Article
Oncology
Amy K. Schulze, Tanya L. Hoskin, Mary M. Mrdutt, Robert W. Mutter, Tina J. Hieken
Summary: This study explores the feasibility and therapeutic impact of repeat sentinel lymph node surgery in patients with local recurrence post-mastectomy. The results show that this approach is successful and informative, reducing axillary dissection rates and potentially guiding adjuvant radiation target volumes and systemic therapies.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Akimitsu Yamada, Naoki Hayashi, Hiraku Kumamaru, Masayuki Nagahashi, Shiori Usune, Sota Asaga, Kotaro Iijima, Takayuki Kadoya, Yasuyuki Kojima, Makoto Kubo, Minoru Miyashita, Hiroaki Miyata, Etsuko Ogo, Kenji Tamura, Kenta Tanakura, Keiichiro Tada, Naoki Niikura, Masayuki Yoshida, Shinji Ohno, Takashi Ishikawa, Kazutaka Narui, Itaru Endo, Shigeru Imoto, Hiromitsu Jinno
Summary: This study aimed to evaluate the prognostic impact of postmastectomy radiotherapy (PMRT) in breast cancer patients with pT1-2 and N1. The analysis of the Japanese National Clinical Database showed that PMRT did not significantly influence locoregional recurrence (LRR) in T1-2 and N1 patients. However, the decision to administer PMRT should be based on individual risks considering tumor size, lymph node metastases, and triple-negative subtype.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Peiyong Li, Ciqiu Yang, Junsheng Zhang, Yitian Chen, Xiaoqi Zhang, Minting Liang, Na Huang, Yilin Chen, Kun Wang
Summary: Sentinel lymph node biopsy can provide survival results equivalent to axillary lymph node dissection for patients with cN0 and T1-2 breast cancer; however, whether it can be performed on patients with T3-4c breast cancer is still controversial.
Article
Oncology
Seong Yong Park, Junghee Lee, Yeong Jeong Jeon, Jong Ho Cho, Hong Kwan Kim, Yong Soo Choi, Jae Il Zo, Young Mog Shim
Summary: The presence of supraclavicular lymph node metastasis did not significantly impact the overall survival of esophageal squamous cell carcinoma patients who underwent 3-field lymph node dissection, regardless of clinical suspicion or pathologic confirmation.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Fei Wang, Ingrid Meszoely, Tuya Pal, Ingrid A. Mayer, Christina E. Bailey, Wei Zheng, Xiao-Ou Shu
Summary: The study found that elderly patients aged 70 and above who had undergone breast-conserving surgery for early-stage breast cancer had higher mortality rates if they did not receive post-surgery radiotherapy. This suggests that the current recommendations for radiotherapy omission in this patient group may need to be reconsidered.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Elisabeth R. M. van Haaren, Merel A. Spiekerman van Weezelenburg, Ingrid G. M. Poodt, Michelle M. W. Feijen, Alfred Janssen, James van Bastelaar, Yvonne L. J. Vissers
Summary: This study evaluated the impact of sentinel node biopsy (SNB) outcome on immediate breast reconstruction (IBR) planning in breast cancer patients undergoing mastectomy. It found that in patients with macrometastases in the SNB, 33% of IBRs were postponed due to the risk of postmastectomy radiation therapy (PMRT).
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Hua Ye, Bin Zheng, Qi Zheng, Ping Chen
Summary: Old age has an impact on lymph node metastasis and prognosis in elderly patients with T1 colorectal cancer. Factors such as tumor size, grading, CEA level, and age are independent prognostic factors that should be considered in medical decision making. Local excision is suitable for elderly patients with T1 colorectal cancer who have smaller tumor size, well differentiation, negative CEA level, and adenocarcinoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Urology & Nephrology
Kai Yao, Yue Chen, Yunlin Ye, Zhiming Wu, Dong Chen, Hui Han, Zaishang Li, Zhuowei Liu, Yanjun Wang, Zike Qin, Yonghong Li, Zhiyong Li, Fangjian Zhou
Summary: The study provides a detailed map of pelvic lymph node metastasis in patients with penile carcinoma, showing that the external iliac and obturator packages are most commonly involved. Pelvic lymph node metastasis is associated with advanced T-stage. Some patients have crossover metastasis.
