Multifaceted Regulation of PTEN Subcellular Distributions and Biological Functions

PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression

(2019) Mi Kyung Park et al.   Nature Communications

Mechanisms of PTEN loss in cancer: It’s all about diversity

(2019) Virginia Álvarez-Garcia et al.   SEMINARS IN CANCER BIOLOGY

Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

(2019) Yu-Ru Lee et al.   SCIENCE

Grb2 binds to PTEN and regulates its nuclear translocation to maintain the genomic stability in DNA damage response

(2019) Bolin Hou et al.   Cell Death & Disease

miR-205-5p regulates epithelial-mesenchymal transition by targeting PTEN via PI3K/AKT signaling pathway in cisplatin-resistant nasopharyngeal carcinoma cells

(2019) Pei Zhang et al.   GENE

PTEN PDZ-binding domain suppresses mammary carcinogenesis in the MMTV-PyMT breast cancer model

(2018) Mingfei Yan et al.   CANCER LETTERS

WWP2 is a physiological ubiquitin ligase for phosphatase and tensin homolog (PTEN) in mice

(2018) Hongchang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CK1α suppresses lung tumour growth by stabilizing PTEN and inducing autophagy

(2018) Junchao Cai et al.   NATURE CELL BIOLOGY

An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer

(2018) Ming Chen et al.   NATURE GENETICS

The functions and regulation of the PTEN tumour suppressor: new modes and prospects

(2018) Yu-Ru Lee et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Clinical implications of PTEN loss in prostate cancer

(2018) Tamara Jamaspishvili et al.   Nature Reviews Urology

Overexpression of Long Noncoding RNA PTENP1 Inhibits Cell Proliferation and Migration via Suppression of miR-19b in Breast Cancer Cells

(2018) Xianbiao Shi et al.   ONCOLOGY RESEARCH

Discovery of small molecule WWP2 ubiquitin ligase inhibitors

(2018) Andrew Chantry et al.   CHEMISTRY-A EUROPEAN JOURNAL

Regulation of PTEN expression by noncoding RNAs

(2018) Wang Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Exosome–transmitted long non-coding RNA PTENP1 suppresses bladder cancer progression

(2018) Rui Zheng et al.   Molecular Cancer

Overexpression of lncRNA PTENP1 suppresses glioma cell proliferation and metastasis in vitro

(2018) Su Hu et al.   OncoTargets and Therapy

Prevalence and Prognostic Significance of PTEN Loss in African-American and European-American Men Undergoing Radical Prostatectomy

(2017) Jeffrey J. Tosoian et al.   EUROPEAN UROLOGY

Redox regulation of the tumor suppressor PTEN by the thioredoxin system and cumene hydroperoxide

(2017) Seong-Jeong Han et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Screening of Anticholinergic Accumulation by Traditional Chinese Medicine

(2017) Ming Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial energy metabolism and signalling in human glioblastoma cell lines with different PTEN gene status

(2017) Marina Comelli et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein

(2017) Muhan Chen et al.   JOURNAL OF CELL BIOLOGY

AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis

(2017) Ni Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell Cycle Control by PTEN

(2017) Andrew Brandmaier et al.   JOURNAL OF MOLECULAR BIOLOGY

Analysis of PIK3CA mutations and PI3K pathway proteins in advanced gastric cancer

(2017) Chie Ito et al.   JOURNAL OF SURGICAL RESEARCH

Mutations in TP53 , PIK3CA , PTEN and other genes in EGFR mutated lung cancers: Correlation with clinical outcomes

(2017) Paul A. VanderLaan et al.   LUNG CANCER

Integrative clinical genomics of metastatic cancer

(2017) Dan R. Robinson et al.   NATURE

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth

(2017) Shafi Kuchay et al.   NATURE

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

(2017) Amaia Zabala-Letona et al.   NATURE

Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization

(2017) Jr-M Yang et al.   ONCOGENE

Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevance

(2017) J Vaquero et al.   ONCOGENE

PTENβ is an alternatively translated isoform of PTEN that regulates rDNA transcription

(2017) Hui Liang et al.   Nature Communications

The PTEN protein: cellular localization and post-translational regulation

(2016) N. R. Leslie et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

PTEN regulates PLK1 and controls chromosomal stability during cell division

(2016) Zhong Zhang et al.   CELL CYCLE

Molecular Features of Phosphatase and Tensin Homolog (PTEN) Regulation by C-terminal Phosphorylation

