Review
Chemistry, Multidisciplinary
Yuzhe Sun, Edward Davis
Summary: The translation mentioned that achieving the promise of stimuli-responsive drug delivery systems for cancer treatment involves challenges like avoiding premature clearance, accumulating in tumors, and exhibiting appropriate payload release. However, the expanding toolbox of design tools from proof-of-concept studies each year helps address these requirements. Recent advances in targeting and stimuli-responsiveness, as well as challenges and potential solutions are discussed to assist researchers in overcoming interdisciplinary knowledge barriers and speeding up development in cancer therapy.
Review
Biotechnology & Applied Microbiology
Neha Kaushik, Shweta B. Borkar, Sondavid K. Nandanwar, Pritam Kumar Panda, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: Nanocarriers (NCs) have attracted significant attention for their structural ability, good biocompatibility, and biodegradability. The development of NCs with stimuli-responsive properties has become a hot topic among scientists. These NCs can deliver drugs to tumors by regulating their pH, temperature, and enzyme responsiveness, thereby improving the accuracy of drug delivery and minimizing side effects. Material carriers for chemotherapeutic medicines are discussed in this review, with a focus on their structural properties and targeting methods that enhance therapeutic efficacy and trigger metabolic pathways. Overall, the development of NCs that respond to endogenous and exogenous stimuli in tumor regions and the understanding of their mechanisms have great potential for advancing tumor therapy and precision diagnosis in the future.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Avelino Corma, Pablo Botella, Eva Rivero-Buceta
Summary: This article introduces silica-based nanomedicines and their significant role in cancer treatment. Silica nanoparticles have been proposed as safe and effective vehicles for delivering antitumor drugs due to their stability, high surface area, and easy functionalization. These silica nanomedicines have specific mechanisms for intracellular drug release, allowing for precise control of drug discharge. By responding to endogenous and exogenous stimuli, these nanomedicines can achieve selective delivery to cancer cells.
Article
Chemistry, Multidisciplinary
Keli An, Xuqian Deng, Hongli Chi, Yuchao Zhang, Yan Li, Ming Cheng, Zhigang Ni, Zhi Yang, Chao Wang, Jinling Chen, Jianbo Bai, Chunyan Ran, Yong Wei, Juan Li, Penghui Zhang, Feng Xu, Weihong Tan
Summary: Proteolysis Targeting Chimeras (PROTACs) are a promising therapeutic modality for tackling undruggable and resistant issues in drug discovery. Researchers have developed a generalized caging strategy to synthesize stimuli-responsive PROTACs (sr-PROTACs) that can be activated and released in response to specific pathological cues and external triggers. These sr-PROTACs showed high solubility, long plasma exposure, and efficient protein degradation in tumor cells, making them potential candidates for personalized treatment and tissue engineering.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Anum Kayani, Arsalan Raza, Jiale Si, Debabrata Dutta, Qinghao Zhou, Zhishen Ge
Summary: Polymersomes have been extensively studied as nanocarriers for drug delivery for two decades. Although they have many advantages, including high stability and simultaneous encapsulation of hydrophilic and hydrophobic drugs, they often face issues with non-targeted delivery and poor membrane permeability. Recent advancements in surface functionalization and membrane permeability control have addressed these challenges and improved the efficiency of drug delivery using polymersomes. This review provides a detailed overview of the role of polymersome membranes and future developments in promoting them as in vivo drug delivery nanocarriers.
Article
Biochemistry & Molecular Biology
Beatriz D. Cardoso, Vanessa F. Cardoso, Senetxu Lanceros-Mendez, Elisabete M. S. Castanheira
Summary: Stimuli-responsive liposomes, particularly solid magnetoliposomes (SMLs), have been designed as lipid-based nanosystems for controlled release of doxorubicin (DOX) in response to thermal, magnetic, and pH stimuli. The combination of lipids and PEGylation plays a crucial role in determining the stability and release kinetics of SMLs. Integrated assessment and characterization of SMLs enable the optimization of lipid formulations for specific controlled release profiles, offering a multi-functional approach to cancer targeting and therapy.