JOURNAL OF UROLOGY
(2021)
Article
Multidisciplinary Sciences
XiaoXi Ma, Xia Yang, Wentao Yang, Ruohong Shui
Summary: Studies have shown that extranodal extension (ENE) is associated with prognosis in breast cancer. ENE is an independent prognostic factor for DRFS and is linked with OS. ENE in the axillary lymph nodes is related to a higher nodal burden. The size of ENE, divided by 3 mm (CD-ENE) or 2 mm (PD-ENE), did not have significant prognostic value.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Kiyonao Nakamura, Yoshiki Norihisa, Itaru Ikeda, Haruo Inokuchi, Rihito Aizawa, Toshiyuki Kamoto, Tomomi Kamba, Takahiro Inoue, Toshinari Yamasaki, Shusuke Akamatsu, Takashi Kobayashi, Osamu Ogawa, Takashi Mizowaki
Summary: This study evaluates the outcomes of whole-pelvic simultaneous integrated boost intensity-modulated radiation therapy combined with androgen deprivation therapy in pelvic node-positive prostate cancer. The results show that the treatment can be safely administered and has low rates of biochemical relapse. Additionally, the International Society of Urological Pathology grade group 5 and post-treatment detectable nadir PSA levels are associated with worse survival and progression of castration resistance.
Article
Oncology
Song Wang, Yiyuan Zhang, Fangxu Yin, Xiaohong Wang, Zhenlin Yang
Summary: In women with early-stage IMPC, breast-conserving treatment was found to be at least equivalent to mastectomy in terms of survival outcomes. BCT should be recommended as the standard surgical treatment, especially for patients with T2 disease, when both procedures are feasible.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Yubo Sun, Wei Sun, Jingzhe Xiang, Hao Zhang
Summary: This study aimed to construct a nomogram that predicts central lymph node metastasis (CLNM) in T1-T2 papillary thyroid carcinoma (PTC) patients without lateral lymph node metastases (LLNM). The nomogram showed good accuracy and applicability in predicting CLNM in both internal and external validation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Tian-Han Zhou, Ling-Qian Zhao, Yu Zhang, Fan Wu, Kai-Ning Lu, Lin-Lin Mao, Ke-Cheng Jiang, Ding-Cun Luo
Summary: This study developed and validated a nomogram for predicting lateral lymph node metastasis in medullary thyroid carcinoma patients. Significant risk factors for LLNM in MTC patients included male sex, tumor size >38mm, multifocality, extrathyroidal extension, and distant metastasis. The nomogram showed good discrimination and clinical utility in predicting LLNM.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Zhenyu Yang, Xingliang Tan, Yanjun Wang, Yuantao Zou, Dong Chen, Zhiming Wu, Zhuowei Liu, Yonghong Li, Zike Qin, Hui Han, Fangjian Zhou, Kai Yao
Summary: The study evaluated the relationship between deep inguinal lymph node metastasis and pelvic lymph node metastasis in PSCC, finding that deep ILNM is the most accurate factor for predicting PLNM. Patients with deep ILNM should be referred for pelvic lymph node dissection, as it indicates poor prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Jun Deng, Shifa Zhou, Zhiwen Wang, Genbo Huang, Jingjun Zeng, Xiujiang Li
Summary: This study compared the differences in lymph node metastasis and prognosis between colonic adenocarcinoma (AC) and rectal AC. The results showed that T1-stage rectal AC had a higher risk of lymph node metastasis compared to colonic AC, but had a similar prognosis.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)