(2016) Zan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model

(2016) Oh-Joon Kwon et al.   JOURNAL OF CLINICAL INVESTIGATION

Promoter Methylation of PTEN Is a Significant Prognostic Factor in Melanoma Survival

(2016) Mi Ryung Roh et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes

(2016) Janine H. van Ree et al.   NATURE CELL BIOLOGY

Inherited PTEN mutations and the prediction of phenotype

(2016) Nicholas R. Leslie et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

MicroRNA-92a promotes metastasis of nasopharyngeal carcinoma by targeting the PTEN/AKT pathway

(2016) Kang Zhu et al.   OncoTargets and Therapy

Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner

(2016) Jia Liu et al.   Cell Discovery

ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells

(2015) Jing-Hong Chen et al.   Autophagy

The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity

(2015) G. R. Masson et al.   BIOCHEMICAL JOURNAL

Molecular functions of NEDD4 E3 ubiquitin ligases in cancer

(2015) Xiao Zou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

MicroRNA-23a enhances migration and invasion through PTEN in osteosarcoma

(2015) K Tian et al.   CANCER GENE THERAPY

BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation

(2015) Alessandro Morotti et al.   CELL CYCLE

Feedback regulation on PTEN/AKT pathway by the ER stress kinase PERK mediated by interaction with the Vault complex

(2015) Wei Zhang et al.   CELLULAR SIGNALLING

Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration

(2015) Maria B. Goncalves et al.   JOURNAL OF NEUROSCIENCE

Kinases, tails and more: Regulation of PTEN function by phosphorylation

(2015) Rita Fragoso et al.   METHODS

PTEN ceRNA networks in human cancer

(2015) Laura Poliseno et al.   METHODS

PTEN–PDZ domain interactions: Binding of PTEN to PDZ domains of PTPN13

(2015) Natalia S. Sotelo et al.   METHODS

PTEN Functions by Recruitment to Cytoplasmic Vesicles

(2015) Adam Naguib et al.   MOLECULAR CELL

Activation of nuclear PTEN by inhibition of Notch signaling induces G2/M cell cycle arrest in gastric cancer

(2015) S-J Kim et al.   ONCOGENE

Superdomains in the protein structure hierarchy: The case of PTP-C2

(2015) Donald T. Haynie et al.   PROTEIN SCIENCE

PTEN regulates cilia through Dishevelled

(2015) Iryna Shnitsar et al.   Nature Communications

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis

(2015) Helena Serra et al.   Nature Communications

Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma

(2015) Leticia De Mattos-Arruda et al.   Nature Communications

PTEN stabilizes TOP2A and regulates the DNA decatenation

(2015) Xi Kang et al.   Scientific Reports

A Functional Dissection of PTEN N-Terminus: Implications in PTEN Subcellular Targeting and Tumor Suppressor Activity

(2015) Anabel Gil et al.   PLoS One

Signaling through C2 domains: More than one lipid target

(2014) Senena Corbalan-Garcia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function

(2014) Antonella Papa et al.   CELL

PTENα, a PTEN Isoform Translated through Alternative Initiation, Regulates Mitochondrial Function and Energy Metabolism

(2014) Hui Liang et al.   Cell Metabolism

Reactivation of oxidized PTP1B and PTEN by thioredoxin 1

(2014) Ulla Schwertassek et al.   FEBS Journal

Cowden syndrome-associated germline SDHD variants alter PTEN nuclear translocation through SRC-induced PTEN oxidation

(2014) Wanfeng Yu et al.   HUMAN MOLECULAR GENETICS

Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes

(2014) Laura Spinelli et al.   JOURNAL OF MEDICAL GENETICS

Heterogeneity and chronology of PTEN deletion and ERG fusion in prostate cancer

(2014) Antje Krohn et al.   MODERN PATHOLOGY

Identification of nucleolus-localized PTEN and its function in regulating ribosome biogenesis

(2014) Pingdong Li et al.   MOLECULAR BIOLOGY REPORTS

NF-kappaB-dependent MicroRNA-425 upregulation promotes gastric cancer cell growth by targeting PTEN upon IL-1β induction

(2014) Jun Ma et al.   Molecular Cancer

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities

(2014) Hoai-Nghia Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab5 and Ndfip1 Are Involved in Pten Ubiquitination and Nuclear Trafficking

(2014) Yijia Li et al.   TRAFFIC

PTEN C-Terminal Deletion Causes Genomic Instability and Tumor Development

(2014) Zhuo Sun et al.   Cell Reports

PTEN Hopping on the Cell Membrane Is Regulated via a Positively-Charged C2 Domain

