Review
Biochemistry & Molecular Biology
Georgia K. Atkin-Smith
Summary: The clearance of dying cells is a well-defined process involving molecular factors and different mechanisms for different types of cell death. It is essential for preventing excessive release of pro-inflammatory mediators and inflammatory diseases.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Maic Audo Eybi Mayer Sihombing, Maharani Safitri, Tian Zhou, Lu Wang, Sean McGinty, Hai-Jun Zhang, Yuxia Yin, Qin Peng, Juhui Qiu, Guixue Wang
Summary: Effective and efficient efferocytosis of dead cells and associated cellular debris are critical to tissue homeostasis and healing of injured tissues. Although the amateur phagocytes (APs) are slower and less efficient than professional phagocytes (PPs) in engulfment and degradation of dead cells, they play a fundamental role in preventing inflammation from spreading over a large area. Understanding their roles is crucial for developing effective intervention strategies for inflammation-related diseases.
DNA AND CELL BIOLOGY
(2021)
Review
Oncology
Allan Scarpitta, Ulrich T. T. Hacker, Hildegard Buening, Olivier Boyer, Sahil Adriouch
Summary: Cancer, the second leading cause of death globally, is often treated with chemotherapeutic drugs which can have side effects, but some of these drugs can stimulate anti-tumor immune responses through the induction of immunogenic cell death. The study discusses the potential of inducing different forms of ICD to enhance immunogenicity and stimulate effective anti-tumor immune responses.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Salome Funes, Daryl A. Bosco
Summary: This article demonstrates a method to differentiate human induced pluripotent stem cells (iPSCs) into microglia-like cells (iMGs) and provides documentation for labeling and isolating synaptosome substrates. These methods have broad applicability in studying the biology of human microglia and their contribution to various diseases.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Cell Biology
Tian Deng, Chao Tang, Guizhong Zhang, Xiaochun Wan
Summary: CAR-T transfer, a rapidly developing immunotherapy, is showing substantial benefits for advanced cancer patients, but is also associated with potentially fatal adverse effects like cytokine release syndrome and neurotoxicity. Understanding the mechanisms behind these toxicities is crucial for improving therapeutic outcomes. Recent studies emphasize the importance of monocytes/macrophages in CAR-T-related toxicities and reveal a novel mechanism mediated by DAMPs released from pyroptotic cells.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Alexis Bonfim-Melo, Ivar Noordstra, Shafali Gupta, Amy H. Chan, Mathew J. K. Jones, Kate Schroder, Alpha S. Yap
Summary: Cell injury poses a challenge to the homeostasis of epithelial tissues, including apoptosis and pyroptosis. This study reveals that pyroptotic cells are eliminated from epithelial monolayers through apical extrusion, accompanied by a temporary defect in barrier function. Rapid lamellipodial responses in neighbor cells contribute to the recovery of barrier integrity. Unlike apoptosis, cell contractility is not required for this resealing response.
Article
Multidisciplinary Sciences
Jiaxin Liu, Chuanshang Cao, Yiran Jin, Yan Wang, Xiaona Ma, Jiahui Li, Songlin Guo, Jiancheng Yang, Jianguo Niu, Xueyun Liang
Summary: Induced neural stem cell transplantation can improve neurological deficits by inhibiting inflammation in an intracerebral hemorrhage rat model. It can also effectively suppress microglial pyroptosis, possibly through inhibiting the NF-kappa B signaling pathway. Induced neural stem cells can regulate microglial polarization and promote the transition from pro-inflammatory to anti-inflammatory phenotypes to exert their anti-inflammatory effects.
Article
Green & Sustainable Science & Technology
Ru Jia, Shanshan Wang
Summary: A modeling framework was developed to investigate the impact of varying ratios of professional and nonprofessional hosts on pricing and outcomes in the sharing market. The study found that a high ratio of professional hosts does not necessarily maximize indicators of hosts' earnings, platform's profit, or supply size. The market may improve with magnified differences in the unique features of two types of hosts.
