How Cancer Exploits Ribosomal RNA Biogenesis: A Journey beyond the Boundaries of rRNA Transcription

The Ribosome Biogenesis—Cancer Connection

(2019) Marianna Penzo et al.   Cells

Uncovering the assembly pathway of human ribosomes and its emerging links to disease

(2019) Katherine E Bohnsack et al.   EMBO JOURNAL

Human UTP14a promotes colorectal cancer progression by forming a positive regulation loop with c-Myc

(2018) Jingyi Zhang et al.   CANCER LETTERS

Tumor suppressor PNRC1 blocks rRNA maturation by recruiting the decapping complex to the nucleolus

(2018) Marco Gaviraghi et al.   EMBO JOURNAL

Sirtuin 7 promotes glioma proliferation and invasion through activation of the ERK/STAT3 signaling pathway

(2018) Pengfei Mu et al.   Oncology Letters

Epigenetic loss of the RNA decapping enzyme NUDT16 mediates C-MYC activation in T-cell acute lymphoblastic leukemia

(2017) C Anadón et al.   LEUKEMIA

AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia

(2017) Fengbiao Zhou et al.   NATURE CELL BIOLOGY

The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma

(2017) T Tao et al.   ONCOGENE

PTENβ is an alternatively translated isoform of PTEN that regulates rDNA transcription

(2017) Hui Liang et al.   Nature Communications

A Pan-cancer Analysis of the Expression and Clinical Relevance of Small Nucleolar RNAs in Human Cancer

(2017) Jing Gong et al.   Cell Reports

Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress

(2016) Emilien Nicolas et al.   Nature Communications

SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing

(2016) Sifan Chen et al.   Nature Communications

The human box C/D snoRNAs U3 and U8 are required for pre-rRNA processing and tumorigenesis

(2016) Jean-Louis Langhendries et al.   Oncotarget

The Role of MDM2 Amplification and Overexpression in Tumorigenesis

(2016) Jonathan D. Oliner et al.   Cold Spring Harbor Perspectives in Medicine

snoRNAs are a novel class of biologically relevant Myc targets

(2015) Eva K Herter et al.   BMC BIOLOGY

The RNA recognition motif of NIFK is required for rRNA maturation during cell cycle progression

(2015) Wen-An Pan et al.   RNA Biology

Self-association of Trimethylguanosine Synthase Tgs1 is required for efficient snRNA/snoRNA trimethylation and pre-rRNA processing

(2015) Kum-Loong Boon et al.   Scientific Reports

The emerging landscape of small nucleolar RNAs in cell biology

(2015) Fabien Dupuis-Sandoval et al.   Wiley Interdisciplinary Reviews-RNA

Regulatory Role of Small Nucleolar RNAs in Human Diseases

(2015) Grigory A. Stepanov et al.   Biomed Research International

Targeting the nucleolus for cancer intervention

(2014) Jaclyn E. Quin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Small nucleolar RNA signatures of lung tumor-initiating cells

(2014) Kaiissar Mannoor et al.   Molecular Cancer

Small RNAs with big implications: new insights into H/ACA snoRNA function and their role in human disease

(2014) Mary McMahon et al.   Wiley Interdisciplinary Reviews-RNA

Beyond microRNA – Novel RNAs derived from small non-coding RNA and their implication in cancer

(2013) Elena S. Martens-Uzunova et al.   CANCER LETTERS

Elevated snoRNA biogenesis is essential in breast cancer

(2013) H Su et al.   ONCOGENE

The nucleolus: an emerging target for cancer therapy

(2013) Nadine Hein et al.   TRENDS IN MOLECULAR MEDICINE

Small nucleolar RNAs in cancer

(2012) Kaiissar Mannoor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Mapping the cleavage sites on mammalian pre-rRNAs: Where do we stand?

(2012) Sahra-Taylor Mullineux et al.   BIOCHIMIE

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

(2012) Megan J. Bywater et al.   CANCER CELL

Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b

(2012) Jeong Kyu Kim et al.   HEPATOLOGY

The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis

(2011) H E Gee et al.   BRITISH JOURNAL OF CANCER

A Weak C' Box Renders U3 snoRNA Levels Dependent on hU3-55K Binding

(2011) A. A. Knox et al.   MOLECULAR AND CELLULAR BIOLOGY

mTOR signaling regulates the processing of pre-rRNA in human cells

(2011) Valentina Iadevaia et al.   NUCLEIC ACIDS RESEARCH

AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

(2011) J. C. Chan et al.   Science Signaling

The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer

(2010) Denis Drygin et al.   Annual Review of Pharmacology and Toxicology

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

(2010) Denis Drygin et al.   CANCER RESEARCH

Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression

(2010) Andrzej B Popławski et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Utp25p, a nucleolar Saccharomyces cerevisiae protein, interacts with U3 snoRNP subunits and affects processing of the 35S pre-rRNA

(2010) Mauricio B. Goldfeder et al.   FEBS Journal

A Small Ribosomal Subunit (SSU) Processome Component, the Human U3 Protein 14A (hUTP14A) Binds p53 and Promotes p53 Degradation

(2010) Lelin Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple mRNA Decapping Enzymes in Mammalian Cells

(2010) Man-Gen Song et al.   MOLECULAR CELL

Box H/ACA Small Ribonucleoproteins

(2010) Tamás Kiss et al.   MOLECULAR CELL

The ARF Tumor Suppressor Controls Ribosome Biogenesis by Regulating the RNA Polymerase I Transcription Factor TTF-I

(2010) Frédéric Lessard et al.   MOLECULAR CELL

The Nucleolus under Stress

(2010) Séverine Boulon et al.   MOLECULAR CELL

Mutations in genes encoding subunits of RNA polymerases I and III cause Treacher Collins syndrome

(2010) Johannes G Dauwerse et al.   NATURE GENETICS

c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation

(2010) Gretchen Poortinga et al.   NUCLEIC ACIDS RESEARCH

The DEAD-box RNA helicase-like Utp25 is an SSU processome component

(2010) J. M. Charette et al.   RNA

High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-  and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response

(2009) M. Remke et al.   BLOOD

Signaling to p53: Ribosomal Proteins Find Their Way

(2009) Yanping Zhang et al.   CANCER CELL

Implication of snoRNA U50 in human breast cancer

(2009) Xue-Yuan Dong et al.   Journal of Genetics and Genomics

Enhancer of decapping proteins 1 and 2 are important for translation during heat stress inSaccharomyces cerevisiae

(2009) Daniel W. Neef et al.   MOLECULAR MICROBIOLOGY

AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply

(2009) S. Hoppe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

c-Jun Supports Ribosomal RNA Processing and Nucleolar Localization of RNA Helicase DDX21

(2008) Tim H. Holmström et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Human snoRNA with MicroRNA-Like Functions

(2008) Christine Ender et al.   MOLECULAR CELL

The Control of mRNA Decapping and P-Body Formation

(2008) Tobias M. Franks et al.   MOLECULAR CELL