(2014) Masato Yasui et al.   PLoS Computational Biology

PTEN Phosphorylation and Nuclear Export Mediate Free Fatty Acid-Induced Oxidative Stress

(2013) Yong Wu et al.   ANTIOXIDANTS & REDOX SIGNALING

ΔNp63α represses nuclear translocation of PTEN by inhibition of NEDD4-1 in keratinocytes

(2013) Mary K. Leonard et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN

(2013) S-W Hong et al.   CELL DEATH AND DIFFERENTIATION

Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner

(2013) A Bononi et al.   CELL DEATH AND DIFFERENTIATION

RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation

(2013) James T Lee et al.   CELL RESEARCH

Loss of Pten promotes angiogenesis and enhanced vegfaa expression in zebrafish

(2013) S. Choorapoikayil et al.   Disease Models & Mechanisms

The multiple layers of non-genetic regulation of PTEN tumour suppressor activity

(2013) Nádia C. Correia et al.   EUROPEAN JOURNAL OF CANCER

High-expression of DJ-1 and Loss of PTEN Associated with Tumor Metastasis and Correlated with Poor Prognosis of Gastric Carcinoma

(2013) Yin Li et al.   International Journal of Medical Sciences

PIASxα Ligase Enhances SUMO1 Modification of PTEN Protein as a SUMO E3 Ligase

(2013) Weibin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pim kinases phosphorylate Chk1 and regulate its functions in acute myeloid leukemia

(2013) L L Yuan et al.   LEUKEMIA

BCR-ABL disrupts PTEN nuclear-cytoplasmic shuttling through phosphorylation-dependent activation of HAUSP

(2013) A Morotti et al.   LEUKEMIA

MC1R Is a Potent Regulator of PTEN after UV Exposure in Melanocytes

(2013) Juxiang Cao et al.   MOLECULAR CELL

Peripheral axon regrowth: New molecular approaches

(2013) K.J. Christie et al.   NEUROSCIENCE

Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium

(2013) H N Nguyen et al.   ONCOGENE

Acid Ceramidase Promotes Nuclear Export of PTEN through Sphingosine 1-Phosphate Mediated Akt Signaling

(2013) Thomas H. Beckham et al.   PLoS One

A Secreted PTEN Phosphatase That Enters Cells to Alter Signaling and Survival

(2013) B. D. Hopkins et al.   SCIENCE

Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress

(2013) C. Bassi et al.   SCIENCE

Epigenetic and genetic features of 24 colon cancer cell lines

(2013) D Ahmed et al.   Oncogenesis

PNUTS Functions as a Proto-Oncogene by Sequestering PTEN

(2012) S. Kavela et al.   CANCER RESEARCH

Pten Loss and RAS/MAPK Activation Cooperate to Promote EMT and Metastasis Initiated from Prostate Cancer Stem/Progenitor Cells

(2012) D. J. Mulholland et al.   CANCER RESEARCH

Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

(2012) Isabel Garcia-Cao et al.   CELL

Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity

(2012) Ana Ortega-Molina et al.   Cell Metabolism

Post-Translational Modifications of PTEN and their Potential Therapeutic Implications

(2012) G. Singh et al.   CURRENT CANCER DRUG TARGETS

The emerging contribution of sequence context to the specificity of protein interactions mediated by PDZ domains

(2012) Katja Luck et al.   FEBS LETTERS

Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia

(2012) Jason Howitt et al.   JOURNAL OF CELL BIOLOGY

Use of mutation profiles to refine the classification of endometrial carcinomas

(2012) Melissa K McConechy et al.   JOURNAL OF PATHOLOGY

Membrane association of the PTEN tumor suppressor: Electrostatic interaction with phosphatidylserine-containing bilayers and regulatory role of the C-terminal tail

(2012) Siddharth S. Shenoy et al.   JOURNAL OF STRUCTURAL BIOLOGY

Ordered Phosphorylation Events in Two Independent Cascades of the PTEN C-tail Revealed by NMR

(2012) Florence Cordier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nucleophosmin/B26 regulates PTEN through interaction with HAUSP in acute myeloid leukemia

(2012) N I Noguera et al.   LEUKEMIA

The functions and regulation of the PTEN tumour suppressor

(2012) Min Sup Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PTEN Protein Phosphatase Activity Correlates with Control of Gene Expression and Invasion, a Tumor-Suppressing Phenotype, But Not with AKT Activity

(2012) P. Tibarewal et al.   Science Signaling

Interference with the PTEN-MAST2 Interaction by a Viral Protein Leads to Cellular Relocalization of PTEN

(2012) E. Terrien et al.   Science Signaling

The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells

(2012) U. Putz et al.   Science Signaling

Loss and reduced expression of PTEN correlate with advanced-stage gastric carcinoma

(2012) XUEHUA ZHU et al.   Experimental and Therapeutic Medicine

PTEN Level in Tumor Suppression: How Much Is Too Little?