Article
Biotechnology & Applied Microbiology
Jinsong Du, Guanping Chen, Xinyi Yuan, Jiang Yuan, Li Li
Summary: We developed a multifunctional Cu-MOFs@Keratin drug delivery system (DDS) for cancer treatment, which effectively delivered the anticancer drug DOX and provided chemodynamic therapy (CDT) against tumor cells. The Cu-MOFs@Keratin system showed reduced toxicity to normal cells and enhanced accumulation in tumor tissues, as well as controlled release of DOX within tumor cells. Additionally, the Cu-MOFs produced hydroxyl radicals (center dot OH) under high intracellular levels of glutathione (GSH) and H2O2, leading to decreased tumor cell viability.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Claudia Battistella, Yifei Liang, Nathan C. Gianneschi
Summary: The recent advances in polymer chemistry, materials sciences, and biotechnology have enabled the development of programmable nanomedicines and materials that can respond precisely to disease triggers. While the majority of research has been focused on oncology, there is high potential impact in expanding applications to cardiovascular disease and diabetes mellitus.
ADVANCED MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Pooyan Makvandi, Rezvan Jamaledin, Guojun Chen, Zahra Baghbantaraghdari, Ehsan Nazarzadeh Zare, Concetta Di Natale, Valentina Onesto, Raffaele Vecchione, Jesse Lee, Franklin R. Tay, Paolo Netti, Virgilio Mattoli, Ana Jaklenec, Zhen Gu, Robert Langer
Summary: Microneedle (MN) patches, made up of miniature needles, have emerged as a promising tool for minimally invasive translocation of biomolecules into the dermis. Stimuli-responsive MN patches are a new drug delivery system that can release cargos in response to internal or external triggers, with various mechanisms of action for different indications. Future opportunities and challenges in clinical translation are also discussed.
Review
Chemistry, Multidisciplinary
Ivanna Amarsy, Sebastien Papot, Gilles Gasser
Summary: Metal-based prodrugs are developed to overcome the drawbacks of metal-based compounds for biomedical applications, by utilizing tumor-associated stimuli for selective delivery. This field has significant applications in oncology.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Nanoscience & Nanotechnology
Aihik Banerjee, Tanvi Jariwala, Youn-Kyung Baek, Dung Thi Hanh To, Youyi Tai, Junze Liu, Hyle Park, Nosang Myung, Jin Nam
Summary: The drawbacks of conventional drug administration are addressed by a magneto-, opto-stimuli responsive drug delivery system based on functionalized electrospun nanofibers with superparamagnetic iron oxide nanoparticles. This system allows on-demand drug delivery at specific times, overcoming the limitations of traditional drug delivery methods.
Review
Chemistry, Multidisciplinary
Peng Zhang, Mingqian Li, Chunsheng Xiao, Xuesi Chen
Summary: This article summarizes the development of polypeptide-based drug delivery systems that respond to physiological stimuli such as pH, redox potential, glucose, and hypoxia. Polypeptides have the potential for controlled drug release.
CHEMICAL COMMUNICATIONS
(2021)
Review
Polymer Science
Tyus J. Yeingst, Julien H. Arrizabalaga, Daniel J. Hayes
Summary: Stimuli-responsive hydrogel drug delivery systems that release drugs under external stimuli, such as ultrasound, have gained importance in the field of drug delivery. This review summarizes the current understanding of ultrasound-responsive hydrogels, including mechanisms of drug release, innovative formulations, and applications in cancer treatment and tissue engineering.
Review
Chemistry, Multidisciplinary
Zhichu Xiang, Mouquan Liu, Jun Song
Summary: Biocompatible nanosystems based on polymeric materials show promise as drug delivery nanocarriers for antitumor therapy, but their efficacy is hindered by nonspecific accumulation and drug release in normal tissues. Stimuli-responsive nanosystems triggered by tumor-specific stimuli have recently garnered interest for their controllable drug release properties. This review discusses various polymers and external stimuli for developing stimuli-responsive polymeric nanosystems, and outlines the challenges in designing such Nanomedicine to enhance therapeutic efficacy.
APPLIED SCIENCES-BASEL
(2021)
Review
Chemistry, Multidisciplinary
Chendi Ding, Chunbo Chen, Xiaowei Zeng, Hongzhong Chen, Yanli Zhao
Summary: Prodrugs are inactive drug molecules that are converted to active drugs after administration. They play a crucial role in drug treatment, especially in cancer therapy. Current research focuses on stimuli-responsive activation mechanisms, regulation of stimuli intensity in vivo, and the design of nanoscale prodrug formulations.