Article
Environmental Sciences
Giuseppa Visalli, Antonio Lagana, Alessio Facciola, Antonella Iaconis, Jessica Curcio, Santa Pollino, Consuelo Celesti, Silvia Scalese, Sebania Libertino, Daniela Iannazzo, Angela Di Pietro
Summary: Micro and nanoplastics, as pervasive pollutants, have adverse health effects on humans. The study investigated the effects of virgin and oxidised polystyrene nano (nPS) and micro particles (mPS) on professional phagocytes in humans. The results showed that the environmental aging processes enhance the adverse health effects of micro and nanoplastics by increasing reactive oxygen species (ROS) and causing DNA damage.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Qi Li, Mayumi Hatakeyama, Takuya Kitaoka
Summary: This study compares the cell death responses of different liver cell types induced by four types of emulsion particles. Emulsion particles stabilized by polysaccharide nanofibers or inorganic nanoparticles cause lactate dehydrogenase release and pyroptotic cell death in hepatocytes and Kupffer cells. These particles also demonstrate biological activity as inflammation mediators when co-cultured with lipopolysaccharide-primed Kupffer cells.
Article
Agricultural Engineering
Lei Gao, Fengjing Wang, Tianyue Wu, Qi Zhou, Duo Zhang, Xinbin Hou, Xinpeng Zhang, Jingrun Ye, Yan Ma, Zhipeng Wang, Lirong Song, Wei Chen
Summary: In this study, a strain of golden algae capable of engulfing Microcystis aeruginosa and accumulating Fucoxanthin (Fx) was isolated and identified. Under mixotrophic cultivation, the content and production rate of Fx in the algal culture significantly increased, along with a high utilization rate of Microcystis aeruginosa. This research is important not only for the efficient production of Fx, but also for addressing harmful cyanobacterial blooms in eutrophic freshwaters.
BIORESOURCE TECHNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
April Strid, Alicia Leytem, Josean Perez, Kaci Buhl, Amy Cross
Summary: The study compared outcomes of using pesticides for bed bug control by professionals and nonprofessionals. It found that misapplications were more likely to be reported in cases involving nonprofessionals, leading to increased human pesticide exposures and adverse outcomes. Professional involvement and adherence to product label instructions may help reduce pesticide incidents related to bed bug control.
AMERICAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Robert Walmsley, Derek S. Steele, Georgina M. Ellison-Hughes, Sotiris Papaspyros, Andrew J. Smith
Summary: This study investigated the effects of imatinib, a receptor tyrosine kinase inhibitor, on human cardiac progenitor cells. It was found that imatinib reduced cell viability, depolarized mitochondria, increased lysosome and autophagosome content, and induced cell death through necroptosis. However, the toxicity could be rescued by RIP1 inhibition and autophagy played a partial role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Csaba Horvath, Izabela Jarabicova, Tomas Rajtik, Linda Bartosova, Kristina Ferenczyova, Barbora Kalocayova, Monika Bartekova, Adrian Szobi, Adriana Adameova
Summary: Diabetes mellitus can cause heart dysfunction and remodeling due to various cell-damaging events, but little is known about its inflammation-associated pathomechanisms involving necrosis-like cell death. This study investigated the signaling pathways of necroptosis and pyroptosis, which can lead to inflammation through plasma membrane rupture. The results showed that despite having no significant heart dysfunction, hearts of Zucker diabetic fatty (ZDF) rats exhibited decreased heart rate and increased activation of RIP3 kinase, suggesting its involvement in non-necroptotic signaling pathways.
PHYSIOLOGICAL RESEARCH
(2023)
Article
Oncology
Yusuke Tamura, Masato Morikawa, Ryo Tanabe, Kohei Miyazono, Daizo Koinuma
Summary: The development of innovative therapeutic modalities for triple negative breast cancer is crucial. Recent research suggests that activation of RIG-I-like receptors in cancer cells can suppress tumor progression. Transfection of polyI:C, a synthetic dsRNA analogue, has shown promise in clinical trials, especially in inhibiting the TGF-beta signaling pathway to promote cancer cell death.
MOLECULAR ONCOLOGY
(2021)
