Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis

Wnt/β-catenin signaling in the mouse embryonic cranial mesenchyme is required to sustain the emerging differentiated meningeal layers

(2019) Gregg DiNuoscio et al.   GENESIS

Human neural crest induction by temporal modulation of WNT activation

(2019) Gustavo A. Gomez et al.   DEVELOPMENTAL BIOLOGY

The diverse neural crest: from embryology to human pathology

(2019) Heather C. Etchevers et al.   DEVELOPMENT

YAP promotes neural crest emigration through interactions with BMP and Wnt activities

(2019) Deepak Kumar et al.   Cell Communication and Signaling

A new transgenic reporter line reveals Wnt-dependent Snai2 re-expression and cranial neural crest differentiation in Xenopus

(2019) Jiejing Li et al.   Scientific Reports

WNT Signaling in Neuroblastoma

(2019) Juergen Becker et al.   Cancers

Integrating chemical and mechanical signals in neural crest cell migration

(2019) Adam Shellard et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

A gene regulatory network underlying the formation of pre-placodal ectoderm in Xenopus laevis

(2018) Santosh Kumar Maharana et al.   BMC BIOLOGY

From instruction to output: Wnt/PCP signaling in development and cancer

(2018) Ashley Ceinwen Humphries et al.   CURRENT OPINION IN CELL BIOLOGY

XenopusADAM19 regulates Wnt signaling and neural crest specification by stabilizing ADAM13

(2018) Jiejing Li et al.   DEVELOPMENT

Wnt signaling in development and tissue homeostasis

(2018) Zachary Steinhart et al.   DEVELOPMENT

The neural border: Induction, specification and maturation of the territory that generates neural crest cells

(2018) Patrick Pla et al.   DEVELOPMENTAL BIOLOGY

Neurocristopathies: New insights 150 years after the neural crest discovery

(2018) Guillermo A. Vega-Lopez et al.   DEVELOPMENTAL BIOLOGY

The b-HLH transcription factor Hes3 participates in neural plate border formation by interfering with Wnt/β-catenin signaling

(2018) Chang-Soo Hong et al.   DEVELOPMENTAL BIOLOGY

Migration and diversification of the vagal neural crest

(2018) Erica J. Hutchins et al.   DEVELOPMENTAL BIOLOGY

Regulation of neural crest development by the formin family protein Daam1

(2018) Olga Ossipova et al.   GENESIS

Draxin acts as a molecular rheostat of canonical Wnt signaling to control cranial neural crest EMT

(2018) Erica J. Hutchins et al.   JOURNAL OF CELL BIOLOGY

Protein Arginine Methyltransferase PRMT1 Is Essential for Palatogenesis

(2018) Y. Gou et al.   JOURNAL OF DENTAL RESEARCH

Bone Morphogenetic Protein 2 Coordinates Early Tooth Mineralization

(2018) Z. Malik et al.   JOURNAL OF DENTAL RESEARCH

Wnt-signaling enhances neural crest migration of melanoma cells and induces an invasive phenotype

(2018) Tobias Sinnberg et al.   Molecular Cancer

An atlas of Wnt activity during embryogenesis in Xenopus tropicalis

(2018) Caroline Borday et al.   PLoS One

Dkk2 promotes neural crest specification by activating Wnt/β-catenin signaling in a GSK3β independent manner

(2018) Arun Devotta et al.   eLife

Mechanisms of Neural Crest Migration

(2018) András Szabó et al.   Annual Review of Genetics

Draxin alters laminin organization during basement membrane remodeling to control cranial neural crest EMT

(2018) Erica J. Hutchins et al.   DEVELOPMENTAL BIOLOGY

Establishment of a murine culture system for modeling the temporal progression of cranial and trunk neural crest cell differentiation

(2018) Maria R. Replogle et al.   Disease Models & Mechanisms

Control of neural crest multipotency by Wnt signaling and the Lin28/let-7 axis

(2018) Debadrita Bhattacharya et al.   eLife

Trunk neural crest cells: formation, migration and beyond

(2017) Guillermo A. Vega-Lopez et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Apolipoprotein C-I mediates Wnt/Ctnnb1 signaling during neural border formation and is required for neural crest development

