/ST2 signaling pathway can enhance PD-L1-mediated immune escape, and ST2 high-expression OSCC patients may benefit from anti-PD-1/L1 therapy.
BRITISH JOURNAL OF CANCER
(2023)
Article
Medicine, Research & Experimental
Chenhang Yu, Xinyang Hu, Qingang Hu, Yongbin Mou, Liang Ding
Summary: Medication-related osteonecrosis of the jaw is a significant side effect of certain drugs, but synthetic derivative of parathyroid hormone, Teriparatide, has shown potential in reducing its incidence through modulation of various signaling pathways.
MEDICAL HYPOTHESES
(2023)
Review
Biochemistry & Molecular Biology
Nisha Zhu, Mengxiang Zhao, Yuxian Song, Liang Ding, Yanhong Ni
Summary: KiSS-1 is an anti-metastasis gene encoding peptide products that act as endogenous ligands for G proteincoupled receptor 54, regulating various physiological activities such as puberty initiation, fertility, and feedback in the HPG axis. It plays a crucial role in cancer biology, serving as a promising biomarker for diagnosis, therapeutic target identification, and prognosis.