(2011) A. Carracedo et al.   CANCER RESEARCH

ΔNp63α regulates keratinocyte proliferation by controlling PTEN expression and localization

(2011) M K Leonard et al.   CELL DEATH AND DIFFERENTIATION

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

(2011) Zhihu Ding et al.   NATURE

A continuum model for tumour suppression

(2011) Alice H. Berger et al.   NATURE

WWP2 is an E3 ubiquitin ligase for PTEN

(2011) Subbareddy Maddika et al.   NATURE CELL BIOLOGY

Serum DNA can define tumor-specific genetic and epigenetic markers in gliomas of various grades

(2011) I. Lavon et al.   NEURO-ONCOLOGY

Interaction prediction and classification of PDZ domains

(2010) Sibel Kalyoncu et al.   BMC BIOINFORMATICS

PTEN Signaling pathways in glioblastoma

(2010) Dimpy Koul   CANCER BIOLOGY & THERAPY

PTEN regulates angiogenesis and VEGF expression through phosphatase-dependent and -independent mechanisms in HepG2 cells

(2010) Tao Tian et al.   CARCINOGENESIS

The ER UDPase ENTPD5 Promotes Protein N-Glycosylation, the Warburg Effect, and Proliferation in the PTEN Pathway

(2010) Min Fang et al.   CELL

Redox regulation of the tumor suppressor PTEN by glutathione

(2010) Yujeong Kim et al.   FEBS LETTERS

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

Subtle variations in Pten dose determine cancer susceptibility

(2010) Andrea Alimonti et al.   NATURE GENETICS

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMPK/TSC2/mTOR-signaling intermediates are not necessary for LKB1-mediated nuclear retention of PTEN tumor suppressor

(2010) J.-L. Liu et al.   NEURO-ONCOLOGY

Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

(2010) C Nogueira et al.   ONCOGENE

The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo

(2009) J. T. Huse et al.   GENES & DEVELOPMENT

X-linked Inhibitor of Apoptosis Protein (XIAP) Regulates PTEN Ubiquitination, Content, and Compartmentalization

(2009) Céline Van Themsche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis

(2009) Jennifer C King et al.   NATURE GENETICS

Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate

(2009) Brett S Carver et al.   NATURE GENETICS

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density

(2009) Wei Feng et al.   NATURE REVIEWS NEUROSCIENCE

Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN

(2009) L Davidson et al.   ONCOGENE

Identification, analysis, and prediction of protein ubiquitination sites

(2009) Predrag Radivojac et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Development of a novel GLUT4 translocation assay for identifying potential novel therapeutic targets for insulin sensitization

(2008) Franklin Liu et al.   BIOCHEMICAL JOURNAL

PTEN Phosphatase Selectively Binds Phosphoinositides and Undergoes Structural Changes†

(2008) Roberta E. Redfern et al.   BIOCHEMISTRY

Is PTEN loss associated with clinical outcome measures in human prostate cancer?

(2008) P McCall et al.   BRITISH JOURNAL OF CANCER

ATP modulates PTEN subcellular localization in multiple cancer cell lines

(2008) Glenn P. Lobo et al.   HUMAN MOLECULAR GENETICS

Oscillations and bistability in the stochastic model of p53 regulation

(2008) Krzysztof Puszyński et al.   JOURNAL OF THEORETICAL BIOLOGY

Absence of TMPRSS2:ERG fusions and PTEN losses in prostate cancer is associated with a favorable outcome

(2008) Maisa Yoshimoto et al.   MODERN PATHOLOGY

PTEN Nuclear Localization Is Regulated by Oxidative Stress and Mediates p53-Dependent Tumor Suppression

(2008) C.-J. Chang et al.   MOLECULAR AND CELLULAR BIOLOGY

The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network

(2008) Min Sup Song et al.   NATURE

Post-translational regulation of PTEN

(2008) X Wang et al.   ONCOGENE

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN

(2008) M. Rahdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA