IGF2/IGF1R Signaling as a Therapeutic Target in MYB-Positive Adenoid Cystic Carcinomas and Other Fusion Gene-Driven Tumors

Tumor mutational load predicts survival after immunotherapy across multiple cancer types

(2019) Robert M. Samstein et al.   NATURE GENETICS

Gene fusion involving the insulin-like growth factor 1 receptor in an ALK-negative inflammatory myofibroblastic tumour

(2019) Giuseppe Piarulli et al.   HISTOPATHOLOGY

Identification of a novel BOC-PLAG1 fusion gene in a case of lipoblastoma

(2019) Yoshihiro Nitta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FET family fusion oncoproteins target the SWI/SNF chromatin remodeling complex

(2019) Malin Lindén et al.   EMBO REPORTS

The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas

(2018) Alena Skálová et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Insulin-like growth factor 1 receptor stabilizes the ETV6–NTRK3 chimeric oncoprotein by blocking its KPC1/Rnf123-mediated proteasomal degradation

(2018) Cristina E. Tognon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogenic fusion proteins adopt the insulin-like growth factor signaling pathway

(2018) Haim Werner et al.   Molecular Cancer

A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies

(2018) Carsten Bahr et al.   NATURE

TRK Fusion Cancers in Children: A Clinical Review and Recommendations for Screening

(2018) Catherine M. Albert et al.   JOURNAL OF CLINICAL ONCOLOGY

NTRK fusion-positive cancers and TRK inhibitor therapy

(2018) Emiliano Cocco et al.   Nature Reviews Clinical Oncology

Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors

(2017) Renata Ferrarotto et al.   JOURNAL OF CLINICAL ONCOLOGY

Involvement of platelet-derived growth factor ligands and receptors in tumorigenesis

(2017) C.-H. Heldin et al.   JOURNAL OF INTERNAL MEDICINE

Targeting the Oncogenic Transcriptional Regulator MYB in Adenoid Cystic Carcinoma by Inhibition of IGF1R/AKT Signaling

(2017) Mattias K. Andersson et al.   JNCI-Journal of the National Cancer Institute

Integrative clinical genomics of metastatic cancer

(2017) Dan R. Robinson et al.   NATURE

DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma

(2017) Nathan C Sheffield et al.   NATURE MEDICINE

ETV6 -NTRK3 in congenital mesoblastic nephroma: A report of the SIOP/GPOH nephroblastoma study

(2017) Christian Vokuhl et al.   PEDIATRIC BLOOD & CANCER

Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions

(2017) Martin G. Dalin et al.   Nature Communications

Targeting the Oncogenic Transcriptional Regulator MYB in Adenoid Cystic Carcinoma by Inhibition of IGF1R/AKT Signaling

(2017) Mattias K. Andersson et al.   JNCI-Journal of the National Cancer Institute

Nuclear Factor I/B: A Master Regulator of Cell Differentiation with Paradoxical Roles in Cancer

(2017) Daiana D. Becker-Santos et al.   EBioMedicine

ETV6-NTRK3 Is Expressed in a Subset of ALK-Negative Inflammatory Myofibroblastic Tumors

(2016) Ali H. Alassiri et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

A Phase I Clinical Trial and Independent Patient-Derived Xenograft Study of Combined Targeted Treatment with Dacomitinib and Figitumumab in Advanced Solid Tumors

(2016) Emiliano Calvo et al.   CLINICAL CANCER RESEARCH

Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin

(2016) Benjamin Z Stanton et al.   NATURE GENETICS

An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma

(2016) Yotam Drier et al.   NATURE GENETICS

The landscape of gene fusions and somatic mutations in salivary gland neoplasms – Implications for diagnosis and therapy

(2016) Mattias K. Andersson et al.   ORAL ONCOLOGY

A phase II study of clinical activity of SCH 717454 (robatumumab) in patients with relapsed osteosarcoma and Ewing sarcoma

(2016) Peter M. Anderson et al.   PEDIATRIC BLOOD & CANCER

EGFR and EML4-ALK Updated Therapies in Non-Small Cell Lung Cancer

(2016) Ramon Mello et al.   Recent Patents on Anti-Cancer Drug Discovery

Emerging role of PLAG1 as a regulator of growth and reproduction

(2015) Almas R Juma et al.   JOURNAL OF ENDOCRINOLOGY

Identification of Targetable Kinase Alterations in Patients with Colorectal Carcinoma That are Preferentially Associated with Wild-Type RAS/RAF

(2015) J. F. Hechtman et al.   MOLECULAR CANCER RESEARCH

Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice

(2015) Rene C. Adam et al.   NATURE

Epigenome Mapping Reveals Distinct Modes of Gene Regulation and Widespread Enhancer Reprogramming by the Oncogenic Fusion Protein EWS-FLI1

(2015) Eleni M. Tomazou et al.   Cell Reports

Landscape of gene fusions in epithelial cancers: seq and ye shall find

(2015) Chandan Kumar-Sinha et al.   Genome Medicine

Abstract 1719: Down-regulation of IGFBP2 is associated with resistance to IGF1R therapy in rhabdomyosarcoma

(2015) Zhigang Kang et al.   CANCER RESEARCH

A phase 2 trial of R1507, a monoclonal antibody to the insulin-like growth factor-1 receptor (IGF-1R), in patients with recurrent or refractory rhabdomyosarcoma, osteosarcoma, synovial sarcoma, and other soft tissue sarcomas: Results of a Sarcoma Alliance