(2017) Chika Yokota et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Neural crest and cancer: Divergent travelers on similar paths

(2017) Kristin L. Gallik et al.   MECHANISMS OF DEVELOPMENT

Generation and characterization of Kctd15 mutations in zebrafish

(2017) Alison Heffer et al.   PLoS One

A molecular atlas of the developing ectoderm defines neural, neural crest, placode, and nonneural progenitor identity in vertebrates

(2017) Jean-Louis Plouhinec et al.   PLOS BIOLOGY

Vestigial-like 3 is a novel Ets1 interacting partner and regulates trigeminal nerve formation and cranial neural crest migration

(2017) Emilie Simon et al.   Biology Open

Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma

(2016) Cecilia Dyberg et al.   BMC CANCER

Wnt/β-catenin signaling in melanoma: Preclinical rationale and novel therapeutic insights

(2016) Gongda Xue et al.   CANCER TREATMENT REVIEWS

Tcf7l1 protects the anterior neural fold from adopting the neural crest fate

(2016) Jan Mašek et al.   DEVELOPMENT

Ror2 signaling is required for local upregulation of GDF6 and activation of BMP signaling at the neural plate border

(2016) Carolin Schille et al.   DEVELOPMENT

Delamination of neural crest cells requires transient and reversible Wnt inhibition mediated by Dact1/2

(2016) M. Angeles Rabadán et al.   DEVELOPMENT

Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists

(2016) Shihai Jia et al.   DEVELOPMENTAL BIOLOGY

Identifying domains of EFHC1 involved in ciliary localization, ciliogenesis, and the regulation of Wnt signaling

(2016) Ying Zhao et al.   DEVELOPMENTAL BIOLOGY

ADAM13 cleavage of cadherin-11 promotes CNC migration independently of the homophilic binding site

(2016) Genevieve Abbruzzese et al.   DEVELOPMENTAL BIOLOGY

Controlled levels of canonical Wnt signaling are required for neural crest migration

(2016) Ewa Maj et al.   DEVELOPMENTAL BIOLOGY

Genes regulated by potassium channel tetramerization domain containing 15 (Kctd15) in the developing neural crest

(2016) Thomas C. B. Wong et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

Wnt signalling is a bi-directional vulnerability of cancer cells

(2016) David J. Duffy et al.   Oncotarget

Premigratory and Migratory Neural Crest Cells Are Multipotent In Vivo

(2015) Arianna Baggiolini et al.   Cell Stem Cell

Establishing neural crest identity: a gene regulatory recipe

(2015) M. Simoes-Costa et al.   DEVELOPMENT

Axud1 Integrates Wnt Signaling and Transcriptional Inputs to Drive Neural Crest Formation

(2015) Marcos Simões-Costa et al.   DEVELOPMENTAL CELL

WNT signaling in glioblastoma and therapeutic opportunities

(2015) Yeri Lee et al.   LABORATORY INVESTIGATION

Enhanced Activation of Canonical Wnt Signaling Confers Mesoderm-Derived Parietal Bone with Similar Osteogenic and Skeletal Healing Capacity to Neural Crest-Derived Frontal Bone

(2015) Shuli Li et al.   PLoS One

The Wnt Co-Receptor Lrp5 Is Required for Cranial Neural Crest Cell Migration in Zebrafish

(2015) Bernd Willems et al.   PLoS One

A PTK7/Ror2 Co-Receptor Complex Affects Xenopus Neural Crest Migration

(2015) Martina Podleschny et al.   PLoS One

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

(2014) X. Varelas   DEVELOPMENT

Tumors of the neural crest: Common themes in development and cancer

(2014) Lillias H. Maguire et al.   DEVELOPMENTAL DYNAMICS

CHD7, the gene mutated in CHARGE syndrome, regulates genes involved in neural crest cell guidance

(2014) Yvonne Schulz et al.   HUMAN GENETICS

Essential role of AWP1 in neural crest specification in Xenopus

(2014) Jeong-Han Seo et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Roles of chromatin remodelers in maintenance mechanisms of multipotency of mouse trunk neural crest cells in the formation of neural crest-derived stem cells

(2014) Kyohei Fujita et al.   MECHANISMS OF DEVELOPMENT

GSK3 and Polo-like kinase regulate ADAM13 function during cranial neural crest cell migration

(2014) Genevieve Abbruzzese et al.   MOLECULAR BIOLOGY OF THE CELL

Rabconnectin-3a Regulates Vesicle Endocytosis and Canonical Wnt Signaling in Zebrafish Neural Crest Migration

(2014) Adam M. Tuttle et al.   PLOS BIOLOGY

Role of the Rap2/TNIK kinase pathway in regulation of LRP6 stability for Wnt signaling

(2013) Dong-Seok Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of the non-canonical Wnt–planar cell polarity pathway in neural crest migration

(2013) Roberto Mayor et al.   BIOCHEMICAL JOURNAL

A secreted splice variant of the Xenopus frizzled-4 receptor is a biphasic modulator of Wnt signalling

(2013) Anne-Kathrin Gorny et al.   Cell Communication and Signaling

Lipid modification in Wnt structure and function

(2013) Jiyuan Ke et al.   CURRENT OPINION IN LIPIDOLOGY

Hirschsprung disease

(2013) Jacob C. Langer   CURRENT OPINION IN PEDIATRICS

The neural crest

(2013) R. Mayor et al.   DEVELOPMENT

A dynamic code of dorsal neural tube genes regulates the segregation between neurogenic and melanogenic neural crest cells

(2013) E. Nitzan et al.   DEVELOPMENT

Ptk7 promotes non-canonical Wnt/PCP-mediated morphogenesis and inhibits Wnt/ -catenin-dependent cell fate decisions during vertebrate development

(2013) M. Hayes et al.   DEVELOPMENT

Loss of Xenopus cadherin-11 leads to increased Wnt/β-catenin signaling and up-regulation of target genes c-myc and cyclin D1 in neural crest

(2013) Almut Koehler et al.   DEVELOPMENTAL BIOLOGY

Role ofSp5as an essential early regulator of neural crest specification inxenopus

(2013) Dong-Seok Park et al.   DEVELOPMENTAL DYNAMICS

Insights into neural crest development and evolution from genomic analysis

(2013) M. Simoes-Costa et al.   GENOME RESEARCH

Chase-and-run between adjacent cell populations promotes directional collective migration

(2013) Eric Theveneau et al.   NATURE CELL BIOLOGY

Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2

(2013) V. E. Zarelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of Sox9 is required for neural crest delamination and is regulated downstream of BMP and canonical Wnt signaling

(2013) J. A. J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue Interactions in Neural Crest Cell Development and Disease

(2013) Y. Takahashi et al.   SCIENCE

Structural Studies of Wnts and Identification of an LRP6 Binding Site

(2013) Matthew Ling-Hon Chu et al.   STRUCTURE

Signals and Switches in Mammalian Neural Crest Cell Differentiation

(2013) S. Bhatt et al.   Cold Spring Harbor Perspectives in Biology

Riding the crest of the wave: parallels between the neural crest and cancer in epithelial-to-mesenchymal transition and migration

(2013) Davalyn R. Powell et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Calponin 2 Acts As an Effector of Noncanonical Wnt-Mediated Cell Polarization during Neural Crest Cell Migration

(2013) Bärbel Ulmer et al.   Cell Reports

Regulation of Tcf7l1 DNA Binding and Protein Stability as Principal Mechanisms of Wnt/β-Catenin Signaling

(2013) Brian R. Shy et al.   Cell Reports

Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

(2012) Vivian S.W. Li et al.   CELL

Current perspectives of the signaling pathways directing neural crest induction

(2012) Timothy J. Stuhlmiller et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Temporal control of neural crest lineage generation by Wnt/ -catenin signaling

(2012) L. Hari et al.   DEVELOPMENT

Development and evolution of the neural crest: An overview

(2012) Marianne E. Bronner et al.   DEVELOPMENTAL BIOLOGY

Neural crest delamination and migration: From epithelium-to-mesenchyme transition to collective cell migration

(2012) Eric Theveneau et al.   DEVELOPMENTAL BIOLOGY

Neural crest induction at the neural plate border in vertebrates

(2012) Cécile Milet et al.   DEVELOPMENTAL BIOLOGY

Neural crest progenitors and stem cells: From early development to adulthood

(2012) Elisabeth Dupin et al.   DEVELOPMENTAL BIOLOGY

Formation and migration of neural crest cells in the vertebrate embryo

(2012) Marianne E. Bronner   HISTOCHEMISTRY AND CELL BIOLOGY

Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2

(2012) R. K. Bikkavilli et al.   JOURNAL OF CELL SCIENCE

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2005-2009

(2012) T. A. Dolecek et al.   NEURO-ONCOLOGY

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

What is bad in cancer is good in the embryo: Importance of EMT in neural crest development

(2012) Laura Kerosuo et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dishevelled3 is a novel arginine methyl transferase substrate

(2012) Rama Kamesh Bikkavilli et al.   Scientific Reports

Wnt/Ca2+ signaling pathway: a brief overview

(2011) Antara De   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas

(2011) William E. Damsky et al.   CANCER CELL

Life at the Leading Edge

(2011) Anne J. Ridley   CELL

Neural crest specification by noncanonical Wnt signaling and PAR-1

(2011) O. Ossipova et al.   DEVELOPMENT

A novel role for MuSK and non-canonical Wnt signaling during segmental neural crest cell migration

(2011) S. Banerjee et al.   DEVELOPMENT

Translocation of the Cytoplasmic Domain of ADAM13 to the Nucleus Is Essential for Calpain8-a Expression and Cranial Neural Crest Cell Migration

(2011) Hélène Cousin et al.   DEVELOPMENTAL CELL

Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling

(2011) Shuo Chen et al.   DEVELOPMENTAL CELL

Vagal neural crest cell migratory behavior: A transition between the cranial and trunk crest

(2011) Bryan R. Kuo et al.   DEVELOPMENTAL DYNAMICS

FGF and retinoic acid activity gradients control the timing of neural crest cell emigration in the trunk

(2011) Patricia L. Martínez-Morales et al.   JOURNAL OF CELL BIOLOGY

Arginine methylation of G3BP1 in response to Wnt3a regulates  -catenin mRNA

(2011) R. K. Bikkavilli et al.   JOURNAL OF CELL SCIENCE

Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling

(2011) B Cha et al.   ONCOGENE

Craniofacial birth defects: The role of neural crest cells in the etiology and pathogenesis of Treacher Collins syndrome and the potential for prevention

(2010) Paul A. Trainor   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Regulation of cell adhesions and motility during initiation of neural crest migration

(2010) Matthew R Clay et al.   CURRENT OPINION IN NEUROBIOLOGY

Evidence for a dynamic spatiotemporal fate map and early fate restrictions of premigratory avian neural crest

(2010) S. Krispin et al.   DEVELOPMENT

Kctd15 inhibits neural crest formation by attenuating Wnt/ -catenin signaling output

(2010) S. Dutta et al.   DEVELOPMENT

Ovo1 links Wnt signaling with N-cadherin localization during neural crest migration

(2010) S. Piloto et al.   DEVELOPMENT

Activity of the RhoU/Wrch1 GTPase is critical for cranial neural crest cell migration

(2010) Philippe Fort et al.   DEVELOPMENTAL BIOLOGY

Early regulative ability of the neuroepithelium to form cardiac neural crest

(2010) Akouavi M. Ezin et al.   DEVELOPMENTAL BIOLOGY

ADAM13 Induces Cranial Neural Crest by Cleaving Class B Ephrins and Regulating Wnt Signaling

(2010) Shuo Wei et al.   DEVELOPMENTAL CELL

Canonical Wnt/β-catenin signaling is required for maintenance but not activation of Pitx2 expression in neural crest during eye development

(2010) Amanda L. Zacharias et al.   DEVELOPMENTAL DYNAMICS

Xenopus Skip Modulates Wnt/β-Catenin Signaling and Functions in Neural Crest Induction

(2010) Ying Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent Advances in Neuroblastoma

(2010) John M. Maris   NEW ENGLAND JOURNAL OF MEDICINE

Control of neural crest cell behavior and migration

(2010) Matthew R. Clay et al.   Cell Adhesion & Migration

Regulation of cadherin expression in the chicken neural crest by the Wnt/ β-catenin signaling pathway

(2010) Abha J. Chalpe et al.   Cell Adhesion & Migration

Early mouse caudal development relies on crosstalk between retinoic acid, Shh and Fgf signalling pathways

(2009) V. Ribes et al.   DEVELOPMENT

The posteriorizing gene Gbx2 is a direct target of Wnt signalling and the earliest factor in neural crest induction

(2009) B. Li et al.   DEVELOPMENT

Myosin-X is critical for migratory ability of Xenopus cranial neural crest cells

(2009) Shuyi Nie et al.   DEVELOPMENTAL BIOLOGY

Comprehensive spatiotemporal analysis of early chick neural crest network genes

(2009) Jane Khudyakov et al.   DEVELOPMENTAL DYNAMICS

Complex and dynamic patterns of Wnt pathway gene expression in the developing chick forebrain

(2009) Robyn Quinlan et al.   Neural Development

Activated Wnt/ss-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model

(2009) A. J. Chien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antagonistic Actions of Msx1 and Osr2 Pattern Mammalian Teeth into a Single Row

(2009) Z. Zhang et al.   SCIENCE

Selective activation mechanisms of Wnt signaling pathways

(2009) Akira Kikuchi et al.   TRENDS IN CELL BIOLOGY

Planar Cell Polarity Signaling: From Fly Development to Human Disease

(2008) Matias Simons et al.   Annual Review of Genetics

Retinoic Acid Synthesis and Signaling during Early Organogenesis

(2008) Gregg Duester   CELL

Ontogeny and Multipotency of Neural Crest-Derived Stem Cells in Mouse Bone Marrow, Dorsal Root Ganglia, and Whisker Pad

(2008) Narihito Nagoshi et al.   Cell Stem Cell

PTK7 recruits dsh to regulate neural crest migration

(2008) I. Shnitsar et al.   DEVELOPMENT

Fgf8a induces neural crest indirectly through the activation of Wnt8 in the paraxial mesoderm

(2008) C.-S. Hong et al.   DEVELOPMENT

Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA

(2008) H. K. Matthews et al.   DEVELOPMENT

Hairy2 functions through both DNA-binding and non DNA-binding mechanisms at the neural plate border in Xenopus

(2008) Massimo Nichane et al.   DEVELOPMENTAL BIOLOGY

Wnt11ris required for cranial neural crest migration

(2008) Helen K. Matthews et al.   DEVELOPMENTAL DYNAMICS

3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19)

(2008) Kristen Summerhurst et al.   GENE EXPRESSION PATTERNS

Extracellular Cleavage of Cadherin-11 by ADAM Metalloproteases Is Essential for Xenopus Cranial Neural Crest Cell Migration

(2008) Catherine McCusker et al.   MOLECULAR BIOLOGY OF THE CELL

Contact inhibition of locomotion in vivo controls neural crest directional migration

(2008) Carlos Carmona-Fontaine et al.   NATURE

A negative modulatory role for rho and rho-associated kinase signaling in delamination of neural crest cells

(2008) Maya Groysman et al.   Neural Development

LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of  -catenin

(2008) C. S. Cselenyi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

(2008) M. A. Newman et al.   RNA