(2014) Alberto S. Pappo et al.   CANCER

EWS-FLI1 Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Activate or Repress Enhancer Elements in Ewing Sarcoma

(2014) Nicolò Riggi et al.   CANCER CELL

Phase 1b study of safety, tolerability and efficacy of R1507, a monoclonal antibody to IGF-1R in combination with multiple standard oncology regimens in patients with advanced solid malignancies

(2014) Daruka Mahadevan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Identification ofCOL3A1andRAB2Aas novel translocation partner genes ofPLAG1in lipoblastoma

(2014) Hideki Yoshida et al.   GENES CHROMOSOMES & CANCER

The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

(2014) Gang Wu et al.   NATURE GENETICS

Normal and Functional TP53 in Genetically Stable Myxoid/Round Cell Liposarcoma

(2014) Anders Ståhlberg et al.   PLoS One

An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

(2014) M. R. Mansour et al.   SCIENCE

Targeting transcription factors

(2013) Jennifer E. Yeh et al.   CURRENT OPINION IN ONCOLOGY

Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, phase 2 trial

(2013) Gary K Schwartz et al.   LANCET ONCOLOGY

Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

(2013) Cigall Kadoch et al.   NATURE GENETICS

Phase 2 trial of cixutumumab in children, adolescents, and young adults with refractory solid tumors: A report from the Children's Oncology Group

(2013) Brenda Weigel et al.   PEDIATRIC BLOOD & CANCER

Drugging the undruggable: Transcription therapy for cancer

(2012) Chunhong Yan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Insulin Growth Factor-Receptor (IGF-1R) Antibody Cixutumumab Combined with the mTOR Inhibitor Temsirolimus in Patients with Refractory Ewing's Sarcoma Family Tumors

(2012) A. Naing et al.   CLINICAL CANCER RESEARCH

Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy

(2012) Cristina E Tognon et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Management of salivary gland tumors

(2012) Guy Andry et al.   Expert Review of Anticancer Therapy

Phase II Study of Ganitumab, a Fully Human Anti–Type-1 Insulin-Like Growth Factor Receptor Antibody, in Patients With Metastatic Ewing Family Tumors or Desmoplastic Small Round Cell Tumors

(2012) William D. Tap et al.   JOURNAL OF CLINICAL ONCOLOGY

IGFBP3 impedes aggressive growth of pediatric liver cancer and is epigenetically silenced in vascular invasive and metastatic tumors

(2012) Ivonne Regel et al.   Molecular Cancer

Gene Expression Responses to FUS, EWS, and TAF15 Reduction and Stress Granule Sequestration Analyses Identifies FET-Protein Non-Redundant Functions

(2012) Jenny Blechingberg et al.   PLoS One

R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor 1 Receptor, in Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors: Results of a Phase II Sarcoma Alliance for Research Through Collaboration Study

(2011) Alberto S. Pappo et al.   JOURNAL OF CLINICAL ONCOLOGY

Preliminary Efficacy of the Anti-Insulin–Like Growth Factor Type 1 Receptor Antibody Figitumumab in Patients With Refractory Ewing Sarcoma

(2011) Heribert Juergens et al.   JOURNAL OF CLINICAL ONCOLOGY

Prioritizing Phase I Treatment Options Through Preclinical Testing on Personalized Tumorgraft

(2011) M. Pia Morelli et al.   JOURNAL OF CLINICAL ONCOLOGY

Involvement of the PI3K/Akt pathway in myxoid/round cell liposarcoma

(2011) Elizabeth G Demicco et al.   MODERN PATHOLOGY

Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms

(2011) Louis B Brill et al.   MODERN PATHOLOGY

A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation

(2011) C E Tognon et al.   ONCOGENE

ALK Inhibition for Non-Small Cell Lung Cancer: From Discovery to Therapy in Record Time

(2010) David E. Gerber et al.   CANCER CELL

Genome-Wide Identification of PAX3-FKHR Binding Sites in Rhabdomyosarcoma Reveals Candidate Target Genes Important for Development and Cancer

(2010) L. Cao et al.   CANCER RESEARCH

ETV6-NTRK3-Mediated Breast Epithelial Cell Transformation Is Blocked by Targeting the IGF1R Signaling Pathway

(2010) C. E. Tognon et al.   CANCER RESEARCH

Combination mTOR and IGF-1R Inhibition: Phase I Trial of Everolimus and Figitumumab in Patients with Advanced Sarcomas and Other Solid Tumors

(2010) R. Quek et al.   CLINICAL CANCER RESEARCH

Systemic therapy in the management of metastatic or locally recurrent adenoid cystic carcinoma of the salivary glands: a systematic review

(2010) Scott A Laurie et al.   LANCET ONCOLOGY

Oncogenic gene fusions in epithelial carcinomas

(2009) John R Prensner et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck

(2009) M. Persson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translation of the Philadelphia chromosome into therapy for CML

(2008) B. J. Druker   BLOOD

The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response

(2008) Mattias K Andersson et al.   BMC CELL BIOLOGY

Chromosomal patterns in a benign human neoplasm, the mixed salivary gland tumour

(2008) JOACHIM MARK et al.   HEREDITAS